CN104688552B - 一种含有薁磺酸钠的抗过敏药用沐浴液 - Google Patents
一种含有薁磺酸钠的抗过敏药用沐浴液 Download PDFInfo
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- 239000007788 liquid Substances 0.000 title claims abstract description 19
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Abstract
一种含有薁磺酸钠的抗过敏药用沐浴液，是由如下重量配比的原辅料配制而成：薁磺酸钠0.01～3份、表面活性剂8～20份、润肤剂0.01～15份、营养添加剂0.1～10份、增稠剂0.1～10份、防腐剂0.005～5份、调理剂0～5份、溶剂60～80份。本发明的一种含有薁磺酸钠的抗过敏药用沐浴液，专为过敏体质人群设计，精心选择每一组分，并添加薁磺酸钠抗过敏成分，将其对人体皮肤的刺激性降到最低。有效避免沐浴出现红、痛、痒等过敏反应，最大限度地保护过敏体质人群。令人感觉清爽舒适。
Description
技术领域
本发明涉及一种沐浴液。特别是涉及一种用于过敏体质人群的含有薁磺酸钠的抗过敏药用沐浴液。
背景技术
薁磺酸钠是一种由天然化合物制成的半合成产品，化学名称为1,4-二甲基-7-异丙基薁-3-磺酸钠。其具有抗炎、抗过敏的功效。因为是半合成产品，故副作用小，使用安全。经医学证明，薁磺酸钠有抑制组织胺释放的作用，故用于抗过敏非常有效。
目前市场上的日用沐浴液，多数是以表面活性剂、泡沫促进剂、泡沫稳定剂、护肤剂、增稠剂、整合剂等配制而成。但是有些特殊人群会对其中的一些成分产生过敏，致使洗后皮肤出现发红、痛、痒等过敏症状。
发明内容
本发明所要解决的技术问题是，提供一种能够有效避免沐浴出现红、痛、痒等过敏反应，最大限度地保护过敏体质人群的含有薁磺酸钠的抗过敏药用沐浴液.
本发明所采用的技术方案是：一种含有薁磺酸钠的抗过敏药用沐浴液，是由如下重量配比的原辅料配制而成：薁磺酸钠0.01～3份、表面活性剂8～20份、润肤剂0.01～15份、营养添加剂0.1～10份、增稠剂0.1～10份、防腐剂0.005～5份、调理剂0～5份、溶剂60～80份。
所述的表面活性剂是十二醇硫酸铵、十二醇聚氧乙烯醚硫酸钠、十二醇聚氧乙烯醚硫酸铵、脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠、烷基糖苷、椰油酰胺丙基甜菜碱、PEG-7橄榄油羧酸钠、PEG-7橄榄油酯、椰油酰基谷氨酸钠、N-月桂酰基谷氨酸钠和椰油酰基谷氨酸TEA盐中的一种或两种以上的组合物。
所述的护肤剂是甘油、乙二醇、羊毛脂、霍霍巴油、沙棘油、鳄梨油、橄榄油、胶原蛋白、透明质酸、玻璃酸钠和维生素E中的一种或两种以上的组合物。
所述的营养添加剂是生姜提取液、人参提取液、当归提取液、枸杞子提取液、芦荟提取液、葡萄籽提取液、银杏提取液和海藻提取液中的一种或两种以上的组合物。
所述的增稠剂是椰子油脂肪酸二乙醇酰胺、聚乙二醇－6000、卡波树脂、羟乙基纤维素、氯化钠和PEG-150二硬脂酸酯中的一种或两种以上的组合物。
所述的卡波树脂是卡波941或卡波2020。
所述的调理剂为pH值调节剂和抗硬水络合剂，其中，所述的pH值调节剂是柠檬酸或碳酸氢钠或三乙醇胺，所述的抗硬水络合剂是EDTA或EDTA二钠。
所述溶剂为水和乙醇之中的一种或两者的混合物。
本发明的一种含有薁磺酸钠的抗过敏药用沐浴液，专为过敏体质人群设计，精心选择每一组分，并添加薁磺酸钠抗过敏成分，将其对人体皮肤的刺激性降到最低。有效避免沐浴出现红、痛、痒等过敏反应，最大限度地保护过敏体质人群。令人感觉清爽舒适。
具体实施方式
下面结合实施例对本发明的一种含有薁磺酸钠的抗过敏药用沐浴液做出详细说明。
本发明的一种含有薁磺酸钠的抗过敏药用沐浴液，其特征在于，是由如下重量配比的原辅料配制而成：薁磺酸钠0.01～3份、表面活性剂8～20份、润肤剂0.01～15份、营养添加剂0.1～10份、增稠剂0.1～10份、防腐剂0.005～5份、调理剂0～5份、溶剂60～80份。所述的薁磺酸钠，可抗炎、抗过敏、深入细胞从根本上抑制致敏因子“组胺”的释放，提高细胞对过敏源的耐受性，彻底改善皮肤的过敏现象。
所述的表面活性剂是十二醇硫酸铵(K12A)、十二醇聚氧乙烯醚硫酸钠(AES)、十二醇聚氧乙烯醚硫酸铵(AESA)、脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠(MES)、烷基糖苷(APG)、椰油酰胺丙基甜菜碱(CAB)、PEG-7橄榄油羧酸钠(SPOC)、PEG-7橄榄油酯(OPE)、椰油酰基谷氨酸钠、N-月桂酰基谷氨酸钠和椰油酰基谷氨酸TEA盐中的一种或两种以上的组合物。
所述的护肤剂是甘油、乙二醇、羊毛脂、霍霍巴油、沙棘油、鳄梨油、橄榄油、胶原蛋白、透明质酸、玻璃酸钠和维生素E中的一种或两种以上的组合物。有助锁定毛孔中的水分，并在体表形成防护膜，帮助肌肤调整饱水度，增加抵抗力。
所述的营养添加剂是生姜提取液、人参提取液、当归提取液、枸杞子提取液、芦荟提取液、葡萄籽提取液、银杏提取液和海藻提取液中的一种或两种以上的组合物。以维护角质层不受伤害、清除自由基，保护组织细胞不被自由基破坏。
所述的增稠剂是椰子油脂肪酸二乙醇酰胺(6501)、聚乙二醇－6000、卡波树脂、羟乙基纤维素、氯化钠和PEG-150二硬脂酸酯中的一种或两种以上的组合物。其中，所述的卡波树脂是卡波941或卡波2020。
所述的调理剂为pH值调节剂和抗硬水络合剂，其中，所述的pH值调节剂是柠檬酸或碳酸氢钠或三乙醇胺，所述的抗硬水络合剂是EDTA或EDTA二钠。
所述溶剂为水和乙醇之中的一种或两者的混合物。
本发明的一种含有薁磺酸钠的抗过敏药用沐浴液，是采用如下操作步骤获得：在反应釜中先加入少部分的去离子水，加热至70℃，加入树脂或纤维素类原料、快速搅拌打散，再加入表面活性剂及乳化剂，加入油脂成分，搅拌40分钟，把料液降温至30-40℃，在加入余量纯化水溶解的剩余原辅料，边加边搅拌，搅拌20分钟后，转入灌装设备，进入自动包装系统。即得沐浴液成品。
具体实例如下：
实例1
薁磺酸钠0.02份、十二醇硫酸铵(K12A)10份、PEG-7橄榄油羧酸钠(SPOC)2份、椰油酰胺丙基甜菜碱(CAB)3份、甘油5份、橄榄油2份、生姜提取液1份、椰子油脂肪酸二乙醇酰胺(6501)2份、咪唑烷基脲0.1份、乙醇0.5份、水74.38份。
实例2
薁磺酸钠0.1份、椰油酰基谷氨酸TEA盐15份、椰油酰胺丙基甜菜碱(CAB)4份、PEG-7橄榄油酯(OPE)2份、芦荟提取液3份、人参提取液2份、沙棘油0.5份、透明质酸1份、咪唑烷基脲0.15份、羟乙基纤维素2份、水70.25份。
实例3
薁磺酸钠1份、椰油酰基谷氨酸钠12份、烷基糖苷(APG)6份、椰油酰基谷氨酸TEA盐2份、卡波941 0.5份、霍霍巴油1份、玻璃酸钠0.5份、银杏提取液3份、咪唑烷基脲0.15份、三乙醇胺0.3份、水73.55份。
实例4
薁磺酸钠1.5份、十二醇硫酸铵(K12A)8份、椰油酰胺丙基甜菜碱(CAB)8份、PEG-7橄榄油酯(OPE)4份、椰油酰基谷氨酸TEA盐3份、当归提取液4份、人参提取液1份、羊毛脂1份、霍霍巴油0.5份、咪唑烷基脲0.2份、聚乙二醇(6000)0.3份、水68.5份。
实例5
薁磺酸钠0.05份、N-月桂酰基谷氨酸钠8份、椰油酰基谷氨酸钠4份、椰油酰基谷氨酸TEA盐2份、沙棘油0.3份、橄榄油0.5份、人参提取液3份、海藻提取液2份、醋酸盐洗必泰0.1份、EDTA二钠0.02份、椰子油脂肪酸二乙醇酰胺(6501)2份、柠檬酸0.2份、氯化钠1份、水76.83份。
实例6
薁磺酸钠0.12份、十二醇聚氧乙烯醚硫酸钠(AES)10份、脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠(MES)3份、烷基糖苷(APG)2份、椰油酰基谷氨酸钠5份、甘油3份、胶原蛋白0.8份、维生素E0.5份、当归提取液4份、海藻提取液3份、椰子油脂肪酸二乙醇酰胺(6501)1.5份、氯化钠2.5份、PEG-150二硬脂酸酯0.05份、柠檬酸0.15份、纯化水64.38份。
实例7
薁磺酸钠1.8份、脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠(MES)5份、椰油酰基谷氨酸TEA盐20份、鳄梨油3份、玻璃酸钠0.8份、人参提取液4份、葡萄籽提取液5份、卡波941 0.2份、咪唑烷基脲0.2份、柠檬酸0.2份、纯化水59.8份。
实例8
薁磺酸钠0.01份、烷基糖苷(APG)3份、PEG-7橄榄油羧酸钠(SPOC)10份、N-月桂酰基谷氨酸钠2份、甘油2份、乙二醇1份、鳄梨油1份、透明质酸0.5份、枸杞子提取液6份、芦荟提取液2份、羟乙基纤维素3份、醋酸洗必泰0.1份、乙醇0.1份、纯化水69.29份。
实例9
薁磺酸钠0.02份、脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠(MES)2份、椰油酰胺丙基甜菜碱(CAB)3份、椰油酰基谷氨酸钠13份、羊毛脂1.5份、霍霍巴油1份、玻璃酸钠1份、人参提取液3份、芦荟提取液5份、椰子油脂肪酸二乙醇酰胺(6501)1份、聚乙二醇(6000)1.5份、三氯羟基二苯醚0.15份、柠檬酸0.16份、EDTA0.02份、乙醇0.1份、纯化水67.55份。
对以上实施例的产品，依据沐浴液的行业执行标准，对稳定性、理化指标及微生物指标进行检测，并对实施例中抗过敏物质薁磺酸钠含量，依据《中国药典》2010版二部中紫外分光光度法进行检测结果列于表一。
对实施例产品依照《化妆品卫生规范》进行了人体皮肤斑贴试验，结果列于表二。
表二
各实施例的皮肤斑贴试验，结果表明，本发明的产品对人体皮肤没有任何刺激性。
人体试用试验，取各实施例产品，每一产品至少找志愿者30人，发试用装免费使用，试用结果列于表三。
表三
| 试用者特征 | 人数 | 试用产品 | 反应程度 | 评分等级 | 皮肤反应 |
| 过敏体质6人 | 31 | 实施例1 | - | 0 | 光滑、滋润无不良反应 |
| 过敏体质9人 | 31 | 实施例2 | - | 0 | 光滑、滋润无不良反应 |
| 过敏体质3人 | 31 | 实施例3 | - | 0 | 光滑、滋润无不良反应 |
| 过敏体质8人 | 31 | 实施例4 | - | 0 | 光滑、滋润无不良反应 |
| 过敏体质4人 | 31 | 实施例5 | - | 0 | 光滑、滋润无不良反应 |
| 过敏体质5人 | 31 | 实施例6 | - | 0 | 光滑、滋润无不良反应 |
| 过敏体质7人 | 31 | 实施例7 | - | 0 | 光滑、滋润无不良反应 |
| 过敏体质5人 | 31 | 实施例8 | - | 0 | 光滑、滋润无不良反应 |
| 过敏体质6人 | 31 | 实施例9 | - | 0 | 光滑、滋润无不良反应 |
注：反应程度为“-”，评分等级为“0”，表示皮肤反应为阴性。
通过实施例产品的试用试验，表明本发明的产品对人体皮肤没有任何刺激性，过敏体质人群使用均没用任何不良反应，且有使皮肤光滑、滋润的效果。
Claims (4)
1.一种含有薁磺酸钠的抗过敏药用沐浴液，其特征在于，是由如下重量配比的原辅料配制而成：薁磺酸钠0.1份、椰油酰基谷氨酸TEA盐15份、椰油酰胺丙基甜菜碱4份、PEG-7橄榄油酯2份、芦荟提取液3份、人参提取液2份、沙棘油0.5 份、透明质酸1份、咪唑烷基脲0.15份、羟乙基纤维素2份、水70.25份。
2.一种含有薁磺酸钠的抗过敏药用沐浴液，其特征在于，是由如下重量配比的原辅料配制而成：薁磺酸钠1.5份、十二醇硫酸铵8份、椰油酰胺丙基甜菜碱8份、PEG-7橄榄油酯4份、椰油酰基谷氨酸TEA盐3份、当归提取液4份、人参提取液1份、羊毛脂1份、霍霍巴油0.5份、咪唑烷基脲0.2份、聚乙二醇6000 0.3份、水68.5份。
3.一种含有薁磺酸钠的抗过敏药用沐浴液，其特征在于，是由如下重量配比的原辅料配制而成：薁磺酸钠0.05份、N-月桂酰基谷氨酸钠8份、椰油酰基谷氨酸钠4份、椰油酰基谷氨酸TEA盐2份、沙棘油0.3份、橄榄油0.5份、人参提取液3份、海藻提取液2份、醋酸盐洗必泰0.1份、EDTA二钠0.02份、椰子油脂肪酸二乙醇酰胺2份、柠檬酸0.2份、氯化钠1份、水76.83份。
4.一种含有薁磺酸钠的抗过敏药用沐浴液，其特征在于，是由如下重量配比的原辅料配制而成：薁磺酸钠0.02份、脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠2份、椰油酰胺丙基甜菜碱3份、椰油酰基谷氨酸钠13份、羊毛脂1.5份、霍霍巴油1份、玻璃酸钠1份、人参提取液3份、芦荟提取液5份、椰子油脂肪酸二乙醇酰胺1份、聚乙二醇6000 1.5份、三氯羟基二苯醚0.15份、柠檬酸0.16份、EDTA0.02份、乙醇0.1份、纯化水67.55份。
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