Summary of the invention
Purpose of the present invention is to replenish wind-induced hemiplegia in existing being used for the treatment of, facial hemiparalysis, aphasia, slobbering, the lower limb flaccidity is useless; the deficiency of the oral drug preparation of symptoms such as frequent micturition, and a kind of bioavailability height is provided, release fast; produce effects fast, and toxic and side effects is littler, and the medicament contg height; taking dose is little; and taking dose is accurate, taking convenience, and be convenient to the drug composition oral preparation thrombus dispelling pill of going out to carry.
Thrombus dispelling pill involved in the present invention is on the basis of Chinese traditional patent formulation embolism extinguishing oral liquid extraction process, is prepared from through specific drop pill preparation technology again.Be prepared by the following technical solutions, can obtain thrombus dispelling pill involved in the present invention:
[preparation of Chinese medicine extract]
In weight portion (g, kg), 20 parts of the Radixs Astragali, each 2 parts of Radix Angelicae Sinensis and Radix Paeoniae Rubra, respectively 1 part on Pheretima, Rhizoma Chuanxiong, Semen Persicae, Flos Carthami, more than seven flavors, decoct with water three times, for the first time 1.5h, second and third time is respectively 1h, and collecting decoction filters, filtrate decompression is concentrated into relative density 1.15-1.25, adds ethanol and makes that to contain alcohol amount be 75%, leaves standstill, get supernatant, reclaim ethanol, concentrated medicament is 1.2~1.5 thick paste to density, or with thick paste through the low-temperature reduced-pressure drying, pulverize, promptly get dry powder.
[drop pill prescription]
1. raw material---through above prepared and contain above seven flavors pure in the pale brown color thick paste of pharmaceutically active ingredient or dry powder (below be referred to as drug extract);
2. substrate---Polyethylene Glycol
(2000,4000,6000,8000,10000,20000), one or more the mixture in pharmaceutically suitable carrier such as polyoxyethylene stearate 40 esters, betacyclodextrin, poloxamer, carboxymethyl starch sodium, sodium lauryl sulphate, stearic acid, sodium stearate, glycerin gelatine, Lac;
3. proportioning---with g or kg is unit, by weight, and drug extract: substrate=1: 1~1: 9.
[preparation method]
1. according to the given ratio of prescription, accurately take by weighing drug extract and substrate, be placed on heating while stirring in the heating container, standby until the fused solution that obtains containing drug extract and substrate and/or emulsion and/or suspension;
2. adopt homemade or general drop pill machine (as the TZDW-1 type drop pill machine of Changzheng Tianmin High Science ﹠ Technology Co., Ltd., Beijing's production), and the temperature control system of adjustment drop pill machine, make the water dropper temperature heating of drop pill machine and remain on (50~90) ℃, the temperature cooling of condensing agent also remains on (40~-5) ℃;
3. treating that the temperature of condensing agent in dropping-pill machine head and the condensation column is stable respectively is in above the 2nd step during desired state of temperature, fused solution and/or the emulsion and/or the suspension that will contain drug extract and substrate, under the state of insulation, place in the water dropper storage vat of drop pill machine, splash in the condensing agent by water dropper.
Condensing agent can be any one in liquid paraffin, methyl-silicone oil, the vegetable oil;
4. will shrink the drop pill taking-up of molding by the outlet of drop pill machine, remove the surface condensation agent, be drying to obtain.
Beneficial effect
According to drug standard WS promulgated by the ministries or commissions of the Central Government
3The embolism extinguishing oral liquid that prescription that provides among-the B-2214-96 and extraction process are prepared from, it is wind-induced hemiplegia during a kind of treatment is used for the treatment of, facial hemiparalysis, aphasia, slobbering, the lower limb flaccidity is useless; the oral syrup class pure Chinese medicinal preparation of symptoms such as frequent micturition, through clinical verification for many years, steady quality; determined curative effect, is clinical and family is used for the treatment of the common drug of apoplexy class disease.
Owing to reasons such as technologies of preparing, the oral formulations of most drug, exist all after taking that dissolve scattered time limit is long, dissolution is low, absorption is relatively poor, problem such as liver sausage first pass effect and bioavailability are lower, thereby influence the performance of drug effect, also directly affect therapeutic effect.And that oral liquid also exists medicament contg is low, and taking dose is big, and taking dose is inaccurate, takes inconvenient characteristics, also is not easy to go out to carry wait deficiency.
Thrombus dispelling pill involved in the present invention is compared with its embolism extinguishing oral liquid, has following beneficial effect:
1. thrombus dispelling pill involved in the present invention; utilize surfactant to be substrate; make solid dispersion with extractum that contains active constituents of medicine or dry powder; making medicine be molecule, colloid or microcrystalline state is scattered in the substrate; the total surface area of medicine increases, and substrate is hydrophilic, and medicine is had wetting action; can make that medicine is rapidly molten to loose into microgranule or solution, thereby make the dissolving of medicine and absorb and accelerate.Thereby improved bioavailability, brought into play efficient, quick-acting effects etc.
Compare with the administering mode of traditional oral formulations, exist essential distinction.Drop pill with the solid dispersion technology preparation can adopt oral and sublingual administration, and effective ingredient is fully contacted with mucomembranous surface, absorbs by mucomembranous epithelial cell, directly enters blood circulation.Owing to directly enter blood circulation without gastrointestinal tract and liver, avoided first pass effect effectively, also avoided gastrointestinal irritation, thereby it is rapid to have an onset, bioavailability height, characteristics such as side effect is little, and medication is convenient.
2. thrombus dispelling pill involved in the present invention contacts promptly with saliva and to dissolve rapidly, and is absorbed by oral mucosa, and is not only rapid-action, and the influence of not taken food, and promptly all can containing take after meal ante cibum.
3. thrombus dispelling pill involved in the present invention mixes the extract that contains active constituents of medicine mutually with molten matrix, splashes in the not miscible condensed fluid and makes.Therefore, the stability of drug height, not facile hydrolysis, oxidation, and the operation be under liquid state, to carry out, no dust pollution is not subject to the influence of crystal formation, thereby has guaranteed the quality of medicine, has increased stability.
In sum, make thrombus dispelling pill involved in the present invention have the advantage of triple effect (quick-acting, efficient, long-acting), three little (taking dose is little, toxicity is little, side effect little), five convenience (convenient for production, store convenience, convenient transportation, easy to carry, easy to use).
The specific embodiment
Now with the test and the result thereof of several groups of specific embodiments, be described further with regard to the preparation method of thrombus dispelling pill of the present invention.
First group: the test of single-matrix
[preparation experiment]
1. it is standby to make drug extract dry powder earlier according to [preparation of Chinese medicine extract] joint;
2. substrate---Polyethylene Glycol
(2000,4000,6000,8000,10000,20000), pharmaceutically suitable carrier such as polyoxyethylene stearate 40 esters, betacyclodextrin, poloxamer, carboxymethyl starch sodium, sodium lauryl sulphate, stearic acid, sodium stearate, glycerin gelatine, Lac;
3. proportioning---with g or kg is unit, by weight, and drug extract: substrate=1: 1~1: 9;
4. be prepared according to [preparation method] joint again, promptly can make the thrombus dispelling pill of various different sizes.
[result of the test]
Test 1: for observe drug extract and different substrates when 1: 1 the proportioning prepared thrombus dispelling pill in qualitative difference, according to 1: 1 ratio, with drug extract respectively with Polyethylene Glycol
2000, Polyethylene Glycol
4000, Polyethylene Glycol
6000, Polyethylene Glycol
8000, Polyethylene Glycol
10000, Polyethylene Glycol
20000, pharmaceutically suitable carrier such as polyoxyethylene stearate 40 esters, betacyclodextrin, poloxamer, carboxymethyl starch sodium, sodium lauryl sulphate, stearic acid, sodium stearate, glycerin gelatine, Lac matches, adopt homemade drop pill machine, be prepared according to the step of stipulating in the preparation method, can obtain 15 pharmaceutical compositions experiments that contain drug extract and different substrates, and obtain 15 groups of different experimental results and see Table 1.
Test 2: for observe drug extract and different substrates when 1: 3 the proportioning prepared thrombus dispelling pill in qualitative difference, according to 1: 3 ratio, with drug extract respectively with Polyethylene Glycol
2000, Polyethylene Glycol
4000, Polyethylene Glycol
6000, Polyethylene Glycol
8000, Polyethylene Glycol
10000, Polyethylene Glycol
20000, pharmaceutically suitable carrier such as polyoxyethylene stearate 40 esters, betacyclodextrin, poloxamer, carboxymethyl starch sodium, sodium lauryl sulphate, stearic acid, sodium stearate, glycerin gelatine, Lac matches, adopt homemade drop pill machine, be prepared according to the step of stipulating in the preparation method, can obtain the experiment of 15 pharmaceutical compositions that drug extract and different substrates constituted, and obtain 15 groups of different experimental results and see Table 2.
Test 3: for observe drug extract and different substrates when 1: 9 the proportioning prepared thrombus dispelling pill in qualitative difference, according to 1: 9 ratio, with drug extract respectively with Polyethylene Glycol
2000, Polyethylene Glycol
4000, Polyethylene Glycol
6000, Polyethylene Glycol
8000, Polyethylene Glycol
10000, Polyethylene Glycol
20000, pharmaceutically suitable carrier such as polyoxyethylene stearate 40 esters, betacyclodextrin, poloxamer, carboxymethyl starch sodium, sodium lauryl sulphate, stearic acid, sodium stearate, glycerin gelatine, Lac matches, adopt homemade drop pill machine, be prepared according to the step of stipulating in the preparation method, can obtain the experiment of 15 pharmaceutical compositions that drug extract and different substrates constituted, and obtain 15 groups of different experimental results and see Table 3.
Second group: the test of mixed-matrix
1. it is standby to make drug extract dry powder earlier according to [preparation of Chinese medicine extract] joint;
2. substrate:
2.1 Polyethylene Glycol---English name Macrogol,
2.2 polyoxyethylene stearate 40 esters---English name Polyoxyl (40) Stearate, molecular formula is with C
17H
35COO (CH
2CH
2O)
nH represents that n is about 40,
2.3 poloxamer---English name Poloxamer, polyoxyethylene poly-oxygen propylene aether, molecular formula HO (C
2H
4O)
a(C
3H
6O)
b(C
2H
4O)
cH,
The sodium salt of the starch carboxymethyl ester that 2.4 carboxymethyl starch sodium---English name Carboxymethylstach Sodium, starch generates with the monoxone effect under alkali condition,
2.5 betacyclodextrin---English name Betacyclodextrin, molecular formula C
6H
10O
5, this product is that ring dextrin glucosyl transferase acts on 7 glucoses that starch generates with α-1, the bonded cyclic oligosaccharide of 4-glycosidic bond;
3. (with g or kg is unit to proportioning, by weight)
3.1 the ratio of composite interstitial substance---polyoxyethylene stearate 40 esters: Polyethylene Glycol or poloxamer: Polyethylene Glycol or carboxymethyl starch sodium: Polyethylene Glycol or betacyclodextrin: Polyethylene Glycol=1: 1~1: 10,
3.2 drug extract: mixed-matrix weight and=1: 1~1: 9.
4. be prepared according to [preparation method] joint again, promptly can make the thrombus dispelling pill of various different sizes.
[result of the test]
Test 4: for observe drug extract and mixed-matrix when 1: 1 the proportioning prepared thrombus dispelling pill in qualitative difference, with polyoxyethylene stearate 40 esters, poloxamer, carboxymethyl starch sodium, 4 kinds of carriers such as betacyclodextrin respectively with Polyethylene Glycol with 1: 1 mixed evenly as mixed-matrix, according to 1: 1 ratio drug extract is mixed mutually with 4 kinds of different mixed-matrixes again and make evenly, adopt homemade drop pill machine, be prepared according to the step of stipulating in the preparation method, can obtain the experiment of 4 pharmaceutical compositions that drug extract and mixed-matrix constituted, and obtain 4 groups of different experimental results and see Table 4.
Test 5: for observe drug extract and mixed-matrix when 1: 3 the proportioning prepared thrombus dispelling pill in qualitative difference, with polyoxyethylene stearate 40 esters, poloxamer, carboxymethyl starch sodium, 4 kinds of carriers such as betacyclodextrin respectively with Polyethylene Glycol with 1: 1 mixed evenly as mixed-matrix, according to 1: 3 ratio drug extract is mixed mutually with 4 kinds of different mixed-matrixes again and make evenly, adopt homemade drop pill machine, be prepared according to the step of stipulating in the preparation method, can obtain the experiment of 4 pharmaceutical compositions that drug extract and mixed-matrix constituted, and obtain 4 groups of different experimental results and see Table 5.
Test 6: for observe drug extract and mixed-matrix when 1: 9 the proportioning prepared thrombus dispelling pill in qualitative difference, with polyoxyethylene stearate 40 esters, poloxamer, carboxymethyl starch sodium, 4 kinds of carriers such as betacyclodextrin respectively with Polyethylene Glycol with 1: 1 mixed evenly as mixed-matrix, according to 1: 9 ratio drug extract is mixed mutually with 4 kinds of different mixed-matrixes again and make evenly, adopt homemade drop pill machine, be prepared according to the step of stipulating in the preparation method, can obtain the experiment of 4 pharmaceutical compositions that drug extract and mixed-matrix constituted, and obtain 4 groups of different experimental results and see Table 6.
Test 7: for observe drug extract and mixed-matrix when 1: 1 the proportioning prepared thrombus dispelling pill in qualitative difference, with polyoxyethylene stearate 40 esters, poloxamer, carboxymethyl starch sodium, 4 kinds of carriers such as betacyclodextrin respectively with Polyethylene Glycol with 1: 5 mixed evenly as mixed-matrix, according to 1: 1 ratio drug extract is mixed mutually with 4 kinds of different mixed-matrixes again and make evenly, adopt homemade drop pill machine, be prepared according to the step of stipulating in the preparation method, can obtain the experiment of 4 pharmaceutical compositions that drug extract and mixed-matrix constituted, and obtain 4 groups of different experimental results and see Table 7.
Test 8: for observe drug extract and mixed-matrix when 1: 3 the proportioning prepared thrombus dispelling pill in qualitative difference, with polyoxyethylene stearate 40 esters, poloxamer, carboxymethyl starch sodium, 4 kinds of carriers such as betacyclodextrin respectively with Polyethylene Glycol with 1: 5 mixed evenly as mixed-matrix, according to 1: 3 ratio drug extract is mixed mutually with 4 kinds of different mixed-matrixes again and make evenly, adopt homemade drop pill machine, be prepared according to the step of stipulating in the preparation method, can obtain the experiment of 4 pharmaceutical compositions that drug extract and mixed-matrix constituted, and obtain 4 groups of different experimental results and see Table 8.
Test 9: for observe drug extract and mixed-matrix when 1: 9 the proportioning prepared thrombus dispelling pill in qualitative difference, with polyoxyethylene stearate 40 esters, poloxamer, carboxymethyl starch sodium, 4 kinds of carriers such as betacyclodextrin respectively with Polyethylene Glycol with 1: 5 mixed evenly as mixed-matrix, according to 1: 9 ratio drug extract is mixed mutually with 4 kinds of different mixed-matrixes again and make evenly, adopt homemade drop pill machine, be prepared according to the step of stipulating in the preparation method, can obtain the experiment of 4 pharmaceutical compositions that drug extract and mixed-matrix constituted, and obtain 4 groups of different experimental results and see Table 9.
Test 10: for observe drug extract and mixed-matrix when 1: 1 the proportioning prepared thrombus dispelling pill in qualitative difference, with polyoxyethylene stearate 40 esters, poloxamer, carboxymethyl starch sodium, 4 kinds of carriers such as betacyclodextrin respectively with Polyethylene Glycol with 1: 10 mixed evenly as mixed-matrix, according to 1: 1 ratio drug extract is mixed mutually with 4 kinds of different mixed-matrixes again and make evenly, adopt homemade drop pill machine, be prepared according to the step of stipulating in the preparation method, can obtain the experiment of 4 pharmaceutical compositions that drug extract and mixed-matrix constituted, and obtain 4 groups of different experimental results and see Table 10.
Test 11: for observe drug extract and mixed-matrix when 1: 3 the proportioning prepared thrombus dispelling pill in qualitative difference, with polyoxyethylene stearate 40 esters, poloxamer, carboxymethyl starch sodium, 4 kinds of carriers such as betacyclodextrin respectively with Polyethylene Glycol with 1: 10 mixed evenly as mixed-matrix, according to 1: 3 ratio drug extract is mixed mutually with 4 kinds of different mixed-matrixes again and make evenly, adopt homemade drop pill machine, be prepared according to the step of stipulating in the preparation method, can obtain the experiment of 4 pharmaceutical compositions that drug extract and mixed-matrix constituted, and obtain 4 groups of different experimental results and see Table 11.
Test 12: for observe drug extract and mixed-matrix when 1: 9 the proportioning prepared thrombus dispelling pill in qualitative difference, with polyoxyethylene stearate 40 esters, poloxamer, carboxymethyl starch sodium, 4 kinds of carriers such as betacyclodextrin respectively with Polyethylene Glycol with 1: 10 mixed evenly as mixed-matrix, according to 1: 9 ratio drug extract is mixed mutually with 4 kinds of different mixed-matrixes again and make evenly, adopt homemade drop pill machine, be prepared according to the step of stipulating in the preparation method, can obtain the experiment of 4 pharmaceutical compositions that drug extract and mixed-matrix constituted, and obtain 4 groups of different experimental results and see Table 12.
The group practices of table 1 drug extract and single-matrix
(drug extract: substrate=1: 1)
The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
Polyethylene Glycol
2000 | 50.0 | 60 | <30 | >10 | + |
Polyethylene Glycol
4000 | 50.0 | 78 | <30 | >10 | ++ |
Polyethylene Glycol
6000 | 50.0 | 82 | <30 | >10 | +++ |
Polyethylene Glycol
8000 | 50.0 | 83 | <30 | >10 | +++ |
Polyethylene Glycol
10000 | 50.0 | 88 | <30 | <10 | +++ |
Polyethylene Glycol
20000 | 50.0 | 86 | <30 | <10 | +++ |
Polyoxyethylene stearate 40 esters | 50.0 | 76 | <30 | >10 | ++ |
Betacyclodextrin | 50.0 | 70 | <30 | >10 | ++ |
Poloxamer | 50.0 | 72 | <30 | >10 | ++ |
Carboxymethyl starch sodium | 50.0 | 71 | <30 | >10 | ++ |
Sodium lauryl sulphate | 50.0 | 69 | <30 | >10 | ++ |
Stearic acid | 50.0 | 52 | <30 | >10 | ++ |
Sodium stearate | 50.0 | 54 | <30 | >10 | +++ |
Glycerin gelatine | 50.0 | 55 | <30 | >10 | +++ |
Lac | 50.0 | 49 | >30 | >10 | +++ |
The group practices of table 2 drug extract and single-matrix
(drug extract: substrate=1: 3)
The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
Polyethylene Glycol
2000 | 25.0 | 78 | <30 | >10 | ++ |
Polyethylene Glycol
4000 | 25.0 | 86 | <30 | <10 | +++ |
Polyethylene Glycol
6000 | 25.0 | 90 | <30 | <10 | +++ |
Polyethylene Glycol
8000 | 25.0 | 90 | <30 | <10 | +++ |
Polyethylene Glycol
10000 | 25.0 | 93 | <30 | <10 | +++ |
Polyethylene Glycol
20000 | 25.0 | 92 | <30 | <10 | +++ |
Polyoxyethylene stearate 40 esters | 25.0 | 87 | <30 | <10 | ++ |
Betacyclodextrin | 25.0 | 82 | <30 | <10 | ++ |
Poloxamer | 25.0 | 86 | <30 | <10 | +++ |
Carboxymethyl starch sodium | 25.0 | 81 | <30 | >10 | ++ |
Sodium lauryl sulphate | 25.0 | 76 | <30 | >10 | ++ |
Stearic acid | 25.0 | 72 | >30 | >10 | ++ |
Sodium stearate | 25.0 | 71 | >30 | >10 | +++ |
Glycerin gelatine | 25.0 | 68 | >30 | >10 | +++ |
Lac | 25.0 | 68 | >30 | >10 | +++ |
The group practices of table 3 drug extract and single-matrix
(drug extract: substrate=1: 9)
The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
Polyethylene Glycol
2000 | 10.0 | 82 | <30 | >10 | ++ |
Polyethylene Glycol
4000 | 10.0 | 89 | <30 | <10 | +++ |
Polyethylene Glycol
6000 | 10.0 | 93 | <30 | <10 | +++ |
Polyethylene Glycol
8000 | 10.0 | 92 | <30 | <10 | +++ |
Polyethylene Glycol
10000 | 10.0 | 93 | <30 | <10 | +++ |
Polyethylene Glycol
20000 | 10.0 | 94 | <30 | <10 | +++ |
Polyoxyethylene stearate 40 esters | 10.0 | 89 | <30 | <10 | ++ |
Betacyclodextrin | 10.0 | 87 | <30 | <10 | ++ |
Poloxamer | 10.0 | 93 | <30 | <10 | +++ |
Carboxymethyl starch sodium | 10.0 | 82 | <30 | >10 | +++ |
Sodium lauryl sulphate | 10.0 | 82 | <30 | >10 | +++ |
Stearic acid | 10.0 | 78 | >30 | >10 | +++ |
Sodium stearate | 10.0 | 80 | >30 | >10 | +++ |
Glycerin gelatine | 10.0 | 73 | >30 | >10 | +++ |
Lac | 10.0 | 76 | >30 | >10 | +++ |
The group practices of table 4 drug extract and mixed-matrix
(drug extract: mixed-matrix=1: 1)
The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
Polyoxyethylene stearate 40 esters: Polyethylene Glycol=1: 1 | 50 | 82 | <30 | >10 | ++ |
Poloxamer: Polyethylene Glycol=1: 1 | 50 | 80 | <30 | >10 | ++ |
Carboxymethyl starch sodium: Polyethylene Glycol=1: 1 | 50 | 75 | <30 | >10 | ++ |
Betacyclodextrin: Polyethylene Glycol=1: 1 | 50 | 70 | <30 | >10 | + |
The group practices of table 5 drug extract and mixed-matrix
(drug extract: mixed-matrix=1: 3)
The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
Polyoxyethylene stearate 40 esters: Polyethylene Glycol=1: 1 | 25 | 86 | <30 | <10 | +++ |
Poloxamer: Polyethylene Glycol=1: 1 | 25 | 89 | <30 | <10 | +++ |
Carboxymethyl starch sodium: Polyethylene Glycol=1: 1 | 25 | 82 | <30 | >10 | ++ |
Betacyclodextrin: Polyethylene Glycol=1: 1 | 25 | 81 | <30 | >10 | ++ |
The group practices of table 6 drug extract and mixed-matrix
(drug extract: mixed-matrix=1: 9)
The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
Polyoxyethylene stearate 40 esters: Polyethylene Glycol=1: 1 | 10 | 88 | <30 | <10 | +++ |
Poloxamer: Polyethylene Glycol=1: 1 | 10 | 86 | <30 | <10 | +++ |
Carboxymethyl starch sodium: Polyethylene Glycol=1: 1 | 10 | 83 | <30 | >10 | +++ |
Betacyclodextrin: Polyethylene Glycol=1: 1 | 10 | 81 | <30 | >10 | +++ |
The group practices of table 7 drug extract and mixed-matrix
(drug extract: mixed-matrix=1: 1)
The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
Polyoxyethylene stearate 40 esters: Polyethylene Glycol=1: 5 | 50 | 92 | <30 | <10 | +++ |
Poloxamer: Polyethylene Glycol=1: 5 | 50 | 93 | <30 | <10 | +++ |
Carboxymethyl starch sodium: Polyethylene Glycol=1: 5 | 50 | 86 | <30 | <10 | +++ |
Betacyclodextrin: Polyethylene Glycol=1: 5 | 50 | 82 | <30 | >10 | ++ |
The group practices of table 8 drug extract and mixed-matrix
(drug extract: mixed-matrix=1: 3)
The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
Polyoxyethylene stearate 40 esters: Polyethylene Glycol=1: 5 | 25 | 91 | <30 | <10 | +++ |
Poloxamer: Polyethylene Glycol=1: 5 | 25 | 91 | <30 | <10 | +++ |
Carboxymethyl starch sodium: Polyethylene Glycol=1: 5 | 25 | 89 | <30 | <10 | +++ |
Betacyclodextrin: Polyethylene Glycol=1: 5 | 25 | 86 | <30 | <10 | ++ |
The group practices of table 9 drug extract and mixed-matrix
(drug extract: mixed-matrix=1: 9)
The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
Polyoxyethylene stearate 40 esters: Polyethylene Glycol=1: 5 | 10 | 95 | <30 | <10 | +++ |
Poloxamer: Polyethylene Glycol=1: 5 | 10 | 93 | <30 | <10 | +++ |
Carboxymethyl starch sodium: Polyethylene Glycol=1: 5 | 10 | 90 | <30 | <10 | +++ |
Betacyclodextrin: Polyethylene Glycol=1: 5 | 10 | 88 | <30 | <10 | +++ |
The group practices of table 10 drug extract and mixed-matrix
(drug extract: mixed-matrix=1: 1)
The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
Polyoxyethylene stearate 40 esters: Polyethylene Glycol=1: 10 | 50 | 92 | <30 | <10 | +++ |
Poloxamer: Polyethylene Glycol=1: 10 | 50 | 91 | <30 | <10 | +++ |
Carboxymethyl starch sodium: Polyethylene Glycol=1: 10 | 50 | 87 | <30 | <10 | +++ |
Betacyclodextrin: Polyethylene Glycol=1: 10 | 50 | 84 | <30 | >10 | +++ |
The group practices of table 11 drug extract and mixed-matrix
(drug extract: mixed-matrix=1: 3)
The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
Polyoxyethylene stearate 40 esters: Polyethylene Glycol=1: 10 | 25 | 92 | <30 | <10 | +++ |
Poloxamer: Polyethylene Glycol=1: 10 | 25 | 92 | <30 | <10 | +++ |
Carboxymethyl starch sodium: Polyethylene Glycol=1: 10 | 25 | 89 | <30 | <10 | +++ |
Betacyclodextrin: Polyethylene Glycol=1: 10 | 25 | 87 | <30 | <10 | +++ |
The group practices of table 12 drug extract and mixed-matrix
(drug extract: mixed-matrix=1: 9)
The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
Polyoxyethylene stearate 40 esters: Polyethylene Glycol=1: 10 | 10 | 91 | <30 | <10 | +++ |
Poloxamer: Polyethylene Glycol=1: 10 | 10 | 92 | <30 | <10 | +++ |
Carboxymethyl starch sodium: Polyethylene Glycol=1: 10 | 10 | 91 | <30 | <10 | +++ |
Betacyclodextrin: Polyethylene Glycol=1: 10 | 10 | 91 | <30 | <10 | +++ |
1. can be seen by the result in the table: when the ratio of drug extract and substrate was 1: 1, its rounding rate, the ball method of double differences was different and index such as hardness is all undesirable, and dissolve scattered time limit influenced not obvious.
2. when the ratio of drug extract and substrate is 1: 3, the rounding rate, the ball method of double differences is different and index such as hardness slightly all begins to enter preferable state.
3. when the ratio of drug extract and substrate is 1: 9, though the rounding rate, the ball method of double differences is different and index such as hardness has raising, and is not obvious.
4. the general effect of composite interstitial substance is better than single-matrix.
5. the hardness method for expressing in the subordinate list adopts drop pill is placed on the glass plate, press...withes one's finger it, observes its metamorphosis."+" expression flicking promptly is out of shape, " ++ " expression distortion of firmly pressing, and " +++" expression is indeformable by it.