CN101564501A - Big activating collateral preparation and preparation method thereof - Google Patents
Big activating collateral preparation and preparation method thereof Download PDFInfo
- Publication number
- CN101564501A CN101564501A CNA2008101051838A CN200810105183A CN101564501A CN 101564501 A CN101564501 A CN 101564501A CN A2008101051838 A CNA2008101051838 A CN A2008101051838A CN 200810105183 A CN200810105183 A CN 200810105183A CN 101564501 A CN101564501 A CN 101564501A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- rhizoma
- preparation
- ultra
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a Chinese medicinal preparation, and in particular to a big activating collateral preparation prepared by adopting ultra-micro pulverizing technology and a preparation method thereof. The invention provides a big activating collateral ultra-micro pulverization preparation prepared by adopting a vibrating ultra-micro pulverizer, and also introduces assistant materials-adding ultra-micro pulverizing technology. The preparation and the method maintain the compound pulverizing homogenization, fully embody the characteristics of Chinese medicinal science, furthest maintain the active ingredient at the same time, improve the utilization factor of medicinal materials, save the medicinal material resources and reduce the production cost.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of big active preparation that superfine communication technique makes and preparation method thereof that adopts belongs to the field of Chinese medicines.
Background technology
DAHUOLUO WAN is now recorded in " Chinese medicine ministry standard " the 6th 12 pages; the weight proportion of its active ingredient raw materials medicine is: 40 parts of Agkistrodons; 40 parts of Zaocyss; 40 parts of Radix Clematidis; 40 parts of Rhizoma Anemones Raddeanae; 40 parts in Herba Ephedrae; 40 parts of Rhizoma Osmundae; 40 parts in Radix Glycyrrhizae; 40 parts of Rhizoma Et Radix Notopterygiis; 40 parts of Cortex Cinnamomis; 40 parts of Herba Pogostemonis; 40 parts of the Radixs Linderae; 40 parts of Rhizoma Coptidis; 40 parts of Radix Rehmanniae Preparata; 40 parts of Radix Et Rhizoma Rhei; 40 parts of the Radix Aucklandiae; 40 parts of Lignum Aquilariae Resinatum; 20 parts of Herba Asaris; 20 parts of Radix Paeoniae Rubra; 20 parts of Myrrha (processed); 20 parts of Flos Caryophyllis; 20 parts of Olibanums (system); 20 parts of Bombyx Batryticatus (stir-fry); 20 parts of Rhizoma Arisaematiss (system); 20 parts on Pericarpium Citri Reticulatae Viride; Rhizoma Drynariae (scalds; unhairing) 20 part; 20 parts in Fructus Amomi Rotundus; 20 parts of Benzoinumes; 20 parts of Radix Scutellariaes; 20 parts of Rhizoma Cyperis (vinegar system); 20 parts of Radix Scrophulariaes; 20 parts of the Rhizoma Atractylodis Macrocephalaes (parched with bran); 50 parts of Radix Saposhnikoviaes; 40 parts of Carapax Et Plastrum Testudiniss (quench in vinegar); 30 parts of Radix Puerariaes; 30 parts of Os Tigriss (short); 30 parts of Radix Angelicae Sinensis; 14 parts of Sanguis Draxonis; 10 parts of Pheretimas; 10 parts of Cornu rhinocerotiss; 10 parts in Moschus; 10 parts of Colophonium; 3 parts of Calculus Boviss; 3 parts of Borneolum Syntheticums; 60 parts of Radix Ginseng Rubra; 40 parts of Radix Aconiti Kusnezoffii Preparatas; 40 parts in Rhizoma Gastrodiae; 40 parts of Scorpios; 40 parts of Radix Polygoni Multiflori; be used for the paralysis that the apoplexy syncope due to accumulation of phlegm causes; arthralgia pain enough withers; spasm of muscles and vessels; lumbago and skelalgia and traumatic injury; walking disorder; diseases such as the thoracic obstruction; it is wind-expelling pain-stopping; the dehumidifying eliminating phlegm, the classics recipe of relaxing muscles and tendons and activating QI and blood in the collateral.It is evident in efficacy, is subjected to the welcome of extensive patients deeply, but finds that in actual applications still there is certain defective in it: the pill dose is big, takes extremely inconvenience, is not easy to carry, and the patient is difficult to be accepted; Prescription Chinese crude drug crushing fine powder granularity is excessive, fails to give full play to the effect of each composition in the medical material.
The thicker medicated powder bioavailability of granularity is lower, and crude drug can not be fully utilized, and because its huge market demand, thereby cause the Chinese material medicine resource serious waste.As seen, study a kind of reasonable, efficient and economically viable preparation technology big active class preparation is had very important significance, thereby further satisfy and ensure national medication demand.
Superfine communication technique is the machining process that makes the fine and super-refinement of material, provides one of important means of ultrafine powder.Micronizing is a new and high technology that grows up over nearly 20 years, refers to utilize machinery or hydromechanical approach that material is crushed to particle diameter less than the process below the 10 μ m.Ultramicro powder is the final products of micronizing, has some special physicochemical properties that general granule does not have, as fine solubility, dispersibility, adsorptivity etc.; For Chinese crude drug, the cell wall breaking rate improves greatly, and up to 90%, each effective constituents is release conditions, and dissolution and bioavailability are multiplied.Since the nineties in 20th century, superfine communication technique is applied to Chinese medicine gradually, has given the more modern high section of Chinese medicine content, and the broken technology of Chinese medicine ultra-fine powder is as the constantly development of a new technology.
Fully comprehend the marrow of the broken technology of Chinese medicine micropowder; choose representative classics side medicine, explore the process that a cover has operability, reasonably improvement and using ultramicro communication technique are in the herbal pharmaceutical industry; and, be one of problem that needs at present primary study with its scale, industrialization.
Summary of the invention
First purpose of the present invention is to provide a kind of big active micronizing preparation.
Another object of the present invention provides the preparation method of this big active preparation.
The object of the invention mainly is to adopt following dual mode to realize:
Mode one: common micronizing
The inventor provides a kind of big active preparation that adopts superfine communication technique to make, and writes out a prescription by Agkistrodon Zaocys, Radix Clematidis, Rhizoma Anemones Raddeanae; Herba Ephedrae, Rhizoma Osmundae, Radix Glycyrrhizae, Rhizoma Et Radix Notopterygii, Cortex Cinnamomi; Herba Pogostemonis, the Radix Linderae, Rhizoma Coptidis, Radix Rehmanniae Preparata, Radix Et Rhizoma Rhei; the Radix Aucklandiae, Lignum Aquilariae Resinatum, Herba Asari, Radix Paeoniae Rubra; Myrrha (processed), Flos Caryophylli, Olibanum (system), Bombyx Batryticatus (stir-fry); Rhizoma Arisaematis (system), Pericarpium Citri Reticulatae Viride, Rhizoma Drynariae (scalds; unhairing), Fructus Amomi Rotundus; Benzoinum, Radix Scutellariae, Rhizoma Cyperi (vinegar system), Radix Scrophulariae; the Rhizoma Atractylodis Macrocephalae (parched with bran), Radix Saposhnikoviae, Carapax Et Plastrum Testudinis (quench in vinegar), Radix Puerariae; Os Tigris (short), Radix Angelicae Sinensis, Sanguis Draxonis, Pheretima; Cornu rhinocerotis, Moschus, Colophonium, Calculus Bovis; Borneolum Syntheticum, Radix Ginseng Rubra, Radix Aconiti Kusnezoffii Preparata, Rhizoma Gastrodiae; Scorpio, Radix Polygoni Multiflori is formed, and big demountable prescription ratio meets each the flavour of a drug proportioning under the 6th DAHUOLUO WAN item of Chinese medicine ministry standard, that is:
40 parts of 40 parts of Rhizoma Anemones Raddeanae of 40 parts of Radix Clematidis of 40 parts of Zaocyss of Agkistrodon
40 parts of 40 portions of Rhizoma Et Radix Notopterygiis of 40 portions of Radix Glycyrrhizaes of 40 parts of Rhizoma Osmundae of Herba Ephedrae
40 parts of 40 parts of Rhizoma Coptidis of 40 parts of Radixs Linderae of 40 parts of Herba Pogostemonis of Cortex Cinnamomi
40 parts of 40 portions of Lignum Aquilariae Resinatum of 40 parts of Radix Aucklandiae of 40 parts of Radix Et Rhizoma Rhei of Radix Rehmanniae Preparata
20 parts of 20 portions of Flos Caryophyllis of 20 parts of Myrrha (processed) of 20 parts of Radix Paeoniae Rubra of Herba Asari
20 parts on 20 parts of Pericarpium Citri Reticulatae Virides of 20 parts of Rhizoma Arisaematiss of 20 parts of Bombyx Batryticatus of Olibanum (system) (stir-fry) (system)
20 parts of 20 parts of Radix Scutellariaes of 20 parts of Rhizoma Drynariae of 20 parts of Fructus Amomi Rotunduss of Benzoinum (boiling hot, unhairing)
50 parts of 20 parts of Radix Saposhnikoviaes of Rhizoma Cyperi (vinegar system) 20 parts of Rhizoma Atractylodis Macrocephalaes of 20 portions of Radix Scrophulariaes (parched with bran)
30 parts of 30 parts of Radix Angelicae Sinensis of Carapax Et Plastrum Testudinis (quench in vinegar) 30 parts of Os Tigriss of 40 parts of Radix Puerariaes (short)
10 parts in 10 parts of Moschus of 10 parts of Cornu rhinocerotiss of 14 parts of Pheretimas of Sanguis Draxonis
60 parts of 3 parts of Radix Ginseng Rubra of 3 parts of Borneolum Syntheticums of 10 parts of Calculus Boviss of Colophonium
40 parts of 40 parts of Radix Polygoni Multiflori of 40 portions of Scorpios of 40 parts of Rhizoma Gastrodiaes of Radix Aconiti Kusnezoffii Preparata
For remedying the deficiency of existing big active preparation, further improve the curative effect of big active preparation, the present invention introduces superfine communication technique among the preparation technology.The broken technology of Chinese medicine ultra-fine powder claims broken technology of Chinese medicine cell grade micropowder or Chinese medicine cell wall breaking technology again, and it is meant the broken and cell grade ultrafine Chinese herb preparation to Chinese medicine cell grade micropowder mostly, is to break the comminution process that the Chinese crude drug cell is a purpose.The broken technology of Chinese medicine ultra-fine powder has plurality of advantages: a improves extraction ratio of effective constituents, thereby improves drug bioavailability, and taking dose reduces, and saves Chinese material medicine resource, meets " sustainable development " strategy; B improves compound recipe and pulverizes homogenization, embodies tcm characteristic; C retains biological activity composition improves curative effect of medication; D reduces the oral granule sense; E avoids outside contamination, parasite killing, adjection such as antibacterial.
The broken device category of Chinese medicine ultra-fine powder is various, normal at present use mainly contain three major types: vibration type super micron mill, air-flowing type super micron mill, mechanical type super micron mill.Though air-flowing type equipment does not have the association heat, it is low to pulverize temperature, but capacity usage ratio is low, and energy consumption is big, the production cost height, and be not suitable for the superfine communication technique that adds adjuvant; Mechanical equipment convenience simple to operation, it is big that charging is suitable for particle size range, but equipment easily heats up, the component of machine serious wear, and the direct contaminated material of wear particle, heavy metal exceeds standard greatly, and the granularity of gained micropowder is bigger than normal; And vibration type equipment adopts full alloy material to make abrasive media, and special principle has farthest been avoided the wearing and tearing of parts, crush efficiency height, gained powder granularity (D simultaneously
50) can reach below the 10 μ m, combine with cryogenic technique simultaneously, be equally applicable to low melting point and thermal sensitivity medical material, applied range is present optimal micronizing equipment.So the present invention adopts the vibration type super micron mill to prepare big active superfine powder, existing crush efficiency height, the micropowder granularity is little, and the advantage that energy consumption is little can be used novel superfine grinding method again---and add the method for adjuvant micronizing, better bring into play the curative effect of preparation.
The invention provides the preparation method of the big active micronizing preparation of employing mode one preparation, be specially: get 40 parts of Agkistrodons, 40 parts of Zaocyss; 40 parts of Radix Clematidis, 40 parts of Rhizoma Anemones Raddeanae, 40 parts in Herba Ephedrae; 40 parts of Rhizoma Osmundae, 40 parts in Radix Glycyrrhizae, 40 parts of Rhizoma Et Radix Notopterygiis; 40 parts of Cortex Cinnamomis, 40 parts of Herba Pogostemonis, 40 parts of the Radixs Linderae; 40 parts of Rhizoma Coptidis, 40 parts of Radix Rehmanniae Preparata, 40 parts of Radix Et Rhizoma Rhei; 40 parts of the Radix Aucklandiae, 40 parts of Lignum Aquilariae Resinatum, 20 parts of Herba Asaris; 20 parts of Radix Paeoniae Rubra, 20 parts of Myrrha (processed), 20 parts of Flos Caryophyllis; 20 parts of Olibanums (system), 20 parts of Bombyx Batryticatus (stir-fry), 20 parts of Rhizoma Arisaematiss (system); 20 parts on Pericarpium Citri Reticulatae Viride, Rhizoma Drynariae (scalds; unhairing) 20 parts, 20 parts in Fructus Amomi Rotundus; 20 parts of Benzoinumes, 20 parts of Radix Scutellariaes, 20 parts of Rhizoma Cyperis (vinegar system); 20 parts of Radix Scrophulariaes, 20 parts of the Rhizoma Atractylodis Macrocephalaes (parched with bran), 50 parts of Radix Saposhnikoviaes; 40 parts of Carapax Et Plastrum Testudiniss (quench in vinegar), 30 parts of Radix Puerariaes, 30 parts of Os Tigriss (short); 30 parts of Radix Angelicae Sinensis, 14 parts of Sanguis Draxonis, 10 parts of Pheretimas; 10 parts of Cornu rhinocerotiss; 10 parts in Moschus, 10 parts of Colophonium, 3 parts of Calculus Boviss; 3 parts of Borneolum Syntheticums; 60 parts of Radix Ginseng Rubra, 40 parts of Radix Aconiti Kusnezoffii Preparatas, 40 parts in Rhizoma Gastrodiae; 40 parts of Scorpios; 40 parts of Radix Polygoni Multiflori are ground into coarse powder, put in the vibration type pulverizing mill micronizing 10～80 minutes; make ultra-fine pharmaceutical composition, make pill according to pharmaceutics conventional formulation technology; tablet or capsule.
For guaranteeing this preparation curative effect, the ultra-fine pharmaceutical composition that preparation adopted must reach the granularity of regulation: D
50Less than 10 μ m, D
90Less than 50 μ m, thereby guarantee sporoderm-broken rate more than 90%, make each effective constituents in the crude drug cell come out preferably and be release conditions, farthest improve drug bioavailability.
Preparation of the present invention can be honey pill agent, water-honeyed pill, capsule or tablet.
Optimization formula of the present invention is formed in the back and is embodied in the specific embodiment.
Mode two: add the adjuvant micronizing
The inventor also provides the big active prescription that adds adjuvant micronizing preparation, and it is composed as follows:
0～10 part of 0～10 part of bioadhesive polymer of prescription 100 parts of wetting agent of medical material
0～10 part of 0～20 portion of efficient disintegrating agent of dispersant
Adjuvant used in the present invention is through screening and the final combination of determining, has uniqueness and irreplaceability, and wherein wetting agent is any or the compositions more than two kinds in lecithin, poloxamer, the Polyethylene Glycol; Bioadhesive polymer is the compositions of any or two kinds in chitosan, the carbomer; Dispersant is any or the compositions more than two kinds in micropowder silica gel, cyclodextrin, starch, the dextrin; Efficient disintegrating agent is that low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, super carboxymethyl starch sodium, crospolyvinylpyrrolidone, cross-linked carboxymethyl cellulose are received, any or the compositions more than two kinds in the microcrystalline Cellulose.
Bioadhesive polymer chitosan, carbomer are macromolecular material, have the bio-adhesive performance, but prolong drug significantly improves bioavailability of medicament in the gastrointestinal holdup time.Self is electronegative under the meta-alkalescence condition for carbomer, and intestinal can provide the environment of meta-alkalescence, and carbomer can form hydrophilic high viscosity gel in intestinal, be adsorbed on the intestinal mucosa, strengthen medicine in the holdup time of intestinal, promote the medicine moistening, strengthen absorbing of effective ingredient; Chitosan is natural biodegradable pasting material and the slow-release material of using always, and tool promotes the effect of medicine mucosa absorption, it is the polycation polysaccharide of the only existence of nature, chitosan be N-acetyl-D-glucamine and D-glucamine by the linear long-chain high-polymer molecular that β (1-4) glycosidic bond is formed by connecting, contain in a large number can with other molecules form hydrogen bonds-OH and-NH
2Group ,-NH
2Protonated formation-NH
3 +Make the molecule positively charged, above-mentioned molecular characterization makes chitosan become good bio-adhesive material, under the condition of acidic pH of gastric juice, chitosan forms hydrophilic high viscosity gel, easily be adsorbed on the gastrointestinal tract mucosa, the holdup time of prolong drug promotes the medicine moistening, strengthens absorbing of effective ingredient; And chitosan can also open epithelial tight connection, further promotes drug absorption.
Wetting agent lecithin, poloxamer, Polyethylene Glycol have certain surface activity effect, abundant moistening micropowders surface, reduce the surface tension of micropowder greatly, prevent that micropowder is coalescent agglomerating, the raising of micropowders wettability has simultaneously strengthened itself and the coupling ability of gastrointestinal wall, fully contacts, discharge effective ingredient, improve bioavailability.
Dispersant micropowder silica gel, cyclodextrin, microcrystalline Cellulose, starch, dextrin, Polyethylene Glycol etc. provide surface area great carrier for the high degree of dispersion of micropowders, the part microgranule that can neutralize simultaneously institute is electrically charged, eliminate the microparticle surfaces air film, make the surface energy of micropowders reduce greatly, the coalescent agglomerating phenomenon of medicine no longer appears, the mobile enhancing can carry out the preparation of preparations such as tablet, capsule fully, the more important thing is to have strengthened stability of drug.
Efficient disintegrating agent low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, super carboxymethyl starch sodium, crospolyvinylpyrrolidone, cross-linked carboxymethyl cellulose are received, the adding of microcrystalline Cellulose etc., be beneficial to preparations such as capsule, tablet, pill and discharge medicine rapidly, reach onset concentration in short period, onset rapidly.
The present invention also provides the preparation method of the big active micronizing preparations of employing mode two preparations, is specially: get 40 parts of Agkistrodons, 40 parts of Zaocyss, 40 parts of Radix Clematidis, 40 parts of Rhizoma Anemones Raddeanae, 40 parts in Herba Ephedrae, 40 parts of Rhizoma Osmundae, 40 parts in Radix Glycyrrhizae, 40 parts of Rhizoma Et Radix Notopterygiis, 40 parts of Cortex Cinnamomis, 40 parts of Herba Pogostemonis, 40 parts of the Radixs Linderae, 40 parts of Rhizoma Coptidis, 40 parts of Radix Rehmanniae Preparata, 40 parts of Radix Et Rhizoma Rhei, 40 parts of the Radix Aucklandiae, 40 parts of Lignum Aquilariae Resinatum, 20 parts of Herba Asaris, 20 parts of Radix Paeoniae Rubra, 20 parts of Myrrha (processed), 20 parts of Flos Caryophyllis, 20 parts of Olibanums (system), 20 parts of Bombyx Batryticatus (stir-fry), 20 parts of Rhizoma Arisaematiss (system), 20 parts on Pericarpium Citri Reticulatae Viride, Rhizoma Drynariae (scalds, unhairing) 20 part, 20 parts in Fructus Amomi Rotundus, 20 parts of Benzoinumes, 20 parts of Radix Scutellariaes, 20 parts of Rhizoma Cyperis (vinegar system), 20 parts of Radix Scrophulariaes, 20 parts of the Rhizoma Atractylodis Macrocephalaes (parched with bran), 50 parts of Radix Saposhnikoviaes, 40 parts of Carapax Et Plastrum Testudiniss (quench in vinegar), 30 parts of Radix Puerariaes, 30 parts of Os Tigriss (short), 30 parts of Radix Angelicae Sinensis, 14 parts of Sanguis Draxonis, 10 parts of Pheretimas, 10 parts of Cornu rhinocerotiss, 10 parts in Moschus, 10 parts of Colophonium, 3 parts of Calculus Boviss, 3 parts of Borneolum Syntheticums, 60 parts of Radix Ginseng Rubra, 40 parts of Radix Aconiti Kusnezoffii Preparatas, 40 parts in Rhizoma Gastrodiae, 40 parts of Scorpios, 40 parts of Radix Polygoni Multiflori are ground into coarse powder, add the recipe quantity pharmaceutical adjunct, put in the vibration type pulverizing mill micronizing 10～80 minutes, and made ultra-fine pharmaceutical composition, make pill according to pharmaceutics conventional formulation technology, tablet or capsule;
For guaranteeing this preparation curative effect, the ultra-fine pharmaceutical composition that preparation adopted must reach the granularity of regulation: D
50Less than 10 μ m, D
90Less than 50 μ m, thereby guarantee sporoderm-broken rate more than 90%, make each effective constituents in the crude drug cell come out preferably and be release conditions, farthest improve drug bioavailability.
Preparation of the present invention can be honey pill agent, water-honeyed pill, capsule or tablet.
Optimization formula of the present invention is formed in the back and is embodied in the specific embodiment.
Beneficial effect
Technical scheme of the present invention is considered from practical angle, adopts innovative technology to make big active micronizing preparation, and concrete advantage is as follows:
1, improves drug bioavailability: adopt big active preparation that this patent invention preparation method makes and common DAHUOLUO WAN agent etc. to compare, significantly improved bioavailability of medicament.The Chinese medicine coarse powder is after micronizing, and the cell wall breaking rate reaches 90%, and intracellular each effective constituents comes out preferably and is release conditions, and effective ingredient dissolution and bioavailability improve greatly, can reach onset concentration within a short period of time, brings into play curative effect rapidly.
2, preparation technology's efficient height, energy consumption is little: it is big to be compared to air-flowing type super micron mill energy consumption, and capacity usage ratio is low, the deficiency that production cost is high, preparation technology of the present invention improves, and adopts the vibration type pulverizing mill that energy consumption is little, efficient is high to carry out micronizing, granule D
50Can reach below the 10 μ m, and also can add necessary adjuvants such as wetting agent among the preparation technology of the present invention, micropowder is reunited, adsorption phenomena is solved, and further strengthens drug effect, and this is that any micronizing mode is beyond one's reach.
3, promoted the application of superfine communication technique in pharmaceuticals industry to a certain extent: the big active micronizing preparation unique preparation process of the present invention provides a practical way for similar technological innovation; along with updating of superfine communication technique; obtain the approval of numerous pharmaceutical researchers surely, the scale of the broken technology of Chinese medicine ultra-fine powder, industrialization are pointed the day and await for it.
4, big active micronizing preparation of the present invention and common big active preparation are comprehensively compared, the result is as follows:
Former technology of table 1 and innovative technology effect comparison sheet of the present invention
Annotate: above-mentionedly more all compare with same dosage form (pill).
As seen, the present invention has obtained outstanding technique effect, has reached goal of the invention.
The specific embodiment
Enumerate embodiment below, further specify the present invention, each embodiment only is used to illustrate the present invention, does not limit the present invention:
Embodiment 1
Agkistrodon 40g Zaocys 40g Radix Clematidis 40g Rhizoma Anemones Raddeanae 40g
Herba Ephedrae 40g Rhizoma Osmundae 40g Radix Glycyrrhizae 40g Rhizoma Et Radix Notopterygii 40g
Cortex Cinnamomi 40g Herba Pogostemonis 40g Radix Linderae 40g Rhizoma Coptidis 40g
Radix Rehmanniae Preparata 40g Radix Et Rhizoma Rhei 40g Radix Aucklandiae 40g Lignum Aquilariae Resinatum 40g
Herba Asari 20g Radix Paeoniae Rubra 20g Myrrha (processed) 20g Flos Caryophylli 20g
Olibanum (system) 20g Bombyx Batryticatus (stir-fry) 20g Rhizoma Arisaematis (system) 20g Pericarpium Citri Reticulatae Viride 20g
Benzoinum 20g Fructus Amomi Rotundus 20g Rhizoma Drynariae (boiling hot, unhairing) 20g Radix Scutellariae 20g
Rhizoma Cyperi (vinegar system) the 20g Radix Scrophulariae 20g Rhizoma Atractylodis Macrocephalae (parched with bran) 20g Radix Saposhnikoviae 50g
Carapax Et Plastrum Testudinis (quench in vinegar) 40g Radix Puerariae 30g Os Tigris (short) 30g Radix Angelicae Sinensis 30g
Sanguis Draxonis 14g Pheretima 10g Cornu rhinocerotis 10g Moschus 10g
Colophonium 10g Calculus Bovis 3g Borneolum Syntheticum 3g Radix Ginseng Rubra 60g
Radix Aconiti Kusnezoffii Preparata 40g Rhizoma Gastrodiae 40g Scorpio 40g Radix Polygoni Multiflori 40g
More than 48 flavors, carry out the flushing coarse pulverization, cross 10 mesh sieves, pulverized 50 minutes in the vibration type super micron mill then, make ultra-fine pharmaceutical composition, add 1.4 times refined honey, make big active small honey pill or big honeyed pills.
Embodiment 2
Agkistrodon 40g Zaocys 40g Radix Clematidis 40g Rhizoma Anemones Raddeanae 40g
Herba Ephedrae 40g Rhizoma Osmundae 40g Radix Glycyrrhizae 40g Rhizoma Et Radix Notopterygii 40g
Cortex Cinnamomi 40g Herba Pogostemonis 40g Radix Linderae 40g Rhizoma Coptidis 40g
Radix Rehmanniae Preparata 40g Radix Et Rhizoma Rhei 40g Radix Aucklandiae 40g Lignum Aquilariae Resinatum 40g
Herba Asari 20g Radix Paeoniae Rubra 20g Myrrha (processed) 20g Flos Caryophylli 20g
Olibanum (system) 20g Bombyx Batryticatus (stir-fry) 20g Rhizoma Arisaematis (system) 20g Pericarpium Citri Reticulatae Viride 20g
Benzoinum 20g Fructus Amomi Rotundus 20g Rhizoma Drynariae (boiling hot, unhairing) 20g Radix Scutellariae 20g
Rhizoma Cyperi (vinegar system) the 20g Radix Scrophulariae 20g Rhizoma Atractylodis Macrocephalae (parched with bran) 20g Radix Saposhnikoviae 50g
Carapax Et Plastrum Testudinis (quench in vinegar) 40g Radix Puerariae 30g Os Tigris (short) 30g Radix Angelicae Sinensis 30g
Sanguis Draxonis 14g Pheretima 10g Cornu rhinocerotis 10g Moschus 10g
Colophonium 10g Calculus Bovis 3g Borneolum Syntheticum 3g Radix Ginseng Rubra 60g
Radix Aconiti Kusnezoffii Preparata 40g Rhizoma Gastrodiae 40g Scorpio 40g Radix Polygoni Multiflori 40g
More than 48 flavors, carry out the flushing coarse pulverization, cross 10 mesh sieves, pulverized 60 minutes in the vibration type super micron mill then, make ultra-fine pharmaceutical composition, adds 0.7 times refined honey and suitable water, make big active water-honeyed pill.
Embodiment 3
Agkistrodon 40g Zaocys 40g Radix Clematidis 40g Rhizoma Anemones Raddeanae 40g
Herba Ephedrae 40g Rhizoma Osmundae 40g Radix Glycyrrhizae 40g Rhizoma Et Radix Notopterygii 40g
Cortex Cinnamomi 40g Herba Pogostemonis 40g Radix Linderae 40g Rhizoma Coptidis 40g
Radix Rehmanniae Preparata 40g Radix Et Rhizoma Rhei 40g Radix Aucklandiae 40g Lignum Aquilariae Resinatum 40g
Herba Asari 20g Radix Paeoniae Rubra 20g Myrrha (processed) 20g Flos Caryophylli 20g
Olibanum (system) 20g Bombyx Batryticatus (stir-fry) 20g Rhizoma Arisaematis (system) 20g Pericarpium Citri Reticulatae Viride 20g
Benzoinum 20g Fructus Amomi Rotundus 20g Rhizoma Drynariae (boiling hot, unhairing) 20g Radix Scutellariae 20g
Rhizoma Cyperi (vinegar system) the 20g Radix Scrophulariae 20g Rhizoma Atractylodis Macrocephalae (parched with bran) 20g Radix Saposhnikoviae 50g
Carapax Et Plastrum Testudinis (quench in vinegar) 40g Radix Puerariae 30g Os Tigris (short) 30g Radix Angelicae Sinensis 30g
Sanguis Draxonis 14g Pheretima 10g Cornu rhinocerotis 10g Moschus 10g
Colophonium 10g Calculus Bovis 3g Borneolum Syntheticum 3g Radix Ginseng Rubra 60g
Radix Aconiti Kusnezoffii Preparata 40g Rhizoma Gastrodiae 40g Scorpio 40g Radix Polygoni Multiflori 40g
More than 48 the flavor, carry out the flushing coarse pulverization, cross 10 mesh sieves, add chitosan 0.4g, lecithin 1g, micropowder silica gel 10g and crospolyvinylpyrrolidone 10g, pulverized 40 minutes in the vibration type super micron mill, make ultra-fine pharmaceutical composition, add 1.4 times refined honey, make big active small honey pill or big honeyed pills.
Embodiment 4
Agkistrodon 40g Zaocys 40g Radix Clematidis 40g Rhizoma Anemones Raddeanae 40g
Herba Ephedrae 40g Rhizoma Osmundae 40g Radix Glycyrrhizae 40g Rhizoma Et Radix Notopterygii 40g
Cortex Cinnamomi 40g Herba Pogostemonis 40g Radix Linderae 40g Rhizoma Coptidis 40g
Radix Rehmanniae Preparata 40g Radix Et Rhizoma Rhei 40g Radix Aucklandiae 40g Lignum Aquilariae Resinatum 40g
Herba Asari 20g Radix Paeoniae Rubra 20g Myrrha (processed) 20g Flos Caryophylli 20g
Olibanum (system) 20g Bombyx Batryticatus (stir-fry) 20g Rhizoma Arisaematis (system) 20g Pericarpium Citri Reticulatae Viride 20g
Benzoinum 20g Fructus Amomi Rotundus 20g Rhizoma Drynariae (boiling hot, unhairing) 20g Radix Scutellariae 20g
Rhizoma Cyperi (vinegar system) the 20g Radix Scrophulariae 20g Rhizoma Atractylodis Macrocephalae (parched with bran) 20g Radix Saposhnikoviae 50g
Carapax Et Plastrum Testudinis (quench in vinegar) 40g Radix Puerariae 30g Os Tigris (short) 30g Radix Angelicae Sinensis 30g
Sanguis Draxonis 14g Pheretima 10g Cornu rhinocerotis 10g Moschus 10g
Colophonium 10g Calculus Bovis 3g Borneolum Syntheticum 3g Radix Ginseng Rubra 60g
Radix Aconiti Kusnezoffii Preparata 40g Rhizoma Gastrodiae 40g Scorpio 40g Radix Polygoni Multiflori 40g
More than 48 the flavor, carry out the flushing coarse pulverization, cross 10 mesh sieves, add carbomer 75g, poloxamer 100g, microcrystalline Cellulose 10g and super carboxymethyl starch sodium 40g, pulverized 60 minutes in the vibration type super micron mill, make ultra-fine pharmaceutical composition, add 1.2 times refined honey, make big active small honey pill or big honeyed pills.
Embodiment 5
Agkistrodon 40g Zaocys 40g Radix Clematidis 40g Rhizoma Anemones Raddeanae 40g
Herba Ephedrae 40g Rhizoma Osmundae 40g Radix Glycyrrhizae 40g Rhizoma Et Radix Notopterygii 40g
Cortex Cinnamomi 40g Herba Pogostemonis 40g Radix Linderae 40g Rhizoma Coptidis 40g
Radix Rehmanniae Preparata 40g Radix Et Rhizoma Rhei 40g Radix Aucklandiae 40g Lignum Aquilariae Resinatum 40g
Herba Asari 20g Radix Paeoniae Rubra 20g Myrrha (processed) 20g Flos Caryophylli 20g
Olibanum (system) 20g Bombyx Batryticatus (stir-fry) 20g Rhizoma Arisaematis (system) 20g Pericarpium Citri Reticulatae Viride 20g
Benzoinum 20g Fructus Amomi Rotundus 20g Rhizoma Drynariae (boiling hot, unhairing) 20g Radix Scutellariae 20g
Rhizoma Cyperi (vinegar system) the 20g Radix Scrophulariae 20g Rhizoma Atractylodis Macrocephalae (parched with bran) 20g Radix Saposhnikoviae 50g
Carapax Et Plastrum Testudinis (quench in vinegar) 40g Radix Puerariae 30g Os Tigris (short) 30g Radix Angelicae Sinensis 30g
Sanguis Draxonis 14g Pheretima 10g Cornu rhinocerotis 10g Moschus 10g
Colophonium 10g Calculus Bovis 3g Borneolum Syntheticum 3g Radix Ginseng Rubra 60g
Radix Aconiti Kusnezoffii Preparata 40g Rhizoma Gastrodiae 40g Scorpio 40g Radix Polygoni Multiflori 40g
More than 48 the flavor, carry out the flushing coarse pulverization, cross 10 mesh sieves, and add carbomer 10g, poloxamer 15g, starch 25g and microcrystalline Cellulose 10g, pulverized 45 minutes in the vibration type super micron mill, make ultra-fine pharmaceutical composition, add newborn proper amount of sugar, and it is an amount of to add debita spissitudo ethanol, make granule, add an amount of magnesium stearate, capsule charge makes Da huoluo capsule.
Embodiment 6
Agkistrodon 40g Zaocys 40g Radix Clematidis 40g Rhizoma Anemones Raddeanae 40g
Herba Ephedrae 40g Rhizoma Osmundae 40g Radix Glycyrrhizae 40g Rhizoma Et Radix Notopterygii 40g
Cortex Cinnamomi 40g Herba Pogostemonis 40g Radix Linderae 40g Rhizoma Coptidis 40g
Radix Rehmanniae Preparata 40g Radix Et Rhizoma Rhei 40g Radix Aucklandiae 40g Lignum Aquilariae Resinatum 40g
Herba Asari 20g Radix Paeoniae Rubra 20g Myrrha (processed) 20g Flos Caryophylli 20g
Olibanum (system) 20g Bombyx Batryticatus (stir-fry) 20g Rhizoma Arisaematis (system) 20g Pericarpium Citri Reticulatae Viride 20g
Benzoinum 20g Fructus Amomi Rotundus 20g Rhizoma Drynariae (boiling hot, unhairing) 20g Radix Scutellariae 20g
Rhizoma Cyperi (vinegar system) the 20g Radix Scrophulariae 20g Rhizoma Atractylodis Macrocephalae (parched with bran) 20g Radix Saposhnikoviae 50g
Carapax Et Plastrum Testudinis (quench in vinegar) 40g Radix Puerariae 30g Os Tigris (short) 30g Radix Angelicae Sinensis 30g
Sanguis Draxonis 14g Pheretima 10g Cornu rhinocerotis 10g Moschus 10g
Colophonium 10g Calculus Bovis 3g Borneolum Syntheticum 3g Radix Ginseng Rubra 60g
Radix Aconiti Kusnezoffii Preparata 40g Rhizoma Gastrodiae 40g Scorpio 40g Radix Polygoni Multiflori 40g
More than 48 the flavor, carry out the flushing coarse pulverization, cross 10 mesh sieves, and add polyvinylpyrrolidone 15g, poloxamer 10g, cyclodextrin 20g, micropowder silica gel 20g and carboxymethyl starch sodium 10g, pulverized 55 minutes in the vibration type super micron mill, make ultra-fine pharmaceutical composition, add starch and microcrystalline Cellulose is an amount of, and it is an amount of to add debita spissitudo ethanol, makes granule, compressed tablets makes big active tablet.
Claims (8)
1, a kind of big active preparation that adopts superfine communication technique to make.
2, big active preparation according to claim 1 is characterized in that the grain graininess D of the ultra-fine pharmaceutical composition of preparation intermediate
50Less than 10 μ m, D
90Less than 50 μ m.
3, big active preparation according to claim 2 is characterized in that adopting following either party's method to make:
A, get the prescription medical material, be ground into coarse powder, put in the vibration type super micron mill micronizing 10～80 minutes, make ultra-fine pharmaceutical composition, make pill, tablet, capsule according to pharmaceutics conventional formulation technology;
B, get the prescription medical material, be ground into coarse powder, add pharmaceutical adjunct, put in the vibration type super micron mill micronizing 10～80 minutes, make ultra-fine pharmaceutical composition, make pill, tablet, capsule according to pharmaceutics conventional formulation technology.
4, big active preparation according to claim 3 is characterized in that the pharmaceutical adjunct among the method b comprises wetting agent, dispersant.
5, big active preparation according to claim 4 is characterized in that pharmaceutical adjunct also comprises bioadhesive polymer, efficient disintegrating agent.
6, big active preparation according to claim 5 is characterized in that wetting agent is any or the compositions more than two kinds in lecithin, poloxamer, the Polyethylene Glycol; Bioadhesive polymer is any or the compositions more than two kinds in chitosan, carbomer, the polyvinylpyrrolidone; Dispersant is any or the compositions more than two kinds in micropowder silica gel, cyclodextrin, starch, the dextrin; Efficient disintegrating agent is that low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, super carboxymethyl starch sodium, crospolyvinylpyrrolidone, cross-linked carboxymethyl cellulose are received, any or the compositions more than two kinds in the microcrystalline Cellulose.
7, big active preparation according to claim 6, the weight proportion of it is characterized in that writing out a prescription medical material and wetting agent, bioadhesive polymer, dispersant and efficient disintegrating agent is: 100: 0～10: 0～10: 0～20: 0～10.
8, the method for preparing the arbitrary described big active preparation of claim 1 to 7 is characterized in that it can being following any method:
A, get 40 parts of Agkistrodons, 40 parts of Zaocyss, 40 parts of Radix Clematidis, 40 parts of Rhizoma Anemones Raddeanae, 40 parts in Herba Ephedrae, 40 parts of Rhizoma Osmundae, 40 parts in Radix Glycyrrhizae, 40 parts of Rhizoma Et Radix Notopterygiis, 40 parts of Cortex Cinnamomis, 40 parts of Herba Pogostemonis, 40 parts of the Radixs Linderae, 40 parts of Rhizoma Coptidis, 40 parts of Radix Rehmanniae Preparata, 40 parts of Radix Et Rhizoma Rhei, 40 parts of the Radix Aucklandiae, 40 parts of Lignum Aquilariae Resinatum, 20 parts of Herba Asaris, 20 parts of Radix Paeoniae Rubra, 20 parts of Myrrha (processed)s, 20 parts of Flos Caryophyllis, 20 parts of Olibanum (processed)s, 20 parts of Bombyx Batryticatus (parched)s, 20 parts of Rhizoma Arisaematis (processed), 20 parts on Pericarpium Citri Reticulatae Viride, 20 parts of Rhizoma drynariae preparatas, 20 parts in Fructus Amomi Rotundus, 20 parts of Benzoinumes, 20 parts of Radix Scutellariaes, 20 parts of Rhizoma Cyperi (processed with vinegar), 20 parts of Radix Scrophulariaes, 20 parts of Rhizoma Atractylodis Macrocephalae (parched with bran), 50 parts of Radix Saposhnikoviaes, 40 parts of quench in vinegar Carapax Et Plastrum Testudiniss, 30 parts of Radix Puerariaes, 30 parts of short Os Tigriss, 30 parts of Radix Angelicae Sinensis, 14 parts of Sanguis Draxonis, 10 parts of Pheretimas, 10 parts of Cornu rhinocerotiss, 10 parts in Moschus, 10 parts of Colophonium, 3 parts of Calculus Boviss, 3 parts of Borneolum Syntheticums, 60 parts of Radix Ginseng Rubra, 40 parts of Radix Aconiti Kusnezoffii Preparatas, 40 parts in Rhizoma Gastrodiae, 40 parts of Scorpios, 40 parts of Radix Polygoni Multiflori are ground into coarse powder, put in the vibration type pulverizing mill micronizing 10～80 minutes, and made ultra-fine pharmaceutical composition, make pill according to pharmaceutics conventional formulation technology, tablet or capsule;
B; get 40 parts of Agkistrodons, 40 parts of Zaocyss, 40 parts of Radix Clematidis; 40 parts of Rhizoma Anemones Raddeanae, 40 parts in Herba Ephedrae, 40 parts of Rhizoma Osmundae; 40 parts in Radix Glycyrrhizae, 40 parts of Rhizoma Et Radix Notopterygiis, 40 parts of Cortex Cinnamomis; 40 parts of Herba Pogostemonis, 40 parts of the Radixs Linderae, 40 parts of Rhizoma Coptidis; 40 parts of Radix Rehmanniae Preparata, 40 parts of Radix Et Rhizoma Rhei, 40 parts of the Radix Aucklandiae; 40 parts of Lignum Aquilariae Resinatum, 20 parts of Herba Asaris, 20 parts of Radix Paeoniae Rubra; 20 parts of Myrrha (processed)s, 20 parts of Flos Caryophyllis, 20 parts of Olibanum (processed)s; 20 parts of Bombyx Batryticatus (parched)s, 20 parts of Rhizoma Arisaematis (processed), 20 parts on Pericarpium Citri Reticulatae Viride; 20 parts of Rhizoma drynariae preparatas, 20 parts in Fructus Amomi Rotundus, 20 parts of Benzoinumes; 20 parts of Radix Scutellariaes, 20 parts of Rhizoma Cyperi (processed with vinegar), 20 parts of Radix Scrophulariaes; 20 parts of Rhizoma Atractylodis Macrocephalae (parched with bran), 50 parts of Radix Saposhnikoviaes, 40 parts of quench in vinegar Carapax Et Plastrum Testudiniss; 30 parts of Radix Puerariaes, 30 parts of short Os Tigriss, 30 parts of Radix Angelicae Sinensis; 14 parts of Sanguis Draxonis, 10 parts of Pheretimas, 10 parts of Cornu rhinocerotiss; 10 parts in Moschus; 10 parts of Colophonium, 3 parts of Calculus Boviss, 3 parts of Borneolum Syntheticums; 60 parts of Radix Ginseng Rubra; 40 parts of Radix Aconiti Kusnezoffii Preparatas, 40 parts in Rhizoma Gastrodiae, 40 parts of Scorpios; 40 parts of Radix Polygoni Multiflori; be ground into coarse powder, add pharmaceutical adjunct, put in the vibration type pulverizing mill micronizing 10～80 minutes; make ultra-fine pharmaceutical composition, make pill according to pharmaceutics conventional formulation technology; tablet or capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101051838A CN101564501A (en) | 2008-04-25 | 2008-04-25 | Big activating collateral preparation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101051838A CN101564501A (en) | 2008-04-25 | 2008-04-25 | Big activating collateral preparation and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101564501A true CN101564501A (en) | 2009-10-28 |
Family
ID=41280977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101051838A Pending CN101564501A (en) | 2008-04-25 | 2008-04-25 | Big activating collateral preparation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101564501A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309550A (en) * | 2010-07-06 | 2012-01-11 | 中国人民解放军第三○二医院 | Traditional Chinese medicinal aerosol for preventing and treating summer humidity disease and preparation method thereof |
| CN103566016A (en) * | 2012-07-26 | 2014-02-12 | 康美药业股份有限公司 | Ultrafine powder piece of prepared rehmannia root, and preparation method and use thereof |
-
2008
- 2008-04-25 CN CNA2008101051838A patent/CN101564501A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309550A (en) * | 2010-07-06 | 2012-01-11 | 中国人民解放军第三○二医院 | Traditional Chinese medicinal aerosol for preventing and treating summer humidity disease and preparation method thereof |
| CN103566016A (en) * | 2012-07-26 | 2014-02-12 | 康美药业股份有限公司 | Ultrafine powder piece of prepared rehmannia root, and preparation method and use thereof |
| CN103566016B (en) * | 2012-07-26 | 2015-12-02 | 康美药业股份有限公司 | A kind of Radix Rehmanniae Preparata superfine powder decoction pieces and its production and use |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101579364A (en) | Pharmaceutical composition and preparation method thereof | |
| CN100515397C (en) | Agastachel patchouli qi-righting fast dispersion solid preparation and its preparation method | |
| CN100515404C (en) | Compound bovine bezoar stomach clearing fast dispersion solid preparation and its preparation method | |
| CN101579506A (en) | Bezoar chest functioning preparation and preparation method thereof | |
| CN100515457C (en) | Mugwort and cyperus palace warming fast dispersion solid preparation and its preparation method | |
| CN100420435C (en) | Tongyou dryness moistening fast dispersion solid preparation and its preparation method | |
| CN100515393C (en) | Perfect major supple mentation fast dispersion solid preparation and its making method | |
| CN101564442A (en) | Preparation of cassia twig and Indian buead and preparation method thereof | |
| CN101564414A (en) | Western bovine bezoar preparation and preparation method thereof | |
| CN101564501A (en) | Big activating collateral preparation and preparation method thereof | |
| CN101564515A (en) | Bony spur preparation and preparation method thereof | |
| CN1785368A (en) | Lingyang lung clearing fast dispersion solid preparation and its preparation method | |
| CN101579505A (en) | Restorative preparation and preparation method thereof | |
| CN100515398C (en) | Six ingredient rehmannia fast dispersion solid preparation and its preparation method | |
| CN100384405C (en) | Hepatitis B support right fast dispersion solid preparation and its preparation method | |
| CN100515399C (en) | Zuojin fast dispersion solid medicine and its preparation method | |
| CN101564500A (en) | Dendrobium noctilucent preparation and preparation method thereof | |
| CN101564441A (en) | Apoplexy rejuvenation preparation and preparation method thereof | |
| CN101564481A (en) | Bone-setting anti-bruise powder preparation and preparation method thereof | |
| CN105561166A (en) | Re-prepared preparation and preparation method thereof | |
| CN101564477A (en) | Small activating collateral preparation and preparation method thereof | |
| CN1785398A (en) | Kunshun fast dispersion solid preparation and its preparation method | |
| CN101564413A (en) | Storax preparation of coronary disease and preparation method thereof | |
| CN1824140A (en) | Anemarrhena, phello dendron and rehmannia fast dispersion solid medicinal preparation and its manufacturing method | |
| CN100515400C (en) | Baohe fast dispetsion solid preparation and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20091028 |