CN100350840C - Bactericidal composition - Google Patents
Bactericidal composition Download PDFInfo
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- CN100350840C CN100350840C CNB2005100802770A CN200510080277A CN100350840C CN 100350840 C CN100350840 C CN 100350840C CN B2005100802770 A CNB2005100802770 A CN B2005100802770A CN 200510080277 A CN200510080277 A CN 200510080277A CN 100350840 C CN100350840 C CN 100350840C
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- isoprothiolane
- composition
- azoles alcohol
- rice
- bactericidal composition
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Abstract
The present invention relates to a fungicide compound for effectively preventing and curing rice blast, rice stripe and rice sheath blight disease. It is formed from isoprothiolane and hexaconazole according to the mixing ratio of 9:1-6:5:1. Said invention also provides its preparation method.
Description
Technical field
The present invention relates to a kind of bactericidal composition of preventing and treating rice sheath blight disease, rice blast and false smut.More particularly, the present invention relates to a kind of bactericidal composition that contains Isoprothiolane and own azoles alcohol.
Background technology
Rice sheath blight disease (Rhizoctonia solani k ü hn) takes place very general, is one of the main disease in present paddy rice producing region.If rice field liquid manure miscarriage, disease often seriously take place, cause not full, the empty flat rate of grain to increase, lodging is withered when serious.General south overweights the north, annual hundred million mu of the about 10-20 of area that take place, and the lighter's underproduction 5-10%, weight person's underproduction is up to 50-70%.
The control rice sheath blight disease mainly relies on chemical agent.The beginning of the eighties main application of special effects medicine mazn, but mazn is a class organic arsenic preparation, contaminated environment not only, and very easily cause poisoning (can not ear) booting stage in paddy rice, thereby banned use of by country.Its alternative medicament is a jinggangmeisu, but owing to produce upward long-term single frequent excessive use jinggangmeisu, its field efficacy is existing to be reduced, and the lasting period is short partially.And use more at present is Isoprothiolane.Isoprothiolane (isoprothiolane) is a systemic fungicide, has prevention and therapeutic action, is mainly used in control rice blast, and can doublely controls brown back rice plant hopper.Rice sheath blight disease, bacterial leaf-blight and diseases such as stripe disease of barley, moire disease had certain preventive and therapeutic effect.Own azoles alcohol then is azoles fungicide newly developed, be sterol demethylation inhibitor, be characterized in super-high-efficient, high activity, for example per hectare 30g control coffee rust, effect is better than triazolone per hectare 250g, but own azoles alcohol also is not used to prevent and treat rice sheath blight disease in China at present.And also do not have it and Isoprothiolane combination to prevent and treat the report of rice sheath blight disease, rice blast and false smut in the patent at home and abroad, so its effect of mixing use with Isoprothiolane can't be expected.
Have now found that, the bactericidal composition that contains Isoprothiolane and own azoles alcohol not only has good therapeutic action to rice sheath blight disease, rice blast and false smut, and the stack that exceeds each composition activity of the effect that it showed or activity level, have unforeseeable synergistic function.
Summary of the invention
One of purpose of the present invention just provides a kind of bactericidal composition that contains Isoprothiolane and own azoles alcohol, and it has excellent synergy control efficiency.
Another object of the present invention provides the preparation method and its usage of described bactericidal composition.
Bactericidal composition of the present invention contains the aforesaid active principles in combination of synergy effective dose, and the ratio between the active component can be arbitrarily, as long as can produce synergistic effect; The weight ratio of Isoprothiolane and own azoles alcohol is preferably 100: 1 to 1: 20, and more preferably 50: 1 to 1: 10, most preferably 9: 1 to 6.5: 1.Generally speaking, the weight percentage of Isoprothiolane is 1～50% in the composition, and the weight percentage of own azoles alcohol is 0.1～20%.
Bactericidal composition of the present invention can be mixed with conventional formulation, as missible oil, suspending agent, wetting powder, granule, water dispersible granules, aqueous emulsion, suspension emulsion, microemulsion, paste, water surface leafing agent etc.Administration form depends on specific application; In all cases, must guarantee that their dispersion is trickle as much as possible and even.
These preparations can prepare in a known manner, for example by reactive compound is mixed with liquid flux and/or solid carrier, if desired, surfactant such as emulsifier, dispersant, wetting agent can be added simultaneously, thickener, defoamer, antifreeze, oxidant, dyestuff etc. can also be added.If use water as thinner, also available other organic solvent is made cosolvent.
The organic solvent that is fit to comprises aromatic compound (for example dimethylbenzene), chlorinated aromatic hydrocarbons compound (for example chlorobenzene), paraffin (for example petroleum distillate), alcohols (for example methyl alcohol, ethanol), ketone (for example cyclohexanone), amine (for example monoethanolamine, dimethyl formamide) etc.
The synthetic mineral matter (for example high molecular silicic acid, silicate etc.) that solid carrier commonly used has natural mineral matter (for example kaolin, talcum, bentonite, attapulgite) and grinds.
Surfactant can be emulsifier, dispersant or wetting agent; Can be nonionic or ionic.For example, lauryl sodium sulfate, Teepol, neopelex, polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether, polyoxyethylene fatty amine or directly use the commercial emulsifier: agricultural newborn 0201B, 0203,0203B, 600# etc.Material as dispersant and wetting agent has: sodium lignin sulfonate, draw back powder, calcium lignosulfonate and sldium lauryl sulfate, alkylol polyoxyethylene groups ether sodium sulfate, octylphenol polyethylene oxyethylene group ether sulfate, alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, sodium alkyl sulfonate, neopelex etc.
Thickener; can be for example carbonyl methylol, polyvinyl alcohol or the polyvinyl acetate that synthesizes; or natural water-soluble polymer; for example xanthans, gelatin, gum Arabic, phenolic resins, shellac, carboxymethyl cellulose and sodium alginate etc. add in the preparation with powder, particle or latex form.
Defoamer is: bubble enemy, silicone, C
8-10Fatty alcohol, phosphoric acid ester, C
10-20Saturated fat acids (as capric acid) and acid amides etc.
Oxidant is: potassium chlorate, sodium chlorate, potassium perchlorate, sodium nitrate, potassium nitrate, potassium permanganate etc.
Antifreeze is urea, calcium chloride etc.
Usually composition contains 0.01 to 90% active component by weight, and usually according to the difference of preparation type, preferably contains 20 to 30% active component by weight.
The application dosage of the present composition, the difference according to factors such as Different Crop, time of application, weather conditions is generally 1-1000g a.i./ha, preferred 5-300g a.i./ha.The general foliage applying that adopts, for example foliar spray is used.
The present composition has the following advantages: the one, and composition shows fabulous synergistic effect in certain ratio range, mixed composition has obviously improved bactericidal effect than its single agent, thereby reduced application dosage, when reducing drug cost, reduced influence environment.The 2nd, enlarged fungicidal spectrum, a kind of medicament can be prevented and treated multiple diseases simultaneously; The present composition all has good therapeutic action to rice sheath blight disease, rice blast and false smut.
Embodiment
Following examples further describe the present invention, but never limit the scope of the present invention.Percentage all is weight percentage in the proportioning of all preparations; The treatment dosage of biologically-active moiety is effective content.
The own azoles alcohol of example of formulations 1 30% Isoprothiolane missible oil
Isoprothiolane 27%,
Own azoles alcohol 3%,
Farming breast 0,203 10%,
Dimethylbenzene 30%,
DMF 10％，
N-hexane supplies 100%.
Take by weighing former medicine, solvent, emulsifier by above-mentioned prescription requirement, mix, use the hot bath heating for dissolving in case of necessity, promptly get transparence missible oil.
The own azoles alcohol of example of formulations 2 10.1% Isoprothiolanes missible oil
Isoprothiolane 10%,
Own azoles alcohol 0.1%,
The newborn 0203B 10% of farming,
Dimethylbenzene 30%,
DMF 10％，
N-hexane supplies 100%.
Take by weighing former medicine, solvent, emulsifier by above-mentioned prescription requirement, mix, use the hot bath heating for dissolving in case of necessity, promptly get transparence missible oil.
The own azoles alcohol of example of formulations 3 30% Isoprothiolanes wetting powder
Isoprothiolane 26%
Own azoles alcohol 4%
Lauryl sodium sulfate 1.5%
Carboxymethyl cellulose 1%
Sodium lignin sulfonate 10%
Precipitated calcium carbonate supplies 100%
By above-mentioned prescription requirement, former medicine, various auxiliary agent and filler etc. are fully mixed, after ultrafine crusher is pulverized, promptly obtain converted products.
Example of formulations 4 20% Isoprothiolane hexaconazole aqueous emulsions
Isoprothiolane 15%
Own azoles alcohol 5%
The newborn 600# 3% of farming
OP-10 phosphate ester salt 4%
Polyvinyl alcohol 0.9%
Dimethylbenzene 30%
DMF 12％
Ethylene glycol 5%
Water supplies 100%
By above-mentioned prescription requirement, former medicine, solvent, emulsifier added with co-emulsifier be in the same place, make and be dissolved into even oil phase.Water, antifreeze etc. is mixed, become the homogeneous water.Under high-speed stirred, water is joined oil phase or oil phase is joined aqueous phase, form the aqueous emulsion of favorable dispersibility.
Biological Examples 1 synergy test
Measure bactericide Isoprothiolane, own azoles alcohol and Different Weight EC with Sun Yunpei (1960) co-toxicity coefficient method than combination
50And relative virus force index (TI), and be calculated as follows theoretical toxicity index (TTI) of mixture and mixture co-toxicity coefficient (CTC):
The active ingredient percentage of toxicity index * A medicine in mixture of the theoretical toxicity index of mixture=A medicine
The active ingredient percentage of the toxicity index of+B medicine * B medicine in mixture
+……
The result is as shown in table 1:
Table 1 Isoprothiolane, own azoles alcohol and mixture thereof are to the toxicity test of Rhizoctonia solani Kuhn
| Prescription (Isoprothiolane: own azoles alcohol) | Virulence regression equation | EC 50(mg/kg) | Toxicity index (TI) | Co-toxicity coefficient (CTC) |
| The agent of Isoprothiolane list | Y＝0.2395(InX)-0.4805 | 76.55 | - | - |
| The single agent of own azoles alcohol | Y＝0.2119(InX)+0.0265 | 9.34 | - | - |
| 27∶3 | Y＝0.1633(InX)-0.0515 | 29.29 | 171.96 | 151.99 |
| 26∶4 | Y＝0.1579(InX)-0.0123 | 25.65 | 195.95 | 152.31 |
As shown in Table 1, the present invention's bactericidal composition of containing Isoprothiolane and own azoles alcohol has obvious synergistic effect.Biological Examples 2 control rice green smut tests
The own azoles alcohol of sample A:30% Isoprothiolane EC (27% Isoprothiolane, 3% own azoles alcohol), the Zhejiang Weir reaches company; Contrast: 20% jinggangmeisu WP, Zhejiang Qian Jiang biochemistry Co., Ltd;
Place: Zhejiang Jiaxing; Dispenser period: late tillering state preceding 2～3 days of cut, the false smut initial phase; Investigation: behind the medicine 30 days; Time: on July 15th, 2003.
The result is as shown in table 2 below.
30 days each chemicals treatment are to the control efficiency of false smut behind table 2 medicine
| Processing method | Disease tassel yield (%) | Average disease tassel yield (%) | Control efficiency (%) | |||
| Repeat 1 | Repeat 2 | Repeat 3 | Repeat 4 | |||
| Sample AEC 30 gram/mus (2000 times) | 7.37 | 8.59 | 7.43 | 7.97 | 7.84 | 67.3 |
| Sample AEC 40 gram/mus (1500 times) | 5.79 | 6.47 | 5.17 | 6.84 | 6.07 | 74.7 |
| Sample AEC 50 gram/mus (1000 times) | 2.15 | 3.23 | 2.75 | 3.64 | 2.94 | 87.8 |
| Contrast WP 30 gram/mus (2000 times) | 12.37 | 13.52 | 13.18 | 14.71 | 13.45 | 43.8 |
| Blank | 25.39 | 24.69 | 24.14 | 21.58 | 23.95 | - |
Conclusion: three of sample AEC all have good control efficiency for examination concentration to rice green smut, and 7 days, 14 days preventive effect is compared with contrast medicament jinggangmeisu and all reached utmost point significance level behind particularly 1500 times, 1000 times secondary medicines.
Biological Examples 3 control rice blast tests
The own azoles alcohol of sample A:30% Isoprothiolane EC (27% Isoprothiolane, 3% own azoles alcohol), the Zhejiang Weir reaches company; Contrast: 40% Fujione EC, change capital goods in the agricultural sector Co., Ltd in the Tianjin;
Place: Jinhua, Zhejiang; Dispenser period: late tillering state preceding 2～3 days of cut, the rice blast initial phase; Investigation: behind the medicine 30 days; Time: on July 15th, 2003.
The result is as shown in table 3 below.
30 days each chemicals treatment are to the control efficiency of paddy rice ear stem pest behind table 3 medicine
| Processing method | Disease index (%) | Average preventive effect (%) | The significance of difference (%) | |||
| Repeat 1 | Repeat 2 | Repeat 3 | Repeat 4 | |||
| Sample AEC 30 gram/mus (2000 times) | 0.69 | 0.88 | 0.65 | 0.67 | 74.19 | B/c |
| Sample AEC 40 gram/mus (1500 times) | 0.58 | 0.59 | 0.56 | 0.37 | 81.69 | AB/bc |
| Sample AEC 50 gram/mus (1000 times) | 0.31 | 0.52 | 0.49 | 0.32 | 88.96 | AB/ab |
| Contrast EC 30 gram/mus (2000 times) | 1.07 | 1.32 | 0.91 | 1.14 | 64.43 | C/d |
| Blank | 3.31 | 4.19 | 3.89 | 3.56 | - | - |
Conclusion: three of sample AEC supply examination concentration that rice blast is all had good control efficiency, and particularly 1500 times, 1000 times preventive effect is compared with contrast medicament 40% Fujione EC and all reached utmost point significance level.Biological Examples 4 is prevented and treated the rice sheath blight disease test
The own azoles alcohol of sample A:30% Isoprothiolane EC (27% Isoprothiolane, 3% own azoles alcohol), the Zhejiang Weir reaches company; Contrast: 20% jinggangmeisu WP, Jiangsu distillation biochemistry Co., Ltd;
Place: the Land of Peach Blossoms, Hunan; Dispenser period: late tillering state, banded sclerotial blight initial phase; Investigation: behind the secondary medicine 7 days; Time: on June 21st, 2003.
The result is as shown in table 4 below.
7 days each chemicals treatment are to the control efficiency of rice sheath blight disease behind the table 4 secondary medicine
| Processing method | Disease index (%) | Average disease refers to (%) | Control efficiency (%) | |||
| Repeat 1 | Repeat 2 | Repeat 3 | Repeat 4 | |||
| Sample AEC 30 gram/mus (2000 times) | 3.72 | 4.34 | 3.87 | 4.16 | 4.02 | 67.74 |
| Sample AEC 40 gram/mus (1500 times) | 2.88 | 3.32 | 3.09 | 3.34 | 3.16 | 74.64 |
| Sample AEC 50 gram/mus (1000 times) | 2.46 | 2.85 | 2.79 | 2.63 | 2.68 | 78.49 |
| Contrast EC 30 gram/mus (2000 times) | 4.68 | 5.20 | 5.06 | 5.13 | 5.02 | 59.71 |
| Blank | 10.87 | 13.82 | 11.74 | 13.40 | 12.46 | - |
Conclusion: three of sample AEC all have good control efficiency for examination concentration to rice sheath blight disease, and 7 days, 14 days preventive effect is compared with contrast medicament jinggangmeisu and all reached utmost point significance level behind particularly 1500 times, 1000 times secondary medicines.
Claims (4)
1. bactericidal composition is characterized in that the weight ratio of Isoprothiolane and own azoles alcohol is 50: 1 to 1: 10 in the said composition.
2. according to the bactericidal composition of claim 1, it is characterized in that the weight ratio of Isoprothiolane and own azoles alcohol is 9: 1 to 6.5: 1 in the said composition.
3. according to arbitrary bactericidal composition of claim 1 or 2, it is characterized in that said composition can be mixed with missible oil, wetting powder or aqueous emulsion.
4. according to arbitrary bactericidal composition of claim 1 or 2, it is characterized in that said composition being used to prevent and treat rice sheath blight disease, rice blast and false smut.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100802770A CN100350840C (en) | 2005-07-01 | 2005-07-01 | Bactericidal composition |
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|---|---|---|---|
| CNB2005100802770A CN100350840C (en) | 2005-07-01 | 2005-07-01 | Bactericidal composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102626088B (en) * | 2009-11-11 | 2013-10-16 | 陕西上格之路生物科学有限公司 | Bactericidal composition containing cyproconazole |
| CN101836637A (en) * | 2010-02-23 | 2010-09-22 | 唐满仓 | Water suspending agent pesticide containing isoprothiolane and hexaconazole and preparation method thereof |
| CN103734141B (en) * | 2014-01-26 | 2016-03-02 | 上海艳紫化工科技有限公司 | Isoprothiolane and the composite agricultural chemicals suspension agent of own azoles alcohol |
| CN111820227B (en) * | 2020-07-28 | 2021-05-07 | 上海明德立达生物科技有限公司 | Isoprothiolane-hexaconazole suspending agent and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1465245A (en) * | 2002-06-30 | 2004-01-07 | 周耀德 | Built disinfectant |
| CN1471824A (en) * | 2003-07-14 | 2004-02-04 | 吴进才 | Compound pesticide for preventing and treating rice sheath blight disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1465245A (en) * | 2002-06-30 | 2004-01-07 | 周耀德 | Built disinfectant |
| CN1471824A (en) * | 2003-07-14 | 2004-02-04 | 吴进才 | Compound pesticide for preventing and treating rice sheath blight disease |
Non-Patent Citations (1)
| Title |
|---|
| 新编农药手册 农业部农药检定所，369.371，农业出版社 1989 * |
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