CN100490791C - 治疗与新血管生成相关疾病的组合物及方法 - Google Patents

治疗与新血管生成相关疾病的组合物及方法 Download PDF

Info

Publication number
CN100490791C
CN100490791C CNB018224156A CN01822415A CN100490791C CN 100490791 C CN100490791 C CN 100490791C CN B018224156 A CNB018224156 A CN B018224156A CN 01822415 A CN01822415 A CN 01822415A CN 100490791 C CN100490791 C CN 100490791C
Authority
CN
China
Prior art keywords
gossypol
pharmaceutically acceptable
acceptable salt
neovascularization
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018224156A
Other languages
English (en)
Chinese (zh)
Other versions
CN1529590A (zh
Inventor
汪建平
汪明中
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wackvom Ltd
Original Assignee
Wackvom Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wackvom Ltd filed Critical Wackvom Ltd
Publication of CN1529590A publication Critical patent/CN1529590A/zh
Application granted granted Critical
Publication of CN100490791C publication Critical patent/CN100490791C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CNB018224156A 2000-12-15 2001-12-14 治疗与新血管生成相关疾病的组合物及方法 Expired - Fee Related CN100490791C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25587600P 2000-12-15 2000-12-15
US60/255,876 2000-12-15

Publications (2)

Publication Number Publication Date
CN1529590A CN1529590A (zh) 2004-09-15
CN100490791C true CN100490791C (zh) 2009-05-27

Family

ID=22970220

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018224156A Expired - Fee Related CN100490791C (zh) 2000-12-15 2001-12-14 治疗与新血管生成相关疾病的组合物及方法

Country Status (7)

Country Link
US (1) US6608107B2 (cg-RX-API-DMAC7.html)
EP (1) EP1343487A2 (cg-RX-API-DMAC7.html)
JP (1) JP2005502579A (cg-RX-API-DMAC7.html)
CN (1) CN100490791C (cg-RX-API-DMAC7.html)
AU (1) AU2002230888A1 (cg-RX-API-DMAC7.html)
MY (1) MY134562A (cg-RX-API-DMAC7.html)
WO (1) WO2002047673A2 (cg-RX-API-DMAC7.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385936A (en) 1990-07-12 1995-01-31 The United States Of America As Represented By The Secretary Of The Department Of The Health And Human Services Gossypol acetic acid for the treatment of cancer
CA2417500C (en) 2000-07-28 2008-11-18 Georgetown University Medical Center Erbb-2 selective small molecule kinase inhibitors
US7432304B2 (en) 2001-05-30 2008-10-07 The Regents Of The University Of Michigan Small molecule antagonists of Bcl-2 family proteins
US7354928B2 (en) 2001-11-01 2008-04-08 The Regents Of The University Of Michigan Small molecule inhibitors targeted at Bcl-2
CN100413493C (zh) * 2003-06-11 2008-08-27 中国科学院动物研究所 棉酚及其衍生物在制备治疗骨髓瘤药物中的应用
US7812058B2 (en) * 2003-06-25 2010-10-12 The Burnham Institute Methods and compounds useful to induce apoptosis in cancer cells
WO2005067627A2 (en) * 2004-01-07 2005-07-28 E-L Management Corporation Cosmetic composition and method for retarding hair growth
SG151299A1 (en) * 2004-03-25 2009-04-30 Univ Michigan Gossypol co-crystals and the use thereof
US20110091552A1 (en) * 2007-08-31 2011-04-21 Mccaffrey Tim Use of Bcl Inhibitors for the Treatment of Scarring Caused By Cutaneous Wounds, Burns and Abrasions
CN101883486B (zh) * 2007-10-01 2014-09-17 阿森达治疗学股份有限公司 制备r-棉酚l-苯丙氨醇二烯胺的方法
SG177327A1 (en) 2009-06-22 2012-02-28 Cabot Microelectronics Corp Cmp compositions and methods for suppressing polysilicon removal rates
EP2460837B1 (en) 2009-07-29 2018-03-21 Teijin Chemicals, Ltd. Polycarbonate/polydiorganosiloxane copolymer
CN101810577B (zh) * 2010-05-06 2011-09-07 山东大学 治疗肿瘤的棉酚静脉注射脂肪乳剂
CN103467538B (zh) * 2012-05-29 2015-08-19 武汉大学 具有抗艾滋病毒活性的棉酚衍生物及其制备方法
US9750761B2 (en) * 2014-05-21 2017-09-05 University Of Rochester LDH inhibitors as treatment for fibrosis and fibrotic-related disorders
EP3950060A4 (en) * 2019-04-04 2023-04-19 Nissan Chemical Corporation Composition for promoting secretion of extracellular vesicles
CN110559449B (zh) * 2019-10-22 2022-09-02 长治医学院 一种聚棉酚前药胶束及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1204510A (zh) * 1997-07-09 1999-01-13 辛国芳 以棉酚或(和)其衍生物为有效成分的药栓及用途
US6114397A (en) * 1990-07-12 2000-09-05 The United States Of America As Represented By The Department Of Health And Human Services Gossypol for the treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260327A (en) * 1985-10-02 1993-11-09 Sloan-Kettering Institute For Cancer Research Methods for inhibiting the proliferation of brain and hepatic metastases by using lonidamine
US5026726A (en) * 1989-12-11 1991-06-25 The University Of New Mexico Gossylic iminolactones and gossylic lactones and their anti-viral activities
US5780675A (en) * 1995-04-28 1998-07-14 The University Of New Mexico Deoxygossylic compounds
US5936120A (en) * 1997-12-10 1999-08-10 University Of New Mexico Deoxygossylic compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6114397A (en) * 1990-07-12 2000-09-05 The United States Of America As Represented By The Department Of Health And Human Services Gossypol for the treatment of cancer
CN1204510A (zh) * 1997-07-09 1999-01-13 辛国芳 以棉酚或(和)其衍生物为有效成分的药栓及用途

Also Published As

Publication number Publication date
MY134562A (en) 2007-12-31
EP1343487A2 (en) 2003-09-17
JP2005502579A (ja) 2005-01-27
AU2002230888A1 (en) 2002-06-24
US6608107B2 (en) 2003-08-19
US20020137801A1 (en) 2002-09-26
CN1529590A (zh) 2004-09-15
WO2002047673A3 (en) 2003-01-03
WO2002047673A2 (en) 2002-06-20

Similar Documents

Publication Publication Date Title
CN100490791C (zh) 治疗与新血管生成相关疾病的组合物及方法
RU2533458C2 (ru) Композиции, содежащие берберин или его аналоги для лечения кожных заболеваний, связанных с розацеа или с покраснением лица
EP1477166B1 (de) Verwendung von Riluzole kombiniert mit geeigneten Hilfs-und Zusatzstoffen zur Behandlung von Krankheiten, die durch eine Hyperproliferation von Keratinozyten gekennzeichnet sind, insbesondere Neurodermitis und Psoriasis
AU2010253864B2 (en) Methods for administration and formulations for the treatment of regional adipose tissue
EP1476195B1 (en) Enhancement of the action of central and peripheral nervous system agents
BR112021006132A2 (pt) compostos bifenil sulfonamida para o tratamento de doenças de colágeno tipo iv
EP1401462A1 (en) Compositions containing an active fraction isolated from ganoderma lucidum and methods of use
CN113056268A (zh) 纤溶酶原激活物抑制剂1(pai-1)抑制剂和其用途
JP2006508047A (ja) 新血管新生に関連する状態を治療する方法及び配合物
WO2004045380A2 (en) Compositions containing an active fraction isolated from tannins and methods of use
ES2528392T3 (es) Eprotiroma para su uso en la prevención y/o tratamiento de trastornos capilares y composiciones de la misma
US20250099491A1 (en) Prevention or treatment of cardiovascular diseases with high penetration prodrugs of aspirin and other nsaids
JP7361448B2 (ja) トランスグルタミナーゼ発現促進剤
JP6656890B2 (ja) フィラグリン産生促進剤
WO2002098438A9 (en) Compositions containing an active fraction isolated from scutellariae barbatae and methods of use
WO2022221988A1 (en) Pharmaceutical hydronidone formulations for diseases
KR102751617B1 (ko) 이소클로로겐산 또는 이의 염을 유효성분으로 포함하는 피부 로사시아 예방 및 개선용 조성물
CN108024972A (zh) 白癜风的治疗
US20020164390A1 (en) Compositions containing an active fraction isolated from tricholoma conglobatum and methods of use
US9566262B2 (en) Itch suppression by fucoxanthin
CN1499979A (zh) 含分离自白花蛇舌草的活性级分的组合物及使用方法
WO2020021544A1 (en) Cannabidiol and methylthio-butyl-isothiocyanate for treating inflammatory diseases
US20020132016A1 (en) Compositions containing an active fraction isolated from hedyotis diffusae and methods of use
CN119656147A (zh) 一种小分子二萜化合物在制备防治急性胰腺炎的药物中的应用
KR20190008236A (ko) 소아기 적용을 위한 카르복실산

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090527

Termination date: 20191214

CF01 Termination of patent right due to non-payment of annual fee