CN100446753C - 克霉唑凝胶剂及其制备方法 - Google Patents
克霉唑凝胶剂及其制备方法 Download PDFInfo
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- CN100446753C CN100446753C CNB2006101096740A CN200610109674A CN100446753C CN 100446753 C CN100446753 C CN 100446753C CN B2006101096740 A CNB2006101096740 A CN B2006101096740A CN 200610109674 A CN200610109674 A CN 200610109674A CN 100446753 C CN100446753 C CN 100446753C
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- clotrimazole
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- distilled water
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- 229910052725 zinc Inorganic materials 0.000 description 1
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Abstract
Description
组别 | 累积渗透方程(μg/cm<sup>2</sup>) | J(μg/cm<sup>2</sup>h) | r |
卡波姆941 | Q=-112.939+92.654t | 92.654 | 0.9875 |
卡波姆940 | Q=-18.339+21.765t | 21.765 | 0.9616 |
卡波姆934 | Q=-97.521+82.869t | 82.869* | 0.9876 |
甲基纤维素 | Q=-53.597+46.325t | 46.325 | 0.9766 |
羧甲基纤维素钠 | Q=-88.199+54.756t | 54.756 | 0.9428 |
交联型聚丙烯酸钠 | Q=-76.130+51.968t | 51.968 | 0.9857 |
组别 | 0天 | 5天 | 10天 |
卡波姆941 | 4.75 | 4.24 | 4.01 |
卡波姆940 | 4.49 | 4.21 | 4.00 |
卡波姆934 | 4.84 | 4.78 | 4.27 |
甲基纤维素 | 5.02 | 4.45 | 4.12 |
羧甲基纤维素钠 | 5.07 | 4.34 | 4.04 |
交联型聚丙烯酸钠 | 4.94 | 4.12 | 4.05 |
卡波姆和三乙醇胺用量 | 克霉唑 | 甘油 | 羟苯乙酯 | 黏度 |
3% | 5% | 10% | 0.06% | 非常大制备困难 |
2% | 5% | 10% | 0.06% | 较大 |
1% | 5% | 10% | 0.06% | 适宜 |
0.8% | 5% | 10% | 0.06% | 较小 |
0.6% | 5% | 10% | 0.06% | 较小,有流动性 |
0.4% | 5% | 10% | 0.06% | 非常小,有流动性 |
Claims (2)
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CN103126974B (zh) * | 2011-11-30 | 2018-04-10 | 王冕 | 一种凝胶剂 |
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CN109431968A (zh) * | 2018-12-29 | 2019-03-08 | 天津凯茵科技有限公司 | 基于克霉唑的妇科用复方组合物 |
CN109431969A (zh) * | 2018-12-29 | 2019-03-08 | 天津凯茵科技有限公司 | 一种妇科复方克霉唑组合物 |
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Non-Patent Citations (2)
Title |
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卡波姆在药剂学中的应用. 王彦.中国药事,第19卷第6期. 2005 * |
阴道内给药凝胶制剂的研究进展. 宁美英.国外医学药学分册,第32卷第5期. 2005 * |
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