CN100353866C - 用含亮氨酸的制剂刺激体内蛋白质的产生 - Google Patents

用含亮氨酸的制剂刺激体内蛋白质的产生 Download PDF

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Publication number
CN100353866C
CN100353866C CNB2003801098651A CN200380109865A CN100353866C CN 100353866 C CN100353866 C CN 100353866C CN B2003801098651 A CNB2003801098651 A CN B2003801098651A CN 200380109865 A CN200380109865 A CN 200380109865A CN 100353866 C CN100353866 C CN 100353866C
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CN
China
Prior art keywords
leucine
formulation
formulation according
amino acids
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB2003801098651A
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English (en)
Chinese (zh)
Other versions
CN1753625A (zh
Inventor
乔治·维尔拉恩
鲁道夫·莱昂纳德斯·洛德韦克·斯梅茨
罗伯特·里斯·沃尔夫
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Nutricia NV
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Nutricia NV
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Publication of CN1753625A publication Critical patent/CN1753625A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNB2003801098651A 2002-12-20 2003-12-15 用含亮氨酸的制剂刺激体内蛋白质的产生 Expired - Lifetime CN100353866C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/325,711 US7288570B2 (en) 2002-12-20 2002-12-20 Stimulation of in vivo production of proteins
US10/325,711 2002-12-20

Publications (2)

Publication Number Publication Date
CN1753625A CN1753625A (zh) 2006-03-29
CN100353866C true CN100353866C (zh) 2007-12-12

Family

ID=32593858

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2003801098651A Expired - Lifetime CN100353866C (zh) 2002-12-20 2003-12-15 用含亮氨酸的制剂刺激体内蛋白质的产生

Country Status (11)

Country Link
US (2) US7288570B2 (enExample)
EP (1) EP1455603B1 (enExample)
JP (1) JP2006510711A (enExample)
CN (1) CN100353866C (enExample)
AT (1) ATE341226T1 (enExample)
AU (1) AU2003290447B2 (enExample)
CA (1) CA2510760C (enExample)
DE (1) DE60308810T2 (enExample)
DK (1) DK1455603T3 (enExample)
ES (1) ES2274299T3 (enExample)
WO (1) WO2004056208A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9878004B2 (en) 2013-09-25 2018-01-30 Axcella Health Inc. Compositions and formulations for treatment of gastrointestinal tract malabsorption diseases and inflammatory conditions and methods of production and use thereof

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4970694B2 (ja) * 2002-12-02 2012-07-11 株式会社明治 持続性筋肉疲労改善剤
US7288570B2 (en) * 2002-12-20 2007-10-30 Nutricia N.V. Stimulation of in vivo production of proteins
CN101106914B (zh) * 2005-01-18 2012-12-26 帝斯曼知识产权资产管理有限公司 营养药物性组合物
EP1774973A1 (en) * 2005-10-12 2007-04-18 Nutricia N.V. Leucine rich composition
AU2006305808B2 (en) * 2005-10-26 2011-01-20 Hill's Pet Nutrition, Inc. Compositions and methods for increasing lean muscle mass and/or reducing fat gain
ES2302463B1 (es) * 2006-12-29 2009-06-05 Madaus, S.A. "composicion a base de fibra de cacao".
AU2007347422B2 (en) 2007-02-23 2011-05-26 Hill's Pet Nutrition, Inc. Compositions and methods for controlling the weight of animals
ES2371789T3 (es) * 2008-03-03 2012-01-10 Nestec S.A. Producto alimenticio gelificado con una elevada eficacia en aporte de hidratos de carbono.
EP2098124A1 (en) * 2008-03-03 2009-09-09 Nestec S.A. Carbohydrate gel
EP2098126A1 (en) * 2008-03-03 2009-09-09 Nestec S.A. Carbohydrate Bar
WO2010002242A1 (en) * 2008-07-02 2010-01-07 N.V. Nutricia Nutritional composition for improving muscle function and daily activity
EP2298090B1 (en) 2009-08-26 2016-01-13 Jeffrey M. Golini Pharmaceutical or nutraceutical composition
DK2327315T3 (da) * 2009-11-29 2014-01-13 Nestec Sa Doseringsprotokoller til forøgelse af proteinsyntese i et aktivt individ
EP2327316B1 (en) * 2009-11-29 2016-11-16 Premier Nutrition Corporation Method of enhancing muscle protein synthesis
WO2011078654A1 (en) * 2009-12-24 2011-06-30 N.V. Nutricia Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis
US20120296403A1 (en) 2010-02-10 2012-11-22 Novartis Ag Methods and compounds for muscle growth
BR112012023025B1 (pt) * 2010-03-12 2021-06-01 Société des Produits Nestlé S.A. Composição nutricional, e método para mascarar sabores estranhos de leucina na mesma
WO2012005568A1 (en) * 2010-07-07 2012-01-12 N.V. Nutricia Nutritional composition for the stimulation of muscle protein synthesis
WO2013012760A1 (en) 2011-07-15 2013-01-24 Numeta Sciences, Inc. Compositions and methods for modulating metabolic pathways
US9198454B2 (en) 2012-03-08 2015-12-01 Nusirt Sciences, Inc. Compositions, methods, and kits for regulating energy metabolism
JP2015518470A (ja) 2012-03-26 2015-07-02 プロニュートリア・インコーポレイテッドＰｒｏｎｕｔｒｉａ， Ｉｎｃ． 栄養タンパク質および方法
SG11201405841RA (en) 2012-03-26 2014-10-30 Pronutria Inc Nutritive fragments, proteins and methods
AU2013240271A1 (en) 2012-03-26 2014-10-02 Axcella Health Inc. Nutritive fragments, proteins and methods
SG10201604464SA (en) 2012-03-26 2016-07-28 Axcella Health Inc Charged nutritive proteins and methods
CN108295058A (zh) 2012-11-13 2018-07-20 纽斯尔特科学公司 用于增强能量代谢的组合物和方法
KR20150130455A (ko) 2013-03-15 2015-11-23 뉴서트 사이언시스, 인크. 지질 수준을 감소시키는 류신 및 니코틴산
US9597367B2 (en) 2013-04-19 2017-03-21 Bioventures, Llc Methods for improving muscle and heart function
BR112015030767B1 (pt) * 2013-06-10 2021-03-30 N.V. Nutricia Uso de uma composição
AU2015222754B2 (en) 2014-02-27 2020-06-25 Nusirt Sciences Inc. Compositions and methods for the reduction or prevention of hepatic steatosis
EP3187185A4 (en) 2014-08-29 2018-04-11 Project PM Co., Ltd. Pharmaceutical composition formed by combining pyridoxamine compound and thiamine compound
US10188135B2 (en) * 2015-11-04 2019-01-29 Stokley-Van Camp, Inc. Method for inducing satiety
RU2601406C1 (ru) * 2015-11-17 2016-11-10 Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Саратовский Государственный Медицинский Университет Имени В.И. Разумовского" Министерства Здравоохранения Российской Федерации Средство, обладающее антикахексическим, противоопухолевым свойствами и снижающее уровень эндогенной интоксикации
JP6105111B1 (ja) * 2016-03-02 2017-03-29 国立大学法人東北大学 自閉スペクトラム症改善用組成物
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
BR112020002419A2 (pt) 2017-08-14 2020-07-28 Axcella Health Inc. aminoácido para o tratamento de doença do fígado
CH714189A1 (de) * 2017-09-25 2019-03-29 Omanda Ag Verfahren zur Herstellung von L-Leucin und Molkenprotein L-Leucin zur Nahrungsanreicherung und dessen Anwendung.
MY209392A (en) 2017-11-02 2025-07-07 Bioventures Llc Use of amino acid supplementation for improved muscle protein synthesis
CN112839643A (zh) 2018-06-20 2021-05-25 胺细拉健康公司 用于治疗肌肉中脂肪浸润的组合物及方法
CH715997A1 (de) * 2019-03-25 2020-09-30 Omanda Ag Proteingetränk und Darreichungseinheit zur Verabreichung von mit L-Leucin-angereicherten Molkenproteinkomponenten als Nahrungsanreicherung und dessen Herstellung.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2758243A1 (fr) * 1995-07-11 1998-07-17 Ajinomoto Kk Compositions nutritives pour animaux, notamment pour chevaux
WO2001058284A1 (en) * 2000-02-10 2001-08-16 N.V. Nutricia Pharmaceutical composition for muscular anabolism
WO2002087562A1 (en) * 2001-04-26 2002-11-07 Novartis Nutrition Ag Use of protein and essential amino acids to treat amenorrhea and related disorders

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3928445A (en) * 1973-12-26 1975-12-23 Allied Chem Synthesis of 2-halo-5-cyano alkyl valerate
JPS6049764A (ja) * 1983-08-29 1985-03-19 Ajinomoto Co Inc 食品組成物
JPS60186261A (ja) * 1984-03-06 1985-09-21 Ajinomoto Co Inc 固体状食品組成物
US4687782A (en) 1984-12-10 1987-08-18 Nutri-Fuels Systems, Inc. Nutritional composition for enhancing skeletal muscle adaptation to exercise training
US5639731A (en) * 1987-05-22 1997-06-17 Pripps Bryggerier Ab Amino acids for the preparation of a beverage
FI892006L (fi) * 1988-04-29 1989-10-30 Phil Gold Lactalbumin saosom tillaeggsaemne i mat.
US5242697A (en) 1990-10-26 1993-09-07 Maurizio Luca Method of preparing nutrified food products
US5817329A (en) * 1997-02-28 1998-10-06 Gardiner; Paul T. Nutritional supplement for increased muscle size and strength for body builders
IT1291127B1 (it) 1997-04-01 1998-12-29 Sigma Tau Ind Farmaceuti Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica
DE29707308U1 (de) 1997-04-23 1997-06-26 Kunz, Armin, 66450 Bexbach Präparat zur Muskelerhaltung bzw. zur Förderung des Muskelaufbaus
US6051236A (en) * 1998-11-12 2000-04-18 Pacifichealth Laboratories, Inc. Composition for optimizing muscle performance during exercise
US6221418B1 (en) * 1999-03-25 2001-04-24 Focused Foods, Inc. High protein edible composition and method of preparing the same
US6241996B1 (en) * 1999-04-09 2001-06-05 Novartis Nutrition Ag Liquid soy nutritional products
ATE320724T1 (de) 1999-12-30 2006-04-15 Kerry Group Services Ltd Aufbaupräparat, das kohlenhydrat- und peptidmaterial enthält und sein gebrauch als energieergänzung nach oder während körperlicher übung oder als metabolischer nährstoff für die orale verabreichung
US6420342B1 (en) * 2000-05-08 2002-07-16 N.V. Nutricia Nutritional preparation comprising ribose and medical use thereof
US6706295B2 (en) * 2000-09-29 2004-03-16 The Procter & Gamble Co. Compositions comprising arabinogalactan and a defined protein component
US7288570B2 (en) * 2002-12-20 2007-10-30 Nutricia N.V. Stimulation of in vivo production of proteins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2758243A1 (fr) * 1995-07-11 1998-07-17 Ajinomoto Kk Compositions nutritives pour animaux, notamment pour chevaux
WO2001058284A1 (en) * 2000-02-10 2001-08-16 N.V. Nutricia Pharmaceutical composition for muscular anabolism
WO2002087562A1 (en) * 2001-04-26 2002-11-07 Novartis Nutrition Ag Use of protein and essential amino acids to treat amenorrhea and related disorders

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9878004B2 (en) 2013-09-25 2018-01-30 Axcella Health Inc. Compositions and formulations for treatment of gastrointestinal tract malabsorption diseases and inflammatory conditions and methods of production and use thereof
US10463711B2 (en) 2013-09-25 2019-11-05 Axcella Health Inc. Nutritive polypeptides and formulations thereof, and methods of production and use thereof
US11357824B2 (en) 2013-09-25 2022-06-14 Axcella Health Inc. Nutritive polypeptides and formulations thereof, and methods of production and use thereof

Also Published As

Publication number Publication date
AU2003290447A1 (en) 2004-07-14
EP1455603B1 (en) 2006-10-04
US7288570B2 (en) 2007-10-30
JP2006510711A (ja) 2006-03-30
AU2003290447B2 (en) 2007-10-04
ATE341226T1 (de) 2006-10-15
DK1455603T3 (da) 2007-02-05
CA2510760C (en) 2011-09-20
WO2004056208A1 (en) 2004-07-08
DE60308810T2 (de) 2007-08-02
CA2510760A1 (en) 2004-07-08
DE60308810D1 (de) 2006-11-16
US20040122097A1 (en) 2004-06-24
HK1065447A1 (en) 2005-02-25
CN1753625A (zh) 2006-03-29
US20080161398A1 (en) 2008-07-03
EP1455603A1 (en) 2004-09-15
AU2003290447A2 (en) 2005-08-25
ES2274299T3 (es) 2007-05-16

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