CN101574080B - Sterilization composition containing tebuconazole and dimetachlone - Google Patents

Abstract

The invention relates to a sterilization composition, in particular to a sterilization composition containing tebuconazole and dimetachlone with a synergistically effective amount; wherein, the weightratio of tebuconazole to dimetachlone is 100:1 to 1:20 preferably, more preferably 50:1 to 1:10, most preferably 9:1 to 1:1. The sterilization composition is applied to preventing the rice sheath bli ght disease and rice false smut in particular.

Description

The bactericidal composition that contains Tebuconazole and dimethachlon

Technical field

The present invention relates to a kind of bactericidal composition of preventing and treating rice sheath blight disease and false smut.More particularly, the present invention relates to a kind of bactericidal composition of Tebuconazole and dimethachlon and purposes that said composition is used to prevent and treat rice sheath blight disease and rice green smut of containing.

Background technology

Rice sheath blight disease and rice green smut are the main diseases on the Rice Production.Rice sheath blight disease all has generation in the main rice workspace of countries such as the U.S., South America, Europe And Africa.The south China of China, Central China and East China morbidity are more serious, and North China, northeast and Yunnan Dao Qu also have generation, and some areas are heavier, the general field piece underproduction 5-10% that falls ill, and the serious field piece underproduction reaches 50-70%.False smut all has generation in each rice workspace of China, and false smut can cause production loss, more seriously influences the paddy rice quality.It is reported that the false smut infected seed has stronger toxicity to the people, raise livestock and poultry, can cause growth of animals or poultry to slow down with infected seed, the internal organ pathology, fecundity descends, even dead.

For a long time, the control of rice sheath blight disease mainly depends on jinggangmeisu on the Rice Production.Jinggangmeisu is longer service life, and dosage increases year by year, and the occurrence frequency and the severity of rice sheath blight disease show ascendant trend.The number of times that now is used to prevent and treat banded sclerotial blight 2 times/year before 20 years is increased to present 4-5 time/year, usage amount also from before 1.5 kilograms/hectare be increased to present 4.5-6.0 kilogram/hectare, continue to prevent and treat rice sheath blight disease and exist huge risk with jinggangmeisu.The control of rice green smut mainly depends on the medicament of organic copper, organic tin, and this type of heavy metal medicament easily produces poisoning to paddy rice and be easily rich long-pending residual in rice, influences the quality of rice.Along with the raising of rapid economy development and living standards of the people, people are more and more higher to the requirement of paddy rice quality and output.Green rice production presses for when reducing the production loss that is caused by damage by disease and insect as far as possible, the consumption of minimizing chemical pesticide and residual, and therefore the natural quality of maintenance rice, is developed new control medicament and is seemed very important and urgent.

Tebuconazole (tebuconazole) is to be had interior suction, protection, treated and root out active triazole bactericidal agent by what Bayer AG developed; belong to ergosterol biosynthesis inhibitor, can be rapidly partially absorbed and mainly shift by plant is vegetative to the top.It not only has bactericidal activity, also can promote plant growing, makes it that well developed root system, leaf look dark green, robust plant, effective tiller increase, thereby improve output.Dimethachlon (dimethachlon) has another name called cyclopropylamine, dimethachlon, and chemical name is N-3,5-dichlorophenyl succimide belongs to systemic fungicide, has therapeutic action, the longevity of residure is long, is mainly used in control sclerotinia rot of colza, the red raw meat disease of tobacco, rice sheath blight disease etc. at present.

Have now found that the bactericidal composition that contains dimethachlon and Tebuconazole not only has good therapeutic action to rice sheath blight disease and false smut, and the stack that exceeds each composition activity of the effect that it showed or activity level, unforeseeable synergistic function had.

Summary of the invention

One of purpose of the present invention just provides a kind of bactericidal composition that contains Tebuconazole and dimethachlon, and it has excellent synergy control efficiency.

Another object of the present invention provides the preparation method of described bactericidal composition and is used to prevent and treat the purposes of rice sheath blight disease and false smut.

Synergistic bactericidal composition of the present invention contains the aforesaid active principles in combination of synergy effective dose, and the ratio between the active component can change within a large range.Wherein, the weight ratio of Tebuconazole and dimethachlon is preferably 100: 1 to 1: 20, more preferably 50: 1 to 1: 10, most preferably is 9: 1 to 1: 1.Generally speaking, the weight percentage of dimethachlon is 1～50% in the composition, and the weight percentage of Tebuconazole is 0.1～50%.

Synergistic bactericidal composition of the present invention can be mixed with various conventional formulations, as missible oil, suspending agent, wetting powder, granule, water dispersible granules, aqueous emulsion, suspension emulsion, microemulsion, paste, water surface leafing agent etc.Administration form depends on specific application; In all cases, must guarantee that their dispersion is trickle as much as possible and even.

These preparations can prepare in a known manner, for example by reactive compound is mixed with liquid flux and/or solid carrier, if desired, surfactant such as emulsifier, dispersant, wetting agent can be added simultaneously, thickener, defoamer, antifreeze, oxidant, dyestuff etc. can also be added.If use water as thinner, also available other organic solvent is made cosolvent.

The organic solvent that is fit to comprises aromatic compound (for example dimethylbenzene), chlorinated aromatic hydrocarbons compound (for example chlorobenzene), paraffin (for example petroleum distillate), alcohols (for example methyl alcohol, ethanol), ketone (for example cyclohexanone), amine (for example monoethanolamine, dimethyl formamide) etc.

The synthetic mineral matter (for example high molecular silicic acid, silicate etc.) that solid carrier commonly used has natural mineral matter (for example kaolin, talcum, bentonite, attapulgite) and grinds.

Surfactant can be emulsifier, dispersant or wetting agent; Material as dispersant and wetting agent has: sodium lignin sulfonate, draw back powder, calcium lignosulfonate and sldium lauryl sulfate, alkylol polyoxyethylene groups ether sodium sulfate, octylphenol polyethylene oxyethylene group ether sulfate, alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, sodium alkyl sulfonate, neopelex etc.

Sticker; can be for example carbonyl methylol, polyvinyl alcohol or the polyvinyl acetate that synthesizes; or natural water-soluble polymer; for example xanthans, gelatin, gum Arabic, phenolic resins, shellac, carboxymethyl cellulose and sodium alginate etc. add in the preparation with powder, particle or latex form.

Usually composition contains 0.01 to 90% active component by weight, and usually according to the difference of preparation type, preferably contains 20 to 30% active component by weight.

The application dosage of the present composition, the difference according to factors such as Different Crop, time of application, weather conditions is generally 50～300g a..i./ha, and preferred 150～300g a..i./ha generally adopts foliar spray.

Bactericidal composition of the present invention has the following advantages: the one, and this bactericidal composition shows fabulous synergistic effect in certain ratio range, mixed composition has obviously improved bactericidal effect than its single agent, thereby reduced application dosage, when reducing drug cost, reduced influence environment; The 2nd, enlarged fungicidal spectrum, a kind of medicament can be prevented and treated multiple diseases simultaneously.Synergistic bactericidal composition of the present invention all has good sterilization therapeutic action to rice sheath blight disease and false smut.

Embodiment

Following examples further describe the present invention, but never limit the scope of the present invention.Percentage all is weight percentage in the proportioning of all preparations; The treatment dosage of biologically-active moiety is effective content.

Example of formulations 1 23% dimethachlon Tebuconazole soluble liquid

Dimethachlon 3%,

Tebuconazole 20%,

Farming breast 0,203 10%,

DMF 30％，

Dimethylbenzene supplies 100%.

Take by weighing former medicine, solvent, emulsifier by above-mentioned prescription requirement, mix, use the hot bath heating for dissolving in case of necessity, promptly get soluble liquid.

Example of formulations 2 10.5% dimethachlon Tebuconazole missible oil

Dimethachlon 0.5%,

Tebuconazole 10%,

The newborn 0203B 10% of farming,

DMF 20％，

Fatty acid methyl ester supplies 100%

Take by weighing former medicine, solvent, emulsifier by above-mentioned prescription requirement, mix, use the hot bath heating for dissolving in case of necessity, promptly get transparence missible oil.

Example of formulations 3 70% dimethachlon Tebuconazole wetting powders

Dimethachlon 35%

Tebuconazole 35%

Lauryl sodium sulfate 1.5%

Carboxymethyl cellulose 1%

Sodium lignin sulfonate 10%

Precipitated calcium carbonate supplies 100%

By above-mentioned prescription requirement, former medicine, various auxiliary agent and filler etc. are fully mixed, after ultrafine crusher is pulverized, promptly obtain converted products.

Example of formulations 4 30% dimethachlon Tebuconazole aqueous suspension agents

Dimethachlon 15%

Tebuconazole 15%

The newborn 600# 3% of farming

OP-10 phosphate ester salt 4%

Polyvinyl alcohol 0.9%

Ethylene glycol 5%

Preservative 0.2%

Water supplies 100%

By above-mentioned prescription requirement, with former medicine, emulsifier and antifreeze, preservative, water, etc. mix, after high-speed stirred, sand milling 2 times forms the aqueous suspension agent of favorable dispersibility.

Example of formulations 5 70% dimethachlon tebuconazole water dispersible granules

Dimethachlon 24%

Tebuconazole 46%

Dispersant 4%

Poly-fumaric acid acrylic acid sodium sulfonate 6.9%

Speed collapses 5%

Suspending agent 2.2%

Filler supplies 100%

Water-dispersible granules also claims dry suspending agent sometimes, is a kind of disintegration dispersion fast in water, and can makes active ingredient form the spheroidizing formulation of higher suspension state in water.Water-dispersible granules is environmentally friendly, can reduce the pollution of chemical pesticide to environment to greatest extent.The water-dispersible granules Recipe requires high, and manufacturing procedure is comparatively complicated.The water-dispersible granules production technology has diversity, and have spray drying process, fluid-bed drying, freeze-drying, the fluidized bed process that adopt are usually at present mediated extrusion etc.

Biological Examples 1 synergy test

Measure bactericide dimethachlon, Tebuconazole and Different Weight EC with Sun Yunpei (1960) co-toxicity coefficient method than combination ₅₀And relative virus force index (TI), and be calculated as follows theoretical toxicity index (TTI) of mixture and mixture co-toxicity coefficient (CTC):

The active ingredient percentage of toxicity index * A medicine in mixture of the theoretical toxicity index of mixture=A medicine

The active ingredient percentage of the toxicity index of+B medicine * B medicine in mixture

+……

The result is as shown in table 1:

Table 1 dimethachlon, Tebuconazole and mixture thereof are to the toxicity test of Rhizoctonia solani Kuhn

Medicament (weight ratio)	Y＝a+bx	LC 50(μg/ml)	Co-toxicity coefficient
				Tebuconazole	Y＝1.3654+1.5664x	208.3	-
Dimethachlon	Y＝1.2189+1.2816x	861.2	-
				Tebuconazole: dimethachlon (1: 1)	Y＝0.1416+2.0681x	219.9	153
Tebuconazole: dimethachlon (3: 2)	Y＝2.7928+0.9830x	176.8	169
				Tebuconazole: dimethachlon (7: 3)	Y＝1.7513+1.5038x	142.5	189
Tebuconazole: dimethachlon (8: 2)	Y＝2.2430+1.3014x	128.3	192
				Tebuconazole: dimethachlon (9: 1)	Y＝1.8806+1.4926x	120.7	187

As shown in Table 1, the present invention's bactericidal composition of containing dimethachlon and Tebuconazole has obvious synergistic effect.

Biological Examples 2 control rice green smut tests

Sample A: dimethachlon Tebuconazole WG (example of formulations 5), the Zhejiang Weir reaches company; Contrast: 20% jinggangmeisu WP, Zhejiang Qian Jiang biochemistry Co., Ltd;

Place: Zhejiang Jiaxing; Dispenser period: late tillering state preceding 2～3 days of cut, the false smut initial phase; Investigation: behind the medicine 30 days; Time: on July 15th, 2008.

The result is as shown in table 2 below.

30 days each chemicals treatment are to the control efficiency of false smut behind table 2 medicine

Conclusion: three of sample A WG all have good control efficiency for examination concentration to rice green smut, and 7 days, 14 days preventive effect is compared with contrast medicament jinggangmeisu and all reached utmost point significance level behind particularly 6500 times, 3000 times secondary medicines.

Biological Examples 3 is prevented and treated the rice sheath blight disease test

Sample A: dimethachlon Tebuconazole WG sample (example of formulations 5), the Zhejiang Weir reaches company; Contrast: 20% jinggangmeisu WP, Jiangsu distillation biochemistry Co., Ltd;

Place: the Land of Peach Blossoms, Hunan; Dispenser period: late tillering state, banded sclerotial blight initial phase; Investigation: behind the secondary medicine 7 days; Time: on June 21st, 2008.

The result is as shown in table 4 below.

7 days each chemicals treatment are to the control efficiency of rice sheath blight disease behind the table 3 secondary medicine

Conclusion: three of sample A WG all have good control efficiency for examination concentration to rice sheath blight disease, and 7 days, 14 days preventive effect is compared with contrast medicament jinggangmeisu and all reached utmost point significance level behind particularly 6500 times, 3000 times secondary medicines.

Claims (2)

1. bactericidal composition it is characterized in that containing the Tebuconazole and the dimethachlon of synergy effective dose, and the weight ratio of Tebuconazole and dimethachlon is 9:1～1:1.

2. the bactericidal composition of claim 1 is used to prevent and treat the purposes of rice sheath blight disease and false smut.