CN100475776C - 用作给药生物活性剂的辅助剂的非α位上的氨基酸二酰胺 - Google Patents

用作给药生物活性剂的辅助剂的非α位上的氨基酸二酰胺 Download PDF

Info

Publication number
CN100475776C
CN100475776C CNB2004800220400A CN200480022040A CN100475776C CN 100475776 C CN100475776 C CN 100475776C CN B2004800220400 A CNB2004800220400 A CN B2004800220400A CN 200480022040 A CN200480022040 A CN 200480022040A CN 100475776 C CN100475776 C CN 100475776C
Authority
CN
China
Prior art keywords
aromatic
compound
mmol
pharmaceutical composition
following structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2004800220400A
Other languages
English (en)
Chinese (zh)
Other versions
CN1829682A (zh
Inventor
J·萨基斯马尔迪吉安
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Farmaceuticos Rovi SA
Original Assignee
Laboratorios Farmaceuticos Rovi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Farmaceuticos Rovi SA filed Critical Laboratorios Farmaceuticos Rovi SA
Publication of CN1829682A publication Critical patent/CN1829682A/zh
Application granted granted Critical
Publication of CN100475776C publication Critical patent/CN100475776C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
CNB2004800220400A 2003-07-28 2004-07-23 用作给药生物活性剂的辅助剂的非α位上的氨基酸二酰胺 Expired - Fee Related CN100475776C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200301781A ES2222822B1 (es) 2003-07-28 2003-07-28 Diamidas de aminoacidos en posicion no alfa utiles como adyuvantes para la administracion de agentes biologicos activos.
ESP200301781 2003-07-28

Publications (2)

Publication Number Publication Date
CN1829682A CN1829682A (zh) 2006-09-06
CN100475776C true CN100475776C (zh) 2009-04-08

Family

ID=34112519

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800220400A Expired - Fee Related CN100475776C (zh) 2003-07-28 2004-07-23 用作给药生物活性剂的辅助剂的非α位上的氨基酸二酰胺

Country Status (17)

Country Link
US (1) US7462735B2 (https=)
EP (1) EP1652836B1 (https=)
JP (1) JP4343227B2 (https=)
KR (1) KR100970216B1 (https=)
CN (1) CN100475776C (https=)
AT (1) ATE367373T1 (https=)
AU (1) AU2004261417C1 (https=)
BR (1) BRPI0413032A (https=)
CA (1) CA2533639A1 (https=)
DE (1) DE602004007665T2 (https=)
DK (1) DK1652836T3 (https=)
ES (2) ES2222822B1 (https=)
PL (1) PL1652836T3 (https=)
PT (1) PT1652836E (https=)
RU (1) RU2368599C2 (https=)
WO (1) WO2005012230A1 (https=)
ZA (1) ZA200600165B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2060253A1 (en) 2007-11-14 2009-05-20 Laboratorios Farmaceuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
ES2296529B1 (es) * 2006-08-07 2009-04-01 Laboratorios Farmaceuticos Rovi, S.A. Composicion farmaceutica con promotores de absorcion.
US8802156B2 (en) 2007-11-14 2014-08-12 Laboratorios Farmacéuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
EP2213282A1 (en) 2009-01-30 2010-08-04 Laboratorios Farmaceuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
CN104230745B (zh) * 2014-07-10 2016-06-22 南京医科大学 一类n-苄基取代的氨基水杨酸与4-氨基丁酸的酰胺衍生物及其药物用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965121A (en) * 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
WO2003015774A1 (en) * 2001-08-17 2003-02-27 Astrazeneca Ab Compounds effecting glucokinase
US6541203B2 (en) * 1998-11-23 2003-04-01 President And Fellows Of Harvard College Detecting structural or synthetic information about chemical compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650386A (en) * 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US6001347A (en) * 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6358504B1 (en) * 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
CN1313439C (zh) * 1998-08-07 2007-05-02 艾米斯菲尔技术有限公司 用于送递活性剂的化合物和组合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965121A (en) * 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6541203B2 (en) * 1998-11-23 2003-04-01 President And Fellows Of Harvard College Detecting structural or synthetic information about chemical compounds
WO2003015774A1 (en) * 2001-08-17 2003-02-27 Astrazeneca Ab Compounds effecting glucokinase

Also Published As

Publication number Publication date
CN1829682A (zh) 2006-09-06
EP1652836A1 (en) 2006-05-03
ES2289534T3 (es) 2008-02-01
KR20060079184A (ko) 2006-07-05
DE602004007665T2 (de) 2008-05-15
ATE367373T1 (de) 2007-08-15
CA2533639A1 (en) 2005-02-10
ES2222822B1 (es) 2005-12-16
DE602004007665D1 (de) 2007-08-30
RU2368599C2 (ru) 2009-09-27
KR100970216B1 (ko) 2010-07-16
ZA200600165B (en) 2007-03-28
BRPI0413032A (pt) 2006-10-03
US20070191302A1 (en) 2007-08-16
AU2004261417B2 (en) 2010-07-01
AU2004261417C1 (en) 2011-02-24
PL1652836T3 (pl) 2007-12-31
AU2004261417A1 (en) 2005-02-10
RU2006101630A (ru) 2007-09-10
ES2222822A1 (es) 2005-02-01
DK1652836T3 (da) 2007-11-05
EP1652836B1 (en) 2007-07-18
JP4343227B2 (ja) 2009-10-14
US7462735B2 (en) 2008-12-09
PT1652836E (pt) 2007-10-23
JP2007533600A (ja) 2007-11-22
WO2005012230A1 (es) 2005-02-10

Similar Documents

Publication Publication Date Title
ES2263428T3 (es) Compuesto y composicion para agentes activos de administracion.
CA2099453A1 (en) N-benzoylamino acid derivatives, pharmaceutical compositions containing them and process for preparing same
WO2022227743A1 (zh) 一种美金刚脲类衍生物及其制备方法和应用
CN100475776C (zh) 用作给药生物活性剂的辅助剂的非α位上的氨基酸二酰胺
ITMI982064A1 (it) Derivati a struttura n-acil vanillinamidica in grado di attivare i recettori periferici dei cannabinoidi
JP2020500204A (ja) ピペリジン−２，６−ジオン誘導体及びクローン病の治療
CN110845425B (zh) 一种酞嗪衍生物及其制备方法和应用
CN115286583A (zh) 一种含二苯基氨基嘧啶类化合物、制备及其作为HDACs酶抑制剂的应用
CN102596321A (zh) 可用作dpp-1抑制剂的炔基衍生物
CN101429191B (zh) 取代的四氢异喹啉衍生物的用途
ES2368199T3 (es) Derivados covalentes de alcanolamidas de ácidos monocarboxílicos y dicarboxílicos funcionalmente activos en el receptor cannabinoide cb2.
US8066970B2 (en) Contrast agents
CN101386617B (zh) 取代的四氢异喹啉衍生物、其制备方法及含有它们的药物组合物
CN104447704B (zh) 一种腈基金刚烷四氮唑化合物、其制备方法和用途
MXPA06001025A (en) Amino acid diamides in non alpha position useful as adjuvants for the administration of active biological agents
CN104356048B (zh) 环己烷羧酸酰胺类衍生物、其制备方法和用途
CN104356046B (zh) 环烷基取代的环己烷羧酸酰胺类衍生物及其用途
CN104530011A (zh) 一种腈基金刚烷四氮唑化合物、其制备方法和用途
CN104356047B (zh) 取代的环己烷羧酸酰胺类衍生物及其药物用途
CN104478859A (zh) 一种羟基金刚烷四氮唑化合物、其制备方法和用途
CN104478861A (zh) 一种硝基金刚烷四氮唑化合物、其制备方法和用途
CN116041300A (zh) 一种2,2-二甲基苯并吡喃类衍生物及其制备方法和应用
CN104447703A (zh) 一种硝基金刚烷四氮唑化合物、其制备方法和用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090408

Termination date: 20120723