CN100378106C - 噻吩并吡咯衍生物的制备方法和中间体 - Google Patents

噻吩并吡咯衍生物的制备方法和中间体 Download PDF

Info

Publication number
CN100378106C
CN100378106C CNB038236176A CN03823617A CN100378106C CN 100378106 C CN100378106 C CN 100378106C CN B038236176 A CNB038236176 A CN B038236176A CN 03823617 A CN03823617 A CN 03823617A CN 100378106 C CN100378106 C CN 100378106C
Authority
CN
China
Prior art keywords
alkyl
formula
carbamoyl
amino
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB038236176A
Other languages
English (en)
Chinese (zh)
Other versions
CN1688587A (zh
Inventor
P·M·墨累
J·S·帕克
P·肖菲尔德
A·斯托克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1688587A publication Critical patent/CN1688587A/zh
Application granted granted Critical
Publication of CN100378106C publication Critical patent/CN100378106C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CNB038236176A 2002-10-03 2003-09-29 噻吩并吡咯衍生物的制备方法和中间体 Expired - Fee Related CN100378106C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0222912.8A GB0222912D0 (en) 2002-10-03 2002-10-03 Novel process and intermediates
GB0222912.8 2002-10-03

Publications (2)

Publication Number Publication Date
CN1688587A CN1688587A (zh) 2005-10-26
CN100378106C true CN100378106C (zh) 2008-04-02

Family

ID=9945219

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038236176A Expired - Fee Related CN100378106C (zh) 2002-10-03 2003-09-29 噻吩并吡咯衍生物的制备方法和中间体

Country Status (13)

Country Link
US (1) US7411074B2 (https=)
EP (1) EP1549654A1 (https=)
JP (1) JP2006505541A (https=)
KR (1) KR20050061503A (https=)
CN (1) CN100378106C (https=)
AU (1) AU2003269219A1 (https=)
BR (1) BR0314966A (https=)
CA (1) CA2500145A1 (https=)
GB (1) GB0222912D0 (https=)
MX (1) MXPA05003327A (https=)
NO (1) NO20051393L (https=)
WO (1) WO2004031194A1 (https=)
ZA (1) ZA200502340B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0205162D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205176D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205170D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205166D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205175D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0222909D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
AU2004312530A1 (en) 2003-12-29 2005-07-21 Sepracor Inc. Pyrrole and pyrazole DAAO inhibitors
NZ569608A (en) 2006-01-06 2011-09-30 Sepracor Inc Tetralone-based monoamine reuptake inhibitors
BRPI0706365A2 (pt) 2006-01-06 2011-03-22 Sepracor Inc Cicloalquilaminas como inibidores da recaptação de monoamina
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
AU2008259841B2 (en) 2007-05-31 2015-02-05 Sunovion Pharmaceuticals Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002020530A1 (en) * 2000-09-06 2002-03-14 Astrazeneca Ab Bicyclic pyrrolyl amides as glucogen phosphorylase inhibitors

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU364613A1 (ru) 1970-11-27 1972-12-28 Всесоюзный научно исследовательский химико фармацевтический институт имени С. Орджоникидзе Способ получения производных 2-аминотиено-
JPH01242587A (ja) * 1988-03-25 1989-09-27 Sankyo Co Ltd 縮環オキサゾロチエノピリミジン誘導体
GB9302622D0 (en) 1993-02-10 1993-03-24 Wellcome Found Heteroaromatic compounds
ATE257480T1 (de) 1999-09-30 2004-01-15 Pfizer Prod Inc Bicyclische pyrrolylamide als glycogenphosphorylase-inhibitoren
AU778042B2 (en) 1999-10-19 2004-11-11 Merck & Co., Inc. Tyrosine kinase inhibitors
SE9903998D0 (sv) 1999-11-03 1999-11-03 Astra Ab New compounds
JP2001294572A (ja) 2000-02-09 2001-10-23 Dai Ichi Seiyaku Co Ltd 新規スルホニル誘導体
EP1136071A3 (en) 2000-03-22 2003-03-26 Pfizer Products Inc. Use of glycogen phosphorylase inhibitors
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
MXPA03000966A (es) 2002-02-28 2003-09-04 Pfizer Prod Inc Agentes antidiabeticos.
GB0205162D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205176D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205166D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205175D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205170D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
WO2003091213A1 (en) 2002-04-25 2003-11-06 Yamanouchi Pharmaceutical Co., Ltd. Novel amide derivatives or salts thereof
EP1543011B1 (en) 2002-09-06 2006-05-03 Janssen Pharmaceutica N.V. Thienopyrrolyl and furanopyrrolyl compounds and their use as histamine h4 receptor ligands
GB0222909D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
CA2503727A1 (en) 2002-11-07 2004-05-21 Pfizer Products Inc. Anti-diabetic agents
US7098235B2 (en) 2002-11-14 2006-08-29 Bristol-Myers Squibb Co. Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
JP2004196702A (ja) 2002-12-18 2004-07-15 Yamanouchi Pharmaceut Co Ltd 新規なアミド誘導体又はその塩
ES2393996T3 (es) 2002-12-25 2013-01-04 Daiichi Sankyo Company, Limited Derivados de diaminociclohexano antitrombóticos
EP1620427A1 (en) 2003-04-17 2006-02-01 Pfizer Products Inc. Carboxamide derivatives as anti-diabetic agents
WO2004096768A1 (en) 2003-04-30 2004-11-11 Pfizer Products Inc. Anti-diabetic agents
WO2004113345A1 (ja) 2003-06-20 2004-12-29 Japan Tobacco Inc. 縮合ピロール化合物及びその医薬用途
GB0318464D0 (en) 2003-08-07 2003-09-10 Astrazeneca Ab Chemical compounds
GB0318463D0 (en) 2003-08-07 2003-09-10 Astrazeneca Ab Chemical compounds
GB0319690D0 (en) 2003-08-22 2003-09-24 Astrazeneca Ab Chemical compounds
GB0319759D0 (en) 2003-08-22 2003-09-24 Astrazeneca Ab Chemical compounds
WO2005020985A1 (en) 2003-08-29 2005-03-10 Astrazeneca Ab Indolamide derivatives which possess glycogen phosphorylase inhibitory activity
WO2005020986A1 (en) 2003-08-29 2005-03-10 Astrazeneca Ab Heterocyclic amide derivatives which posses glycogen phosphorylase inhibitory activity
GB0320422D0 (en) 2003-08-30 2003-10-01 Astrazeneca Ab Chemical compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002020530A1 (en) * 2000-09-06 2002-03-14 Astrazeneca Ab Bicyclic pyrrolyl amides as glucogen phosphorylase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Construction of heterocyclic compounds by useofalpha-diazaphosphonates: new one-pot syntheses ofindolesand isocoumarines. YOSHINORI NAKAMURA.ORGANIC LETTERS.,Vol.4 No.14. 2002 *

Also Published As

Publication number Publication date
US7411074B2 (en) 2008-08-12
MXPA05003327A (es) 2005-07-05
BR0314966A (pt) 2005-08-02
NO20051393L (no) 2005-04-20
KR20050061503A (ko) 2005-06-22
WO2004031194A1 (en) 2004-04-15
CN1688587A (zh) 2005-10-26
GB0222912D0 (en) 2002-11-13
US20060035953A1 (en) 2006-02-16
AU2003269219A1 (en) 2004-04-23
ZA200502340B (en) 2005-09-19
CA2500145A1 (en) 2004-04-15
JP2006505541A (ja) 2006-02-16
EP1549654A1 (en) 2005-07-06

Similar Documents

Publication Publication Date Title
CN100378106C (zh) 噻吩并吡咯衍生物的制备方法和中间体
CN103154004B (zh) 具有hiv整合酶抑制活性的化合物的制造方法
TWI450890B (zh) 用於製備胺甲醯吡啶酮ｈｉｖ整合酶抑制劑之方法及中間體
CN116964058A (zh) Kras g12d抑制剂及其在医药上的应用
US7307174B2 (en) Process and intermediates for the preparation of thienopyrrole derivatives
WO2007082131A1 (en) Process for the preparation of hydroxy substituted heterocycles
CN118955505A (zh) 布鲁顿酪氨酸激酶抑制剂
WO2014023191A1 (zh) N-取代吡唑并[3,4-d]嘧啶酮类化合物、其制备方法及其应用
JP2003515591A (ja) 抗ピコルナウイルス化合物及び組成物、その医薬的使用及びその合成のための物質
ES2975520T3 (es) Métodos de preparación de productos intermedios para moduladores de receptores tipo peaje
CN114685473B (zh) 5-烷基-2-吡唑-恶唑烷-4-酮类衍生物及其用途
WO2021121420A1 (zh) 苯并吡唑类化合物及其中间体、制备方法和应用
CN101195626A (zh) 一种合成吡唑并[3,4-d]嘧啶-4(5H)-酮类化合物的方法
CN104016929B (zh) 一种合成喹唑啉-4(3h)-酮的方法
CN102127076A (zh) 一种合成2，3-二氢吡啶并[2，3-d]嘧啶-4-（3H）-酮的方法
KR102713340B1 (ko) 고리화첨가 반응과 고리축소 반응의 연속 반응을 이용한 피롤로[1,2-a]퀴놀린의 제조방법
AU2008321625A1 (en) Process for the preparation of 2H-chromene-3-carbamate derivatives
JP4153644B2 (ja) ２−アルキル−３−アミノチオフェン誘導体の製造方法および３−アミノチオフェン誘導体
CN105111209B (zh) 一种氮杂吲哚啉化合物及其制备方法
CN105037372B (zh) 一种合成吡唑并[3,4-d]嘧啶-4-酮类化合物的方法
CN107973742A (zh) 制备3-吲哚酮类化合物的方法
JP4745315B2 (ja) ３−アミノチオフェン誘導体
CN102020615A (zh) 一种吗啉酮衍生物及其制备方法
MXPA00007824A (https=)
HUP0100869A2 (hu) Eljárások és közbenső termékek folsavgátló anyagok előállítására

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20080402

Termination date: 20091029