CN101564441A - Apoplexy rejuvenation preparation and preparation method thereof - Google Patents
Apoplexy rejuvenation preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal preparation, and in particular to an apoplexy rejuvenation preparation prepared by adopting ultra-micro pulverizing technology and a preparation method thereof. The invention provides an apoplexy rejuvenation ultra-micro pulverization preparation prepared by adopting a vibrating ultra-micro pulverizer, and also introduces assistant materials-adding ultra-micro pulverization technology. The preparation and the method maintain the compound pulverization homogenization, fully embody the characteristics of Chinese medicinal science, furthest maintain active ingredients at the same time, improve the utilization factor of medicinal materials, save the medicinal material resources and reduce the production cost.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of apoplexy treating Zhongfenghuichun that superfine communication technique makes and preparation method thereof that adopts belongs to the field of Chinese medicines.
Background technology
ZHONGFENG HUICHUN WAN is now recorded in " 375 pages of Chinese pharmacopoeia versions in 2005, the weight proportion of its active ingredient raw materials medicine is: 30 parts of Radix Angelicae Sinensis (processed with wine), 30 parts of Rhizoma Chuanxiongs (processed with wine), 10 parts on Flos Carthami, 30 parts in Semen Persicae, 100 parts of Radix Salviae Miltiorrhizaes, 100 parts of Caulis Spatholobis, 100 parts of Caulis Loniceraes, 60 parts of Caulis Trachelospermis, 90 parts of Pheretimas (stir-fry), 30 parts of Eupolyphaga Seu Steleophagas (stir-fry), 60 parts of Herba Lycopodiis, 100 parts of Radix Cyathulaes, 5 parts of Scolopendras, 30 parts of Fructus Leonuris (stir-fry), 10 parts of Scorpios, 30 parts of Radix Clematidis (processed with wine), 30 parts of Bombyx Batryticatus (parched with bran), 50 parts of Fructus Chaenomeliss, 6 parts of Bungarus Parvus, be used for the apoplexy due to the phlegm stagnation in collateral, disease is seen hemiplegia, numb limbs and tense tendons, diseases such as crooked mouth and tongue, be blood circulation promoting and blood stasis dispelling, the classics recipe of channels sootheing and network vessel quickening.It is evident in efficacy, is subjected to the welcome of extensive patients deeply, but finds that in actual applications still there is certain defective in it: the pill dose is big, takes extremely inconvenience, is not easy to carry, and the patient is difficult to be accepted; Prescription Chinese crude drug crushing fine powder granularity is excessive, fails to give full play to the effect of each composition in the medical material.
The thicker medicated powder bioavailability of granularity is lower, and crude drug can not be fully utilized, and because its huge market demand, thereby cause the Chinese material medicine resource serious waste.As seen, study a kind of reasonable, efficient and economically viable preparation technology apoplexy return of spring class preparation is had very important significance, thereby further satisfy and ensure national medication demand.
Superfine communication technique is the machining process that makes the fine and super-refinement of material, provides one of important means of ultrafine powder.Micronizing is a new and high technology that grows up over nearly 20 years, refers to utilize machinery or hydromechanical approach that material is crushed to particle diameter less than the process below the 10 μ m.Ultramicro powder is the final products of micronizing, has some special physicochemical properties that general granule does not have, as fine solubility, dispersibility, adsorptivity etc.; For Chinese crude drug, the cell wall breaking rate improves greatly, and up to 90%, each effective constituents is release conditions, and dissolution and bioavailability are multiplied.Since the nineties in 20th century, superfine communication technique is applied to Chinese medicine gradually, has given the more modern high section of Chinese medicine content, and the broken technology of Chinese medicine ultra-fine powder is as the constantly development of a new technology.
Fully comprehend the marrow of the broken technology of Chinese medicine micropowder; choose representative classics side medicine, explore the process that a cover has operability, reasonably improvement and using ultramicro communication technique are in the herbal pharmaceutical industry; and, be one of problem that needs at present primary study with its scale, industrialization.
Summary of the invention
First purpose of the present invention is to provide a kind of apoplexy return of spring micronizing preparation.
Another object of the present invention provides the preparation method of this apoplexy treating Zhongfenghuichun.
The object of the invention mainly is to adopt following dual mode to realize:
Mode one: common micronizing
The inventor provides a kind of apoplexy treating Zhongfenghuichun that adopts superfine communication technique to make, and writes out a prescription by Radix Angelicae Sinensis (processed with wine) Rhizoma Chuanxiong (processed with wine), Flos Carthami, Semen Persicae, Radix Salviae Miltiorrhizae, Caulis Spatholobi, Caulis Lonicerae, Caulis Trachelospermi, Pheretima (stir-fry), Eupolyphaga Seu Steleophaga (stir-fry), Herba Lycopodii, Radix Cyathulae, Scolopendra, Fructus Leonuri (stir-fry), Scorpio, Radix Clematidis (processed with wine), Bombyx Batryticatus (parched with bran), Fructus Chaenomelis, Bungarus Parvus is formed, and the prescription ratio that apoplexy is rejuvenated meets each the flavour of a drug proportioning under ZHONGFENG HUICHUN WAN item of Chinese Pharmacopoeia version in 2005, that is:
10 parts on 30 parts of Flos Carthamis of 30 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis (processed with wine) (processed with wine)
100 parts of 100 portions of Caulis Spatholobis of 30 parts of Radix Salviae Miltiorrhizaes of Semen Persicae
90 parts of Caulis Lonicerae 60 parts of Pheretimas of 100 portions of Caulis Trachelospermis (stir-fry)
100 parts of 60 portions of Radix Cyathulaes of 30 parts of Herba Lycopodiis of Eupolyphaga Seu Steleophaga (stir-fry)
10 parts of 30 portions of Scorpios of 5 parts of Fructus Leonuris of Scolopendra (stir-fry)
50 parts of 30 portions of Fructus Chaenomeliss of 30 parts of Bombyx Batryticatus of Radix Clematidis (processed with wine) (parched with bran)
6 parts of Bungarus Parvus
For remedying the deficiency of existing apoplexy treating Zhongfenghuichun, further improve the curative effect of apoplexy treating Zhongfenghuichun, the present invention introduces superfine communication technique among the preparation technology.The broken technology of Chinese medicine ultra-fine powder claims broken technology of Chinese medicine cell grade micropowder or Chinese medicine cell wall breaking technology again, and it is meant the broken and cell grade ultrafine Chinese herb preparation to Chinese medicine cell grade micropowder mostly, is to break the comminution process that the Chinese crude drug cell is a purpose.The broken technology of Chinese medicine ultra-fine powder has plurality of advantages: a improves extraction ratio of effective constituents, thereby improves drug bioavailability, and taking dose reduces, and saves Chinese material medicine resource, meets " sustainable development " strategy; B improves compound recipe and pulverizes homogenization, embodies tcm characteristic; C retains biological activity composition improves curative effect of medication; D reduces the oral granule sense; E avoids outside contamination, parasite killing, adjection such as antibacterial.
The broken device category of Chinese medicine ultra-fine powder is various, normal at present use mainly contain three major types: vibration type super micron mill, air-flowing type super micron mill, mechanical type super micron mill.Though air-flowing type equipment does not have the association heat, it is low to pulverize temperature, but capacity usage ratio is low, and energy consumption is big, the production cost height, and be not suitable for the superfine communication technique that adds adjuvant; Mechanical equipment convenience simple to operation, it is big that charging is suitable for particle size range, but equipment easily heats up, the component of machine serious wear, and the direct contaminated material of wear particle, heavy metal exceeds standard greatly, and the granularity of gained micropowder is bigger than normal; And vibration type equipment adopts full alloy material to make abrasive media, and special principle has farthest been avoided the wearing and tearing of parts, crush efficiency height, gained powder granularity (D simultaneously
50) can reach below the 10 μ m, combine with cryogenic technique simultaneously, be equally applicable to low melting point and thermal sensitivity medical material, applied range is present optimal micronizing equipment.So the present invention adopts the vibration type super micron mill to prepare apoplexy return of spring superfine powder, existing crush efficiency height, the micropowder granularity is little, the advantage that energy consumption is little, can use novel superfine grinding method again---add the method for adjuvant micronizing, better bring into play the curative effect of preparation.
The present invention also provides the preparation method of employing mode one preparation apoplexy return of spring micronizing preparation, is specially:
(1) gets 30 parts of Radix Angelicae Sinensis (processed with wine), 30 parts of Rhizoma Chuanxiongs (processed with wine), 10 parts on Flos Carthami, 30 parts in Semen Persicae, 100 parts of Radix Salviae Miltiorrhizaes, 100 parts of Caulis Spatholobis, 100 parts of Caulis Loniceraes, 60 parts of Caulis Trachelospermis, 90 parts of Pheretimas (stir-fry), 30 parts of Eupolyphaga Seu Steleophagas (stir-fry), 60 parts of Herba Lycopodiis, 100 parts of Radix Cyathulaes, 5 parts of Scolopendras, 30 parts of Fructus Leonuris (stir-fry), 10 parts of Scorpios, 30 parts of Radix Clematidis (processed with wine), 30 parts of Bombyx Batryticatus (parched with bran), 50 parts of Fructus Chaenomeliss, 6 parts of Bungarus Parvus are ground into coarse powder, put in the vibration type pulverizing mill micronizing 10～80 minutes, make ultra-fine pharmaceutical composition, make pill according to pharmaceutics conventional formulation technology, tablet or capsule;
(2) get 10 parts on Flos Carthami, 30 parts in Semen Persicae, 100 parts of Caulis Spatholobis, 100 parts of Caulis Loniceraes, 60 parts of Caulis Trachelospermis, 60 parts of Herba Lycopodiis, 100 parts of Radix Cyathulaes, 30 parts of Fructus Leonuris (stir-fry), 30 parts of Radix Clematidis, 50 parts of Fructus Chaenomeliss, Radix Salviae Miltiorrhizae decocts with water for 50 parts, concentrates, dry, 30 parts of Radix Angelicae Sinensis (processed with wine), 3 parts of Rhizoma Chuanxiongs (processed with wine), 90 parts of Pheretimas (stir-fry), 30 parts of Eupolyphaga Seu Steleophagas (stir-fry), 5 parts of Scolopendras, 6 parts of Bungarus Parvus, 10 parts of Scorpios, 30 parts of Bombyx Batryticatus, 50 parts of Radix Salviae Miltiorrhizaes are ground into coarse powder, merge with extract, put in the vibration type pulverizing mill micronizing 10～80 minutes, and made ultra-fine pharmaceutical composition, make concentrated pill according to pharmaceutics conventional formulation technology, tablet, capsule.
For guaranteeing this preparation curative effect, the ultra-fine pharmaceutical composition that preparation adopted must reach the granularity of regulation: D
50Less than 10 μ m, D
90Less than 50 μ m, thereby guarantee sporoderm-broken rate more than 90%, make each effective constituents in the crude drug cell come out preferably and be release conditions, farthest improve drug bioavailability.
Preparation of the present invention can be honey pill agent, water-honeyed pill, capsule or tablet.
Optimization formula of the present invention is formed in the back and is embodied in the specific embodiment.
Mode two: add the adjuvant micronizing
The inventor provides the apoplexy return of spring to add the prescription of adjuvant micronizing preparation, and it is composed as follows:
0～10 part of 0～10 part of bioadhesive polymer of prescription 100 parts of wetting agent of medical material
0～10 part of 0～20 portion of efficient disintegrating agent of dispersant
Adjuvant used in the present invention is through screening and the final combination of determining, has uniqueness and irreplaceability, and wherein wetting agent is any or the compositions more than two kinds in lecithin, poloxamer, the Polyethylene Glycol; Bioadhesive polymer is the compositions of any or two kinds in chitosan, the carbomer; Dispersant is any or the compositions more than two kinds in micropowder silica gel, cyclodextrin, starch, the dextrin; Efficient disintegrating agent is that low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, super carboxymethyl starch sodium, crospolyvinylpyrrolidone, cross-linked carboxymethyl cellulose are received, any or the compositions more than two kinds in the microcrystalline Cellulose.
Bioadhesive polymer chitosan, carbomer are macromolecular material, have the bio-adhesive performance, but prolong drug significantly improves bioavailability of medicament in the gastrointestinal holdup time.Self is electronegative under the meta-alkalescence condition for carbomer, and intestinal can provide the environment of meta-alkalescence, and carbomer can form hydrophilic high viscosity gel in intestinal, be adsorbed on the intestinal mucosa, strengthen medicine in the holdup time of intestinal, promote the medicine moistening, strengthen absorbing of effective ingredient; Chitosan is natural biodegradable pasting material and the slow-release material of using always, and tool promotes the effect of medicine mucosa absorption, it is the polycation polysaccharide of the only existence of nature, chitosan be N-acetyl-D-glucamine and D-glucamine by the linear long-chain high-polymer molecular that β (1-4) glycosidic bond is formed by connecting, contain in a large number can with other molecules form hydrogen bonds-OH and-NH
2Group ,-NH
2Protonated formation-NH
3 +Make the molecule positively charged, above-mentioned molecular characterization makes chitosan become good bio-adhesive material, under the condition of acidic pH of gastric juice, chitosan forms hydrophilic high viscosity gel, easily be adsorbed on the gastrointestinal tract mucosa, the holdup time of prolong drug promotes the medicine moistening, strengthens absorbing of effective ingredient; And chitosan can also open epithelial tight connection, further promotes drug absorption.
Wetting agent lecithin, poloxamer, Polyethylene Glycol have certain surface activity effect, abundant moistening micropowders surface, reduce the surface tension of micropowder greatly, prevent that micropowder is coalescent agglomerating, the raising of micropowders wettability has simultaneously strengthened itself and the coupling ability of gastrointestinal wall, fully contacts, discharge effective ingredient, improve bioavailability.
Dispersant micropowder silica gel, cyclodextrin, microcrystalline Cellulose, starch, dextrin, Polyethylene Glycol etc. provide surface area great carrier for the high degree of dispersion of micropowders, the part microgranule that can neutralize simultaneously institute is electrically charged, eliminate the microparticle surfaces air film, make the surface energy of micropowders reduce greatly, the coalescent agglomerating phenomenon of medicine no longer appears, the mobile enhancing can carry out the preparation of preparations such as tablet, capsule fully, the more important thing is to have strengthened stability of drug.
Efficient disintegrating agent low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, super carboxymethyl starch sodium, crospolyvinylpyrrolidone, cross-linked carboxymethyl cellulose are received, the adding of microcrystalline Cellulose etc., be beneficial to preparations such as capsule, tablet, pill and discharge medicine rapidly, reach onset concentration in short period, onset rapidly.
The present invention also provides the preparation method of employing mode two preparation apoplexy return of spring micronizing preparations, is specially:
(1) gets 30 parts of Radix Angelicae Sinensis (processed with wine), 30 parts of Rhizoma Chuanxiongs (processed with wine), 10 parts on Flos Carthami, 30 parts in Semen Persicae, 100 parts of Radix Salviae Miltiorrhizaes, 100 parts of Caulis Spatholobis, 100 parts of Caulis Loniceraes, 60 parts of Caulis Trachelospermis, 90 parts of Pheretimas (stir-fry), 30 parts of Eupolyphaga Seu Steleophagas (stir-fry), 60 parts of Herba Lycopodiis, 100 parts of Radix Cyathulaes, 5 parts of Scolopendras, 30 parts of Fructus Leonuris (stir-fry), 10 parts of Scorpios, 30 parts of Radix Clematidis (processed with wine), 30 parts of Bombyx Batryticatus (parched with bran), 50 parts of Fructus Chaenomeliss, 6 parts of Bungarus Parvus are ground into coarse powder, add the recipe quantity pharmaceutical adjunct, put in the vibration type pulverizing mill micronizing 10～80 minutes, and made ultra-fine pharmaceutical composition, make pill according to pharmaceutics conventional formulation technology, tablet or capsule;
(2) get 10 parts on Flos Carthami, 30 parts in Semen Persicae, 100 parts of Caulis Spatholobis, 100 parts of Caulis Loniceraes, 60 parts of Caulis Trachelospermis, 60 parts of Herba Lycopodiis, 100 parts of Radix Cyathulaes, 30 parts of Fructus Leonuris (stir-fry), 30 parts of Radix Clematidis, 50 parts of Fructus Chaenomeliss, Radix Salviae Miltiorrhizae decocts with water for 50 parts, concentrates, dry, 30 parts of Radix Angelicae Sinensis (processed with wine), 3 parts of Rhizoma Chuanxiongs (processed with wine), 90 parts of Pheretimas (stir-fry), 30 parts of Eupolyphaga Seu Steleophagas (stir-fry), 5 parts of Scolopendras, 6 parts of Bungarus Parvus, 10 parts of Scorpios, 30 parts of Bombyx Batryticatus, 50 parts of Radix Salviae Miltiorrhizaes, be ground into coarse powder, merge with extract, add pharmaceutical adjunct, put in the vibration type pulverizing mill micronizing 10～80 minutes, make ultra-fine pharmaceutical composition, make concentrated pill according to pharmaceutics conventional formulation technology, tablet, capsule.
For guaranteeing this preparation curative effect, the ultra-fine pharmaceutical composition that preparation adopted must reach the granularity of regulation: D
50Less than 10 μ m, D
90Less than 50 μ m, thereby guarantee sporoderm-broken rate more than 90%, make each effective constituents in the crude drug cell come out preferably and be release conditions, farthest improve drug bioavailability.
Preparation of the present invention can be honey pill agent, water-honeyed pill, capsule or tablet.
Optimization formula of the present invention is formed in the back and is embodied in the specific embodiment.
Beneficial effect
Technical scheme of the present invention is considered from practical angle, adopts innovative technology to make apoplexy return of spring micronizing preparation,
Concrete advantage is as follows:
1, improves drug bioavailability: adopt apoplexy treating Zhongfenghuichun that this patent invention preparation method makes and common ZHONGFENG HUICHUN WAN agent etc. to compare, significantly improved bioavailability of medicament.The Chinese medicine coarse powder is after micronizing, and the cell wall breaking rate reaches 90%, and intracellular each effective constituents comes out preferably and is release conditions, and effective ingredient dissolution and bioavailability improve greatly, can reach onset concentration within a short period of time, brings into play curative effect rapidly.
2, preparation technology's efficient height, energy consumption is little: it is big to be compared to air-flowing type super micron mill energy consumption, and capacity usage ratio is low, the deficiency that production cost is high, preparation technology of the present invention improves, and adopts the vibration type pulverizing mill that energy consumption is little, efficient is high to carry out micronizing, granule D
50Can reach below the 10 μ m, and also can add necessary adjuvants such as wetting agent among the preparation technology of the present invention, micropowder is reunited, adsorption phenomena is solved, and further strengthens drug effect, and this is that any micronizing mode is beyond one's reach.
3, promoted the application of superfine communication technique in pharmaceuticals industry to a certain extent: apoplexy return of spring micronizing preparation unique preparation process of the present invention provides a practical way for similar technological innovation; along with updating of superfine communication technique; obtain the approval of numerous pharmaceutical researchers surely, the scale of the broken technology of Chinese medicine ultra-fine powder, industrialization are pointed the day and await for it.
4, apoplexy return of spring micronizing preparation of the present invention and common apoplexy treating Zhongfenghuichun are comprehensively compared, the result is as follows:
Former technology of table 1 and innovative technology effect comparison sheet of the present invention
Annotate: above-mentionedly more all compare with same dosage form (pill).
As seen, the present invention has obtained outstanding technique effect, has reached goal of the invention.
The specific embodiment
Enumerate embodiment below, further specify the present invention, each embodiment only is used to illustrate the present invention, does not limit the present invention:
Embodiment 1
Radix Angelicae Sinensis (processed with wine) 30g Rhizoma Chuanxiong (processed with wine) 30g Flos Carthami 10g
Semen Persicae 30g Radix Salviae Miltiorrhizae 100g Caulis Spatholobi 100g
Caulis Lonicerae 100g Caulis Trachelospermi 60g Pheretima (stir-fry) 90g
Eupolyphaga Seu Steleophaga (stir-fry) 30g Herba Lycopodii 60g Radix Cyathulae 100g
Scolopendra 5g Fructus Leonuri (stir-fry) 30g Scorpio 10g
Radix Clematidis (processed with wine) 30g Bombyx Batryticatus (parched with bran) 30g Fructus Chaenomelis 50g
Bungarus Parvus 6g
More than 19 flavors, carry out the flushing coarse pulverization, cross 10 mesh sieves, pulverized 45 minutes in the vibration type super micron mill then, make ultra-fine pharmaceutical composition, add 1.2 times refined honey, make apoplexy return of spring small honey pill or big honeyed pills.
Embodiment 2
Radix Angelicae Sinensis (processed with wine) 30g Rhizoma Chuanxiong (processed with wine) 30g Flos Carthami 10g
Semen Persicae 30g Radix Salviae Miltiorrhizae 100g Caulis Spatholobi 100g
Caulis Lonicerae 100g Caulis Trachelospermi 60g Pheretima (stir-fry) 90g
Eupolyphaga Seu Steleophaga (stir-fry) 30g Herba Lycopodii 60g Radix Cyathulae 100g
Scolopendra 5g Fructus Leonuri (stir-fry) 30g Scorpio 10g
Radix Clematidis (processed with wine) 30g Bombyx Batryticatus (parched with bran) 30g Fructus Chaenomelis 50g
Bungarus Parvus 6g
More than 19 flavors, carry out the flushing coarse pulverization, cross 10 mesh sieves, pulverized 65 minutes in the vibration type super micron mill then, make ultra-fine pharmaceutical composition, adds 0.6 times refined honey and suitable water, make apoplexy return of spring water-honeyed pill.
Embodiment 3
Radix Angelicae Sinensis (processed with wine) 30g Rhizoma Chuanxiong (processed with wine) 30g Flos Carthami 10g
Semen Persicae 30g Radix Salviae Miltiorrhizae 100g Caulis Spatholobi 100g
Caulis Lonicerae 100g Caulis Trachelospermi 60g Pheretima (stir-fry) 90g
Eupolyphaga Seu Steleophaga (stir-fry) 30g Herba Lycopodii 60g Radix Cyathulae 100g
Scolopendra 5g Fructus Leonuri (stir-fry) 30g Scorpio 10g
Radix Clematidis (processed with wine) 30g Bombyx Batryticatus (parched with bran) 30g Fructus Chaenomelis 50g
Bungarus Parvus 6g
More than 19 the flavor, carry out the flushing coarse pulverization, cross 10 mesh sieves, add chitosan 0.6g, lecithin 1.2g, cyclodextrin 8g and low-substituted hydroxypropyl cellulose 10g, pulverized 35 minutes in the vibration type super micron mill, make ultra-fine pharmaceutical composition, add 1.2 times refined honey, make apoplexy return of spring small honey pill or big honeyed pills.
Embodiment 4
Radix Angelicae Sinensis (processed with wine) 30g Rhizoma Chuanxiong (processed with wine) 30g Flos Carthami 10g
Semen Persicae 30g Radix Salviae Miltiorrhizae 100g Caulis Spatholobi 100g
Caulis Lonicerae 100g Caulis Trachelospermi 60g Pheretima (stir-fry) 90g
Eupolyphaga Seu Steleophaga (stir-fry) 30g Herba Lycopodii 60g Radix Cyathulae 100g
Scolopendra 5g Fructus Leonuri (stir-fry) 30g Scorpio 10g
Radix Clematidis (processed with wine) 30g Bombyx Batryticatus (parched with bran) 30g Fructus Chaenomelis 50g
Bungarus Parvus 6g
More than 19 the flavor, carry out the flushing coarse pulverization, cross 10 mesh sieves, add chitosan 55g, lecithin 80g, microcrystalline Cellulose 10g and super carboxymethyl starch sodium 45g, pulverized 75 minutes in the vibration type super micron mill, make ultra-fine pharmaceutical composition, add 1.1 times refined honey, make apoplexy return of spring small honey pill or big honeyed pills.
Embodiment 5
Radix Angelicae Sinensis (processed with wine) 30g Rhizoma Chuanxiong (processed with wine) 30g Flos Carthami 10g
Semen Persicae 30g Radix Salviae Miltiorrhizae 100g Caulis Spatholobi 100g
Caulis Lonicerae 100g Caulis Trachelospermi 60g Pheretima (stir-fry) 90g
Eupolyphaga Seu Steleophaga (stir-fry) 30g Herba Lycopodii 60g Radix Cyathulae 100g
Scolopendra 5g Fructus Leonuri (stir-fry) 30g Scorpio 10g
Radix Clematidis (processed with wine) 30g Bombyx Batryticatus (parched with bran) 30g Fructus Chaenomelis 50g
Bungarus Parvus 6g
More than 19 the flavor, carry out the flushing coarse pulverization, cross 10 mesh sieves, and add carbomer 8g, poloxamer 12g, cyclodextrin 22g and low-substituted hydroxypropyl cellulose 12g, pulverized 55 minutes in the vibration type super micron mill, make ultra-fine pharmaceutical composition, add newborn proper amount of sugar, and it is an amount of to add debita spissitudo ethanol, make granule, add an amount of magnesium stearate, capsule charge makes apoplexy return of spring capsule.
Embodiment 6
Radix Angelicae Sinensis (processed with wine) 30g Rhizoma Chuanxiong (processed with wine) 30g Flos Carthami 10g
Semen Persicae 30g Radix Salviae Miltiorrhizae 100g Caulis Spatholobi 100g
Caulis Lonicerae 100g Caulis Trachelospermi 60g Pheretima (stir-fry) 90g
Eupolyphaga Seu Steleophaga (stir-fry) 30g Herba Lycopodii 60g Radix Cyathulae 100g
Scolopendra 5g Fructus Leonuri (stir-fry) 30g Scorpio 10g
Radix Clematidis (processed with wine) 30g Bombyx Batryticatus (parched with bran) 30g Fructus Chaenomelis 50g
Bungarus Parvus 6g
More than 19 the flavor, carry out the flushing coarse pulverization, cross 10 mesh sieves, and add chitosan 15g, poloxamer 8g, starch 20g, micropowder silica gel 10g and low-substituted hydroxypropyl cellulose 15g, pulverized 55 minutes in the vibration type super micron mill, make ultra-fine pharmaceutical composition, add starch and microcrystalline Cellulose is an amount of, and it is an amount of to add debita spissitudo ethanol, makes granule, compressed tablets makes apoplexy return of spring tablet.
Embodiment 7
Radix Angelicae Sinensis (processed with wine) 30g Rhizoma Chuanxiong (processed with wine) 30g Flos Carthami 10g
Semen Persicae 30g Radix Salviae Miltiorrhizae 100g Caulis Spatholobi 100g
Caulis Lonicerae 100g Caulis Trachelospermi 60g Pheretima (stir-fry) 90g
Eupolyphaga Seu Steleophaga (stir-fry) 30g Herba Lycopodii 60g Radix Cyathulae 100g
Scolopendra 5g Fructus Leonuri (stir-fry) 30g Scorpio 10g
Radix Clematidis (processed with wine) 30g Bombyx Batryticatus (parched with bran) 30g Fructus Chaenomelis 50g
Bungarus Parvus 6g
More than 19 flavors, Flos Carthami, Semen Persicae, Caulis Spatholobi, Caulis Lonicerae, Caulis Trachelospermi, Herba Lycopodii, Radix Cyathulae, Fructus Leonuri (stir-frys), Radix Clematidis, Fructus Chaenomelis and 1/2 amount Radix Salviae Miltiorrhizae add 10 times of water gagings decoctions twice, each 2 hours, decocting liquid filters, filtrate decompression concentrates, and drying is standby; All the other eight flavor Chinese crude drugs and Radix Salviae Miltiorrhizae remainder carry out the flushing coarse pulverization, cross 10 mesh sieves, and add chitosan 10g, poloxamer 15g, polyethylene glycol 6000 2.1g and low-substituted hydroxypropyl cellulose 20g, and arise from the vibration type super micron mill with above-mentioned dry thing one and pulverized 40 minutes, make ultra-fine pharmaceutical composition, it is an amount of to add dextrin, and it is an amount of to add dehydrated alcohol, makes granule, adds an amount of magnesium stearate, capsule charge makes apoplexy return of spring capsule.
Embodiment 8
Radix Angelicae Sinensis (processed with wine) 30g Rhizoma Chuanxiong (processed with wine) 30g Flos Carthami 10g
Semen Persicae 30g Radix Salviae Miltiorrhizae 100g Caulis Spatholobi 100g
Caulis Lonicerae 100g Caulis Trachelospermi 60g Pheretima (stir-fry) 90g
Eupolyphaga Seu Steleophaga (stir-fry) 30g Herba Lycopodii 60g Radix Cyathulae 100g
Scolopendra 5g Fructus Leonuri (stir-fry) 30g Scorpio 10g
Radix Clematidis (processed with wine) 30g Bombyx Batryticatus (parched with bran) 30g Fructus Chaenomelis 50g
Bungarus Parvus 6g
More than 19 flavors, Flos Carthami, Semen Persicae, Caulis Spatholobi, Caulis Lonicerae, Caulis Trachelospermi, Herba Lycopodii, Radix Cyathulae, Fructus Leonuri (stir-frys), Radix Clematidis, Fructus Chaenomelis and 1/2 amount Radix Salviae Miltiorrhizae add 10 times of water gagings decoctions twice, each 2 hours, decocting liquid filters, filtrate decompression concentrates, and drying is standby; All the other eight flavor Chinese crude drugs and Radix Salviae Miltiorrhizae remainder carry out the flushing coarse pulverization, cross 10 mesh sieves, and add carbomer 10g, chitosan 20g, poloxamer 6g, starch 18.6g and carboxymethyl starch sodium 20g, and arise from the vibration type super micron mill with above-mentioned dry thing one and pulverized 65 minutes, make ultra-fine pharmaceutical composition, mix with above-mentioned concentrated solution, it is an amount of to add dextrin, and it is an amount of to add dehydrated alcohol, makes granule, compressed tablets makes apoplexy return of spring tablet.
Embodiment 9
Radix Angelicae Sinensis (processed with wine) 30g Rhizoma Chuanxiong (processed with wine) 30g Flos Carthami 10g
Semen Persicae 30g Radix Salviae Miltiorrhizae 100g Caulis Spatholobi 100g
Caulis Lonicerae 100g Caulis Trachelospermi 60g Pheretima (stir-fry) 90g
Eupolyphaga Seu Steleophaga (stir-fry) 30g Herba Lycopodii 60g Radix Cyathulae 100g
Scolopendra 5g Fructus Leonuri (stir-fry) 30g Scorpio 10g
Radix Clematidis (processed with wine) 30g Bombyx Batryticatus (parched with bran) 30g Fructus Chaenomelis 50g
Bungarus Parvus 6g
More than 19 flavors, Flos Carthami, Semen Persicae, Caulis Spatholobi, Caulis Lonicerae, Caulis Trachelospermi, Herba Lycopodii, Radix Cyathulae, Fructus Leonuri (stir-frys), Radix Clematidis, Fructus Chaenomelis and 1/2 amount Radix Salviae Miltiorrhizae add 10 times of water gagings decoctions twice, each 2 hours, decocting liquid filters, filtrate decompression concentrates, and drying is standby; All the other eight flavor Chinese crude drugs and Radix Salviae Miltiorrhizae remainder carry out the flushing coarse pulverization, cross 10 mesh sieves, mix with above-mentioned medicinal material coarse powder.Pulverized 50 minutes in the vibration type super micron mill then, make ultra-fine pharmaceutical composition, add 1.3 times refined honey, make apoplexy return of spring small honey pill or big honeyed pills.
Embodiment 10
Radix Angelicae Sinensis (processed with wine) 30g Rhizoma Chuanxiong (processed with wine) 30g Flos Carthami 10g
Semen Persicae 30g Radix Salviae Miltiorrhizae 100g Caulis Spatholobi 100g
Caulis Lonicerae 100g Caulis Trachelospermi 60g Pheretima (stir-fry) 90g
Eupolyphaga Seu Steleophaga (stir-fry) 30g Herba Lycopodii 60g Radix Cyathulae 100g
Scolopendra 5g Fructus Leonuri (stir-fry) 30g Scorpio 10g
Radix Clematidis (processed with wine) 30g Bombyx Batryticatus (parched with bran) 30g Fructus Chaenomelis 50g
Bungarus Parvus 6g
More than 19 flavors, Flos Carthami, Semen Persicae, Caulis Spatholobi, Caulis Lonicerae, Caulis Trachelospermi, Herba Lycopodii, Radix Cyathulae, Fructus Leonuri (stir-frys), Radix Clematidis, Fructus Chaenomelis and 1/2 amount Radix Salviae Miltiorrhizae add 10 times of water gagings decoctions twice, each 2 hours, decocting liquid filters, filtrate decompression concentrates, and drying is standby; All the other eight flavor Chinese crude drugs and Radix Salviae Miltiorrhizae remainder carry out the flushing coarse pulverization, cross 10 mesh sieves, mix with above-mentioned medicinal material coarse powder, add chitosan 10g, lecithin 20g, cyclodextrin 10g, microcrystalline Cellulose 20g and low-substituted hydroxypropyl cellulose 8g, pulverized 45 minutes in the vibration type super micron mill then, make ultra-fine pharmaceutical composition, add 0.5 times refined honey and suitable water, make apoplexy return of spring water-honeyed pill.
Claims (8)
1, a kind of apoplexy treating Zhongfenghuichun that adopts superfine communication technique to make.
2, apoplexy treating Zhongfenghuichun according to claim 1 is characterized in that the grain graininess D of preparation intermediate
50Less than 10 μ m and D
90Less than 50 μ m.
3, apoplexy treating Zhongfenghuichun according to claim 2 is characterized in that adopting following either party's method to make:
A, get the prescription medical material, be ground into coarse powder, put in the vibration type super micron mill micronizing 10～80 minutes, make ultra-fine pharmaceutical composition, make pill, tablet, capsule according to pharmaceutics conventional formulation technology;
B, get the prescription medical material, be ground into coarse powder, add pharmaceutical adjunct, put in the vibration type super micron mill micronizing 10～80 minutes, make ultra-fine pharmaceutical composition, make pill, tablet, capsule according to pharmaceutics conventional formulation technology;
C, Flos Carthami, Semen Persicae, Caulis Spatholobi, Caulis Lonicerae, Caulis Trachelospermi, Herba Lycopodii, Radix Cyathulae, Fructus Leonuri (parched), Radix Clematidis, Fructus Chaenomelis and the 1/2 amount Radix Salviae Miltiorrhizae got in the prescription decoct with water, concentrated, dry, all the other eight flavor Chinese crude drugs and Radix Salviae Miltiorrhizae remainder are ground into coarse powder in the prescription, merge with extract, put in the vibration type pulverizing mill micronizing 10～80 minutes, make ultra-fine pharmaceutical composition, make concentrated pill, tablet, capsule according to pharmaceutics conventional formulation technology;
D, Flos Carthami, Semen Persicae, Caulis Spatholobi, Caulis Lonicerae, Caulis Trachelospermi, Herba Lycopodii, Radix Cyathulae, Fructus Leonuri (parched), Radix Clematidis, Fructus Chaenomelis and the 1/2 amount Radix Salviae Miltiorrhizae got in the prescription decoct with water, concentrated, dry, all the other eight flavor Chinese crude drugs and Radix Salviae Miltiorrhizae remainder are ground into coarse powder in the prescription, merge with extract, add pharmaceutical adjunct, put in the vibration type pulverizing mill micronizing 10～80 minutes, and made ultra-fine pharmaceutical composition, make concentrated pill, tablet, capsule according to pharmaceutics conventional formulation technology.
4, apoplexy treating Zhongfenghuichun according to claim 3 is characterized in that the pharmaceutical adjunct in b, the d method comprises wetting agent, dispersant.
5, apoplexy treating Zhongfenghuichun according to claim 4 is characterized in that pharmaceutical adjunct also comprises bioadhesive polymer, efficient disintegrating agent.
6, apoplexy treating Zhongfenghuichun according to claim 5 is characterized in that wetting agent is any or the compositions more than two kinds in lecithin, poloxamer, the Polyethylene Glycol; Bioadhesive polymer is any or the compositions more than two kinds in chitosan, carbomer, the polyvinylpyrrolidone; Dispersant is any or the compositions more than two kinds in micropowder silica gel, cyclodextrin, starch, the dextrin; Efficient disintegrating agent is that low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, super carboxymethyl starch sodium, crospolyvinylpyrrolidone, cross-linked carboxymethyl cellulose are received, any or the compositions more than two kinds in the microcrystalline Cellulose.
7, apoplexy treating Zhongfenghuichun according to claim 6, the weight proportion of it is characterized in that writing out a prescription medical material and wetting agent, bioadhesive polymer, dispersant and efficient disintegrating agent is: 100: 0～10: 0～10: 0～20: 0～10.
8, the method for preparing the arbitrary described apoplexy treating Zhongfenghuichun of claim 1 to 7 is characterized in that it can being following any method:
A, get 30 parts of Radix Angelicae Sinensis (processed with wine), 30 parts of Rhizoma Chuanxiong (processed with wine), 10 parts on Flos Carthami, 30 parts in Semen Persicae, 100 parts of Radix Salviae Miltiorrhizaes, 100 parts of Caulis Spatholobis, 100 parts of Caulis Loniceraes, 60 parts of Caulis Trachelospermis, 90 parts of Pheretima (parched), 30 parts of Eupolyphaga (parched), 60 parts of Herba Lycopodiis, 100 parts of Radix Cyathulaes, 5 parts of Scolopendras, 30 parts of Fructus Leonuri (parched), 10 parts of Scorpios, 30 parts of Radix et Rhizoma Clematidis Chinensis (processed with wine), 30 parts of Bombyx Batryticatus (parched with bran), 50 parts of Fructus Chaenomeliss, 6 parts of Bungarus Parvus are ground into coarse powder, put in the vibration type pulverizing mill micronizing 10～80 minutes, make ultra-fine pharmaceutical composition, make pill, tablet or capsule according to pharmaceutics conventional formulation technology;
B, get 30 parts of Radix Angelicae Sinensis (processed with wine), 30 parts of Rhizoma Chuanxiong (processed with wine), 10 parts on Flos Carthami, 30 parts in Semen Persicae, 100 parts of Radix Salviae Miltiorrhizaes, 100 parts of Caulis Spatholobis, 100 parts of Caulis Loniceraes, 60 parts of Caulis Trachelospermis, 90 parts of Pheretima (parched), 30 parts of Eupolyphaga (parched), 60 parts of Herba Lycopodiis, 100 parts of Radix Cyathulaes, 5 parts of Scolopendras, 30 parts of Fructus Leonuri (parched), 10 parts of Scorpios, 30 parts of Radix et Rhizoma Clematidis Chinensis (processed with wine), 30 parts of Bombyx Batryticatus (parched with bran), 50 parts of Fructus Chaenomeliss, 6 parts of Bungarus Parvus are ground into coarse powder, add pharmaceutical adjunct, put in the vibration type pulverizing mill micronizing 10～80 minutes, and made ultra-fine pharmaceutical composition, make pill according to pharmaceutics conventional formulation technology, tablet or capsule;
C, get 10 parts on Flos Carthami, 30 parts in Semen Persicae, 100 parts of Caulis Spatholobis, 100 parts of Caulis Loniceraes, 60 parts of Caulis Trachelospermis, 60 parts of Herba Lycopodiis, 100 parts of Radix Cyathulaes, 30 parts of Fructus Leonuri (parched), 30 parts of Radix Clematidis, 50 parts of Fructus Chaenomeliss, Radix Salviae Miltiorrhizae decocts with water for 50 parts, concentrates, dry, 30 parts of Radix Angelicae Sinensis (processed with wine), 3 parts of Rhizoma Chuanxiong (processed with wine), 90 parts of Pheretima (parched), 30 parts of Eupolyphaga (parched), 5 parts of Scolopendras, 6 parts of Bungarus Parvus, 10 parts of Scorpios, 30 parts of Bombyx Batryticatus, 50 parts of Radix Salviae Miltiorrhizaes are ground into coarse powder, merge with extract, put in the vibration type pulverizing mill micronizing 10～80 minutes, and made ultra-fine pharmaceutical composition, make concentrated pill according to pharmaceutics conventional formulation technology, tablet or capsule;
D, get 10 parts on Flos Carthami, 30 parts in Semen Persicae, 100 parts of Caulis Spatholobis, 100 parts of Caulis Loniceraes, 60 parts of Caulis Trachelospermis, 60 parts of Herba Lycopodiis, 100 parts of Radix Cyathulaes, 30 parts of Fructus Leonuri (parched), 30 parts of Radix Clematidis, 50 parts of Fructus Chaenomeliss, Radix Salviae Miltiorrhizae decocts with water for 50 parts, concentrates, dry, 30 parts of Radix Angelicae Sinensis (processed with wine), 3 parts of Rhizoma Chuanxiong (processed with wine), 90 parts of Pheretima (parched), 30 parts of Eupolyphaga (parched), 5 parts of Scolopendras, 6 parts of Bungarus Parvus, 10 parts of Scorpios, 30 parts of Bombyx Batryticatus, 50 parts of Radix Salviae Miltiorrhizaes, be ground into coarse powder, merge with extract, add pharmaceutical adjunct, put in the vibration type pulverizing mill micronizing 10～80 minutes, make ultra-fine pharmaceutical composition, make concentrated pill according to pharmaceutics conventional formulation technology, tablet or capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101051819A CN101564441A (en) | 2008-04-25 | 2008-04-25 | Apoplexy rejuvenation preparation and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101051819A CN101564441A (en) | 2008-04-25 | 2008-04-25 | Apoplexy rejuvenation preparation and preparation method thereof |
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| CN101564441A true CN101564441A (en) | 2009-10-28 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133239B (en) * | 2010-01-21 | 2014-08-13 | 天士力制药集团股份有限公司 | Chinese medical concentrated pill and preparation method thereof |
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2008
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133239B (en) * | 2010-01-21 | 2014-08-13 | 天士力制药集团股份有限公司 | Chinese medical concentrated pill and preparation method thereof |
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Open date: 20091028 |