CN1593584A - Novel formulation of 'Xiaoyan Lidan' and its preparation method - Google Patents
Novel formulation of 'Xiaoyan Lidan' and its preparation method Download PDFInfo
- Publication number
- CN1593584A CN1593584A CN 200410041023 CN200410041023A CN1593584A CN 1593584 A CN1593584 A CN 1593584A CN 200410041023 CN200410041023 CN 200410041023 CN 200410041023 A CN200410041023 A CN 200410041023A CN 1593584 A CN1593584 A CN 1593584A
- Authority
- CN
- China
- Prior art keywords
- ramulus
- extractum
- herba
- folium picrasmae
- herba andrographis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a novel formulation of 'Xiaoyan Lidan' and its preparation method, which is the medicinal composition comprising green chiretta, Rabdosia serrr, and quassiawood extraction concrete as the principal ingredients. Compared with the existing dosage forms, the drop pill preparation has the advantages of quick-effectiveness, high biological availability, and good taste.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind ofly comprise Herba Andrographis, Herba Rabdosiae Lophanthoidis, Ramulus Et Folium Picrasmae to extract extractum be novel form of Main Ingredients and Appearance and preparation method thereof.
Background technology
Rise the seventies, extracting extractum with Herba Andrographis, Herba Rabdosiae Lophanthoidis, Ramulus Et Folium Picrasmae is that the anti-inflammatory and choleretic oral formulations of Main Ingredients and Appearance just is applied to clinical, XIAOYAN LIDAN PIAN at present commonly used is exactly to be the compound preparation that raw material is made with Herba Andrographis, Herba Rabdosiae Lophanthoidis, Ramulus Et Folium Picrasmae, effect with heat clearing away, damp eliminating function of gallbladder promoting, be used for bitter taste, costalgia that dampness-heat in the liver and gallbladder causes clinically, and be used for the treatment of diseases such as acute cholecystitis, biliary tract inflammation, be the Chinese medicine compound preparation of treatment biliary tract, gallbladder disease.XIAOYAN LIDAN PIAN is the kind that Chinese Pharmacopoeia nineteen ninety-five version enlarged edition in 1997 records, and Herba Andrographis is monarch drug in the side.The anti-inflammatory and choleretic oral formulations is many clinically at present, but preparation type tradition relatively, such as XIAOYAN LIDAN PIAN, Xiaoyanlidan capsules etc., conventional formulation is long because of disintegration time, absorb slow, the performance of problems affect curative effect such as bioavailability is low.How to overcome these shortcomings, make the medicine quick acting become the problem of people's active research, drop pill is a kind of spheric pill that utilizes the solid dispersion technology system of dripping to form, it utilizes water-solubility carrier to improve the dissolubility and the dissolution rate of medicine, improve the infiltration rate and the absorbtivity of medicine, thereby improves bioavailability of medicament and improve the curative effect of medicine, but the composition between medicine active ingredient and the adjuvant then is the factor that influences drop pill that the present invention forms just on this basis.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, provide a kind of rapid-action, oral anti-inflammatory and choleretic novel form that bioavailability is high and preparation method thereof, preferred dropping pill formulation.
Anti-inflammatory and choleretic pharmaceutical composition of the present invention is that to extract extractum with Herba Andrographis, Herba Rabdosiae Lophanthoidis, Ramulus Et Folium Picrasmae be Main Ingredients and Appearance, is pharmaceutic adjuvant with Polyethylene Glycol or poloxamer or its mixture.
The weight ratio that feeds intake of the Herba Andrographis of raw material described in the present invention, Herba Rabdosiae Lophanthoidis, Ramulus Et Folium Picrasmae is 1: 1: 1.
In the present invention, described Herba Andrographis, Herba Rabdosiae Lophanthoidis, Ramulus Et Folium Picrasmae extraction extractum are following extracting method:
Herba Andrographis, Ramulus Et Folium Picrasmae extract the extractum preparation: gets the ethanol heating extraction that Herba Andrographis, Ramulus Et Folium Picrasmae add 6 times of amount 80%-85%, extracts 2 times, and each two hours, filter, reclaim purely, being concentrated into relative density is the extractum of 1.10 (80 ℃ of surveys).
Herba Rabdosiae Lophanthoidis extracts the preparation of extractum: get the water extraction 2 times that Herba Rabdosiae Lophanthoidis adds 8 times of amounts, and each 2 hours, concentrate, add 5 times of amounts of 70% ethanol, placed 24 hours, filter, reclaim purely, be concentrated into relative density and be 1.20 extractum.
Described in the present invention Herba Andrographis, Ramulus Et Folium Picrasmae extract the following method that is prepared as of extractum Benexate Hydrochloride:
The beta-schardinger dextrin-of getting Ramulus Et Folium Picrasmae crude drug weight 10%-100% joins Herba Andrographis, Ramulus Et Folium Picrasmae extracts in the extractum, mills 20 minutes with colloid mill, takes out, and oven dry is pulverized.
Prior art has been instructed the method for preparing drop pills of many active ingredients, but the inventor finds in pilot study: except water-insoluble substrate significant discomfort is used to prepare the anti-inflammatory and choleretic drop pill, after conventional employing raw material adds appropriate solvent (ethanol equal solvent) and water-soluble base (for example polyethylene glycol 6000), find in the process of the anti-inflammatory and choleretic drop pill of preparation: the two mixing is inhomogeneous, cause drop pill surface piebaldism, the drop pill roundness is poor, in dissolution test, dissolution time is elongated, this shows that the preparation of anti-inflammatory and choleretic drop pill and physicochemical property thereof are difficult to expect, disagree with traditional theory.
The inventor determines to adopt following substrate to prepare the anti-inflammatory and choleretic drop pill: poloxamer, PEG400, Macrogol 4000, polyethylene glycol 6000, cetomacrogol 1000 0 or its mixed system.In a technical scheme, when adopting single adjuvant, be preferably polyethylene glycol 6000; In another technical scheme, when adopting the adjuvant of two or more form of mixtures, its ratio is: PEG400: poloxamer: PEG4000: PEG6000: PEG10000=(0-1): (0-1): (0-1): (0-1): (0-1), in the time must adopting two or more adjuvant mixed system, be preferably PEG400: poloxamer: PEG4000: PEG6000: PEG10000=0-0.2: 0-0.5: 0-1: 0-1: 0-0.1.
The principal agent that drop pill adopted can extract extractum and Herba Rabdosiae Lophanthoidis extraction extractum for Herba Andrographis, Ramulus Et Folium Picrasmae; The Benexate Hydrochloride and the Herba Rabdosiae Lophanthoidis that also can adopt Herba Andrographis, Ramulus Et Folium Picrasmae to extract extractum extract extractum.The advantage that adopts Herba Andrographis, Ramulus Et Folium Picrasmae to extract the Benexate Hydrochloride of extractum makes its mouthfeel good after being that it carries out enclose to taste extremely bitter Ramulus Et Folium Picrasmae, Herba Andrographis extract, be easy to the patient and take, can mouthful in buccal.
After drop pill is finished, can adopt plain ball directly to use; Or adopted film-coated technique that plain ball is carried out coating, can effectively cover the bitterness of medicine and prevent the moist and drop pill moisture absorption that cause of drawing of principal agent, the dissolve accretions phenomenon, guarantee drop pill in preservation not dried ball, split ball, also guarantee the stability of drop pill in the middle of storing.Described coating material comprises for example conventional coating material or Opadry coating material.
In addition, in the drop pill of the present invention exemplary compositions and preparation process parameter thereof select such as following table example:
The scope of project preferable range
PEG400 0-1 0-0.2
Poloxamer 0-0.5 0-0.3
Macrogol 4000 0-1 0-1
Polyethylene glycol 6000 0-1 0-1
Cetomacrogol 1000 0 0-1 0-0.1
Principal agent-substrate ratio 1: 1.0-5.5 1: 2.5-3.5
Change 70-100 ℃ 85-95 ℃ of material temperature
Drip 70-100 ℃ 80-95 ℃ of system temperature
Cooling medium liquid paraffin, dimethicone, Semen sojae atricolor-
Oil
Liquid paraffin 5-12 ℃, silicone oil
Condensate temperature 5-20 ℃ 6-18 ℃
Soybean oil 5-15 ℃
Water dropper to condensed fluid apart from 0-60cm 25-45cm
Coating solution concentration 8-20% 12-15%
Coating weightening finish 1-8% 2-6%
Anti-inflammatory and choleretic drop pill smooth surface of the present invention, hardness is suitable and roundness good, and particle diameter can be 2-5mm, is suitable for easily, without any the administration of uncomfortable ground.
Following table is the comparing data of anti-inflammatory and choleretic drop pill and marketed tablet.
Project drop pill tablet
The molten diffusing time (minute) 5.0 25-35
5 minutes dissolution 75% above 5-20%
Measuring the dissolution method is: change the basket method, dissolution medium is a 500ml water, 37 ℃ of temperature, and rotating speed is 100r/min, calculates with total andrographolides.
Following examples are intended to further specify, and the scope of the invention are not limited.
Embodiment 1
Drop pill (plain ball 1)
Prescription is formed consumption
Herba Andrographis, the hardship of recipe quantity (crude drug 1: 1: 1)
10g
Wood extracts extractum and Herba Rabdosiae Lophanthoidis extracts extractum
Polyethylene glycol 6000 30g
Preparation process: in putting of 30g polyethylene glycol 6000 batch can, changing the batch can temperature is 90 ℃, makes its fusion, stirs, the Herba Andrographis, the Ramulus Et Folium Picrasmae that add 10g recipe quantity (crude drug Herba Andrographis, Ramulus Et Folium Picrasmae, Herba Rabdosiae Lophanthoidis 1: 1: 1) extract extractum and Herba Rabdosiae Lophanthoidis extraction extractum, stir; With the preheating of drop pill machine, it is 95 ℃ that the fluid storage compartment temperature is promptly dripped system temperature constant temperature, and cooling medium adopts liquid paraffin, and being chilled to temperature in advance is 8 ℃, regulate water dropper to condensed fluid apart from 25cm.Pour medicinal liquid into fluid storage compartment, start valve, medicinal liquid is splashed into to condensed fluid,, absorb surface condensation liquid, promptly in collecting a mouthful collection drop pill.
Embodiment 2
Drop pill (plain ball 2)
Prescription is formed consumption
Herba Andrographis, the hardship of recipe quantity (crude drug 1: 1: 1)
10g
Wood extracts extractum and Herba Rabdosiae Lophanthoidis extracts extractum
Poloxamer 5g
Polyethylene glycol 6000 20g
Preparation process: in 20g polyethylene glycol 6000, putting of 5g poloxamer batch can, changing the batch can temperature is 85 ℃, make its fusion, stir, the Herba Andrographis, the Ramulus Et Folium Picrasmae that add 10g recipe quantity (crude drug Herba Andrographis, Ramulus Et Folium Picrasmae, Herba Rabdosiae Lophanthoidis 1: 1: 1) extract extractum and Herba Rabdosiae Lophanthoidis extraction extractum, stir; With the preheating of drop pill machine, it is 90 ℃ that the fluid storage compartment temperature is promptly dripped system temperature constant temperature, and cooling medium adopts soybean oil, and being chilled to temperature in advance is 6 ℃, regulate water dropper to condensed fluid apart from 30cm.Pour medicinal liquid into fluid storage compartment, start valve, medicinal liquid is splashed into to condensed fluid,, absorb surface condensation liquid, promptly in collecting a mouthful collection drop pill.
Embodiment 3
Drop pill (plain ball 3)
Prescription is formed consumption
The Herba Andrographis of recipe quantity (crude drug 1: 1: 1), Ramulus Et Folium Picrasmae extract extractum
15g
Benexate Hydrochloride and Herba Rabdosiae Lophanthoidis extract extractum
PEG400 2g
Macrogol 4000 40g
Preparation process: in 2g PEG400, putting of 40g Macrogol 4000 batch can, changing the batch can temperature is 80 ℃, make its fusion, stir, the Herba Andrographis, the Ramulus Et Folium Picrasmae that add 15g recipe quantity (crude drug Herba Andrographis, Ramulus Et Folium Picrasmae, Herba Rabdosiae Lophanthoidis 1: 1: 1) extract extractum Benexate Hydrochloride and Herba Rabdosiae Lophanthoidis extraction extractum, stir; With the preheating of drop pill machine, it is 85 ℃ that the fluid storage compartment temperature is promptly dripped system temperature constant temperature, and cooling medium adopts liquid paraffin, and being chilled to temperature in advance is 8 ℃, regulate water dropper to condensed fluid apart from 30cm.Pour medicinal liquid into fluid storage compartment, start valve, medicinal liquid is splashed into to condensed fluid,, absorb surface condensation liquid, promptly in collecting a mouthful collection drop pill.
Embodiment 4
Drop pill (plain ball 4)
Prescription is formed consumption
The Herba Andrographis of recipe quantity (crude drug 1: 1: 1), Ramulus Et Folium Picrasmae extract extractum
15g
Benexate Hydrochloride and Herba Rabdosiae Lophanthoidis extract extractum
PEG400 2g
Macrogol 4000 20g
Polyethylene glycol 6000 10g
Preparation process: in 2g PEG400,20g Macrogol 4000,10 putting of gram polyethylene glycol 6000 batch cans, changing the batch can temperature is 95 ℃, make its fusion, stir, the Herba Andrographis, the Ramulus Et Folium Picrasmae that add 15g recipe quantity (crude drug Herba Andrographis, Ramulus Et Folium Picrasmae, Herba Rabdosiae Lophanthoidis 1: 1: 1) extract extractum and Herba Rabdosiae Lophanthoidis Benexate Hydrochloride extraction extractum, stir; With the preheating of drop pill machine, it is 95 ℃ that the fluid storage compartment temperature is promptly dripped system temperature constant temperature, and cooling medium adopts silicone oil, and being chilled to temperature in advance is 10 ℃, regulate water dropper to condensed fluid apart from 25cm.Pour medicinal liquid into fluid storage compartment, start valve, medicinal liquid is splashed into to condensed fluid,, absorb surface condensation liquid, promptly in collecting a mouthful collection drop pill.
Embodiment 5
Drop pill (plain ball 5)
Prescription is formed consumption
The Herba Andrographis of recipe quantity (crude drug 1: 1: 1), Ramulus Et Folium Picrasmae extract extractum
10g
Extract extractum with Herba Rabdosiae Lophanthoidis
PEG400 2g
Macrogol 4000 20g
Cetomacrogol 1000 0 2g
Preparation process: in 2g PEG400,20g Macrogol 4000,2 gram cetomacrogol 1000s, 0 putting batch can, changing the batch can temperature is 95 ℃, make its fusion, stir, the Herba Andrographis, the Ramulus Et Folium Picrasmae that add 10g recipe quantity (crude drug Herba Andrographis, Ramulus Et Folium Picrasmae, Herba Rabdosiae Lophanthoidis 1: 1: 1) extract extractum and Herba Rabdosiae Lophanthoidis extraction extractum, stir; With the preheating of drop pill machine, it is 95 ℃ that the fluid storage compartment temperature is promptly dripped system temperature constant temperature, and cooling medium adopts liquid paraffin, and being chilled to temperature in advance is 12 ℃, regulate water dropper to condensed fluid apart from 35cm.Pour medicinal liquid into fluid storage compartment, start valve, medicinal liquid is splashed into to condensed fluid,, absorb surface condensation liquid, promptly in collecting a mouthful collection drop pill.
Embodiment 6
Drop pill (plain ball 6)
Prescription is formed consumption
The Herba Andrographis of recipe quantity (crude drug 1: 1: 1), Ramulus Et Folium Picrasmae extract extractum
15g
Benexate Hydrochloride and Herba Rabdosiae Lophanthoidis extract extractum
Poloxamer 10g
Polyethylene glycol 6000 20g
Preparation process: in 10g poloxamer, putting of 20g polyethylene glycol 6000 batch can, changing the batch can temperature is 90 ℃, make its fusion, stir, the Herba Andrographis, the Ramulus Et Folium Picrasmae that add 15g recipe quantity (crude drug Herba Andrographis, Ramulus Et Folium Picrasmae, Herba Rabdosiae Lophanthoidis 1: 1: 1) extract extractum Benexate Hydrochloride and Herba Rabdosiae Lophanthoidis extraction extractum, stir; With the preheating of drop pill machine, it is 90 ℃ that the fluid storage compartment temperature is promptly dripped system temperature constant temperature, and cooling medium adopts soybean oil, and being chilled to temperature in advance is 10 ℃, regulate water dropper to condensed fluid apart from 25cm.Pour medicinal liquid into fluid storage compartment, start valve, medicinal liquid is splashed into to condensed fluid,, absorb surface condensation liquid, promptly in collecting a mouthful collection drop pill.
Embodiment 7
Coated drop pill
Preparation process:
1). get the plain ball of embodiment 1 gained, carry out following operation.
2). drop pill adopts Opardry II coating materials, presses the conventional preparation of Opardry II coating materials coating solution, carries out coating.Full water is solvent, coating solution solid content 15%.Inlet temperature is 85 ℃, and the sheet bed tempertaure is 35-38 ℃, and atomizing pressure is 1.5bar, and the coating pan rotating speed is 15-23 rev/min, charging flow velocity 3-4g/min.Product clothing film-strength is good, and adhesive force is better, uniform coloring.
Claims (10)
1. anti-inflammatory and choleretic pharmaceutical composition is characterized in that extracting extractum with Herba Andrographis, Herba Rabdosiae Lophanthoidis, Ramulus Et Folium Picrasmae is Main Ingredients and Appearance, is pharmaceutic adjuvant with Polyethylene Glycol or poloxamer or its mixture.
2. pharmaceutical composition according to claim 1, wherein Herba Andrographis, Ramulus Et Folium Picrasmae extract the Benexate Hydrochloride that extractum is Herba Andrographis, Ramulus Et Folium Picrasmae extraction extractum.
3. according to the compositions of claim 1, wherein said pharmaceutic adjuvant is selected from PEG400, Macrogol 4000, polyethylene glycol 6000, cetomacrogol 1000 0, poloxamer or their mixture.
4. compositions according to claim 3, pharmaceutic adjuvant are selected from and are polyethylene glycol 6000, Macrogol 4000 or their mixture.
5. compositions according to claim 4, pharmaceutic adjuvant are polyethylene glycol 6000.
6. compositions according to claim 1 is wherein saidly extracted Main Ingredients and Appearance that extractum forms and the weight ratio of adjuvant is 1: 1.0-5.5 by Herba Andrographis, Herba Rabdosiae Lophanthoidis, Ramulus Et Folium Picrasmae.
7. compositions according to claim 6 is wherein saidly extracted Main Ingredients and Appearance that extractum forms and the weight ratio of adjuvant is 1: 2.5-3.5 by Herba Andrographis, Herba Rabdosiae Lophanthoidis, Ramulus Et Folium Picrasmae.
8. compositions according to claim 1, the weight ratio that wherein said Herba Andrographis, Herba Rabdosiae Lophanthoidis, Ramulus Et Folium Picrasmae extract its crude drug of extractum is 1: 1: 1.
9. according to each described compositions among the claim 1-8, it is characterized in that this pharmaceutical preparation is drop pill.
10. each described preparation of compositions method among the claim 1-9 is followed successively by the following step:
(1) by the weight proportion of each component, with heating in poloxamer, putting of the Polyethylene Glycol batch can, make its fusion, stir, add Herba Andrographis, Ramulus Et Folium Picrasmae extraction extractum or the Herba Andrographis of recipe quantity, Benexate Hydrochloride and the Herba Rabdosiae Lophanthoidis extraction extractum that Ramulus Et Folium Picrasmae extracts extractum, stir;
(2) with the preheating of drop pill machine, fluid storage compartment temperature constant temperature is fluid temperature, and selecting cooling medium is liquid paraffin or silicone oil or soybean oil, and being chilled to temperature in advance is 5-20 ℃.
(3) pour medicinal liquid into fluid storage compartment, start valve, medicinal liquid is splashed into to condensed fluid,, absorb surface condensation liquid, promptly get plain ball in collecting a mouthful collection drop pill.
(4) plain ball is adopted conventional coating material or Opadry coating material carry out coating, get coated drop pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100410233A CN100488528C (en) | 2004-06-18 | 2004-06-18 | Inflammation-diminishing gallbladder-benefiting dripping pills and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100410233A CN100488528C (en) | 2004-06-18 | 2004-06-18 | Inflammation-diminishing gallbladder-benefiting dripping pills and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1593584A true CN1593584A (en) | 2005-03-16 |
| CN100488528C CN100488528C (en) | 2009-05-20 |
Family
ID=34664840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100410233A Expired - Fee Related CN100488528C (en) | 2004-06-18 | 2004-06-18 | Inflammation-diminishing gallbladder-benefiting dripping pills and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100488528C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100427066C (en) * | 2005-07-28 | 2008-10-22 | 叶耀良 | Pharmaceutical preparation with functions of clearing heat, removing dampness and benefiting gallbladder |
| CN101612193B (en) * | 2009-07-17 | 2012-02-22 | 吉林紫鑫药业股份有限公司 | Medicine composition used for treating cholecystitis and cholangitis |
| CN102526179A (en) * | 2012-01-19 | 2012-07-04 | 叶耀良 | Purpose of anti-inflammation and bile benefiting preparation |
| CN103083269A (en) * | 2013-02-19 | 2013-05-08 | 青岛正大海尔制药有限公司 | Dropping pills containing mannose ester and preparation method thereof |
-
2004
- 2004-06-18 CN CNB2004100410233A patent/CN100488528C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100427066C (en) * | 2005-07-28 | 2008-10-22 | 叶耀良 | Pharmaceutical preparation with functions of clearing heat, removing dampness and benefiting gallbladder |
| CN101612193B (en) * | 2009-07-17 | 2012-02-22 | 吉林紫鑫药业股份有限公司 | Medicine composition used for treating cholecystitis and cholangitis |
| CN102526179A (en) * | 2012-01-19 | 2012-07-04 | 叶耀良 | Purpose of anti-inflammation and bile benefiting preparation |
| CN103083269A (en) * | 2013-02-19 | 2013-05-08 | 青岛正大海尔制药有限公司 | Dropping pills containing mannose ester and preparation method thereof |
| CN103083269B (en) * | 2013-02-19 | 2014-06-25 | 青岛正大海尔制药有限公司 | Dropping pills containing mannose ester and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100488528C (en) | 2009-05-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1593584A (en) | Novel formulation of 'Xiaoyan Lidan' and its preparation method | |
| CN1316961C (en) | Grosvenor's momordica fruit drip pill an dits preparation method | |
| CN1634476A (en) | Chinese ephedra and almond containing cough stopping dripping pills and its preparing process | |
| CN100341487C (en) | 'Shuanghuang' antiphlogistic drop pill in use relieving inflammation and preparation method | |
| CN1660364A (en) | 'Lianzhi' anti inflammation drop pill in use for clearing away heat and toxic material and preparation method | |
| CN1292737C (en) | Oral administration dripping pill for nourishing heart to calm mind and its preparing method | |
| CN1297255C (en) | Dripping pills for treating high blood fat and its preparing method | |
| CN1297254C (en) | Drop pills containing bear gall and tendril-leaved fritillary bulb and preparation method thereof | |
| CN1679675A (en) | Chuanhuang anti-inflammation drops for clearing away heat and detoxicating, and preparation thereof | |
| CN1634509A (en) | Yitongshu drop pill for treating pain and its preparation method | |
| CN1287771C (en) | Almond cough-relieving drop pills and preparation method thereof | |
| CN1634478A (en) | Tendril-leaved fritillary bulb loquat drop pills and preparation method thereof | |
| CN1919255A (en) | Aim Naoluotong drop pill and its preparation method | |
| CN1284529C (en) | Compound gastrodia elata drop pills | |
| CN1634452A (en) | Yin-nourishing lung-heat clearing drop pills | |
| CN1698780A (en) | Dripping pills for treating all kinds of rhinitis and its preparation method | |
| CN1660316A (en) | Drop pills preparation in use for treating bronchitis and preparation method | |
| CN1679669A (en) | Polygala dropping balls and preparation thereof | |
| CN1686454A (en) | Xiaoke drip pill used for suppressing cough and transforming phlegm and its preparation method | |
| CN1686388A (en) | Kangai drip pill for treating tumour, hepatitis B and its preparation method | |
| CN1294901C (en) | Embolism eliminatinging drop pills with qi invigorating, blood flow promoting and collateral dredging function | |
| CN1301095C (en) | 'Yinchai' drop pills for treating cold, fever and cough and preparation method | |
| CN1307978C (en) | Drop pill for diminishing inflammation in four seasons and its preparation method | |
| CN1284530C (en) | Compound tornado drop pills | |
| CN1679671A (en) | Compound berberine dropping ball and preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090520 Termination date: 20140618 |
|
| EXPY | Termination of patent right or utility model |