CN1205940C - Erigeron breviscapus slow release capsule and its preparation method - Google Patents
Erigeron breviscapus slow release capsule and its preparation method Download PDFInfo
- Publication number
- CN1205940C CN1205940C CN 02129313 CN02129313A CN1205940C CN 1205940 C CN1205940 C CN 1205940C CN 02129313 CN02129313 CN 02129313 CN 02129313 A CN02129313 A CN 02129313A CN 1205940 C CN1205940 C CN 1205940C
- Authority
- CN
- China
- Prior art keywords
- polyvinylpyrrolidone
- ethyl cellulose
- breviscapine
- capsule
- piller
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention provides a breviscapine slow-release capsule and a preparation method thereof, which relates to a medicinal agent type of a Chinese medicine breviscapine slow-release capsule, and preparation process. The capsule comprises active component breviscapine, an empty pill core, adhesive by which breviscapine powder is attached to the empty pill core, and a coating layer for sealing the surface; the adhesive and the coating layer are composed of polyvinylpyrrolidone and ethyl cellulose, and each capsule comprises 60 mg of breviscapine. When the capsule is in the preparation, the empty pill core is put in a coating granulating machine, and breviscapine powder is added in; simultaneously, the adhesive is sprayed; a small pill with medicine is manufactured and is sealed on the surface; thereby, the slow-release capsule is manufactured. The present invention overcomes the defects of poor original agent type dissolution and short medicine function time; required effective blood medicine concentration is reached in the short time, and the required effective blood medicine concentration is kept in a long time. The present invention has the advantage of high biological availability, reduces daily taking dosage and frequency, is only taken twice per day for one granule, and is medicine for well keeping patients who have a coronary heart disease, angina pectoris, myocardial infarction, etc.
Description
Technical field
The present invention relates to a kind of breviscapine pharmaceutical dosage form, relate in particular to a kind of erigeron breviscapus slow release capsule and preparation method thereof, is the good medicament forms that is used for treatment for diseases such as paralysis due to windstroke, coronary heart disease, angina pectoris, prevention, belongs to the Chinese medicine technical field.
Background technology
The active component breviscapine is from Yunnan specialty medical material Erigeron breviscapus (Vant.) Hand.-Mazz. platymiscium Herba Erigerontis (Erigeronbreviscapusvaut in the capsule, Hand Mazz) extract in refining and, have expansion blood capillary, microcirculation improvement, blood viscosity lowering, inhibition platelet aggregation, promote fibrinolytic, anti-bolt thrombolytic, increase the perfused tissue amount, remove effects such as free radical, blood fat reducing, blood sugar lowering.Since the eighties, how tame plant produced such as Yunnan bio-pharmaceuticals factory, institute of materia medica, Yunnan, biological pharmaceutical factory, Geju City, Yunnan have Herba Erigerontis sheet and Herba Erigerontis tablet, and wherein effective ingredient is total flavones or lamp-dish flower acetic, and every indicates dosage is 20mg, the heavy 120mg of sheet.Take every day 4 times, each 2～3, the tablet of traditional handicraft preparation is insoluble in water, and dissolution is relatively poor, and bioavailability is low.
Summary of the invention
The objective of the invention is to propose a kind of novel Breviscapine slow release dosage form one erigeron breviscapus slow release capsule and preparation method thereof, the tablet that can overcome the traditional handicraft preparation is insoluble in water, and dissolution is relatively poor, the defective that bioavailability is low.
The present invention is achieved through the following technical solutions: a kind of erigeron breviscapus slow release capsule pharmaceutical dosage form, its implant comprises breviscapine, the celphere as active component and is used for the breviscapine powder is adhered to the binding agent on the celphere and the coatings of surface sealing usefulness, described binding agent and coatings are made up of polyvinylpyrrolidone and ethyl cellulose, wherein polyvinylpyrrolidone accounts for 12.5% of total implant weight, and ethyl cellulose accounts for 1% of total implant weight.
The present invention also provides the method for preparing above-mentioned erigeron breviscapus slow release capsule, and this method comprises following recipe step:
A.1000 grain is write out a prescription
Raw material: breviscapine 60g
Adjuvant: 25-30 purpose celphere 287g
Polyvinylpyrrolidone 50g
Ethyl cellulose 4g
95% ethanol is an amount of
B. by the prescription proportioning, utilize polyvinylpyrrolidone and ethyl cellulose to form binding agent, the breviscapine powder is adhered on the celphere, in the outer solution of forming with polyvinylpyrrolidone and ethyl cellulose of medicine carrying piller piller is sealed again, formation has the film controlled piller of slow release effect, loads in No. 0 capsule by labelled amount.
Preparation method provided by the present invention is carried out as follows:
(1) takes by weighing polyvinylpyrrolidone and ethyl cellulose in 1: 0.04～0.12 ratio, put into 95% alcoholic solution swelling, it is dissolved fully, make alcoholic solution, making wherein, the concentration of polyvinylpyrrolidone is 40-60mg/ml, the concentration of ethyl cellulose is 2-6mg/ml, and is standby as binding agent;
(2) taking by weighing the recipe quantity celphere puts in the coating pelletizing machine, regulate 120 ± 2 rev/mins of engine speeds, hydrojet speed 6～12ml/ branch, 20～35 ℃ of hot blast temperatures, 20～35 ℃ of pill control temperature, spout pressure 0.1～0.15 MPa, under these conditions, evenly add the breviscapine powder, the alcoholic solution that sprays into step (1) preparation simultaneously carries out bonding, sprayed until solution, made the pastille piller;
(3) piller is put into the coating pelletizing machine, regulate 120 ± 2 rev/mins of engine speeds, hydrojet speed 4～12ml/ branch, 25～45 ℃ of hot blast temperatures, 25～45 ℃ of pill control temperature, spout pressure 0.1～0.2 MPa, under these conditions, the mixed ethanol solution that sprays with polyvinylpyrrolidone and ethyl cellulose in pastille piller surface carries out the surface sealing, polyvinylpyrrolidone and ethyl cellulose are that recipe quantity deducts bonding consumption in the mixed ethanol solution of sealing usefulness, and wherein the concentration of polyvinylpyrrolidone is 40-60mg/ml, and the concentration of ethyl cellulose is 2-6mg/ml, sprayed until solution, promptly got the film-controlled slow-release piller;
(4) drying, sieve, adorn capsule, be erigeron breviscapus slow release capsule.
The erigeron breviscapus slow release capsule that is provided among the present invention can discharge with fast speed, and the dissolution that has overcome original dosage form is poor, the shortcoming that drug treating time is short, can reach required effective blood drug concentration in the short period of time, and can keep required blood drug level in a long time, the bioavailability height has improved the curative effect of medicine, reduced dose and number of times every day, and patient's taking convenience is easy to carry, and takes number of times and reduces, only need take twice, each 1 on 1st.It is patients' such as coronary heart disease, angina pectoris, myocardial infarction well maintained medicine; Method therefor of the present invention has whole advance at the design of Chinese medicine characteristics, and flow process is simple, makes slow releasing capsule and possesses the external feature of obvious slow release.
The gained capsule is respectively 10-25%, the 30-50% of labelled amount (it is 60mg that every capsules contains breviscapine) in the release of 1 hour, 2 hours, 4 hours and 7 hours, more than the 55-75% and 80%.
Drug release determination method: get erigeron breviscapus slow release capsule, according to dissolution determination one method (2000 editions two appendix XC I of Chinese Pharmacopoeia), (get potassium dihydrogen phosphate 68.05g with phosphate buffer, add water 9000ml dissolving, transfer pH=6.30 ± 0.05 with 10% sodium hydroxide, adding water to 10000ml) 900ml is solvent, 30 rev/mins of rotating speeds, operation in accordance with the law was through 1 hour, 2 hours, 4 hours and 7 hours, respectively get solution 4ml, filter, and additional simultaneously uniform temp, the phosphate buffer of equal volume is got subsequent filtrate as need testing solution, measures respectively according to following chromatographic condition; It is an amount of that other gets the scutellarin reference substance, adds the phosphate buffer dissolved dilution and become reference substance solution, contains 0.05mg scutellarin reference substance in every 1ml reference substance solution, measures with method.Calculate the release value of capsule by external standard method at each time point.
The drug release determination chromatographic condition: with octadecylsilane chemically bonded silica is filler; So that 0.05mol/L sodium dihydrogen phosphate (containing 0.01% triethylamine, is 4.3 with the phosphoric acid adjust pH)-acetonitrile (80: 20) is a mobile phase; Detect wavelength 335nm, flow velocity 1.00ml/min; Sample size 20 μ l; Column temperature: room temperature.
In the bioavailability test, the slow releasing capsule and the common marketed tablet that make with above-mentioned preparation method compare, and have tangible sustained releasing character and effect, referring to table 1 in vivo.
Table 1 erigeron breviscapus slow release capsule and Herba Erigerontis tablet pharmacokinetic parameter
Parameter erigeron breviscapus slow release capsule Herba Erigerontis tablet
K(h
-1) 0.13 0.27
K
a(h
-1) 0.33 1.39
T
1/2(h) 5.8 2.6
T
a1/2(h) 2.1 0.5
T
max(h) 4.8 1.6
C
max(μg/ml) 8.4 15.6
AUC(μg*h/ml) 109.1 85.5
Annotate: K: apparent elimination rate constant; K
a: apparent infiltration rate constant; T
1/2: eliminate the half-life; T
A1/2: absorb the half-life; T
Max: peak time; C
MaxPeak blood drug level; AUC: lower area of blood concentration-time curve.
The specific embodiment
Below by the specific embodiment that provides the present invention can be described clearly further, but not as a limitation of the invention.Polyvinylpyrrolidone and ethyl cellulose that the present invention is used are the commercial goods.
Embodiment one:
(1) take by weighing polyvinylpyrrolidone 25g and ethyl cellulose 2g (100: 8), put into 95% alcoholic solution swelling, jolting after the dissolving, is added 95% ethanol and is mixed with bonding with polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution 500ml fully.
(2) take by weighing polyvinylpyrrolidone 25g and ethyl cellulose 2g (100: 8), put into 95% alcoholic solution swelling, jolting after the dissolving, is added 95% ethanol and is mixed with sealing polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution 500ml fully.
(3) take by weighing the recipe quantity celphere and put in the coating pelletizing machine,, evenly add the breviscapine powder, spray simultaneously with bonding and sprayed until solution, make the pastille piller with polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution according to operating parameter table parameter.
(4) in identical coating pelletizing machine, according to operating parameter table parameter, with sealing polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution, sprayed until solution in the spray of pastille piller surface, promptly get breviscapine film-controlled slow-release piller.
After (5) 37 ℃ of dryings, sieve, adorn capsule, be erigeron breviscapus slow release capsule, every capsules contains breviscapine 60mg, the heavy 0.4g of capsule (± 0.04g).
The operating parameter table:
| Engine speed (rev/min) | Hydrojet speed (ml/ branch) | Hot blast temperature (℃) | Pill control temperature (℃) | Whiff pressure (MPa) | |
| Slurry | 120 | 9 | 25 | 20 | 0.1 |
| Confining liquid | 120 | 6 | 35 | 30 | 0.15 |
Embodiment two:
(1) take by weighing polyvinylpyrrolidone 25g and ethyl cellulose 1.5g (100: 6), put into 95% alcoholic solution swelling, jolting after the dissolving, is added 95% ethanol and is mixed with bonding with polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution 500ml fully.
(2) take by weighing polyvinylpyrrolidone 25g and ethyl cellulose 2.5g (100: 10), put into 95% alcoholic solution swelling, jolting after the dissolving, is added 95% ethanol and is mixed with sealing polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution 500ml fully.
(3) take by weighing the recipe quantity celphere and put in the coating pelletizing machine,, evenly add the breviscapine powder, spray simultaneously with bonding and sprayed until solution, make the pastille piller with polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution according to operating parameter table parameter.
(4) in identical coating pelletizing machine, according to operating parameter table parameter, with sealing polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution, sprayed until solution in the spray of pastille piller surface, promptly get breviscapine film-controlled slow-release piller.
After (5) 37 ℃ of dryings, sieve, adorn capsule, be erigeron breviscapus slow release capsule, every capsules contains breviscapine 60mg, the heavy 0.4g of capsule (± 0.04g).
The operating parameter table:
| Engine speed (rev/min) | Hydrojet speed (ml/ branch) | Hot blast temperature (℃) | Pill control temperature (℃) | Whiff pressure (MPa) | |
| Slurry | 120 | 6 | 25 | 20 | 0.15 |
| Confining liquid | 120 | 4 | 30 | 25 | 0.15 |
Embodiment three:
(1) take by weighing polyvinylpyrrolidone 25g and ethyl cellulose 1g (100: 4), put into 95% alcoholic solution swelling, jolting after the dissolving, is added 95% ethanol and is mixed with bonding with polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution 500ml fully.
(2) take by weighing polyvinylpyrrolidone 25g and ethyl cellulose 3g (100: 12), put into 95% alcoholic solution swelling, jolting after the dissolving, is added 95% ethanol and is mixed with sealing polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution 500ml fully.
(3) take by weighing the recipe quantity celphere and put in the coating pelletizing machine,, evenly add the breviscapine powder, spray simultaneously with bonding and sprayed until solution, make the pastille piller with polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution according to operating parameter table parameter.
(4) in identical coating pelletizing machine, according to operating parameter table parameter, with sealing polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution, sprayed until solution in the spray of pastille piller surface, promptly get breviscapine film-controlled slow-release piller.
After (5) 37 ℃ of dryings, sieve, adorn capsule, be erigeron breviscapus slow release capsule, every capsules contains breviscapine 60mg, the heavy 0.4g of capsule (± 0.04g).
The operating parameter table:
| Engine speed (rev/min) | Hydrojet speed (ml/ branch) | Hot blast temperature (℃) | Pill control temperature (℃) | Whiff pressure (MPa) | |
| Slurry | 120 | 8 | 30 | 30 | 0.1 |
| Confining liquid | 120 | 8 | 30 | 30 | 0.1 |
Embodiment four:
(1) take by weighing polyvinylpyrrolidone 25g and ethyl cellulose 2.5g (100: 10), put into 95% alcoholic solution swelling, jolting after the dissolving, is added 95% ethanol and is mixed with bonding with polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution 500ml fully.
(2) take by weighing polyvinylpyrrolidone 25g and ethyl cellulose 1.5g (100: 6), put into 95% alcoholic solution swelling, jolting after the dissolving, is added 95% ethanol and is mixed with sealing polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution 500ml fully.
(3) take by weighing the recipe quantity celphere and put in the coating pelletizing machine,, evenly add the breviscapine powder, spray simultaneously with bonding and sprayed until solution, make the pastille piller with polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution according to operating parameter table parameter.
(4) in identical coating pelletizing machine, according to operating parameter table parameter, with sealing polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution, sprayed until solution in the spray of pastille piller surface, promptly get breviscapine film-controlled slow-release piller.
After (5) 37 ℃ of dryings, sieve, adorn capsule, be erigeron breviscapus slow release capsule, every capsules contains breviscapine 60mg, the heavy 0.4g of capsule (± 0.04g).
The operating parameter table:
| Engine speed (rev/min) | Hydrojet speed (ml/ branch) | Hot blast temperature (℃) | Pill control temperature (℃) | Whiff pressure (MPa) | |
| Slurry | 120 | 12 | 25 | 25 | 0.12 |
| Confining liquid | 120 | 6 | 40 | 40 | 0.12 |
Embodiment five:
(1) take by weighing polyvinylpyrrolidone 25g and ethyl cellulose 3g (100: 12), put into 95% alcoholic solution swelling, jolting after the dissolving, is added 95% ethanol and is mixed with bonding with polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution 500ml fully.
(2) take by weighing polyvinylpyrrolidone 25g and ethyl cellulose 1g (100: 4), put into 95% alcoholic solution swelling, jolting after the dissolving, is added 95% ethanol and is mixed with sealing polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution 500ml fully.
(3) take by weighing the recipe quantity celphere and put in the coating pelletizing machine,, evenly add the breviscapine powder, spray simultaneously with bonding and sprayed until solution, make the pastille piller with polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution according to operating parameter table parameter.
(4) in identical coating pelletizing machine, according to operating parameter table parameter, with sealing polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution, sprayed until solution in the spray of pastille piller surface, promptly get breviscapine film-controlled slow-release piller.
After (5) 37 ℃ of dryings, sieve, adorn capsule, be erigeron breviscapus slow release capsule, every capsules contains breviscapine 60mg, the heavy 0.4g of capsule (± 0.04g).
The operating parameter table:
| Engine speed (rev/min) | Hydrojet speed (ml/ branch) | Hot blast temperature (℃) | Pill control temperature (℃) | Whiff pressure (MPa) | |
| Slurry | 120 | 10 | 35 | 35 | 0.15 |
| Confining liquid | 120 | 10 | 45 | 40 | 0.2 |
Embodiment six:
(1) take by weighing polyvinylpyrrolidone 20g and ethyl cellulose 2g (100: 10), put into 95% alcoholic solution swelling, jolting after the dissolving, is added 95% ethanol and is mixed with bonding with polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution 500ml fully.
(2) take by weighing polyvinylpyrrolidone 30g and ethyl cellulose 2g (100: 6.7), put into 95% alcoholic solution swelling, jolting after the dissolving, is added 95% ethanol and is mixed with sealing polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution 500ml fully.
(3) take by weighing the recipe quantity celphere and put in the coating pelletizing machine,, evenly add the breviscapine powder, spray simultaneously with bonding and sprayed until solution, make the pastille piller with polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution according to operating parameter table parameter.
(4) in identical coating pelletizing machine, according to operating parameter table parameter, with sealing polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution, sprayed until solution in the spray of pastille piller surface, promptly get breviscapine film-controlled slow-release piller.
After (5) 37 ℃ of dryings, sieve, adorn capsule, be erigeron breviscapus slow release capsule, every capsules contains breviscapine 60mg, the heavy 0.4g of capsule (± 0.04g).
The operating parameter table:
| Engine speed (rev/min) | Hydrojet speed (ml/ branch) | Hot blast temperature (℃) | Pill control temperature (℃) | Whiff pressure (MPa) | |
| Slurry | 120 | 12 | 23 | 20 | 0.15 |
| Confining liquid | 120 | 8 | 45 | 40 | 0.15 |
Embodiment seven:
(1) take by weighing polyvinylpyrrolidone 30g and ethyl cellulose 2g (100: 6.7), put into 95% alcoholic solution swelling, jolting after the dissolving, is added 95% ethanol and is mixed with bonding with polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution 500ml fully.
(2) take by weighing polyvinylpyrrolidone 20g and ethyl cellulose 2g (100: 10), put into 95% alcoholic solution swelling, jolting after the dissolving, is added 95% ethanol and is mixed with sealing polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution 500ml fully.
(3) take by weighing the recipe quantity celphere and put in the coating pelletizing machine,, evenly add the breviscapine powder, spray simultaneously with bonding and sprayed until solution, make the pastille piller with polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution according to operating parameter table parameter.
(4) in identical coating pelletizing machine, according to operating parameter table parameter, with sealing polyvinylpyrrolidone and ethyl cellulose mixed ethanol solution, sprayed until solution in the spray of pastille piller surface, promptly get breviscapine film-controlled slow-release piller.
After (5) 37 ℃ of dryings, sieve, adorn capsule, be erigeron breviscapus slow release capsule, every capsules contains breviscapine 60mg, the heavy 0.4g of capsule (± 0.04g).
The operating parameter table:
| Engine speed (rev/min) | Hydrojet speed (ml/ branch) | Hot blast temperature (℃) | Pill control temperature (℃) | Whiff pressure (MPa) | |
| Slurry | 120 | 10 | 25 | 20 | 0.1 |
| Confining liquid | 120 | 10 | 30 | 25 | 0.2 |
Claims (3)
1. erigeron breviscapus slow release capsule pharmaceutical dosage form, it is characterized in that: its implant comprises breviscapine, the celphere as active component and is used for the breviscapine powder is adhered to the binding agent on the celphere and the coatings of surface sealing usefulness, described binding agent and coatings are made up of polyvinylpyrrolidone and ethyl cellulose, wherein polyvinylpyrrolidone accounts for 12.5% of total implant weight, and ethyl cellulose accounts for 1% of total implant weight.
2. implement the preparation method of erigeron breviscapus slow release capsule according to claim 1, this method comprises following prescription and step:
A.1000 grain is write out a prescription
Raw material: breviscapine 60g
Adjuvant: 25-30 purpose celphere 287g
Polyvinylpyrrolidone 50g
Ethyl cellulose 4g
95% ethanol is an amount of;
B. by the prescription proportioning, utilize polyvinylpyrrolidone and ethyl cellulose to form binding agent, the breviscapine powder is adhered on the celphere, in the outer solution of forming with polyvinylpyrrolidone and ethyl cellulose of medicine carrying piller piller is sealed again, formation has the film controlled piller of slow release effect, loads in No. 0 capsule by labelled amount.
3. according to the described preparation method of claim 2, this method is carried out as follows:
(1) takes by weighing polyvinylpyrrolidone and ethyl cellulose in 1: 0.04～0.12 ratio, put into 95% alcoholic solution swelling, it is dissolved fully, make alcoholic solution, making wherein, the concentration of polyvinylpyrrolidone is 40-60mg/ml, the concentration of ethyl cellulose is 2-6mg/ml, and is standby as binding agent;
(2) taking by weighing the recipe quantity celphere puts in the coating pelletizing machine, regulate 120 ± 2 rev/mins of engine speeds, hydrojet speed 6～12ml/ branch, 20～35 ℃ of hot blast temperatures, 20～35 ℃ of pill control temperature, spout pressure 0.1～0.15 MPa, under these conditions, evenly add the breviscapine powder, the alcoholic solution that sprays into step (1) preparation simultaneously carries out bonding, sprayed until solution, made the pastille piller;
(3) the pastille piller is put into the coating pelletizing machine, regulate 120 ± 2 rev/mins of engine speeds, hydrojet speed 4～12ml/ branch, 25～45 ℃ of hot blast temperatures, 25～45 ℃ of pill control temperature, spout pressure 0.1～0.2 MPa, under these conditions, the mixed ethanol solution that sprays with polyvinylpyrrolidone and ethyl cellulose in pastille piller surface carries out the surface sealing, polyvinylpyrrolidone and ethyl cellulose are that recipe quantity deducts bonding consumption in the mixed ethanol solution of sealing usefulness, and wherein the concentration of polyvinylpyrrolidone is 40-60mg/ml, and the concentration of ethyl cellulose is 2-6mg/ml, sprayed until solution, promptly got the film-controlled slow-release piller;
(4) drying, sieve, adorn capsule, be erigeron breviscapus slow release capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02129313 CN1205940C (en) | 2002-08-30 | 2002-08-30 | Erigeron breviscapus slow release capsule and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02129313 CN1205940C (en) | 2002-08-30 | 2002-08-30 | Erigeron breviscapus slow release capsule and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1478480A CN1478480A (en) | 2004-03-03 |
| CN1205940C true CN1205940C (en) | 2005-06-15 |
Family
ID=34144106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02129313 Expired - Fee Related CN1205940C (en) | 2002-08-30 | 2002-08-30 | Erigeron breviscapus slow release capsule and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1205940C (en) |
-
2002
- 2002-08-30 CN CN 02129313 patent/CN1205940C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1478480A (en) | 2004-03-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8962017B2 (en) | Formulation of silymarin with high efficacy and prolonged action and the preparation method thereof | |
| US9023388B2 (en) | Formulation of silibinin with high efficacy and prolonged action and the preparation method thereof | |
| CN1171623C (en) | Prepn of medicine for treating hepatosis | |
| CN1225464C (en) | Extraction technology of Hanbaicalein, medicinal composition and preparation technology of medicine | |
| CN1205940C (en) | Erigeron breviscapus slow release capsule and its preparation method | |
| CN101032462A (en) | Mexiletine Hydrochloride slow release reagent and preparing method thereof | |
| CN1301098C (en) | Hairy holly root drip pill and its preparation method | |
| CN100335064C (en) | Pueraria flavone micro pill prepn and its prepn process | |
| CN105412039A (en) | Frovatriptan succinate controlled-release tablet and preparation method thereof | |
| CN102351722A (en) | L-carnitine compound and composite thereof | |
| CN1919197A (en) | Slow release drop pills comprising toraesmide active ingredient and method for preparing same | |
| CN1660372A (en) | Oral drop pill in use for clearing sway heat and toxic material, relieving inflammation and dysentery, and preparation method | |
| CN1939301A (en) | Slow-releasing preparation containing Vitamin E niacin ester and its making method | |
| CN1307981C (en) | Xuening dripping pill having hemostatic function and its preparing method | |
| CN1256082C (en) | Slow-released preparation | |
| CN1274295C (en) | Method for preparing oral slow/coutrolled release medicinal micro granule | |
| CN1175812C (en) | Slow-released indapamide capsule and its prepn process | |
| CN1593584A (en) | Novel formulation of 'Xiaoyan Lidan' and its preparation method | |
| CN1164265C (en) | Release controlled tuoteluoding tartrate and its preparing process | |
| CN1660267A (en) | 'Yankening' pharmaceutical preparation and preparing method | |
| CN1634104A (en) | Sustained release mini pills of breviscapine and its preparing process | |
| CN1823876A (en) | Persimmon leaf extract controlled slow-release preparation and its preparation method | |
| CN1228044C (en) | Water-soluble medicine particle-type slow-release composition, preparation and its preparing method | |
| CN1768740A (en) | Medicinal composition containing carthamin yellow and its preparation process and usage | |
| CN112022823A (en) | Metformin hydrochloride and glimepiride sustained-release tablet and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |