EA009526B1 - Сложноэфирные производные декагидроизохинолин-3-карбоновой кислоты в качестве анальгетиков - Google Patents

Сложноэфирные производные декагидроизохинолин-3-карбоновой кислоты в качестве анальгетиков Download PDF

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Publication number
EA009526B1
EA009526B1 EA200401432A EA200401432A EA009526B1 EA 009526 B1 EA009526 B1 EA 009526B1 EA 200401432 A EA200401432 A EA 200401432A EA 200401432 A EA200401432 A EA 200401432A EA 009526 B1 EA009526 B1 EA 009526B1
Authority
EA
Eurasian Patent Office
Prior art keywords
ethyl
compound
decahydroisoquinoline
carboxylic acid
pharmaceutically acceptable
Prior art date
Application number
EA200401432A
Other languages
English (en)
Russian (ru)
Other versions
EA200401432A1 (ru
Inventor
Пол Лесли Орнштейн
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200401432A1 publication Critical patent/EA200401432A1/ru
Publication of EA009526B1 publication Critical patent/EA009526B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EA200401432A 2002-04-26 2003-04-14 Сложноэфирные производные декагидроизохинолин-3-карбоновой кислоты в качестве анальгетиков EA009526B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37612002P 2002-04-26 2002-04-26
PCT/US2003/010466 WO2003091243A1 (en) 2002-04-26 2003-04-14 Ester derivatives of a decahydroisoquinoline-3-carboxylic acid as analgestics

Publications (2)

Publication Number Publication Date
EA200401432A1 EA200401432A1 (ru) 2005-04-28
EA009526B1 true EA009526B1 (ru) 2008-02-28

Family

ID=29270765

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401432A EA009526B1 (ru) 2002-04-26 2003-04-14 Сложноэфирные производные декагидроизохинолин-3-карбоновой кислоты в качестве анальгетиков

Country Status (18)

Country Link
US (1) US7247644B2 (https=)
EP (1) EP1511741B1 (https=)
JP (2) JP2005529892A (https=)
KR (1) KR100757787B1 (https=)
CN (1) CN100436446C (https=)
AU (1) AU2003226277B2 (https=)
BR (1) BR0308911A (https=)
CA (1) CA2480026C (https=)
DK (1) DK1511741T3 (https=)
EA (1) EA009526B1 (https=)
ES (1) ES2398225T3 (https=)
IL (1) IL164773A (https=)
MX (1) MXPA04009857A (https=)
NZ (1) NZ535245A (https=)
PT (1) PT1511741E (https=)
SI (1) SI1511741T1 (https=)
WO (1) WO2003091243A1 (https=)
ZA (1) ZA200409552B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100757787B1 (ko) * 2002-04-26 2007-09-11 일라이 릴리 앤드 캄파니 진통제로서의 데카히드로이소퀴놀린-3-카르복실산의 에스테르 유도체
US8603980B2 (en) 2007-01-16 2013-12-10 The Johns Hopkins University Glutamate receptor antagonists and methods of use
MX2022016223A (es) 2020-07-02 2023-02-23 Sea Pharmaceuticals Llc Composiciones farmaceuticas de acido 6-(2-(2h-tetrazol-5-il)etil)- 6-fluorodecahidroisoquinolina-3-carboxilico y derivados de ester del mismo.
WO2022261287A1 (en) * 2021-06-09 2022-12-15 Proniras Corporation Methods of treating nerve agent-induced seizures
WO2023130008A2 (en) * 2022-01-01 2023-07-06 Sea Pharmaceuticals Llc Pharmaceutical compositions of 6-(2-(2h-tetrazol-5-yl)ethyl)decahydroisoquinoline-3-carboxylic acid and derivatives thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0590789A1 (en) * 1992-09-03 1994-04-06 Eli Lilly And Company Excitatory amino acid receptor antagonists
WO2001002367A2 (en) * 1999-07-06 2001-01-11 Eli Lilly And Company Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
DK406686D0 (da) * 1986-08-26 1986-08-26 Hans Bundgaard Carboxylsyrederivater
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5356902A (en) 1992-11-06 1994-10-18 Eli Lilly And Company Decahydroisoquinoline compounds as excitatory amino acid receptor antagonists
US5446051A (en) 1994-05-31 1995-08-29 Eli Lilly And Company Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists
US5767117A (en) 1994-11-18 1998-06-16 The General Hospital Corporation Method for treating vascular headaches
HUP0002030A3 (en) 1997-04-07 2002-01-28 Lilly Co Eli Use of glur5 receptorantagonists for the treatment of pain
EP1200073B1 (en) 1999-07-06 2007-01-10 Eli Lilly And Company SELECTIVE iGluR 5? RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MIGRAINE
AU2574801A (en) 1999-12-22 2001-07-03 Eli Lilly And Company Selective iGLUR5 receptor antagonists
WO2002053556A2 (en) 2001-01-05 2002-07-11 Eli Lilly And Company Pyrrolidinylmethyl substituted decahydroisoquinolines as excitatory amino acid receptor antagonists
WO2003024453A1 (en) 2001-01-05 2003-03-27 Eli Lilly And Company Excitatory amino acid receptor antagonists
AU2002227020A1 (en) 2001-01-05 2002-07-16 Eli Lilly And Company Pyrrolidinylmethyl- and piperidinyl substituted decahydroisoquinolines as excitatory amino acid receptor antagonists
WO2003024934A2 (en) 2001-01-05 2003-03-27 Eli Lilly And Company Derivatives of the (3s, 4ar, 6s, 8ar) 6-phenylamino-1, 2, 3, 4, 4a, 5, 6, 7, 8, 8a-decahydro isoquinoline-3-carboxylic acid as excitatory amino acid receptor antagonists for the treatment of neurological disorders and neurodegenerative diseases
WO2003082856A1 (en) 2002-03-22 2003-10-09 Eli Lilly And Company Isoquinoline-3-carboxylic acid derivatives as excitatory amino acid receptor antagonists
KR100757787B1 (ko) * 2002-04-26 2007-09-11 일라이 릴리 앤드 캄파니 진통제로서의 데카히드로이소퀴놀린-3-카르복실산의 에스테르 유도체

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0590789A1 (en) * 1992-09-03 1994-04-06 Eli Lilly And Company Excitatory amino acid receptor antagonists
WO2001002367A2 (en) * 1999-07-06 2001-01-11 Eli Lilly And Company Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Bleakman D. et al.: "Pharmacological discrimination of glur5 and glur6 kainate receptor subtypes, by(3s,4ar,6r,8ar)-6-2-(1(2)h-tetrazole-5-yl)ethyl decahydroisoquinoline-3 carboxylicACID", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 49, no. 4, 1996, pages 581-585, XP000942899, ISSN: 0026-895X, page 582, column 1, line 9 - line 10, page 583, column 1, line 63 - line 64, page 584, column 1, line 9 - line 10; figure 1 *

Also Published As

Publication number Publication date
WO2003091243A8 (en) 2005-03-31
CN1649862A (zh) 2005-08-03
ZA200409552B (en) 2006-02-22
IL164773A (en) 2011-08-31
NZ535245A (en) 2007-11-30
PT1511741E (pt) 2013-02-05
JP2010235623A (ja) 2010-10-21
AU2003226277A1 (en) 2003-11-10
IL164773A0 (en) 2005-12-18
DK1511741T3 (da) 2013-01-21
KR20040102171A (ko) 2004-12-03
CA2480026A1 (en) 2003-11-06
SI1511741T1 (sl) 2013-02-28
CA2480026C (en) 2011-06-07
WO2003091243A1 (en) 2003-11-06
US7247644B2 (en) 2007-07-24
KR100757787B1 (ko) 2007-09-11
EP1511741B1 (en) 2012-12-26
MXPA04009857A (es) 2004-12-07
AU2003226277B2 (en) 2009-03-26
US20050256155A1 (en) 2005-11-17
EP1511741A1 (en) 2005-03-09
JP2005529892A (ja) 2005-10-06
CN100436446C (zh) 2008-11-26
BR0308911A (pt) 2005-01-04
ES2398225T3 (es) 2013-03-14
EA200401432A1 (ru) 2005-04-28

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Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU