CN101564515A - Bony spur preparation and preparation method thereof - Google Patents
Bony spur preparation and preparation method thereof Download PDFInfo
- Publication number
- CN101564515A CN101564515A CNA2008101051861A CN200810105186A CN101564515A CN 101564515 A CN101564515 A CN 101564515A CN A2008101051861 A CNA2008101051861 A CN A2008101051861A CN 200810105186 A CN200810105186 A CN 200810105186A CN 101564515 A CN101564515 A CN 101564515A
- Authority
- CN
- China
- Prior art keywords
- preparation
- radix
- bony spur
- ultra
- make
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Chinese medicinal preparation, and in particular to a bony spur preparation prepared by adopting ultra-micro pulverization technology and a preparation method thereof. The invention provides a bony spur ultra-micro pulverization preparation prepared by adopting a vibrating ultra-micro pulverizer, and also introduces assistant materials-adding ultra-micro pulverization technology. The preparation and the method maintain the compound pulverization homogenization, fully embody the characteristics of Chinese medicinal science, furthest maintain the active ingredient at the same time, improve the utilization factor of medicinal materials, save the medicinal material resources and reduce the production cost.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of bony spur preparation that superfine communication technique makes and preparation method thereof that adopts belongs to the field of Chinese medicines.
Background technology
Bony spur pill now records in " Chinese medicine ministry standard " the 11 129 pages, and the weight proportion of its active ingredient raw materials medicine is: 1 part of Radix Aconiti Preparata, 1 part of Radix Aconiti Kusnezoffii Preparata, 1 part of Rhizoma Arisaematis (system), 1 part of Radix Gentianae Macrophyllae, 1 part of the Radix Angelicae Dahuricae, 1 part of Radix Angelicae Sinensis, 1 part in Radix Glycyrrhizae, 1 part of Semen Coicis (stir-fry), 1 part of Rhizoma Dioscoreae Nipponicae, Dioscorea septemloba Thunb. are separated 2 parts, 2 parts on Flos Carthami, 3 parts of Radix Cynanchi Paniculatis are used for hyperosteogeny, rheumatic arthritis, rheumatalgia is the classics recipe of wind-expelling pain-stopping.It is evident in efficacy, is subjected to the welcome of extensive patients deeply, but finds that in actual applications still there is certain defective in it: the pill dose is big, takes extremely inconvenience, is not easy to carry, and the patient is difficult to be accepted; Prescription Chinese crude drug crushing fine powder granularity is excessive, fails to give full play to the effect of each composition in the medical material.
The thicker medicated powder bioavailability of granularity is lower, and crude drug can not be fully utilized, and because its huge market demand, thereby cause the Chinese material medicine resource serious waste.As seen, study a kind of reasonable, efficient and economically viable preparation technology bony spur class preparation is had very important significance, thereby further satisfy and ensure national medication demand.
Superfine communication technique is the machining process that makes the fine and super-refinement of material, provides one of important means of ultrafine powder.Micronizing is a new and high technology that grows up over nearly 20 years, refers to utilize machinery or hydromechanical approach that material is crushed to particle diameter less than the process below the 10 μ m.Ultramicro powder is the final products of micronizing, has some special physicochemical properties that general granule does not have, as fine solubility, dispersibility, adsorptivity etc.; For Chinese crude drug, the cell wall breaking rate improves greatly, and up to 90%, each effective constituents is release conditions, and dissolution and bioavailability are multiplied.Since the nineties in 20th century, superfine communication technique is applied to Chinese medicine gradually, has given the more modern high section of Chinese medicine content, and the broken technology of Chinese medicine ultra-fine powder is as the constantly development of a new technology.
Fully comprehend the marrow of the broken technology of Chinese medicine micropowder; choose representative classics side medicine, explore the process that a cover has operability, reasonably improvement and using ultramicro communication technique are in the herbal pharmaceutical industry; and, be one of problem that needs at present primary study with its scale, industrialization.
Summary of the invention
First purpose of the present invention is to provide a kind of bony spur micronizing preparation.
Another object of the present invention provides the preparation method of this bony spur preparation.
The object of the invention mainly is to adopt following dual mode to realize:
Mode one: common micronizing
The inventor provides a kind of bony spur preparation that adopts superfine communication technique to make, and writes out a prescription by Radix Aconiti Preparata Radix Aconiti Kusnezoffii Preparata, Rhizoma Arisaematis (system), Radix Gentianae Macrophyllae, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Radix Glycyrrhizae, Semen Coicis (stir-fry), Rhizoma Dioscoreae Nipponicae, Dioscorea septemloba Thunb. is separated, Flos Carthami, and Radix Cynanchi Paniculati is formed, the prescription ratio of bony spur meets each the flavour of a drug proportioning under the ten bony spur pill item of Chinese medicine ministry standard, that is:
1 part of Radix Aconiti Preparata 1 part of Rhizoma Arisaematis of 1 part of Radix Aconiti Kusnezoffii Preparata (system)
1 part of 1 part of Radix Angelicae Sinensis of 1 part of Radix Angelicae Dahuricae of Radix Gentianae Macrophyllae
1 part of 1 portion of Rhizoma Dioscoreae Nipponicae of 1 part of Semen Coicis of Radix Glycyrrhizae (stir-fry)
Dioscorea septemloba Thunb. is separated 3 parts of 2 parts of Radix Cynanchi Paniculatis of 2 parts of Flos Carthamis
For remedying the deficiency of existing bony spur preparation, further improve the curative effect of bony spur preparation, the present invention introduces superfine communication technique among the preparation technology.The broken technology of Chinese medicine ultra-fine powder claims broken technology of Chinese medicine cell grade micropowder or Chinese medicine cell wall breaking technology again, and it is meant the broken and cell grade ultrafine Chinese herb preparation to Chinese medicine cell grade micropowder mostly, is to break the comminution process that the Chinese crude drug cell is a purpose.The broken technology of Chinese medicine ultra-fine powder has plurality of advantages: a improves extraction ratio of effective constituents, thereby improves drug bioavailability, and taking dose reduces, and saves Chinese material medicine resource, meets " sustainable development " strategy; B improves compound recipe and pulverizes homogenization, embodies tcm characteristic; C retains biological activity composition improves curative effect of medication; D reduces the oral granule sense; E avoids outside contamination, parasite killing, adjection such as antibacterial.
The broken device category of Chinese medicine ultra-fine powder is various, normal at present use mainly contain three major types: vibration type super micron mill, air-flowing type super micron mill, mechanical type super micron mill.Though air-flowing type equipment does not have the association heat, it is low to pulverize temperature, but capacity usage ratio is low, and energy consumption is big, the production cost height, and be not suitable for the superfine communication technique that adds adjuvant; Mechanical equipment convenience simple to operation, it is big that charging is suitable for particle size range, but equipment easily heats up, the component of machine serious wear, and the direct contaminated material of wear particle, heavy metal exceeds standard greatly, and the granularity of gained micropowder is bigger than normal; And vibration type equipment adopts full alloy material to make abrasive media, and special principle has farthest been avoided the wearing and tearing of parts, crush efficiency height, gained powder granularity (D simultaneously
50) can reach below the 10 μ m, combine with cryogenic technique simultaneously, be equally applicable to low melting point and thermal sensitivity medical material, applied range is present optimal micronizing equipment.So the present invention adopts the vibration type super micron mill to prepare the bony spur superfine powder, existing crush efficiency height, the micropowder granularity is little, and the advantage that energy consumption is little can be used novel superfine grinding method again---and add the method for adjuvant micronizing, better bring into play the curative effect of preparation.
The invention provides the preparation method of employing mode one preparation bony spur micronizing preparation, be specially: get 1 part of Radix Aconiti Preparata, 1 part of Radix Aconiti Kusnezoffii Preparata, 1 part of Rhizoma Arisaematis (system), 1 part of Radix Gentianae Macrophyllae, 1 part of the Radix Angelicae Dahuricae, 1 part of Radix Angelicae Sinensis, 1 part in Radix Glycyrrhizae, 1 part of Semen Coicis (stir-fry), 1 part of Rhizoma Dioscoreae Nipponicae, Dioscorea septemloba Thunb. are separated 2 parts, 2 parts on Flos Carthami, 3 parts of Radix Cynanchi Paniculatis are ground into coarse powder, put in the vibration type pulverizing mill micronizing 10～80 minutes, make ultra-fine pharmaceutical composition, make pill, tablet or capsule according to pharmaceutics conventional formulation technology.
For guaranteeing this preparation curative effect, the ultra-fine pharmaceutical composition that preparation adopted must reach the granularity of regulation: D
50Less than 10 μ m, D
90Less than 50 μ m, thereby guarantee sporoderm-broken rate more than 90%, make each effective constituents in the crude drug cell come out preferably and be release conditions, farthest improve drug bioavailability.
Preparation of the present invention can be honey pill agent, water-honeyed pill, capsule or tablet.
Optimization formula of the present invention is formed in the back and is embodied in the specific embodiment.
Mode two: add the adjuvant micronizing
The inventor also provides bony spur to add the prescription of adjuvant micronizing preparation, and it is composed as follows:
0～10 part of 0～10 part of bioadhesive polymer of prescription 100 parts of wetting agent of medical material
0～10 part of 0～20 portion of efficient disintegrating agent of dispersant
Adjuvant used in the present invention is through screening and the final combination of determining, has uniqueness and irreplaceability, and wherein wetting agent is any or the compositions more than two kinds in lecithin, poloxamer, the Polyethylene Glycol; Bioadhesive polymer is the compositions of any or two kinds in chitosan, the carbomer; Dispersant is any or the compositions more than two kinds in micropowder silica gel, cyclodextrin, starch, the dextrin; Efficient disintegrating agent is that low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, super carboxymethyl starch sodium, crospolyvinylpyrrolidone, cross-linked carboxymethyl cellulose are received, any or the compositions more than two kinds in the microcrystalline Cellulose.
Bioadhesive polymer chitosan, carbomer are macromolecular material, have the bio-adhesive performance, but prolong drug significantly improves bioavailability of medicament in the gastrointestinal holdup time.Self is electronegative under the meta-alkalescence condition for carbomer, and intestinal can provide the environment of meta-alkalescence, and carbomer can form hydrophilic high viscosity gel in intestinal, be adsorbed on the intestinal mucosa, strengthen medicine in the holdup time of intestinal, promote the medicine moistening, strengthen absorbing of effective ingredient; Chitosan is natural biodegradable pasting material and the slow-release material of using always, and tool promotes the effect of medicine mucosa absorption, it is the polycation polysaccharide of the only existence of nature, chitosan be N-acetyl-D-glucamine and D-glucamine by the linear long-chain high-polymer molecular that β (1-4) glycosidic bond is formed by connecting, contain in a large number can with other molecules form hydrogen bonds-OH and-NH
2Group ,-NH
2Protonated formation-NH
3 +Make the molecule positively charged, above-mentioned molecular characterization makes chitosan become good bio-adhesive material, under the condition of acidic pH of gastric juice, chitosan forms hydrophilic high viscosity gel, easily be adsorbed on the gastrointestinal tract mucosa, the holdup time of prolong drug promotes the medicine moistening, strengthens absorbing of effective ingredient; And chitosan can also open epithelial tight connection, further promotes drug absorption.
Wetting agent lecithin, poloxamer, Polyethylene Glycol have certain surface activity effect, abundant moistening micropowders surface, reduce the surface tension of micropowder greatly, prevent that micropowder is coalescent agglomerating, the raising of micropowders wettability has simultaneously strengthened itself and the coupling ability of gastrointestinal wall, fully contacts, discharge effective ingredient, improve bioavailability.
Dispersant micropowder silica gel, cyclodextrin, microcrystalline Cellulose, starch, dextrin, Polyethylene Glycol etc. provide surface area great carrier for the high degree of dispersion of micropowders, the part microgranule that can neutralize simultaneously institute is electrically charged, eliminate the microparticle surfaces air film, make the surface energy of micropowders reduce greatly, the coalescent agglomerating phenomenon of medicine no longer appears, the mobile enhancing can carry out the preparation of preparations such as tablet, capsule fully, the more important thing is to have strengthened stability of drug.
Efficient disintegrating agent low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, super carboxymethyl starch sodium, crospolyvinylpyrrolidone, cross-linked carboxymethyl cellulose are received, the adding of microcrystalline Cellulose etc., be beneficial to preparations such as capsule, tablet, pill and discharge medicine rapidly, reach onset concentration in short period, onset rapidly.
The present invention also provides the preparation method of employing mode two preparation bony spur micronizing preparations, be specially: get 1 part of Radix Aconiti Preparata, 1 part of Radix Aconiti Kusnezoffii Preparata, 1 part of Rhizoma Arisaematis (system), 1 part of Radix Gentianae Macrophyllae, 1 part of the Radix Angelicae Dahuricae, 1 part of Radix Angelicae Sinensis, 1 part in Radix Glycyrrhizae, 1 part of Semen Coicis (stir-fry), 1 part of Rhizoma Dioscoreae Nipponicae, Dioscorea septemloba Thunb. is separated 2 parts, 2 parts on Flos Carthami, 3 parts of Radix Cynanchi Paniculatis are ground into coarse powder, add the recipe quantity pharmaceutical adjunct, put in the vibration type pulverizing mill micronizing 10～80 minutes, and made ultra-fine pharmaceutical composition, make pill, tablet or capsule according to pharmaceutics conventional formulation technology;
For guaranteeing this preparation curative effect, the ultra-fine pharmaceutical composition that preparation adopted must reach the granularity of regulation: D
50Less than 10 μ m, D
90Less than 50 μ m, thereby guarantee sporoderm-broken rate more than 90%, make each effective constituents in the crude drug cell come out preferably and be release conditions, farthest improve drug bioavailability.
Preparation of the present invention can be honey pill agent, water-honeyed pill, capsule or tablet.
Optimization formula of the present invention is formed in the back and is embodied in the specific embodiment.
Beneficial effect
Technical scheme of the present invention is considered from practical angle, adopts innovative technology to make bony spur micronizing preparation, and concrete advantage is as follows:
1, improves drug bioavailability: adopt bony spur preparation that this patent invention preparation method makes and common bony spur pill etc. to compare, significantly improved bioavailability of medicament.The Chinese medicine coarse powder is after micronizing, and the cell wall breaking rate reaches 90%, and intracellular each effective constituents comes out preferably and is release conditions, and effective ingredient dissolution and bioavailability improve greatly, can reach onset concentration within a short period of time, brings into play curative effect rapidly.
2, preparation technology's efficient height, energy consumption is little: it is big to be compared to air-flowing type super micron mill energy consumption, and capacity usage ratio is low, the deficiency that production cost is high, preparation technology of the present invention improves, and adopts the vibration type pulverizing mill that energy consumption is little, efficient is high to carry out micronizing, granule D
50Can reach below the 10 μ m, and also can add necessary adjuvants such as wetting agent among the preparation technology of the present invention, micropowder is reunited, adsorption phenomena is solved, and further strengthens drug effect, and this is that any micronizing mode is beyond one's reach.
3, promoted the application of superfine communication technique in pharmaceuticals industry to a certain extent: bony spur micronizing preparation unique preparation process of the present invention provides a practical way for similar technological innovation; along with updating of superfine communication technique; obtain the approval of numerous pharmaceutical researchers surely, the scale of the broken technology of Chinese medicine ultra-fine powder, industrialization are pointed the day and await for it.
4, bony spur micronizing preparation of the present invention and common bony spur preparation are comprehensively compared, the result is as follows:
Former technology of table 1 and innovative technology effect comparison sheet of the present invention
Annotate: above-mentionedly more all compare with same dosage form (pill).
As seen, the present invention has obtained outstanding technique effect, has reached goal of the invention.
The specific embodiment
Enumerate embodiment below, further specify the present invention, each embodiment only is used to illustrate the present invention, does not limit the present invention:
Embodiment 1
Radix Aconiti Preparata 500g Radix Aconiti Kusnezoffii Preparata 500g Rhizoma Arisaematis (system) 500g
Radix Gentianae Macrophyllae 500g Radix Angelicae Dahuricae 500g Radix Angelicae Sinensis 500g
Radix Glycyrrhizae 500g Semen Coicis (stir-fry) 500g Rhizoma Dioscoreae Nipponicae 1000g
Dioscorea septemloba Thunb. is separated 1000g Flos Carthami 1000g Radix Cynanchi Paniculati 1500g
More than 12 flavors, carry out the flushing coarse pulverization, cross 10 mesh sieves, pulverized 50 minutes in the vibration type super micron mill then, make ultra-fine pharmaceutical composition, add 1.3 times refined honey, make bony spur small honey pill or big honeyed pills.
Embodiment 2
Radix Aconiti Preparata 500g Radix Aconiti Kusnezoffii Preparata 500g Rhizoma Arisaematis (system) 500g
Radix Gentianae Macrophyllae 500g Radix Angelicae Dahuricae 500g Radix Angelicae Sinensis 500g
Radix Glycyrrhizae 500g Semen Coicis (stir-fry) 500g Rhizoma Dioscoreae Nipponicae 1000g
Dioscorea septemloba Thunb. is separated 1000g Flos Carthami 1000g Radix Cynanchi Paniculati 1500g
More than 12 flavors, carry out the flushing coarse pulverization, cross 10 mesh sieves, pulverized 65 minutes in the vibration type super micron mill then, make ultra-fine pharmaceutical composition, adds 0.7 times refined honey and suitable water, make the bony spur water-honeyed pill.
Embodiment 3
Radix Aconiti Preparata 500g Radix Aconiti Kusnezoffii Preparata 500g Rhizoma Arisaematis (system) 500g
Radix Gentianae Macrophyllae 500g Radix Angelicae Dahuricae 500g Radix Angelicae Sinensis 500g
Radix Glycyrrhizae 500g Semen Coicis (stir-fry) 500g Rhizoma Dioscoreae Nipponicae 1000g
Dioscorea septemloba Thunb. is separated 1000g Flos Carthami 1000g Radix Cynanchi Paniculati 1500g
More than 12 the flavor, carry out the flushing coarse pulverization, cross 10 mesh sieves, add chitosan 0.5g, lecithin 1g, cyclodextrin 10g and low-substituted hydroxypropyl cellulose 8g, pulverized 35 minutes in the vibration type super micron mill, make ultra-fine pharmaceutical composition, add 1.4 times refined honey, make bony spur small honey pill or big honeyed pills.
Embodiment 4
Radix Aconiti Preparata 500g Radix Aconiti Kusnezoffii Preparata 500g Rhizoma Arisaematis (system) 500g
Radix Gentianae Macrophyllae 500g Radix Angelicae Dahuricae 500g Radix Angelicae Sinensis 500g
Radix Glycyrrhizae 500g Semen Coicis (stir-fry) 500g Rhizoma Dioscoreae Nipponicae 1000g
Dioscorea septemloba Thunb. is separated 1000g Flos Carthami 1000g Radix Cynanchi Paniculati 1500g
More than 12 the flavor, carry out the flushing coarse pulverization, cross 10 mesh sieves, add chitosan 80g, poloxamer 100g, microcrystalline Cellulose 10g and super carboxymethyl starch sodium 35g, pulverized 65 minutes in the vibration type super micron mill, make ultra-fine pharmaceutical composition, add 1.2 times refined honey, make bony spur small honey pill or big honeyed pills.
Embodiment 5
Radix Aconiti Preparata 500g Radix Aconiti Kusnezoffii Preparata 500g Rhizoma Arisaematis (system) 500g
Radix Gentianae Macrophyllae 500g Radix Angelicae Dahuricae 500g Radix Angelicae Sinensis 500g
Radix Glycyrrhizae 500g Semen Coicis (stir-fry) 500g Rhizoma Dioscoreae Nipponicae 1000g
Dioscorea septemloba Thunb. is separated 1000g Flos Carthami 1000g Radix Cynanchi Paniculati 1500g
More than 12 the flavor, carry out the flushing coarse pulverization, cross 10 mesh sieves, and add polyvinylpyrrolidone 8g, Polyethylene Glycol 15g, dextrin 22g and low-substituted hydroxypropyl cellulose 10g, pulverized 60 minutes in the vibration type super micron mill, make ultra-fine pharmaceutical composition, add newborn proper amount of sugar, and it is an amount of to add debita spissitudo ethanol, make granule, add an amount of magnesium stearate, capsule charge makes bone spur capsule.
Embodiment 6
Radix Aconiti Preparata 500g Radix Aconiti Kusnezoffii Preparata 500g Rhizoma Arisaematis (system) 500g
Radix Gentianae Macrophyllae 500g Radix Angelicae Dahuricae 500g Radix Angelicae Sinensis 500g
Radix Glycyrrhizae 500g Semen Coicis (stir-fry) 500g Rhizoma Dioscoreae Nipponicae 1000g
Dioscorea septemloba Thunb. is separated 1000g Flos Carthami 1000g Radix Cynanchi Paniculati 1500g
More than 12 the flavor, carry out the flushing coarse pulverization, cross 10 mesh sieves, and add polyvinylpyrrolidone 15g, poloxamer 10g, dextrin 25g, micropowder silica gel 15g and carboxymethyl starch sodium 10g, pulverized 70 minutes in the vibration type super micron mill, make ultra-fine pharmaceutical composition, add starch and microcrystalline Cellulose is an amount of, and it is an amount of to add debita spissitudo ethanol, makes granule, compressed tablets makes the bony spur tablet.
Claims (8)
1, a kind of bony spur preparation that adopts superfine communication technique to make.
2, bony spur preparation according to claim 1 is characterized in that the grain graininess D of the ultra-fine pharmaceutical composition of preparation intermediate
50Less than 10 μ m and D
90Less than 50 μ m.
3, bony spur preparation according to claim 2 is characterized in that adopting following either party's method to make:
A, get the prescription medical material, be ground into coarse powder, put in the vibration type super micron mill micronizing 10～80 minutes, make ultra-fine pharmaceutical composition, make pill, tablet, capsule according to pharmaceutics conventional formulation technology;
B, get the prescription medical material, be ground into coarse powder, add pharmaceutical adjunct, put in the vibration type super micron mill micronizing 10～80 minutes, make ultra-fine pharmaceutical composition, make pill, tablet, capsule according to pharmaceutics conventional formulation technology.
4, bony spur preparation according to claim 3 is characterized in that the pharmaceutical adjunct among the method b comprises wetting agent, dispersant.
5, bony spur preparation according to claim 4 is characterized in that pharmaceutical adjunct also comprises bioadhesive polymer, efficient disintegrating agent.
6, bony spur preparation according to claim 5 is characterized in that wetting agent is any or the compositions more than two kinds in lecithin, poloxamer, the Polyethylene Glycol; Bioadhesive polymer is any or the compositions more than two kinds in chitosan, carbomer, the polyvinylpyrrolidone; Dispersant is any or the compositions more than two kinds in micropowder silica gel, cyclodextrin, starch, the dextrin; Efficient disintegrating agent is that low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, super carboxymethyl starch sodium, crospolyvinylpyrrolidone, cross-linked carboxymethyl cellulose are received, any or the compositions more than two kinds in the microcrystalline Cellulose.
7, bony spur preparation according to claim 6, the weight proportion of it is characterized in that writing out a prescription medical material and wetting agent, bioadhesive polymer, dispersant and efficient disintegrating agent is: 100: 0～10: 0～10: 0～20: 0～10.
8, the method for preparing the arbitrary described bony spur preparation of claim 1 to 7 is characterized in that it can being following any method:
A, get 1 part of Radix Aconiti Preparata, 1 part of Radix Aconiti Kusnezoffii Preparata, 1 part of Rhizoma Arisaematis (processed), 1 part of Radix Gentianae Macrophyllae, 1 part of the Radix Angelicae Dahuricae, 1 part of Radix Angelicae Sinensis, 1 part in Radix Glycyrrhizae, 1 part of Semen Coicis (parched), 1 part of Rhizoma Dioscoreae Nipponicae, Dioscorea septemloba Thunb. is separated 2 parts, 2 parts on Flos Carthami, 3 parts of Radix Cynanchi Paniculatis, be ground into coarse powder, put in the vibration type pulverizing mill micronizing 10～80 minutes, and made ultra-fine pharmaceutical composition, make pill, tablet or capsule according to pharmaceutics conventional formulation technology;
B, get 1 part of Radix Aconiti Preparata, 1 part of Radix Aconiti Kusnezoffii Preparata, 1 part of Rhizoma Arisaematis (processed), 1 part of Radix Gentianae Macrophyllae, 1 part of the Radix Angelicae Dahuricae, 1 part of Radix Angelicae Sinensis, 1 part in Radix Glycyrrhizae, 1 part of Semen Coicis (parched), 1 part of Rhizoma Dioscoreae Nipponicae, Dioscorea septemloba Thunb. is separated 2 parts, 2 parts on Flos Carthami, 3 parts of Radix Cynanchi Paniculatis, be ground into coarse powder, add pharmaceutical adjunct, put in the vibration type pulverizing mill micronizing 10～80 minutes, make ultra-fine pharmaceutical composition, make pill, tablet or capsule according to pharmaceutics conventional formulation technology.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101051861A CN101564515A (en) | 2008-04-25 | 2008-04-25 | Bony spur preparation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101051861A CN101564515A (en) | 2008-04-25 | 2008-04-25 | Bony spur preparation and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101564515A true CN101564515A (en) | 2009-10-28 |
Family
ID=41280991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101051861A Pending CN101564515A (en) | 2008-04-25 | 2008-04-25 | Bony spur preparation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101564515A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194440A (en) * | 2015-10-30 | 2015-12-30 | 王玉龙 | Pharmaceutical composition for treating hyperostosis and preparation method of pharmaceutical composition |
| CN106511830A (en) * | 2016-12-06 | 2017-03-22 | 谭俊杰 | Traditional Chinese medicine composition for treating arthropathy |
| CN108114195A (en) * | 2017-12-22 | 2018-06-05 | 长沙爱扬医药科技有限公司 | A kind of Chinese medicine preparation for treating Osteoarthritis |
-
2008
- 2008-04-25 CN CNA2008101051861A patent/CN101564515A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194440A (en) * | 2015-10-30 | 2015-12-30 | 王玉龙 | Pharmaceutical composition for treating hyperostosis and preparation method of pharmaceutical composition |
| CN106511830A (en) * | 2016-12-06 | 2017-03-22 | 谭俊杰 | Traditional Chinese medicine composition for treating arthropathy |
| CN108114195A (en) * | 2017-12-22 | 2018-06-05 | 长沙爱扬医药科技有限公司 | A kind of Chinese medicine preparation for treating Osteoarthritis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101579506A (en) | Bezoar chest functioning preparation and preparation method thereof | |
| CN100515404C (en) | Compound bovine bezoar stomach clearing fast dispersion solid preparation and its preparation method | |
| CN100515407C (en) | Spleen-tonifying Zisheng fast dispersion solid preparation and its preparation method | |
| CN100515457C (en) | Mugwort and cyperus palace warming fast dispersion solid preparation and its preparation method | |
| CN101564414A (en) | Western bovine bezoar preparation and preparation method thereof | |
| CN101564442A (en) | Preparation of cassia twig and Indian buead and preparation method thereof | |
| CN100515393C (en) | Perfect major supple mentation fast dispersion solid preparation and its making method | |
| CN101564515A (en) | Bony spur preparation and preparation method thereof | |
| CN1785336A (en) | Tongyou dryness moistening fast dispersion solid preparation and its preparation method | |
| CN100488493C (en) | Antelope horn fast dispersion solid preparation for clearing lung | |
| CN101564500A (en) | Dendrobium noctilucent preparation and preparation method thereof | |
| CN100515471C (en) | Liver kidney nourishing fast dispersion solid preparation and its preparation method | |
| CN101564501A (en) | Big activating collateral preparation and preparation method thereof | |
| CN101564481A (en) | Bone-setting anti-bruise powder preparation and preparation method thereof | |
| CN101564477A (en) | Small activating collateral preparation and preparation method thereof | |
| CN101564413A (en) | Storax preparation of coronary disease and preparation method thereof | |
| CN100364502C (en) | Anemarrhena, phello dendron and rehmannia fast dispersion solid medicinal preparation and its manufacturing method | |
| CN100515399C (en) | Zuojin fast dispersion solid medicine and its preparation method | |
| CN100515409C (en) | Lumbar invigorating kidney fortifying fast dispersion solid medicine and its preparation method | |
| CN101579428A (en) | Zhuhuang Chuihou preparation and preparation technology thereof | |
| CN100428929C (en) | Kunshun fast dispersion solid preparation and its preparation method | |
| CN101564441A (en) | Apoplexy rejuvenation preparation and preparation method thereof | |
| CN101564434A (en) | Huli powder preparation and preparation method thereof | |
| CN1785259A (en) | Jinsuo emission-arresting fast dispersing solid preparation and its preparation method | |
| CN105561166A (en) | Re-prepared preparation and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20091028 |