CN100436446C - 用于止痛的十氢异喹啉-3-羧酸的酯衍生物 - Google Patents

用于止痛的十氢异喹啉-3-羧酸的酯衍生物 Download PDF

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Publication number
CN100436446C
CN100436446C CNB038094606A CN03809460A CN100436446C CN 100436446 C CN100436446 C CN 100436446C CN B038094606 A CNB038094606 A CN B038094606A CN 03809460 A CN03809460 A CN 03809460A CN 100436446 C CN100436446 C CN 100436446C
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CN
China
Prior art keywords
ethyl
acceptable salt
pharmaceutically acceptable
acid
meant
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Expired - Fee Related
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CNB038094606A
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English (en)
Chinese (zh)
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CN1649862A (zh
Inventor
P·L·奥恩施泰因
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Eli Lilly and Co
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Eli Lilly and Co
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Publication of CN1649862A publication Critical patent/CN1649862A/zh
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Publication of CN100436446C publication Critical patent/CN100436446C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB038094606A 2002-04-26 2003-04-14 用于止痛的十氢异喹啉-3-羧酸的酯衍生物 Expired - Fee Related CN100436446C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37612002P 2002-04-26 2002-04-26
US60/376,120 2002-04-26

Publications (2)

Publication Number Publication Date
CN1649862A CN1649862A (zh) 2005-08-03
CN100436446C true CN100436446C (zh) 2008-11-26

Family

ID=29270765

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038094606A Expired - Fee Related CN100436446C (zh) 2002-04-26 2003-04-14 用于止痛的十氢异喹啉-3-羧酸的酯衍生物

Country Status (18)

Country Link
US (1) US7247644B2 (https=)
EP (1) EP1511741B1 (https=)
JP (2) JP2005529892A (https=)
KR (1) KR100757787B1 (https=)
CN (1) CN100436446C (https=)
AU (1) AU2003226277B2 (https=)
BR (1) BR0308911A (https=)
CA (1) CA2480026C (https=)
DK (1) DK1511741T3 (https=)
EA (1) EA009526B1 (https=)
ES (1) ES2398225T3 (https=)
IL (1) IL164773A (https=)
MX (1) MXPA04009857A (https=)
NZ (1) NZ535245A (https=)
PT (1) PT1511741E (https=)
SI (1) SI1511741T1 (https=)
WO (1) WO2003091243A1 (https=)
ZA (1) ZA200409552B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100757787B1 (ko) * 2002-04-26 2007-09-11 일라이 릴리 앤드 캄파니 진통제로서의 데카히드로이소퀴놀린-3-카르복실산의 에스테르 유도체
US8603980B2 (en) 2007-01-16 2013-12-10 The Johns Hopkins University Glutamate receptor antagonists and methods of use
MX2022016223A (es) 2020-07-02 2023-02-23 Sea Pharmaceuticals Llc Composiciones farmaceuticas de acido 6-(2-(2h-tetrazol-5-il)etil)- 6-fluorodecahidroisoquinolina-3-carboxilico y derivados de ester del mismo.
WO2022261287A1 (en) * 2021-06-09 2022-12-15 Proniras Corporation Methods of treating nerve agent-induced seizures
WO2023130008A2 (en) * 2022-01-01 2023-07-06 Sea Pharmaceuticals Llc Pharmaceutical compositions of 6-(2-(2h-tetrazol-5-yl)ethyl)decahydroisoquinoline-3-carboxylic acid and derivatives thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0590789A1 (en) * 1992-09-03 1994-04-06 Eli Lilly And Company Excitatory amino acid receptor antagonists
WO2001002367A2 (en) * 1999-07-06 2001-01-11 Eli Lilly And Company Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK406686D0 (da) * 1986-08-26 1986-08-26 Hans Bundgaard Carboxylsyrederivater
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5356902A (en) 1992-11-06 1994-10-18 Eli Lilly And Company Decahydroisoquinoline compounds as excitatory amino acid receptor antagonists
US5446051A (en) 1994-05-31 1995-08-29 Eli Lilly And Company Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists
US5767117A (en) 1994-11-18 1998-06-16 The General Hospital Corporation Method for treating vascular headaches
HUP0002030A3 (en) 1997-04-07 2002-01-28 Lilly Co Eli Use of glur5 receptorantagonists for the treatment of pain
EP1200073B1 (en) 1999-07-06 2007-01-10 Eli Lilly And Company SELECTIVE iGluR 5? RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MIGRAINE
AU2574801A (en) 1999-12-22 2001-07-03 Eli Lilly And Company Selective iGLUR5 receptor antagonists
WO2002053556A2 (en) 2001-01-05 2002-07-11 Eli Lilly And Company Pyrrolidinylmethyl substituted decahydroisoquinolines as excitatory amino acid receptor antagonists
WO2003024453A1 (en) 2001-01-05 2003-03-27 Eli Lilly And Company Excitatory amino acid receptor antagonists
AU2002227020A1 (en) 2001-01-05 2002-07-16 Eli Lilly And Company Pyrrolidinylmethyl- and piperidinyl substituted decahydroisoquinolines as excitatory amino acid receptor antagonists
WO2003024934A2 (en) 2001-01-05 2003-03-27 Eli Lilly And Company Derivatives of the (3s, 4ar, 6s, 8ar) 6-phenylamino-1, 2, 3, 4, 4a, 5, 6, 7, 8, 8a-decahydro isoquinoline-3-carboxylic acid as excitatory amino acid receptor antagonists for the treatment of neurological disorders and neurodegenerative diseases
WO2003082856A1 (en) 2002-03-22 2003-10-09 Eli Lilly And Company Isoquinoline-3-carboxylic acid derivatives as excitatory amino acid receptor antagonists
KR100757787B1 (ko) * 2002-04-26 2007-09-11 일라이 릴리 앤드 캄파니 진통제로서의 데카히드로이소퀴놀린-3-카르복실산의 에스테르 유도체

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0590789A1 (en) * 1992-09-03 1994-04-06 Eli Lilly And Company Excitatory amino acid receptor antagonists
WO2001002367A2 (en) * 1999-07-06 2001-01-11 Eli Lilly And Company Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PHARMACOLOGICAL ......-3 CARBOXYLIC ACID. BLEAKMAN D ET AL.MOLECULAR PHARMACOLOGY,Vol.49 No.4. 1996 *

Also Published As

Publication number Publication date
WO2003091243A8 (en) 2005-03-31
CN1649862A (zh) 2005-08-03
ZA200409552B (en) 2006-02-22
IL164773A (en) 2011-08-31
NZ535245A (en) 2007-11-30
PT1511741E (pt) 2013-02-05
JP2010235623A (ja) 2010-10-21
AU2003226277A1 (en) 2003-11-10
IL164773A0 (en) 2005-12-18
DK1511741T3 (da) 2013-01-21
KR20040102171A (ko) 2004-12-03
EA009526B1 (ru) 2008-02-28
CA2480026A1 (en) 2003-11-06
SI1511741T1 (sl) 2013-02-28
CA2480026C (en) 2011-06-07
WO2003091243A1 (en) 2003-11-06
US7247644B2 (en) 2007-07-24
KR100757787B1 (ko) 2007-09-11
EP1511741B1 (en) 2012-12-26
MXPA04009857A (es) 2004-12-07
AU2003226277B2 (en) 2009-03-26
US20050256155A1 (en) 2005-11-17
EP1511741A1 (en) 2005-03-09
JP2005529892A (ja) 2005-10-06
BR0308911A (pt) 2005-01-04
ES2398225T3 (es) 2013-03-14
EA200401432A1 (ru) 2005-04-28

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20081126

Termination date: 20130414