CN100484518C - 药物剂量逐渐增加的剂型 - Google Patents

药物剂量逐渐增加的剂型 Download PDF

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Publication number
CN100484518C
CN100484518C CNB97197439XA CN97197439A CN100484518C CN 100484518 C CN100484518 C CN 100484518C CN B97197439X A CNB97197439X A CN B97197439XA CN 97197439 A CN97197439 A CN 97197439A CN 100484518 C CN100484518 C CN 100484518C
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CN
China
Prior art keywords
layer
drug
dosage form
molecular weight
average molecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CNB97197439XA
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English (en)
Chinese (zh)
Other versions
CN1228691A (zh
Inventor
P·施瓦纳德
A·D·阿耶
J·D·威里格特
A·拉穆
L·G·哈默尔
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Alza Corp
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Alza Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21814183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN100484518(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corp filed Critical Alza Corp
Publication of CN1228691A publication Critical patent/CN1228691A/zh
Application granted granted Critical
Publication of CN100484518C publication Critical patent/CN100484518C/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
CNB97197439XA 1996-08-16 1997-08-08 药物剂量逐渐增加的剂型 Expired - Lifetime CN100484518C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2328696P 1996-08-16 1996-08-16
US60/023,286 1996-08-16

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN200910129895.8A Division CN101518517B (zh) 1996-08-16 1997-08-08 药物剂量逐渐增加的剂型

Publications (2)

Publication Number Publication Date
CN1228691A CN1228691A (zh) 1999-09-15
CN100484518C true CN100484518C (zh) 2009-05-06

Family

ID=21814183

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB97197439XA Expired - Lifetime CN100484518C (zh) 1996-08-16 1997-08-08 药物剂量逐渐增加的剂型
CN200910129895.8A Expired - Lifetime CN101518517B (zh) 1996-08-16 1997-08-08 药物剂量逐渐增加的剂型

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200910129895.8A Expired - Lifetime CN101518517B (zh) 1996-08-16 1997-08-08 药物剂量逐渐增加的剂型

Country Status (13)

Country Link
EP (1) EP0957899B1 (enExample)
JP (1) JP4393587B2 (enExample)
CN (2) CN100484518C (enExample)
AT (1) ATE234602T1 (enExample)
AU (1) AU3909597A (enExample)
CA (1) CA2263558A1 (enExample)
CY (1) CY2475B1 (enExample)
DE (1) DE69720055T2 (enExample)
DK (1) DK0957899T3 (enExample)
ES (1) ES2194210T3 (enExample)
PT (1) PT957899E (enExample)
WO (1) WO1998006380A2 (enExample)
ZA (1) ZA977254B (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6440457B1 (en) 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
US5837284A (en) 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
DE69735581T2 (de) * 1996-09-30 2007-01-25 Alza Corp., Palo Alto Dosierungsform für eine verzögerte und zunehmende wirkstoffsfreisetzung
EP1690531A3 (en) * 1996-09-30 2010-01-20 Alza Corporation Dosage form and method for administering drug
US6919373B1 (en) 1996-11-12 2005-07-19 Alza Corporation Methods and devices for providing prolonged drug therapy
CN100477986C (zh) * 1996-11-25 2009-04-15 阿尔萨公司 递增剂量的剂型
US6962997B1 (en) 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
AU2012232984B2 (en) * 1998-06-03 2015-10-29 Alza Corporation Methods and devices for providing prolonged drug therapy
AU2004200938B2 (en) * 1998-06-03 2006-09-14 Alza Corporation Methods and devices for providing prolonged drug therapy
KR100890537B1 (ko) * 1998-06-03 2009-03-27 알자 코포레이션 연장된 약물 치료를 제공하기 위한 방법 및 장치
KR100827254B1 (ko) * 1998-06-03 2008-05-07 알자 코포레이션 연장된 약물 치료를 제공하기 위한 방법 및 장치
HK1046638B (zh) * 1998-06-03 2006-02-24 阿尔扎有限公司 提供药物长效治疗的方法和装置
DK1126826T6 (en) 1998-11-02 2019-06-24 Alkermes Pharma Ireland Ltd Multiparticulate modified release of methylphenidate
US6673367B1 (en) * 1998-12-17 2004-01-06 Euro-Celtique, S.A. Controlled/modified release oral methylphenidate formulations
US6419960B1 (en) 1998-12-17 2002-07-16 Euro-Celtique S.A. Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations
EP1165054A4 (en) 1999-04-06 2005-02-09 Pharmaquest Ltd PHARMACEUTICAL DOSAGE FORM FOR INTERMITTENT DELIVERY OF METHYLPHENIDATE
KR20020072290A (ko) * 2000-01-20 2002-09-14 델시스 파머수티컬 코포레이션 다단계 약물 투여 형태
JP4500679B2 (ja) * 2002-07-29 2010-07-14 アルザ・コーポレーシヨン パリペリドンを制御送達する方法および投薬形態物
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
EP1556017A1 (en) * 2002-10-31 2005-07-27 ALZA Corporation Dosage form providing ascending release of liquid formulation
US7988993B2 (en) 2002-12-09 2011-08-02 Andrx Pharmaceuticals, Inc. Oral controlled release dosage form
AU2004275835B2 (en) * 2003-09-26 2011-06-23 Alza Corporation Controlled release formulations exhibiting an ascending rate of release
KR20060092255A (ko) 2003-09-26 2006-08-22 알자 코포레이션 고도의 약물적재를 제공하는 약물코팅제 및 그의 제조방법
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
PL116330U1 (en) 2005-10-31 2007-04-02 Alza Corp Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation
US9226907B2 (en) 2008-02-01 2016-01-05 Abbvie Inc. Extended release hydrocodone acetaminophen and related methods and uses thereof
WO2015001488A1 (en) 2013-07-01 2015-01-08 Ranbaxy Laboratories Limited Extended-release tablets of paliperidone and processes of preparation thereof
CA2936746C (en) 2014-10-31 2017-06-27 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
US20180360817A1 (en) * 2015-12-31 2018-12-20 Cadila Healthcare Limited Extended release osmotic dosage form comprising high methylphenidate hydrochloride load
EP3501504A1 (en) 2017-12-22 2019-06-26 Pharmacia Polonica sp. z o.o. Modified release tablet of paliperidone and a process for the preparation thereof
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327725A (en) * 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4814181A (en) * 1987-09-03 1989-03-21 Alza Corporation Dosage form comprising fast agent delivery followed by slow agent delivery

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4842867A (en) * 1986-05-09 1989-06-27 Alza Corporation Pulsed drug delivery of doxylamine
GB2206046B (en) * 1987-06-25 1991-04-03 Alza Corp Multi-unit delivery system
US4874388A (en) * 1987-06-25 1989-10-17 Alza Corporation Multi-layer delivery system
US4915954A (en) * 1987-09-03 1990-04-10 Alza Corporation Dosage form for delivering a drug at two different rates
US5017381A (en) * 1990-05-02 1991-05-21 Alza Corporation Multi-unit pulsatile delivery system
DE69425453T2 (de) * 1993-04-23 2001-04-12 Novartis Ag, Basel Wirkstoffabgabevorrichtung mit gesteuerter Freigabe
GB9402203D0 (en) * 1994-02-04 1994-03-30 Smithkline Beecham Plc Pharmaceutical formulation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327725A (en) * 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4814181A (en) * 1987-09-03 1989-03-21 Alza Corporation Dosage form comprising fast agent delivery followed by slow agent delivery

Also Published As

Publication number Publication date
EP0957899B1 (en) 2003-03-19
CN1228691A (zh) 1999-09-15
WO1998006380A3 (en) 1998-05-14
HK1021886A1 (zh) 2000-07-14
CA2263558A1 (en) 1998-02-19
WO1998006380A2 (en) 1998-02-19
CN101518517B (zh) 2014-11-26
JP2000516610A (ja) 2000-12-12
DK0957899T3 (da) 2003-04-22
DE69720055T2 (de) 2003-09-11
CN101518517A (zh) 2009-09-02
ATE234602T1 (de) 2003-04-15
JP4393587B2 (ja) 2010-01-06
HK1137355A1 (zh) 2010-07-30
ZA977254B (en) 1998-05-11
CY2475B1 (en) 2005-06-03
ES2194210T3 (es) 2003-11-16
DE69720055D1 (de) 2003-04-24
EP0957899A2 (en) 1999-11-24
PT957899E (pt) 2003-07-31
AU3909597A (en) 1998-03-06

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