CN101836637A - Water suspending agent pesticide containing isoprothiolane and hexaconazole and preparation method thereof - Google Patents
Water suspending agent pesticide containing isoprothiolane and hexaconazole and preparation method thereof Download PDFInfo
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- CN101836637A CN101836637A CN201010114251A CN201010114251A CN101836637A CN 101836637 A CN101836637 A CN 101836637A CN 201010114251 A CN201010114251 A CN 201010114251A CN 201010114251 A CN201010114251 A CN 201010114251A CN 101836637 A CN101836637 A CN 101836637A
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- isoprothiolane
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Abstract
The invention relates to a water suspending agent pesticide containing isoprothiolane and hexaconazole and a preparation method thereof. The water suspending agent pesticide contains the two bactericidal drugs of the isoprothiolane and the hexaconazole with ratio of 1-12:1, wherein the total weight ratio of the isoprothiolane and the hexaconazole accounts for 10-50% of the formulation. The water suspending agent pesticide contains the following auxiliary agents: 1-10% of dispersing agent, 0.5-5% of wetting agent, 0.1-1% of thickening agent and suspension stabilizer, 1-5% of antifreezing agent, 0.1-1% of antifoaming agent and the balance of water. The water suspending agent pesticide is prepared by the following steps of: adding weighed isoprothiolane, hexaconazole, dispersing agent, wetting agent, antifreezing agent and water into a reaction kettle, shearing for 10-40 min, grinding 2-4 times, adding weighed antifoaming agent while grinding, adding weighed thickening agent into the grinded material and shearing for 10-30 min to obtain the water suspending agent pesticide. The invention overcomes the defect of the single drug of the isoprothiolane or hexaconazole. The novel mixed pesticide has remarkable synergism for rice blasts, can delay the occurrence of drug resistance of pathogenic bacteria, widen antimicrobial spectrum, improve drug effects, reduce use level and save cost.
Description
Technical field
The present invention relates to a kind of composition and method of making the same of agriculture chemicals fungicide, specifically contain aqueous suspension agriculture chemicals fungicide of Isoprothiolane and own azoles alcohol and preparation method thereof.
Background technology
Isoprothiolane and own azoles alcohol are two kinds of germ killing drugs using always
Isoprothiolane: 1,3-dithiolane-2-pitches Diisopropyl malonate
Physicochemical property: faint yellow crystalline solid, frowziness slightly, fusing point 54.5-55 ℃, boiling point 167-169 ℃/166.7Pa, steam pressure is 18.7MPa during 1.044,25 ℃ of relative densities.Solvability is 48mg/L in 20 ℃ of water, and Isoprothiolane is soluble in benzene, pure and mild acetone and other organic solvent.All stable to light, temperature, pH value 3-10, in water, ultraviolet ray is unstable down.
Use: belong to the low toxicity bactericide.The oral LD50 of former powder rat acute is 1340 milligrams/kilogram, and rat acute is through skin LD50＞10250 milligram/kilogram.Toxicity in fish is medium, to honeybee and birds safety.Efficient systemic fungicide is the special effect agent of control rice blast.Rice blast is had prevention and therapeutic action, can be inhaled the people by each position of paddy rice, and be accumulated to leaf portion tissue, thus the performance drug effect, and resistance of rainwater washing against also can doublely be controlled plant hopper.Simultaneously rice sheath blight disease, culm rot and bacterial leaf-blight there is certain preventive effect.
Own azoles alcohol: (RS)-2-(2,4 dichloro benzene base)-1-(1H-1,2,4-triazol-1-yl)-oneself-2-alcohol
Physicochemical property: pure product are clear crystal, 111 ℃ of fusing points, 25 ℃ of vapour pressure 0.11mPa (20 ℃), density 1.29g/cm3.Dissolubility (20 ℃), water 0.018mg/L, methyl alcohol 246g/L, toluene 59g/L, stability, room temperature (below 40 ℃) is not decomposed in 9 months at least, and is stable in 30 days in acid, alkalescence (PH5,7-9) aqueous solution.PH7 aqueous solution middle-ultraviolet lamp shines in following 10 days stable.
Use: belong to azoles fungicide, sterol demethylation inhibitor, the disease that fungi especially Basidiomycota and Ascomycota are caused has the protection and the therapeutic action of broad spectrum activity.Destroy and stop the biosynthesis of the cell membrane important composition composition ergosterol of germ, cause cell membrane not form, make germ death.Have interior suction, protection and therapeutic activity.Prevent and treat disease due to sac fungi, basidiomycetes and the imperfect fungus effectively, especially disease that Basidiomycetes and Ascomycetes are caused such as powdery mildew, rust, scab, brown spot, anthracnose etc. have excellent protection and eradicant action.Rice sheath blight disease there is good preventive effect.Suitable crop and safety fruit tree such as apple, grape, banana, vegetables (melon and fruit, capsicum etc.), peanut, coffee, cereal crop and ornamental plants etc.Under recommended dose, use,, but sometimes some apple variety is had poisoning environment, crop safety.
Summary of the invention
The objective of the invention is to, overcome the pure deficiency that exists of single medicine Isoprothiolane or own azoles, provide a kind of and can delay the drug-fast generation of pathogen, enlarge the new germ killing drugs of antimicrobial spectrum, raising drug effect, the dosage that reduces, saving cost.
The present invention is achieved in that
The present invention is an aqueous suspension agent, contains two kinds of germ killing drugs of Isoprothiolane and own azoles alcohol, and the proportioning of the two is 1--12: 1, and optimal proportion is 6: 1, the two part by weight shared in prescription is total up to 10-50%.And contain following various auxiliary agent: dispersant 1-10%, wetting agent 0.5-5%, thickener and suspension stabilizer 0.1-1%, antifreezing agent 1-5%, defoamer 0.1-1%, surplus is a water.
1. dispersant has:
1) industrial by-products dispersant is as lignin and derivative thereof etc.
2) the dispersant alkylsurfuric acid salt of anionic surfactant, alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate etc.
3) dispersant of nonionic surface active agent is as alkyl phenol polyoxypropylene base ether block copolymers, alkylphenol-polyethenoxy phosphate etc.
4) water-soluble high-molecular substance dispersant and inorganic dispersant.
Can be above-mentioned a kind of and several mixing, dispersant dosage be 1-10%.
2. wetting agent has: the alkylsurfuric acid salt, alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate draws back powder, SOPA, neopelex, detergent, newborn 2000 series of farming, wetting and penetrating agent T, polyoxyethylene groups ethers etc.
Can be above-mentioned a kind of and several mixing, the wetting agent consumption be 0.5-5%.
3. thickener and suspension stabilizer have: natural and synthetic two kinds, comprise water-soluble resin, xanthans, carboxymethyl cellulose, hydroxyethylcellulose, hydroxypropyl cellulose, methylcellulose, bentonite, gaseous state silica, polyvinyl alcohol, Magnesiumaluminumsilicate etc.
Thickener and suspension stabilizer consumption are 0.1-1%.
4. antifreezing agent has: ethylene glycol, propane diols, urea, glycerine etc.
The antifreezing agent consumption is 1-5%.
5. defoamer has: organosilicon ketone, the fatty alcohol of C8-10, C10-20 representative examples of saturated aliphatic carboxylic and ester class thereof, ester-ether type compound etc.
The defoamer consumption is 0.1-1%.
The present invention's preparation method is:
1) Isoprothiolane that measures, own azoles alcohol, dispersant, wetting agent, antifreezing agent and water are dropped in the reactor; 2) sheared 10-40 minute;
3) will shear good improved grinding 2-4 time, add the defoamer that measures while grinding;
4) add the thickener that measures at ground material, sheared 10-30 minute, get final product.
The present invention overcomes the deficiency of single medicine Isoprothiolane or the existence of own azoles alcohol, and the new drug after being mixed has obvious synergistic effect to rice blast.Can delay the drug-fast generation of pathogen, enlarge antimicrobial spectrum, improve drug effect, reduce dosage, save Financial cost.
Description of drawings
Aqueous suspension agent preparation process figure
Narration four embodiment of the present invention below the embodiment
1000 kilograms of embodiment 1. preparation aqueous suspension agent germ killing drugs
The proportioning of principal component Isoprothiolane and own azoles alcohol is 6: 1; The two part by weight shared in prescription is total up to 35%, promptly 350 kilograms.And contain following various auxiliary agent, dispersant NNO 3%, promptly 30 kilograms, dispersant lignin 4%, promptly 40 kilograms; Wetting agent neopelex 3%, promptly 30 kilograms; Thickener and suspension stabilizer xanthans 0.5%, promptly 5 kilograms; Antifreeze glycol 3%, promptly 30 kilograms; Defoamer 0.5%, promptly 5 kilograms; 510 kilograms of excess waters.
Preparation technology is: the water, Isoprothiolane, own azoles alcohol, dispersant NNO, wetting agent neopelex, dispersant lignin, the antifreeze glycol that measure are dropped into reactor, sheared 30 minutes, grind 3 times through sand mill shearing good material, add the defoamer that measures while grinding.Grind and finish, in ground material, add the thickener xanthans that measures, sheared 20 minutes, get final product.
Detect qualified back packing; As defective, continue to grind, up to qualified.
Embodiment 2. preparation aqueous suspension agent germ killing drugs
The proportioning of principal component Isoprothiolane and own azoles alcohol is 1: 1; The two part by weight shared in prescription is total up to 10%, promptly 100 kilograms.And contain following various auxiliary agent, dispersant 2,700 1%, promptly 10 kilograms; Wetting agent 1,004 0.5%, promptly 5 kilograms; Thickener and suspension stabilizer xanthans 1%, promptly 10 kilograms; Antifreeze glycol 5%, promptly 50 kilograms; Defoamer 0.1%, promptly 1 kilogram; Surplus is 824 kilograms in a water.
Preparation technology: the water, Isoprothiolane, own azoles alcohol, dispersant NNO, wetting agent neopelex, dispersant lignin, the antifreeze glycol that measure are dropped into reactor, sheared 10 minutes; Grind 4 times through sand mill shearing good material, add the defoamer that measures while grinding; Grind and finish, ground material is added the thickener xanthans that measures, sheared 10 minutes, get final product.
Detect qualified back packing.As defective, continue to grind, up to qualified.
Preparing process is with above-mentioned embodiment 1
1000 kilograms of embodiment 3. preparation aqueous suspension agent germ killing drugs
The proportioning of the two is 12: 1, and the two part by weight shared in prescription is total up to 50%, promptly 500 kilograms.And contain following various auxiliary agent: dispersant 10%, promptly 100 kilograms; Wetting agent 5%, promptly 50 kilograms; Thickener and suspension stabilizer 0.1%, promptly 1 kilogram; Antifreezing agent 1%, promptly 10 kilograms; Defoamer 1%, promptly 10 kilograms; 329 kilograms of excess waters.
Preparation technology: the water, Isoprothiolane, own azoles alcohol, dispersant NNO, wetting agent neopelex, dispersant lignin, the antifreeze glycol that measure are dropped into reactor, sheared 40 minutes; With shearing good material, grind 2 times through sand mill, add the defoamer that measures while grinding; Grind and finish, in ground material, add the thickener xanthans that measures, sheared 30 minutes, get final product.
Detect qualified back packing.As defective, continue to grind, up to qualified.
1000 kilograms of embodiment 4. preparation aqueous suspension agent insecticidal materials
The proportioning of principal component Isoprothiolane and own azoles alcohol is 8: 1; The two part by weight shared in prescription is total up to 40%, promptly 400 kilograms.And contain following various auxiliary agent, dispersant 2,500 6%, promptly 60 kilograms; Wetting agent 1,004 2%, promptly 20 kilograms; Thickener and suspension stabilizer xanthans 0.3%, promptly 3 kilograms; Antifreeze glycol 3%, promptly 30 kilograms; Defoamer 0.6%, promptly 6 kilograms; Surplus is 481 kilograms in a water.
Preparing process is with embodiment 1.
Claims (3)
1. contain the aqueous suspension agent agricultural chemicals of Isoprothiolane and own azoles alcohol, it is characterized in that: contain two kinds of germ killing drugs of Isoprothiolane and own azoles alcohol, the proportioning of the two is 1--12: 1, and the two part by weight shared in prescription is total up to 10-50%.And contain following various auxiliary agent: dispersant 1-10%, wetting agent 0.5-5%, thickener and suspension stabilizer 0.1-1%, antifreezing agent 1-5%, defoamer 0.1-1%, surplus is a water.
2. contain the preparation method of the aqueous suspension agent agricultural chemicals of Isoprothiolane and own azoles alcohol, it is characterized in that, carry out according to following step:
1) Isoprothiolane that measures, own azoles alcohol, dispersant, wetting agent, antifreezing agent and water are dropped in the reactor; 2) sheared 10-40 minute;
3) will shear good improved grinding 2-4 time, add the defoamer that measures while grinding;
4) ground material is added the thickener that measures, sheared 10-30 minute, get final product.
3. according to the described aqueous suspension agent agricultural chemicals that contains Isoprothiolane and own azoles alcohol of claim 1, it is characterized in that:
The optimal proportion of Isoprothiolane and own azoles alcohol is 6: 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010114251A CN101836637A (en) | 2010-02-23 | 2010-02-23 | Water suspending agent pesticide containing isoprothiolane and hexaconazole and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010114251A CN101836637A (en) | 2010-02-23 | 2010-02-23 | Water suspending agent pesticide containing isoprothiolane and hexaconazole and preparation method thereof |
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| CN101836637A true CN101836637A (en) | 2010-09-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201010114251A Pending CN101836637A (en) | 2010-02-23 | 2010-02-23 | Water suspending agent pesticide containing isoprothiolane and hexaconazole and preparation method thereof |
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| CN (1) | CN101836637A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102342292A (en) * | 2011-08-22 | 2012-02-08 | 中国农业大学 | Aqueous suspension of plant-growth regulator, its preparation method and its application |
| CN103734141A (en) * | 2014-01-26 | 2014-04-23 | 上海艳紫化工科技有限公司 | Compound pesticide suspension agent containing isoprothiolane and hexaconazole |
| CN104621105A (en) * | 2015-02-26 | 2015-05-20 | 天津市施普乐农药技术发展有限公司 | Preparation method of isoprothiolane suspending agent by employing water as solvent |
| CN104705309A (en) * | 2013-12-12 | 2015-06-17 | 南京华洲药业有限公司 | Sterilization composition containing penconazole and isoprothiolane, and applications thereof |
| CN111820227A (en) * | 2020-07-28 | 2020-10-27 | 上海明德立达生物科技有限公司 | Isoprothiolane-hexaconazole suspending agent and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1891042A (en) * | 2005-07-01 | 2007-01-10 | 浙江威尔达化工有限公司 | Bactericidal composition |
-
2010
- 2010-02-23 CN CN201010114251A patent/CN101836637A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1891042A (en) * | 2005-07-01 | 2007-01-10 | 浙江威尔达化工有限公司 | Bactericidal composition |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102342292A (en) * | 2011-08-22 | 2012-02-08 | 中国农业大学 | Aqueous suspension of plant-growth regulator, its preparation method and its application |
| CN104705309A (en) * | 2013-12-12 | 2015-06-17 | 南京华洲药业有限公司 | Sterilization composition containing penconazole and isoprothiolane, and applications thereof |
| CN103734141A (en) * | 2014-01-26 | 2014-04-23 | 上海艳紫化工科技有限公司 | Compound pesticide suspension agent containing isoprothiolane and hexaconazole |
| CN103734141B (en) * | 2014-01-26 | 2016-03-02 | 上海艳紫化工科技有限公司 | Isoprothiolane and the composite agricultural chemicals suspension agent of own azoles alcohol |
| CN104621105A (en) * | 2015-02-26 | 2015-05-20 | 天津市施普乐农药技术发展有限公司 | Preparation method of isoprothiolane suspending agent by employing water as solvent |
| CN111820227A (en) * | 2020-07-28 | 2020-10-27 | 上海明德立达生物科技有限公司 | Isoprothiolane-hexaconazole suspending agent and preparation method thereof |
| CN111820227B (en) * | 2020-07-28 | 2021-05-07 | 上海明德立达生物科技有限公司 | Isoprothiolane-hexaconazole suspending agent and preparation method thereof |
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Application publication date: 20100922 |