CN110522816A - A kind of cow-bezoar infantile umbilical paste and preparation method thereof - Google Patents
A kind of cow-bezoar infantile umbilical paste and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of cow-bezoar infantile umbilical pastes, including substrate and the drug moiety being attached in substrate, the drug moiety includes 1~8 part of In vitro cultured Calculus Bovis, 700~2500 parts of antipyretic and antidotal type Chinese medicine, dry 200~1000 parts of class Chinese medicine of heat-clearing drop, matrix component part includes 10~80 parts of Dihydroxyaluminium Aminoacetate, 5~40 parts of menthol, 100~800 parts of Sodium Polyacrylate, 10~80 parts of polyvinylpyrrolidone, 1000~2000 parts of glycerol, 100~800 parts of sorbierite, 20~140 parts of crospovidone, 2000~6000 parts of purified water, 10~80 parts of citric acid, 100~800 parts of propylene glycol, 100~220 parts of Laurocapram.The preparation method of above-mentioned cow-bezoar infantile umbilical paste has also been devised in the present invention.The present invention can effectively bring down a fever, and traditional Chinese medicinal components pass through extraction process, and Small side effects are highly-safe, and entire defervescence plaster used each group distribution ratio is reasonable, and traditional Chinese medicine ingredients transdermal absorption factor is high.
Description
Technical field
The present invention relates to pharmaceutical technology fields more particularly to a kind of cow-bezoar infantile umbilical paste and preparation method thereof.
Background technique
Infantile umbilical paste is that intracorporal excessive heat is volatilized away by moisture content vaporization in gel, to reach reduction body
The effect of temperature allows children's health safety cooling, while not destroying the intracorporal immune function system reaction of children.It belongs to physics drop
Warm articles, because it is brought down a fever fastly, good cooling effect is safe and non-toxic secondary and be widely used and have a fever in fever in children.
Current existing defervescence plaster used essential structure includes non-woven cloth and medical polymer gel, generally can also be added thin
The ingredients such as lotus, borneol and water, gel layer are its major part.Using gel as carrier, gone away by the vaporization zone of moisture in gel
Body part amount of heat, plays the role of cooling.
In order to play better therapeutic effect, there is the defervescence plaster used manufacturer in part at present, can add in defervescence plaster used gel
Enter some Chinese medicines, while physiotherapy, is aided with drug therapy.Generally all to add based on the drug of antipyretic and antidotal type.So
And for children, the growth and development of each tissue of body is also unsound, and autoimmune ability is also not so good as adult, is using
It is this kind of be added to traditional Chinese medicine ingredients it is defervescence plaster used when, the effect is unsatisfactory for this mode through percutaneous drug delivery, this administration mode, medicine
Object ingredient is difficult to absorb by skin.Furthermore at present defervescence plaster used, traditional Chinese medicinal components are added in gel with pulvis, right
For children, there are biggish drug risks.This kind of Chinese medicine powder granularity is larger, after skin enters in children's body, easily
Cause the side effects such as allergy.
Summary of the invention
The present invention for the technical problems in the prior art, provides a kind of cow-bezoar infantile umbilical paste and its preparation side
Method can effectively bring down a fever, and traditional Chinese medicinal components pass through extraction process, and Small side effects are highly-safe, and entire defervescence plaster used each group distribution ratio is closed
Reason, traditional Chinese medicine ingredients transdermal absorption factor are high.
The technical scheme to solve the above technical problems is that a kind of cow-bezoar infantile umbilical paste, including substrate and attached
Drug moiety in substrate, the drug moiety include 1~8 part of In vitro cultured Calculus Bovis, antipyretic and antidotal type Chinese medicine 700~2500
Dry 200~1000 parts of class Chinese medicine of part, heat-clearing drop, matrix component part include 10~80 parts of Dihydroxyaluminium Aminoacetate, 5~40 parts of menthol, gather
100~800 parts of sodium acrylate, 10~80 parts of polyvinylpyrrolidone, 1000~2000 parts of glycerol, 100~800 parts of sorbierite,
20~140 parts of crospovidone, 2000~6000 parts of purified water, 10~80 parts of citric acid, 100~800 parts of propylene glycol, laurel nitrogen
100~220 parts of tall and erect ketone.
Based on the above technical solution, the present invention can also be improved as follows.
Further, the antipyretic and antidotal type Chinese medicine includes 300~1000 parts of honeysuckle, 300~1000 parts of radix bupleuri, schizonepeta
100~500 parts.
Further, it includes 100~500 parts of cape jasmine, 100~500 parts of Radix picrorrhizae that dry class Chinese medicine drops in the heat-clearing.
Further, the drug moiety further includes having 1~10 part of ethyl hydroxy benzoate.
The present invention also provides the preparation methods of above-mentioned cow-bezoar infantile umbilical paste, comprising the following steps:
1) extraction of antipyretic and antidotal type Chinese medicine: taking 700~2500 parts of antipyretic and antidotal type Chinese medicine, soaks in water rear vapor and steams
Extraction is evaporated, the aqueous solution filtering after distillation adds ethyl alcohol to make alcohol content 60% or more after filtrate concentration, cooling, stir evenly,
Cooling, stratification, takes supernatant, obtains the extracting solution of antipyretic and antidotal type Chinese medicine；
2) extraction and the Chinese medicine cream of dry class Chinese medicine drop in heat-clearing: take heat-clearing drop it is dry 200~1000 parts of class Chinese medicine, add 60% with
Upper alcohol reflux extracts 2 times, and merging filtrate merges with the extracting solution of step 1), recycles ethyl alcohol, is concentrated under reduced pressure into paste, obtains
To Chinese medical extract lotion；
3) it prepares menthol solution: 5~40 parts of menthol is added in 100~800 parts of propylene glycol, sufficiently dissolve, stir
It mixes uniformly mixed, obtains menthol solution；
4) it prepares I part: by 100~800 parts of Sodium Polyacrylate, 10~80 parts of Dihydroxyaluminium Aminoacetate, 100~800 parts of sorbierite, handing over
20~140 parts of povidone of connection, 100~220 parts of Laurocapram be added in 1000~2000 parts of glycerol and be mixed, body is then added
Chinese medical extract lotion made from menthol solution made from 1~8 part of outer cultured ox gallstone, step 3) and step 2), is sufficiently stirred
Uniformly, I part is obtained；
5) it prepares II part: taking 10~80 parts of polyvinylpyrrolidones to be added in 2000~6000 parts of purified waters and be sufficiently swollen
Afterwards, 10~80 parts of citric acids are added, dissolves, stir evenly, obtain II part；
6) preparation of cow-bezoar infantile umbilical paste: II part made from step 5) is added in I part made from step 4),
It is stirred under vacuum uniformly, obtains drug moiety, said medicine part is coated onto substrate, be sliced, stand sizing to get small to cow-bezoar
Youngster is defervescence plaster used.
Based on the above technical solution, the present invention can also be improved as follows.
Further, in the step 1), the antipyretic and antidotal type Chinese medicine include 300~1000 parts of honeysuckle, radix bupleuri 300~
1000 parts, 100~500 parts of schizonepeta.
Further, in the step 2), the heat-clearing drop dry class Chinese medicine include 100~500 parts of cape jasmine, Radix picrorrhizae 100~
500 parts.
Further, in the step 4), it is also necessary to add 1~10 part of ethyl hydroxy benzoate into glycerol.
Further, in the step 1), operation is soaked in water to add 8 times of amount water to impregnate 2 hours, steam distillation extracts 4
Hour, it is 1.08~1.10 that filtrate is concentrated into relative density at a temperature of 55~65 DEG C.
Further, in the step 2), alcohol reflux is added to extract 2 times, for the first time plus 10 times of 60% ethyl alcohol of amount extractions 1.5 are small
When, for the second time plus 8 times of 60% ethyl alcohol of amount extract 1 hour；Decompression and concentration operation is concentrated into opposite under the conditions of 55~60 DEG C of temperature
Density is 1.35~1.38.
Further, in the step 5), crystallization operation need to be at 20~25 DEG C, humidity 70% arranged below 12 hour.
It is dropped in dry two groups the beneficial effects of the present invention are: the present invention in defervescence plaster used, introduces clearing heat and detoxicating and heat-clearing
Medicine ingredient, effect of bringing down a fever is good, except physics is brought down a fever in addition to effect, also with certain therapeutic effect；The present invention is added to part alcohols
And skin penetration enhancer, the transdermal absorption factor of drug ingedient can be effectively improved；Preparation method of the invention, to traditional Chinese medicine ingredients
It has passed through special technique to extract, other than it can effectively improve transdermal absorption factor, moreover it is possible to sensitization be greatly reduced, greatly
Guarantee drug safety.
Detailed description of the invention
Fig. 1 is the process flow chart of preparation method of the present invention；
Fig. 2 is the structural schematic diagram of the embodiment of the present invention；
In attached drawing, parts list represented by the reference numerals are as follows:
1, substrate, 2, drug moiety, 3, cover lining.
Specific embodiment
The principle and features of the present invention will be described below with reference to the accompanying drawings, and the given examples are served only to explain the present invention, and
It is non-to be used to limit the scope of the invention.
As shown in Fig. 2, cow-bezoar infantile umbilical paste of the invention, including substrate 1 and attached drug moiety 2 on the base 1.It must
The cover lining 3 on drug moiety 2 can also be overlayed on when wanting with lid.
The formula of drug moiety 2 of the present invention is as follows:
Drug moiety 2 includes 1~8 part of In vitro cultured Calculus Bovis, 700~2500 parts of antipyretic and antidotal type Chinese medicine, the dry class of heat-clearing drop
200~1000 parts of Chinese medicine；5~40 parts of menthol, 100~800 parts of propylene glycol；10~80 parts of Dihydroxyaluminium Aminoacetate, Sodium Polyacrylate 100~
800 parts, 100~800 parts of sorbierite, 20~140 parts of crospovidone, 100~220 parts of Laurocapram, glycerol 1000~
2000 parts；10~80 parts of polyvinylpyrrolidone, 10~80 parts of citric acid, 2000~6000 parts of purified water.
The Chinese medicine of antipyretic and antidotal type can choose radix scutellariae, Cortex Phellodendri, gypsum, Fructus Forsythiae, Radix Isatidis, dandelion, honeysuckle, bavin
Recklessly, schizonepeta etc..
Preferred honeysuckle, radix bupleuri and schizonepeta in the present invention, wherein 300~1000 parts of honeysuckle, 300~1000 parts of radix bupleuri,
100~500 parts of schizonepeta.
Dry class Chinese medicine drops in heat-clearing can choose the coptis, radix rehmanniae recen, cape jasmine, Radix picrorrhizae, radix polygonati officinalis etc..
Preferred cape jasmine and Radix picrorrhizae in the present invention, wherein 100~500 parts of cape jasmine, 100~500 parts of Radix picrorrhizae.
It is furthermore preferred that drug moiety 2 of the present invention can also add 1~10 part of ethyl hydroxy benzoate.
As shown in Figure 1, the preparation method of above-mentioned cow-bezoar infantile umbilical paste has also been devised in the present invention, comprising the following steps:
1) extraction of antipyretic and antidotal type Chinese medicine: taking 700~2500 parts of antipyretic and antidotal type Chinese medicine, soaks in water rear vapor and steams
Extraction is evaporated, the aqueous solution filtering after distillation adds ethyl alcohol to make alcohol content 60% or more after filtrate concentration, cooling, stir evenly,
Cooling, stratification, takes supernatant, obtains the extracting solution of antipyretic and antidotal type Chinese medicine；
2) extraction and the Chinese medicine cream of dry class Chinese medicine drop in heat-clearing: take heat-clearing drop it is dry 200~1000 parts of class Chinese medicine, add 60% with
Upper alcohol reflux extracts 2 times, and merging filtrate merges with the extracting solution of step 1), recycles ethyl alcohol, is concentrated under reduced pressure into paste, obtains
To Chinese medical extract lotion；
3) it prepares menthol solution: 5~40 parts of menthol is added in 100~800 parts of propylene glycol, sufficiently dissolve, stir
It mixes uniformly mixed, obtains menthol solution；
4) it prepares I part: by 100~800 parts of Sodium Polyacrylate, 10~80 parts of Dihydroxyaluminium Aminoacetate, 100~800 parts of sorbierite, handing over
20~140 parts of povidone of connection, 100~220 parts of Laurocapram be added in 1000~2000 parts of glycerol and be mixed, body is then added
Chinese medical extract lotion made from menthol solution made from 1~8 part of outer cultured ox gallstone, step 3) and step 2), is sufficiently stirred
Uniformly, I part is obtained；
5) it prepares II part: taking 10~80 parts of polyvinylpyrrolidones to be added in 2000~6000 parts of purified waters and be sufficiently swollen
Afterwards, 10~80 parts of citric acids are added, dissolves, stir evenly, obtain II part；
6) preparation of cow-bezoar infantile umbilical paste: II part made from step 5) is added in I part made from step 4),
It is stirred under vacuum uniformly, obtains drug moiety, said medicine part is coated onto substrate, be sliced, stand sizing to get small to cow-bezoar
Youngster is defervescence plaster used.
Above-mentioned steps 1) and step 2) in, be all made of ethyl alcohol extraction mode handle traditional Chinese medicinal components, mentioned from traditional Chinese medicinal components
Take effective medicinal ingredient.By the traditional Chinese medicinal components that ethyl alcohol extracts, granularity can substantially reduce, and sensitization also can after being absorbed by children
It is greatly reduced, greatly improves the safety of medication.
Secondly, after ethyl alcohol extracts, then dealcoholation treatment, the percutaneous abilities of the Chinese medical extract extracted can greatly improve,
Along with a small amount of Laurocapram is added to, defervescence plaster used and use glycerol is major auxiliary burden, and percutaneous abilities can be promoted further,
After tested, the transdermal absorption factor of Chinese medical extract 4h can reach 32.7% or more to the present invention.
Preferably, in the step 1), the antipyretic and antidotal type Chinese medicine include 300~1000 parts of honeysuckle, radix bupleuri 300~
1000 parts, 100~500 parts of schizonepeta.
Preferably, in the step 2), the heat-clearing drop dry class Chinese medicine include 100~500 parts of cape jasmine, Radix picrorrhizae 100~
500 parts.
Preferably, in the step 4), it is also necessary to add 1~10 part of ethyl hydroxy benzoate into glycerol.
The present invention also provides improved technical solutions, in improved technical solution, the concrete operations of the step 1)
It is as follows:
Honeysuckle, radix bupleuri and the schizonepeta for taking formula ratio, after adding 8 times of amount water to impregnate 2 hours, steam distillation is extracted 4 hours,
Volatile oil order is set；To the aqueous solution filtering after distillation, filtrate be concentrated at a temperature of 55~65 DEG C relative density to 1.08~
1.10；After cooling, adds ethyl alcohol to make alcohol content 60%, stir evenly, it is cooling, 12 hours are stood, supernatant is taken.
The present invention also provides improved technical solutions, in improved technical solution, the concrete operations of the step 2)
It is as follows:
Cape jasmine, the Radix picrorrhizae for taking formula ratio add 60% alcohol reflux to extract 2 times, and for the first time plus 10 times of amounts extractions 1.5 are small
When, it filters to get filtrate, for the second time plus 8 times of amounts are extracted 1 hour, are filtered to get filtrate, are merged the filtrate of refluxing extraction twice；It will merge
Filtrate merge with the Chinese medicine extract of step 1), recycling ethyl alcohol be concentrated under reduced pressure into phase then under the conditions of 55~60 DEG C of temperature
The thick paste for being 1.35~1.38 to density.
The present invention also provides improved technical solutions, in improved technical solution, in the step 5), and crystallization operation
Need to 20~25 DEG C, humidity 70% it is below under the conditions of, place 12 hours.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of cow-bezoar infantile umbilical paste, including substrate (1) and the drug moiety (2) being attached on substrate (1), it is characterised in that:
The drug moiety (2) includes that 1~8 part of In vitro cultured Calculus Bovis, 700~2500 parts of antipyretic and antidotal type Chinese medicine, heat-clearing are dropped in dry class
200~1000 parts of medicine, matrix component part includes 10~80 parts of Dihydroxyaluminium Aminoacetate, 5~40 parts of menthol, Sodium Polyacrylate 100~800
Part, 10~80 parts of polyvinylpyrrolidone, 1000~2000 parts of glycerol, 100~800 parts of sorbierite, crospovidone 20~140
Part, 2000~6000 parts of purified water, 10~80 parts of citric acid, 100~800 parts of propylene glycol, 100~220 parts of Laurocapram.
2. cow-bezoar infantile umbilical paste according to claim 1, it is characterised in that: the antipyretic and antidotal type Chinese medicine includes gold and silver
Spend 300~1000 parts, 300~1000 parts of radix bupleuri, 100~500 parts of schizonepeta.
3. cow-bezoar infantile umbilical paste according to claim 2, it is characterised in that: it includes cape jasmine that dry class Chinese medicine drops in the heat-clearing
100~500 parts, 100~500 parts of Radix picrorrhizae.
4. cow-bezoar infantile umbilical paste according to claim 1, it is characterised in that: the drug moiety (2) further includes having hydroxyl
1~10 part of phenethyl ester.
5. a kind of preparation method of cow-bezoar infantile umbilical paste described in claim 1, it is characterised in that the following steps are included:
1) extraction of heat-clearing and detoxifying herb: taking 700~2500 parts of antipyretic and antidotal type Chinese medicine, soaks in water rear steam distillation and mentions
It taking, the aqueous solution filtering after distillation adds ethyl alcohol to make alcohol content 60% or more after filtrate concentration, cooling, stir evenly, cool down,
Stratification takes supernatant, obtains the extracting solution of antipyretic and antidotal type Chinese medicine；
2) extraction and the Chinese medicine cream of dry Chinese medicine drop in heat-clearing: taking dry 200~1000 parts of class Chinese medicine of heat-clearing drop, add 60% or more ethyl alcohol
Refluxing extraction 2 times, merging filtrate merges with the extracting solution of step 1), recycles ethyl alcohol, is concentrated under reduced pressure into paste, obtains Chinese medicine
Extract lotion；
3) it prepares menthol solution: 5~40 parts of menthol is added in 100~800 parts of propylene glycol, sufficiently dissolve, stirring is mixed
It closes uniformly, obtains menthol solution；
4) I part is prepared: 100~800 parts of Sodium Polyacrylate, 10~80 parts of Dihydroxyaluminium Aminoacetate, 100~800 parts of sorbierite, crosslinking is poly-
20~140 parts of ketone of dimension, 100~220 parts of Laurocapram be added in 1000~2000 parts of glycerol and be mixed, external training is then added
Chinese medical extract lotion made from menthol solution made from 1~8 part of induced bezoar, step 3) and step 2), stirs,
Obtain I part；
5) II part is prepared: after taking 10~80 parts of polyvinylpyrrolidones that sufficiently swelling is added in 2000~6000 parts of purified waters,
10~80 parts of citric acids are added, dissolves, stir evenly, obtain II part；
6) preparation of cow-bezoar infantile umbilical paste: II part made from step 5) is added in I part made from step 4), vacuum
It stirs evenly, obtains drug moiety (2), said medicine part (2) are coated on substrate (1), be sliced, stand sizing to get arriving
Cow-bezoar infantile umbilical paste.
6. the preparation method of cow-bezoar infantile umbilical paste according to claim 5, it is characterised in that: in the step 1), clearly
Thermal detoxification Chinese medicine includes 300~1000 parts of honeysuckle, 300~1000 parts of radix bupleuri, 100~500 parts of schizonepeta.
7. the preparation method of cow-bezoar infantile umbilical paste according to claim 5, it is characterised in that: in the step 2), clearly
The dry Chinese medicine of heat drop includes 100~500 parts of cape jasmine, 100~500 parts of Radix picrorrhizae.
8. the preparation method of cow-bezoar infantile umbilical paste according to claim 5, it is characterised in that: in the step 4), also
It needs to add 1~10 part of ethyl hydroxy benzoate into glycerol.
9. the preparation method of cow-bezoar infantile umbilical paste according to claim 6, it is characterised in that: in the step 1), add
Water dip operation is plus 8 times of amount water impregnate 2 hours, and steam distillation is extracted 4 hours, and filtrate is concentrated at a temperature of 55~65 DEG C
Relative density is 1.08~1.10.
10. the preparation method of cow-bezoar infantile umbilical paste according to claim 7, it is characterised in that: in the step 2), add
Alcohol reflux extracts 2 times, and for the first time plus 10 times of 60% ethyl alcohol of amount extract 1.5 hours, and for the second time plus 8 times of 60% ethyl alcohol of amount extract 1
Hour；For decompression and concentration operation under the conditions of 55~60 DEG C of temperature, being concentrated into relative density is 1.35~1.38.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679520A (en) * | 2005-01-11 | 2005-10-12 | 中国人民解放军第二军医大学 | Compound analgesic agent |
| CN1876044A (en) * | 2006-04-19 | 2006-12-13 | 武汉健民中药工程有限责任公司 | A Chinese medicinal composition for treating infant fever caused by exogenous pathogen and preparation method thereof |
| CN104706768A (en) * | 2015-03-12 | 2015-06-17 | 施敬东 | Patch capable of calming nerves and helping sleep and preparation method of patch |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679520A (en) * | 2005-01-11 | 2005-10-12 | 中国人民解放军第二军医大学 | Compound analgesic agent |
| CN1876044A (en) * | 2006-04-19 | 2006-12-13 | 武汉健民中药工程有限责任公司 | A Chinese medicinal composition for treating infant fever caused by exogenous pathogen and preparation method thereof |
| CN104706768A (en) * | 2015-03-12 | 2015-06-17 | 施敬东 | Patch capable of calming nerves and helping sleep and preparation method of patch |
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Application publication date: 20191203 |