CN100358556C - Bone-recovering particles - Google Patents
Bone-recovering particles Download PDFInfo
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- CN100358556C CN100358556C CNB2004101553554A CN200410155355A CN100358556C CN 100358556 C CN100358556 C CN 100358556C CN B2004101553554 A CNB2004101553554 A CN B2004101553554A CN 200410155355 A CN200410155355 A CN 200410155355A CN 100358556 C CN100358556 C CN 100358556C
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Abstract
The present invention discloses a bone-recovery granule and a preparation method thereof. Malytea scurfpea fruit, basjoo roots, dipsacus roots, notoginseng and wood sorrel are used as raw material medicine, ultramicro medicinal powder is formed in the mode of processing under specific process conditions by using a micronizer, dissolution is carried out, a proper amount of auxiliary materials are added inside, and a pelletized granule is made according to the suitable granule making process. Compared with a capsule, the pelletized granule of the present invention is obviously superior to the capsule in terms of medicine dissolution, bioavailability and medicine stability, the medicinal material dosage can be reduced by about 30%, the unforeseen technical effect is obtained, and the precious Chinese herbal medicine resource is greatly saved. The medicine dose of the present invention per time is smaller than that of the capsule, and a patient's burden of medicine taking is reduced.
Description
Technical field
The present invention relates to a kind of preparation method of Chinese medicine granules, belong to technical field of medicaments.
Technical background
The bone recovering capsule is a kind of Chinese patent medicine for the treatment of fracture, osteoporosis, though therapeutic effect is pretty good, because processing technology, exists that the ingredient dissolution is not high, bioavailability is not high, dose big, the problem of property of medicine less stable.Be that Radix Notoginseng, Radix Musae are pulverized in the preparation method of green bone recovering capsule, again with Herba Oxalidis Corniculatae, Fructus Psoraleae, Radix Dipsaci decocts with water, and cream powder and dry powder mixing are encapsulated then.
Summary of the invention
The object of the invention is: a kind of bone-recovering particles and preparation method thereof is provided, solves the problem of prior art existence and increase a kind of bone health novel form.
Technical scheme of the present invention is such: bone-recovering particles, it is characterized in that: use following raw medicaments in portion by weight, Fructus Psoraleae 500-600 gram, Radix Musae 400-500 gram, Radix Dipsaci 300-400 gram, Radix Notoginseng 150-200 gram, Herba Oxalidis Corniculatae 400-500 gram add appropriate amount of auxiliary materials and make as follows; This method is:
A, above-mentioned raw materials medicated powder be broken into be not less than 60 purpose coarse granules, the A product;
B, A product and air after lyophilization are injected super micron mill jointly, adopt high velocity air to pulverize to make particle diameter to be not less than the ultra tiny medicated powder of 1250 purposes; Get the B product;
C, the B product are fully dissolved, soak, filter with solvent; Get the C product;
D, in the C product, add cane sugar powder, an amount of, the micro-pigment of steviosin a little, granulate with wetting, spray drying, granulate is made granule, packing.
Above-mentioned bone-recovering particles, in step b, the air ratio after lyophilization is that temperature is that 0-10 ℃, water content are not higher than 0.5% air preferably, the reasonable operating temperature of super micron mill is 0-10 ℃.
Aforesaid bone-recovering particles, in step b, the pressure the when air after lyophilization injects super micron mill is preferably 1.5MPa, and used compressed-air actuated pressure is preferably lower than 1MPa, and the operating pressure of super micron mill is preferably 0.8-1.5MPa.
Aforesaid bone-recovering particles, in step c, one or both in the optional water of described solvent, the ethanol, the time of immersion is 1-1.5 hour, and soaking temperature is a 0-110 ℃ of preferable range, and 80-110 ℃ is applicable to water, and 0-60 ℃ is applicable to ethanol.
In the aforesaid bone-recovering particles, described crude drug preferably, Fructus Psoraleae 500 gram, Radix Musae 400 grams, Radix Dipsaci 300 grams, Radix Notoginseng 150 grams, Herba Oxalidis Corniculatae 400 grams.
Aforesaid bone-recovering particles; In step a, preferably crude drug being ground into particle diameter is 60-80 purpose coarse granule; In step b, preferably adopting high velocity air to pulverize and making particle diameter is the ultra tiny medicated powder of 1250 orders-2500 purpose.
The present invention through testing repeatedly, contrast, conclude, summing up, has researched and developed and suitable has prepared the production technology of bone-recovering particles with superfine communication technique on green bone recovering capsule prescription basis, has obtained the bone-recovering particles agent.This granule is compared with capsule, all obviously is better than capsule on the stability of drug dissolution, bioavailability, medicine, but the messenger drug material use quantity reduces about 30%, has obtained beyond thought technique effect, has saved valuable Chinese herbal medicine resource greatly.The each dose of medicine of the present invention has besides also reduced patient's the burden of taking medicine less than capsule.
Experimental result:
| Disintegration | Dissolution | Each dose | Storage period | |
| The bone recovering capsule | 30 minutes | 70％ | The 3-4 ball | 1.5 year |
| Bone-recovering particles | 5 minutes | 98％ | 1 bag | 2 years |
The present invention is the micronizing production method of herbal raw material employing and the difference of common superfine powder technology; In crushing process, make the medical material granularity reach the degree of unlikely destruction plant cell wall through the air after the lyophilization, preserved the former property of medicine preferably, and reduced dosage.Simultaneously, the solid preparation that adopts the granule dosage form to make also has the dissolution of reaching biggest advantage.
The specific embodiment
The embodiment of the invention: take following raw medicaments in portion by weight, Fructus Psoraleae 500 grams, Radix Musae 400 grams, Radix Dipsaci 300 grams, Radix Notoginseng 150 grams, Herba Oxalidis Corniculatae 400 grams.Make bone-recovering particles as follows.
A, above-mentioned raw materials medicated powder is broken into 60-80 purpose coarse granule, the A product;
B, A product and air after lyophilization are injected super micron mill jointly, adopt high velocity air to pulverize and make the ultra tiny medicated powder of particle diameter 1250 purposes; Get the B product.Wherein, the air after lyophilization is that temperature is that 0-5 ℃, water content are not higher than 0.5% air, and the pressure when injecting super micron mill is 1.5Mpa; Used compressed-air actuated pressure is lower than 1Mpa; The operating pressure of super micron mill is 0.8-1.5Mpa, and the operating temperature of super micron mill is 8 ℃.The subsidiary air-flow that ultra tiny Chinese medicine powder is arranged that the Chinese medicine coarse granule is discharged after micronizing, after filtration, dedusting obtains ultra tiny Chinese medicine powder after collecting.
C, with the B product with 50-60% ethanol as solvent 30-40 ℃ of fully dissolving, and keep temperature to soak 1 hour, filter; Get the C product;
D, 80-110 ℃ of water of the surplus solid reuse of institute fully dissolve as solvent, and the maintenance temperature can be higher, and keep temperature to soak 1.5 hours, filter; Get the D product;
E, C, D product merged add an amount of cane sugar powder, steviosin, micro-pigment, moistening granulation, spray drying, granulate is made granule, is packaged into bag, every bag 2 gram (wherein contain the medicine composition and account for 65%, 1.3 gram).
Finished product is used for the treatment of fracture.Blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain are arranged, channels sootheing and network vessel quickening, the invigorating the kidney and strengthening the bones effect is particularly suitable for middle-aged and elderly people and takes.Oral one time 1 bag, three times on the one.
Claims (5)
1. bone-recovering particles is characterized in that: use following raw medicaments in portion by weight, Fructus Psoraleae 500-600 gram, Radix Musae 400-500 gram, Radix Dipsaci 300-400 gram, Radix Notoginseng 150-200 gram, Herba Oxalidis Corniculatae 400-500 gram add appropriate amount of auxiliary materials and make as follows; This method is:
A, above-mentioned raw materials medicated powder be broken into be not less than 60 purpose coarse granules, the A product;
B, A product and air after lyophilization are injected super micron mill jointly, adopt high velocity air to pulverize to make particle diameter to be not less than the ultra tiny medicated powder of 1250 purposes; Get the B product;
C, with the B product with 50-60% ethanol as solvent 60-70 ℃ of fully dissolving, soak, filter; Get the C product;
D, the 80-110 ℃ of water of solid reuse after will filtering fully dissolve as solvent, and keep temperature to soak 1-1.5 hour, filter; Get the D product;
E, C, D product merged add an amount of cane sugar powder, steviosin, micro-pigment, moistening granulation, spray drying, granulate is made granule, packing.
2. bone-recovering particles according to claim 1 is characterized in that: among the step b, the air after lyophilization is that temperature is 0-10 ℃, and water content is not higher than 0.5% air, and the operating temperature of super micron mill is 0-10 ℃
3. bone-recovering particles according to claim 2 is characterized in that: among the step b, the pressure that the air after lyophilization injects super micron mill is 1.5MPa, and compressed-air actuated pressure is for being lower than 1MPa, and the operating pressure of super micron mill is 0.8-1.5MPa.
4. according to the described bone-recovering particles of arbitrary claim in the claim 1 to 3, it is characterized in that: described crude drug is Fructus Psoraleae 500 grams, Radix Musae 400 grams, Radix Dipsaci 300 grams, Radix Notoginseng 150 grams, Herba Oxalidis Corniculatae 400 grams.
5. bone-recovering particles according to claim 4 is characterized in that: among the step a, be that crude drug is ground into particle diameter is 60-80 purpose coarse granule; Among the step b, be to adopt high velocity air to pulverize to make the ultra tiny medicated powder of particle diameter 1250 orders-2500 purpose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004101553554A CN100358556C (en) | 2004-10-15 | 2004-10-15 | Bone-recovering particles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004101553554A CN100358556C (en) | 2004-10-15 | 2004-10-15 | Bone-recovering particles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1742897A CN1742897A (en) | 2006-03-08 |
| CN100358556C true CN100358556C (en) | 2008-01-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004101553554A Active CN100358556C (en) | 2004-10-15 | 2004-10-15 | Bone-recovering particles |
Country Status (1)
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|---|---|
| CN (1) | CN100358556C (en) |
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2004
- 2004-10-15 CN CNB2004101553554A patent/CN100358556C/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 国家中成药标准汇编 骨伤科. 311-312，国家药品监督管理局. 2002 * |
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| Publication number | Publication date |
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| CN1742897A (en) | 2006-03-08 |
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Address after: 6, 9 floor, 42 international office building, No. 550002 South Road, Nanming District, Guiyang, Guizhou, China Patentee after: Guizhou Weikang pharmaceutical Limited by Share Ltd subsidiary. Address before: 550002 Guizhou city of Guiyang province of China Road No. 45 Building 9 floor E block Huakun development Patentee before: Weikang Pharmaceutical Co., Ltd., Guizhou |