CN100389106C - 具有稳定性的薁磺酸钠合成工艺 - Google Patents
具有稳定性的薁磺酸钠合成工艺 Download PDFInfo
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- CN100389106C CN100389106C CNB2005100130792A CN200510013079A CN100389106C CN 100389106 C CN100389106 C CN 100389106C CN B2005100130792 A CNB2005100130792 A CN B2005100130792A CN 200510013079 A CN200510013079 A CN 200510013079A CN 100389106 C CN100389106 C CN 100389106C
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- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims abstract description 16
- 230000002194 synthesizing effect Effects 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229930195733 hydrocarbon Natural products 0.000 claims abstract description 18
- 150000002430 hydrocarbons Chemical class 0.000 claims abstract description 18
- 239000003960 organic solvent Substances 0.000 claims abstract description 18
- 238000001953 recrystallisation Methods 0.000 claims abstract description 17
- 238000005406 washing Methods 0.000 claims abstract description 16
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 239000004215 Carbon black (E152) Substances 0.000 claims abstract description 12
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 11
- 238000003786 synthesis reaction Methods 0.000 claims abstract description 11
- 238000007259 addition reaction Methods 0.000 claims abstract description 7
- 238000001816 cooling Methods 0.000 claims abstract description 4
- 238000000926 separation method Methods 0.000 claims abstract description 4
- 239000000376 reactant Substances 0.000 claims abstract description 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 14
- 238000006277 sulfonation reaction Methods 0.000 claims description 14
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims description 13
- 238000005194 fractionation Methods 0.000 claims description 12
- 238000000605 extraction Methods 0.000 claims description 8
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 7
- 235000017550 sodium carbonate Nutrition 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 3
- 229960002152 chlorhexidine acetate Drugs 0.000 claims description 2
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical group CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 abstract description 5
- 239000013078 crystal Substances 0.000 abstract description 5
- 239000003795 chemical substances by application Substances 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 2
- 238000004508 fractional distillation Methods 0.000 abstract 2
- 239000003381 stabilizer Substances 0.000 abstract 2
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 abstract 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- HIFJUMGIHIZEPX-UHFFFAOYSA-N sulfuric acid;sulfur trioxide Chemical compound O=S(=O)=O.OS(O)(=O)=O HIFJUMGIHIZEPX-UHFFFAOYSA-N 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 239000002699 waste material Substances 0.000 abstract 1
- 239000010410 layer Substances 0.000 description 8
- 239000010813 municipal solid waste Substances 0.000 description 8
- AKEJUJNQAAGONA-UHFFFAOYSA-N sulfur trioxide Chemical compound O=S(=O)=O AKEJUJNQAAGONA-UHFFFAOYSA-N 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 4
- 239000012044 organic layer Substances 0.000 description 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- 239000003208 petroleum Substances 0.000 description 3
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 241000255964 Pieridae Species 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002467 anti-pepsin effect Effects 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- RMCAUKPOUZTMOV-UHFFFAOYSA-N cyclohepta[d][1,3]thiazol-2-one Chemical compound C1=CC=CC=C2SC(=O)N=C21 RMCAUKPOUZTMOV-UHFFFAOYSA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- -1 diox sulphur trioxide adducts Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
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Abstract
Description
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100130792A CN100389106C (zh) | 2005-01-10 | 2005-01-10 | 具有稳定性的薁磺酸钠合成工艺 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100130792A CN100389106C (zh) | 2005-01-10 | 2005-01-10 | 具有稳定性的薁磺酸钠合成工艺 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1803768A CN1803768A (zh) | 2006-07-19 |
| CN100389106C true CN100389106C (zh) | 2008-05-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100130792A Active CN100389106C (zh) | 2005-01-10 | 2005-01-10 | 具有稳定性的薁磺酸钠合成工艺 |
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| Country | Link |
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| CN (1) | CN100389106C (zh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666285B (zh) * | 2015-01-30 | 2017-08-22 | 天津顶硕药业股份有限公司 | 薁磺酸钠抗过敏免洗快干净手剂 |
| CN104688552B (zh) * | 2015-01-30 | 2018-04-27 | 天津顶硕药业股份有限公司 | 一种含有薁磺酸钠的抗过敏药用沐浴液 |
| CN104586638B (zh) * | 2015-01-30 | 2017-10-13 | 天津顶硕药业股份有限公司 | 一种含有薁磺酸钠的头皮护理液及洗发水 |
| CN106748912B (zh) * | 2016-12-30 | 2019-06-21 | 南京济群医药科技股份有限公司 | 一种薁磺酸钠一水合物的合成工艺 |
| CN108863859A (zh) * | 2018-09-04 | 2018-11-23 | 江西依思特香料有限公司 | 薁磺酸钠的制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0977694A (ja) * | 1995-09-13 | 1997-03-25 | Takasago Internatl Corp | グアイアズレンまたはその誘導体の新規製造方法 |
-
2005
- 2005-01-10 CN CNB2005100130792A patent/CN100389106C/zh active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0977694A (ja) * | 1995-09-13 | 1997-03-25 | Takasago Internatl Corp | グアイアズレンまたはその誘導体の新規製造方法 |
Non-Patent Citations (6)
| Title |
|---|
| 呱仑酸钠的合成. 张占辉等.中国医药工业杂志，第33卷第4期. 2002 |
| 呱仑酸钠的合成. 张占辉等.中国医药工业杂志，第33卷第4期. 2002 * |
| 日本对S－愈疮木 及S－愈疮木 -3-磺酸钠的开发和应用（上）. 郑志方.香料香精化妆品，第4期. 2001 |
| 日本对S－愈疮木 及S－愈疮木 -3-磺酸钠的开发和应用（下）. 郑志方.香料香精化妆品，第5期. 2001 |
| 日本对S－愈疮木 及S－愈疮木 -3-磺酸钠的开发和应用（上）. 郑志方.香料香精化妆品，第4期. 2001 * |
| 日本对S－愈疮木 及S－愈疮木 -3-磺酸钠的开发和应用（下）. 郑志方.香料香精化妆品，第5期. 2001 * |
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| Publication number | Publication date |
|---|---|
| CN1803768A (zh) | 2006-07-19 |
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