CN100337731C - 使用浓缩水相生产个人护理产品的方法 - Google Patents
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- CN100337731C CN100337731C CNB2003801062363A CN200380106236A CN100337731C CN 100337731 C CN100337731 C CN 100337731C CN B2003801062363 A CNB2003801062363 A CN B2003801062363A CN 200380106236 A CN200380106236 A CN 200380106236A CN 100337731 C CN100337731 C CN 100337731C
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- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
- Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
- Y10S516/929—Specified combination of agitation steps, e.g. mixing to make subcombination composition followed by homogenization
Abstract
本发明涉及一种生产个人护理组合物的方法，该方法可以是连续的。该方法包括：将含有几乎所有该组合物的水溶性组分的浓缩物形式的第一水相加入共混管中。将第二相和第三水相也加入共混管中，其中第二相可以是油性的或含水的，第三水相基本上是纯水。所有相经由共混管以10—5000psi的压力和5—5000lbs/分钟的流速送入共混管中。优选，该共混管通向均化器例如sonolator。
Description
技术领域
本发明涉及一种生产液体个人护理产品的方法，该方法使设备需要最小化、提高了容量和减少了生产时间。
背景技术
最广泛使用的液体型个人护理产品是洗发剂、淋浴凝胶和护肤液。通常，这些产品各自以各种颜色、不同的香料和促进(promotional)组分销售。仍然在寻求生产它们的更有效的方法。
特别需要能使设备需求最小化、提高容量和降低配制时间的体系。
发明内容
在第一方面，本发明涉及一种生产个人护理组合物的方法，包括：
(i)将粘度为约50-30,000厘泊(cps)的第一水相加入共混管中；
(ii)将第二相加入共混管中；
(iii)将粘度小于30厘泊的第三相加入共混管中，所述第三相占该组合物的至少约15％；
(iv)将所有三相混合在一起，每个相作为液体料流在约10-5000psi的压力和约2.274-2270kg(5-约5000磅)/分钟的流速下被泵入共混管中；和
(v)将所得混合物作为个人护理组合物回收。
本发明还涉及以下实施方案：
1、一种生产个人护理组合物的方法，包括：
(i)将粘度为50-30,000厘泊的第一水相加入共混管中，所述第一水相包含基于第一相的大于5重量％的除水之外的其它组分；
(ii)将第二相加入共混管中，所述第二相或者是油相，或者是表面活性剂总含量是占第二相的15-90重量％的水相；
(iii)将第三相加入共混管中，所述第三相的粘度小于30厘泊，且包含基于第三相的不大于10重量％的除水之外的其它组分，所述第三相占该组合物的至少15％，其中第一相与第三相按照1∶1至1∶40的相对重量比加入共混管中；
(iv)将所有三相混合在一起，每个相作为液体料流在10-5000psi的压力和2.274-2270kg/分钟的流速下被泵入共混管中；和
(v)将所得混合物作为个人护理组合物回收。
2、根据实施方案1的方法，其中第一相包含基于第一相的大于40重量％的除水之外的其它组分。
3、根据实施方案1的方法，其中第一相与第三相按照1∶1至1∶10的相对重量比加入共混管中。
4、根据实施方案1的方法，其中第三相包含基于第三相的不大于2重量％的除水之外的其它组分。
5、根据实施方案1的方法，其中共混管的体积是0.0016387-1638.7cm3。
6、根据实施方案1的方法，其中共混管的体积是0.16387-81.94cm3。
7、根据实施方案1的方法，其中各相的混合是通过声波搅拌进行。
8、根据实施方案1的方法，其中进入该管的第一相的温度比进入该管的第二相低至少5℃。
9、根据实施方案1的方法，其中第一、第二和第三相在100-1000psi的压力下被泵入该管。
附图说明
本发明的优点和特征将结合附图更明显，其中：
图1是本发明方法的第一个实施方案的示意图；和
图2是本发明方法的第二个实施方案的示意图。
具体实施方式
现在发现对于个人护理组合物的生产可以达到显著的生产效率。这种进步是基于在第一水相浓缩物中引入大部分在最终个人护理组合物中的任何水溶性组分。该浓缩物然后与第二相共混。当最终的个人护理组合物是乳液例如护肤乳时，第二相将是油相。其它不含油相的产品例如洗发剂将用含水的并含有一种或多种表面活性剂的第二相生产。第三相提供额外的水。一般，第三相将纯粹是水，但有时可以携带少量的其它组分。
所有三相在管中共混。在本发明中，术语“共混管”可以包括用于所有三相在一起混合的任何室、容器和管道。一般，共混管的体积是较小的。该体积可以是约0.0016387-1638.7cm3(0.0001-约100立方英寸)，优选0.016387-327.74cm3(0.001-约20立方英寸)，更优选0.16387-81.94cm3(0.01-约5立方英寸)，和最好是约1.6387-16.387cm3(0.1-约1立方英寸)。
虽然大多数水被从第一水相浓缩物中排除，但是大多数水溶性组分仍然可以放入溶液或被悬浮。发现保持容器/共混容器的益处是比常规非浓缩方法的尺寸显著更小。较小的混合设备是必要的，且需要较小的容器空间。顶部排出的额外水(第三)相形式的水再次构成混合时的浓缩物。一般对于制备第三(水)相不是必须使用保持罐或混合器。该相可以直接从任何水源例如井或城市水车泵入共混管中。
第一水相浓缩物的粘度将显著高于第三(水)相的粘度。更具体地说，第一水相的粘度是约50-30,000厘泊，优选约150-20000厘泊，最好是约300-5000厘泊，该粘度是使用Brookfield RVT Viscosmeter用No.RV6转子在20rpm下于25℃检测1分钟测得的。
第三(水)相通常实际上不含其它添加剂。该相的粘度通常小于5厘泊，优选约1-4厘泊，该粘度是使用Brookfield RVT Viscosmeter用No.RV6转子在20rpm下于25℃检测1分钟测得的。
图1是本发明方法的流程图。浓缩的第一水相2在罐4内配制。浓缩物的再次形成可以需要纯水重量的2-50倍以达到所需要的组成。第一相经由泵6从管道输送到共混管8。
第二相10保持在罐12内。通常当所需要的组合物是皮肤护理产品时，该制剂将是需要水相和油相的乳液。在这种情况下，第二相将是油相。产品例如洗发剂和淋浴凝胶通常不需要油相。对于这些类型的产品，第二相将是含水的，通常输送一种或多种表面活性剂。表面活性剂在洗发剂和淋浴凝胶中的含量通常大于10％。所以，这些类型的产品可以使用含水的第二相，其可以包括的表面活性剂总含量是占第二相的约15-90重量％，优选约25-75重量％。
第二相输送到共混管中的操作是用泵14调节。典型的泵可以是Triplex Cat或Progressive Cavity Pumps(来自Moyno/Seepex)。
第三相16通常仅仅由水构成，但是有时可以含有一些添加剂，第三相也被加入共混管中。输送是通过泵18促进的。后者可以是Moyno/Seepex Progressive Cavity泵，Waukesha或Positive Displacement泵。
在离开共混管8之后，相2、10和16的结合物进入Sonolator20，它作为均化器操作，将所有相在高压和剪切下完全混合在一起。所得的流体然后通过背压阀22输送。在下游，三向阀门24将大部分产品输送到储罐或直接输送到包装填充器26。一般，少量产品经由三向阀门被输送到再操作储器28，用于经由泵30再循环到第一相的料流中。再操作的量可以是从共混管已经从Sonolator排出的总产品的0-50％，优选1-20％，最好是约5％。
典型的是，该方法包括在第一反应器中形成第一水相，其中各组分混合并保持在约10-70℃，优选约18-58℃，最好是约24-52℃。在大多数、但不是全部情况下，优选第一相的温度比互相混合时第二相(特别是该相是油相时)温度低至少约5℃，优选至少约11℃。
第二相将在反应器中通过将各组分在约10-150℃、优选约40-165℃、最好约66-95℃的温度下混合形成。
第三相可以保持在约0-57℃、优选约5-45℃、最好约15-38℃的温度。
第二相的粘度是使用Brookfield RVT Viscosmeter用No.RV6转子在20rpm下于25℃检测1分钟测得的，可以是约50-200,000厘泊，优选约1000-100000厘泊，最好是约5000-50000厘泊。
最终个人护理产品的粘度通常是约1000-30,000厘泊，优选约5000-30000厘泊，最好是约10000-25000厘泊，是使用Brookfield RVTViscosmeter用No.RV6转子在20rpm下于25℃检测1分钟测得的。
将来自含有第一和第二相的流体输送到共混管8中的操作可以通过一对电控制的伺服驱动(servo-driven)旋转泵进行。流量的小心控制是通过使用来自Oden Corporation的共混阀由E&H质流计监控进行的。该设备可以包括静态混合元件和背压阀。
第一水相和第二相进入共混管8的流速可以是约2.274-2270kg(5-约5000lbs)/分钟。优选该流速是约22.7-454kg(50-约10001bs)/分钟，最好是约68.10-363.20kg(150-约800lbs)/分钟。
共混管8的几何结构应该使得共混的第一、第二和第三相的停留时间是约0.0001秒到约5分钟，优选约0.001-120秒，最好是约0.01-10秒。
在第二相是油相的体系中，在共混管8中的乳液温度通常应该低于第二(油)相离开反应罐时的温度。典型的在共混管8中的乳液温度是约10-82℃、优选约27-65℃、最好是约35-55℃。
在优选的实施方案中，油相和水相(第一相和第三相)在较高的压力下泵送，该压力可以是约10-5000psi，优选约100-1000psi，最好是约150-250psi。
在优选的实施方案中，第二相在100-1000psi的压力下泵入共混管。
在本发明的一个实施方案中，油相和第一水相从各自的反应器经由正位移进料泵例如Waukesha PD Gear Pump输送。然后，每个相经由高压泵例如来自Giant Corporation，Toledo，Ohio或来自CatCorporation的三缸柱塞型泵输送。由此，每个水相和油相被加入共混管8，其中在优选实施方案中，共混管8是来自Sonic Corporation，General Signal的Sonolator。
Sonolator是一种在线设备，能将高速度液体料流的动能转化为高强度混合作用。这种转化是通过将液体经由在液体注射流中的叶片状挡板上的孔隙泵送完成的。液体本身按照静态旋涡方式振动，这进而引起叶片状档板共振，导致高度的空穴、湍动和剪切。叶片或刀片通过流体运动形成超声波振动，引起液体中的空穴。
而除sonolator之外，供应高压的均化器是从APV MantonCorporation获得的Manton Gaulin型均化器，和从MicfofluidicsCorporation获得的Microfluidizer。这些类型的高压均化器含有压在固定阀座上阀门(水利学或通过弹簧)。在高压下，流体流过阀座中的开孔，然后经过有阀门和阀座之间的间隙。尽管不同高压均化器的几何形状可以在细节上不同和甚至可以用锋利刀刃粗糙化，但是它们通常是相似的。通常，高压均化器可以包括两个或更多个阀门-阀座的组合。
第一水相(浓缩物)与第三(水)相的重量比将取决于个人护理组合物的类型和特别是制剂组分。该重量比可以是约1∶1至约1∶40，优选约1∶1至约1∶10，最好是约1∶1至约1∶6。
第一水相和第二相的重量比是约50∶1至约1∶50，优选约10∶1至约1∶10。
通常，第三相将仅仅由水构成。但是，在某些情况下，该相可以含有少量的添加剂(除水之外的其它组分)。通常，这些添加剂的量将占第三相的不超过10重量％，优选不超过5重量％，最好不超过2重量％。相比之下，第一水相(浓缩物)通常可以包含大于5重量％、优选大于10重量％、最优选大于15重量％和最好大于40重量％的除水之外的浓缩物组分。
图2显示对于图1所示方法略微改进的方法。改进之处包括将水中的增稠剂作为第四相32经由泵34加入共混管。通常，增稠剂可以通过第一相配制。但是，一些类型的最终产品需要特别地粘。对于这些情况，发现单独的相更能有效地引入较大量的增稠剂。
本发明的个人护理组合物可以包括洗发剂、淋浴凝胶、洗手液、液体洗牙组合物、护肤液和护肤霜、头发着色剂、洗面剂以及在擦拭制品上被吸收的浸渍液体。
通常，第一相和/或第二相将含有表面活性剂。有用的表面活性剂包括非离子、阴离子、阳离子、两亲性、两性离子表面活性剂及其组合。表面活性剂的总量是个人护理组合物总量的约0.1-50重量％，优选约2-40重量％，最好是约15-25重量％。
适合的非离子表面活性剂的非限定性例子包括与2-100摩尔环氧乙烷或环氧丙烷/摩尔疏水物质缩合的C10-C20脂肪醇或酸疏水物质；与2-20摩尔氧化烯缩合的C2-C10烷基酚；乙二醇的单-和二-脂肪酸酯，例如乙二醇二硬脂酸酯；脂肪酸单甘油酯；脱水山梨醇单-和二-C8-C20脂肪酸；和作为Polysorbate 80和Tween 80获得的聚氧乙烯脱水山梨醇，以及上述任何表面活性剂的组合。
其它有用的非离子表面活性剂包括烷基聚苷(APG)，糖脂肪酰胺(例如甲基葡糖酰胺)以及长链氧化叔胺。长链氧化叔胺的例子是：二甲基十二烷基氧化胺，油基二(2-羟基乙基)氧化胺，二甲基辛基氧化胺，二甲基癸基氧化胺，二甲基十四烷基氧化胺，二(2-羟乙基)十四烷基氧化胺，3-双十二烷氧基-2-羟丙基二(3-羟丙基)氧化胺，以及二甲基十六烷基氧化胺。
阴离子表面活性剂的非限定性例子包括以下：
(1)烷基苯磺酸盐，其中在直链或支链结构中的烷基含有9-15个碳原子，优选11-14个碳原子。特别优选的是在烷基链中含有约12个碳原子的直链烷基苯磺酸盐。
(2)通过将具有8-22个碳原子、优选12-16个碳原子的醇硫酸盐化获得的烷基硫酸盐。烷基硫酸盐具有式ROSO3-M+，其中R是C8-C22烷基，M是单-和/或二价阳离子。
(3)在烷基结构部分中具有8-22个碳原子、优选12-16个碳原子的链烷烃磺酸盐。
(4)具有8-22个碳原子、优选12-16个碳原子的烯烃磺酸盐。最优选的是C14-C16烯烃磺酸钠，作为Bioterge AS 40获得。
(5)烷基醚硫酸盐，其从具有8-22个碳原子、优选12-16个碳原子的醇衍生，被小于30摩尔、优选小于12摩尔的环氧乙烷乙氧基化。最优选的是被2摩尔平均乙氧基化的月桂基醚硫酸钠，作为Standopol ES-2获得。
(6)在烷基结构部分中具有8-22个碳原子、优选12-16个碳原子的烷基甘油基醚磺酸盐。
(7)式R1CH(SO3-M+)CO2R2的脂肪酸酯磺酸盐，其中R1是约C1-C18、优选C12-C16的直链或支链烷基，R2是约C1-C6、优选C1的直链或支链烷基，M+表示单-或二价阳离子。
(8)具有6-18个碳原子、优选8-16个碳原子的仲醇硫酸盐。
(9)具有10-22个碳原子的脂肪酰基、羟乙基磺酸盐，其中可可酰基羟乙基磺酸钠是优选的。
(10)单-和二-烷基磺基琥珀酸盐，其中烷基各自含有3-20个碳原子。
(11)烷酰基肌氨酸盐，对应于式RCON(CH3)CH2CH2CO2M，其中R是约10-20个碳原子的烷基或链烯基，M是水溶性阳离子，例如铵、钠、钾和三链烷醇铵。最优选的是月桂酰基肌氨酸钠。
阳离子表面活性剂例如是C8-C22烷基C1-C4二烷基铵盐，例如十六烷基二甲基氯化铵，硬脂基二甲基硫酸二甲铵，油基二乙基磷酸铵，和月桂基二甲基硼酸铵。特别优选的是cetrimonium chloride，它是十六烷基二甲基氯化铵的通用名。
用于本发明的两亲性表面活性剂包括甜菜碱，其具有通式RN+(R1)2R2-COO-，其中R是疏水结构部分，选自含有10-22个碳原子、优选12-18个碳原子的烷基；含有10-22个碳原子的烷基芳基和芳基烷基，其中苯环被认为等价于约2个碳原子，和被酰氨基或醚键中断的相似结构处理；每个R1是含有1-3个碳原子的烷基；R2是含有约1-6个碳原子的亚烷基。磺基甜菜碱例如可可酰氨基丙基羟基磺基甜菜碱也是合适的。
优选的甜菜碱例如是十二烷基二甲基甜菜碱，十六烷基二甲基甜菜碱，十二烷基酰氨基丙基二甲基甜菜碱，十四烷基二甲基甜菜碱，十四烷基酰氨基丙基二甲基甜菜碱，和十二烷基二甲基己酸铵。最优选的是可可酰氨基丙基甜菜碱，作为Tegobetaine F由德国的Th.Goldschmidt AG销售。
多元醇通常存在于本发明的水相中。典型的多元醇包括甘油(已知的glycerin)，聚亚烷基多元醇和更优选亚烷基多元醇以及它们的衍生物，包括丙二醇、二丙二醇、聚丙二醇、聚乙二醇及其衍生物，山梨醇，羟丙基山梨醇，己二醇，丁二醇，1，2，5-己三醇，乙氧基化甘油，丙氧基化甘油以及它们的混合物。最优选的是甘油。多元醇的用量可以是个人护理组合物总量的约0.5-50重量％，优选约1-15重量％。
增稠剂/增粘剂也可以包括在第一水相和/或在独立的第四水相中，其用量是个人护理组合物总量的约0.01-10重量％。如本领域技术人员熟知的那样，增稠剂的精确用量可以根据所需要的组合物的稠度和厚度变化。增稠剂例如是黄原胶、羧甲基纤维素钠、羟烷基和烷基纤维素(特别是羟丙基纤维素)，和交联的丙烯酸聚合物，例如作为Carbopol由B.F.Goodrich销售的那些。
增稠剂例如改性淀粉和粘土也可以用于增稠水相。例如，淀粉辛烯基琥珀酸铝(作为DryFlo从National Starch and ChemicalCompany获得)是特别有用的。粘土包括硅酸铝镁(作为Veegum获得)、锂蒙脱石粘土、蒙脱土粘土、膨润土(例如Bentone38)以及它们的混合物。
水溶性调节剂也可以加入水相中。单体和聚合物形式的阳离子试剂特别用于此目的。阳离子纤维素衍生物、阳离子淀粉、二烯丙基季铵盐和丙烯酰胺共聚物、季化乙烯基吡咯烷酮乙烯基咪唑聚合物、聚二醇胺缩合物、季化胶原多肽、聚乙烯亚胺、阳离子化有机硅聚合物(例如Amodimethicone)、商品名为Dow Corning 929的与其它组分的混合物形式的阳离子有机硅聚合物(阳离子化乳液)、己二酸和二甲基氨基羟丙基二亚乙基三胺的共聚物、阳离子甲壳质衍生物、阳离子瓜尔胶(例如JaguarC-B-S，JaguarC-17，JaguarC-16)和季铵盐聚合物(例如MirapolA-15，MirapolAD-1，MirapolZA-1等，由Miranol Division of the Rhone Poulenc Company生产)。
单体阳离子调节剂例如是下面通式结构的盐：
其中R1是选自具有12-22个碳原子的烷基，或者具有12-22个碳原子的芳族、芳基或烷芳基团；R2、R3和R4是独立地选自氢，具有1-22个碳原子的烷基，或者具有12-22个碳原子的芳族、芳基或烷芳基团；X-是阴离子，选自氯离子、溴离子、碘离子、乙酸根、硝酸根、硫酸根、甲基硫酸根、乙基硫酸根、甲苯磺酸根、乳酸根、柠檬酸根、甘醇酸根以及它们的混合物。另外，烷基还可以含有醚键或氨基取代基(例如烷基可以含有聚乙二醇和聚丙二醇结构部分)。
本发明的乳液形式的组合物可以是油包水或水包油型，但是优选水包油型。乳液中水相与油相的相对重量比可以是约1000∶1至约1∶10，优选约100∶1至约1∶5，最好是约10∶1至约1∶2，按照个人护理组合物总量计。
通常在第一水相中和有时在其它水相中存在的另一种组分是防腐剂。它们被引入以防止潜在有害微生物的生长。合适的常规防腐剂是EDTA盐和对羟基苯甲酸的烷基酯。其它最近使用的防腐剂包括乙内酰脲衍生物、丙酸盐以及各种季铵化合物。化妆品领域的化学家熟知适宜的防腐剂，通常选择它们以满足防腐实验和提供产品稳定性。
特别优选的防腐剂是氨基甲酸碘代丙炔基丁基酯，苯氧基乙醇，对羟基苯甲酸甲酯，对羟基苯甲酸丙酯，咪唑烷基脲，脱氢乙酸钠和苄基醇。防腐剂应该根据组合物的使用和在防腐剂与组合物中其它组分之间可能的不相容性进行选择。防腐剂的用量通常是个人护理组合物总量的约0.01-2重量％。
当第二相是油相时，它通常含有疏水性组分。通常，油相中将引入润肤剂，可以选自烃、有机硅以及合成或植物的酯。润肤剂的用量在任何时候可以是个人护理组合物总量的约0.1-30重量％，优选约0.5-10重量％。
适用于本发明的烃包括异链烷烃、矿物油、矿脂和烃蜡例如聚乙烯类。
有机硅可以分为挥发性和非挥发性的类型。这里使用的术语“挥发性”表示在环境温度下具有可测量的蒸气压的那些物质。挥发性硅油优选选自含有约3-9个、优选约4-5个硅原子的环状或线型聚二甲基硅氧烷。
用作润肤材料的非挥发型有机硅包括聚烷基硅氧烷，聚烷基芳基硅氧烷和聚醚硅氧烷共聚物。这里使用的基本非挥发型的聚烷基硅氧烷包括例如25℃下的粘度为约5-100000厘沲的聚二甲基硅氧烷。
合适的酯类润肤剂是：
(1)具有10-20个碳原子的脂肪酸的链烯基或烷基酯。例子包括棕榈酸异丙酯，异壬酸异壬酯，十四烷酸油基酯，硬脂酸油基酯，硬脂酸十六/十八醇酯和油酸油基酯。
(2)醚酯类，例如乙氧基化脂肪醇的脂肪酸酯。
(3)多元醇酯。合适的多元醇酯是乙二醇单-和二-脂肪酸酯，二甘醇单-和二-脂肪酸酯，聚乙二醇(200-6000)单-和二-脂肪酸酯，丙二醇单-和二-脂肪酸酯，聚丙二醇2000单油酸酯，聚丙二醇2000单硬脂酸酯，乙氧基化丙二醇单硬脂酸酯，甘油单-和二-脂肪酸酯，聚甘油脂肪酸酯，乙氧基化甘油单硬脂酸酯，1，3-丁二醇单硬脂酸酯，1，3-丁二醇二硬脂酸酯，聚氧化乙烯多元醇脂肪酸酯，脱水山梨醇脂肪酸酯，以及聚氧乙烯脱水山梨醇脂肪酸酯。
(4)蜡酯，例如蜂蜡、鲸蜡、肉豆蔻酸肉豆蔻酯、硬脂酸硬脂基酯。
(5)甾族酯，例如是大豆甾醇和胆甾醇脂肪酸酯。
最优选的植物酯润肤剂是葵花籽油、大豆甾醇酯、琉璃苣籽油、马来酸化豆油、蔗糖聚棉籽油、tribehenin、蔗糖聚山萮酸酯以及它们的混合物。
脂肪酸也可以包括在油相中。这些脂肪酸可以具有10-30个碳原子。它们例如是壬酸、月桂酸、肉豆蔻酸、棕榈酸、硬脂酸、异硬脂酸、羟基硬脂酸、油酸、亚油酸、蓖麻酸、花生酸、山萮酸和芥酸。其用量可以是个人护理组合物总量的0.1-25重量％。
香料、着色剂和促进组分也可以包括油相和任何水相中。本发明的着色剂例如包括红No.4、红No.40和FD&C着色剂红No.3、红No.6、红No.28、红No.33、蓝No.1、绿No.5、黄No.5，它们都是水溶性的。也可以使用油溶性染料，例如绿No.6和D&C紫No.2。这些着色剂的活性含量可以是个人护理组合物总量的约0.0001-1重量％，优选约0.001-0.1重量％。
术语“香料”定义为有气味组分的混合物，任选与合适的溶剂、稀释剂或载体混合，用于赋予所需要的气味。
香料组分及其混合物可以从天然产品获得，例如精油、净油、香树脂、树脂和浓缩物，以及从合成产品获得，例如烃、醇、醛、酮、醚、羧酸、酯、缩醛、缩酮、腈等，包括饱和和不饱和的化合物，脂族、碳环和杂环化合物。
合适的用于上述香料组分的溶剂、稀释剂或载体是例如：乙醇、异丙醇、二甘醇单乙醚、二丙二醇和柠檬酸三乙脂。
特别优选的香料组分是环状和无环的萜烯和萜类化合物。这些材料是基于异戊二烯重复单元。例子包括α-和β-蒎烯、月桂烯、香叶醇和乙酸香叶酯、莰烯、dl-宁烯、α-和β-水芹烯、三环烯、萜品油烯、allocimmane、香叶醇、橙花醇、里哪醇(linanool)、二氢里哪醇、柠檬醛、紫罗兰酮、甲基紫罗兰酮、香茅醇、香茅醛、α-萜品醇、β-萜品醇、α-小茴香醇、冰片、异冰片、樟脑、萜品烯-1-醇、萜品-4-醇、二氢萜品醇、甲基佳味酚、茴香脑、1，4和1，8-桉树脑、香叶基腈、乙酸异冰片酯、乙酸里哪基酯、石竹烯、α-柏木烯、愈创醇、绿叶醇、α-和β-檀香醇以及它们的混合物。
香料的量可以是约0.00001-2％，优选约0.0001-1％，最好是约0.01-0.5％，最优选是约0.05-0.25％，基于个人护理组合物的重量。
维生素是促进组分的例子。这些包括维生素A(视黄醇)、维生素A衍生物(棕榈酸视黄基酯、亚油酸视黄基酯、乙酸视黄基酯和视黄酸)、维生素C、维生素C衍生物(例如四异棕榈酸抗坏血基酯和磷酸抗坏血基镁)、维生素E、维生素E衍生物(例如乙酸生育酚酯)、生物素、烟酸和DL-泛醇以及它们的混合物。
促进组分的用量可以是最终个人护理组合物总量的约0.00001-2重量％，优选约0.0001-1重量％，最好是约0.001-0.5重量％。
组合的第一和第三水相可以构成最终个人护理组合物总量的约5-99.5重量％，优选约20-90重量％，更优选约35-80重量％，最好是约45-70重量％。
组合的第一和第三水相将含有水作为主要组分。通常，水的量可以构成第一和第三水相组合总量的约30-99.9重量％，优选约50-95重量％，更优选约65-80重量％，最好是约55-70重量％。
术语“包含”表示不限于任何随后陈述的元素，而且包括没有指出的主要和次要的元素。换句话说，列出的步骤、元素或选择不是穷尽性的。在使用术语“包括”或“具有”时，它们表示相当于上面定义的“包含”的意义。
实施例
除了在操作实施例和对比实施例中或除了另有说明，所有本说明书中表示物质的量的数字应该理解为包括“约”。
以下实施例将更完全地说明本发明的实施方案。在这里和所附权利要求中的所有份数、百分比和比例都以重量计，除非另有说明。
实施例1
制备一对护肤液以反映2X和10X水平的浓缩物。这两种具有适量添加水的浓缩物都能获得具有表I所示的所得组合物。
表I
| 相 | 组分名称 | 所得组合物(2个料流) | 2X(3个料流) | 10X(4个料流) |
| 油相 | 硬脂酸 | 2.0217 | 2.0217 | 2.0217 |
| 硬脂酸二醇酯/硬脂酰胺AMP | 1.1939 | 1.1939 | 1.1939 | |
| 单硬脂酸甘油酯 | 0.5572 | 0.5572 | 0.5572 | |
| 十六醇 | 0.3184 | 0.3184 | 0.3184 | |
| 矿脂 | 0.5 | 0.5 | 0.5 | |
| 矿物油 | 1.4 | 1.4 | 1.4 | |
| 聚二甲基硅氧烷 | 0.3 | 0.3 | 0.3 | |
| 水相 | 水 | 79.4078 | 32.5534 | 3.1699 |
| EDTA四钠 | 0.1017 | 0.1017 | 0.1017 | |
| 硅酸铝镁 | 0.2 | 0.2 | 0.2 | |
| 甘油 | 3.5 | 3.5 | 3.5 | |
| 对羟基苯甲酸甲酯 | 0.1425 | 0.1425 | 0.1425 | |
| 二氧化钛(可水分散的) | 0.1 | 0.1 | 0.1 | |
| Carbopol 934(2％活性，在水中) | 9 | 9 | 0 | |
| 三乙醇胺 | 0.7568 | 0.7568 | 0.7568 | |
| Aloe Vera Gel | 0.09 | 0.09 | 0.09 | |
| DMDM乙内酰脲 | 0.25 | 0.25 | 0.25 | |
| 香料 | 0.16 | 0.16 | 0.16 | |
| 仅有水 | - | 46.8544 | 76.2379 | |
| 仅有Carbopol934 | - | - | 9 |
油相和水相各自独立地装在相应的第一罐和第二罐中。在逐步模腔泵(来自Moyno/Seepex)的帮助下，这些相分别经由管道加入Sonolator的共混管前室部分。组合的流速精确地保持在200psi下的9.08kg(20lbs)/分钟。水相浓缩物保持在24-52℃的温度，罐的容量是约3000加仑。油相在250加仑的罐中保持在65-93℃的温度。
从第三个罐，2X浓缩物实验中输送第三料流，该料流是在与第一水相和油相相同的压力下调节的纯水。纯水相保持在15-38℃的温度，并泵入Sonolator的共混管前室部分。所有相然后在Sonolator中在500psi下均化。然后，组合的料流被送入储存容器，在那里所得产品保持在24-44℃。一部分所得的护肤液组合物通过正位移泵作为回流泵入Sonolator的共混管中。这种回流的量对于新开始时或作为再操作产品而言是约5％保留在贮存容器中的组合物被送至包装线上以填充空瓶。
10X浓缩物使用水/增稠剂的第四料流(Carbopol 934)。第四料流以相似的压力和流速(与其在最终组合物中的比例成比例)泵送入Sonolator的共混管前室中。所有其它加工与上述对于2X浓缩物所描述的相同。
实施例2
制备一组干性皮肤调理液以反映2X、4X和6X水平的浓缩物。这三种具有适量添加水的浓缩物都能获得具有表II所示的所得组合物。
表II
| 相 | 组分名称 | 所得组合物(2个料流) | 2X(3个料流) | 4X(3个料流) | 6X(3个料流) |
| 油相 | 硬脂酸 | 2.54 | 2.54 | 2.54 | 2.54 |
| 硬脂酸二醇酯/硬脂酰胺AMP | 1.5 | 1.5 | 1.5 | 1.5 | |
| 单硬脂酸甘油酯 | 0.7 | 0.7 | 0.7 | 0.7 | |
| 十六醇 | 0.4 | 0.4 | 0.4 | 0.4 | |
| 葵花籽油 | 1.25 | 1.25 | 1.25 | 1.25 | |
| 硅油200 | 0.26 | 0.26 | 0.26 | 0.26 | |
| 大豆甾醇 | 0.08 | 0.08 | 0.08 | 0.08 | |
| 乙酸维生素E | 0.01 | 0.01 | 0.01 | 0.01 | |
| 卵磷脂 | 0.04 | 0.04 | 0.04 | 0.04 | |
| 硬脂酰基乳酸钠 | 0.1 | 0.1 | 0.1 | 0.1 | |
| 矿脂 | 0.9375 | 0.9375 | 0.9375 | 0.9375 | |
| 棕榈酸甲酯 | 0.3125 | 0.3125 | 0.3125 | 0.3125 | |
| 水相 | 水 | 81.6605 | 35.7205 | 12.7605 | 5.1005 |
| 甘油 | 5.5 | 5.5 | 5.5 | 5.5 | |
| EDTA二钠 | 0.05 | 0.05 | 0.05 | 0.05 | |
| 无机共混物 | 0.001 | 0.001 | 0.001 | 0.001 | |
| 硅酸铝镁 | 0.2 | 0.2 | 0.2 | 0.2 | |
| 燕麦蛋白质 | 0.001 | 0.001 | 0.001 | 0.001 | |
| 对羟基苯甲酸甲酯 | 0.1425 | 0.1425 | 0.1425 | 0.1425 | |
| 二氧化钛(水可分散的) | 0.1 | 0.1 | 0.1 | 0.1 | |
| Carbopol 934(2％活性) | 3 | 3 | 3 | 3 | |
| 三乙醇胺 | 0.813 | 0.813 | 0.813 | 0.813 | |
| DMDM乙内酰脲 | 0.25 | 0.25 | 0.25 | 0.25 | |
| 香料 | 0.15 | 0.15 | 0.15 | 0.15 | |
| 维生素A硬脂酸酯 | 0.001 | 0.001 | 0.001 | 0.001 | |
| 角蛋白 | 0.001 | 0.001 | 0.001 | 0.001 | |
| 总量 | 91.87 | 15.31 | |||
| 仅有水 | - | 45.94 | 68.9 | 76.56 |
油相和水相各自独立地装在相应的第一罐和第二罐中。在逐步模腔泵(来自Moyno/Seepex)的帮助下，这些相分别经由管道加入Sonolator的共混管前室部分。组合的流速精确地保持在800psi下的22.7kg(50lbs)/分钟。水相浓缩物保持在24-52℃的温度，罐的容量是约5000加仑。油相在250加仑的罐中保持在65-93℃的温度。
从第三个罐，2X浓缩物实验中输送第三料流，该料流是在与第一水相和油相相同的压力下调节的纯水。纯水相保持在15-38℃的温度，并泵入Sonolator的共混管前室部分。所有相然后在Sonolator中在1000psi下均化。然后，组合的料流被送入储存容器，在那里所得产品保持在24-44℃。一部分所得的干性皮肤护理液组合物通过正位移泵作为回流泵入Sonolator的共混管中。这种回流的量对于新开始时或作为再操作产品而言是约5％。其余保持在储存容器中的组合物被送入包装线以填充到空瓶中。
对于4X和6X浓缩物的加工与上述对于2X浓缩物所描述的相同。
实施例3
制备一组洗发制剂以反映2X、4X和8X水平的浓缩物。这三种具有适量添加水的浓缩物都能获得具有表III所示的所得组合物。
表III
| 相 | 组分名称 | 所得组合物(2个料流) | 2X(3个料流) | 4X(3个料流) | 8X(3个料流) |
| 水相 | 水 | 79.5278 | 38.5288 | 18.0278 | 7.7768 |
| 香料 | 0.5000 | 0.5000 | 0.5000 | 0.5000 | |
| D&C RED#33 | 0.0002 | 0.0002 | 0.0002 | 0.0002 | |
| 乙酸维生素E | 0.0010 | 0.0010 | 0.0010 | 0.0010 | |
| rasberry提取物 | 0.0010 | 0.0010 | 0.0010 | 0.0010 | |
| 柠檬酸(50％活性) | 0.0300 | 0.0300 | 0.0300 | 0.0300 | |
| 羟丙基甲基纤维素 | 0.1500 | 0.1500 | 0.1500 | 0.1500 | |
| EDTA四钠 | 0.2000 | 0.2000 | 0.2000 | 0.2000 | |
| Glydant | 0.1000 | 0.1000 | 0.1000 | 0.1000 | |
| Kathon CG | 0.0400 | 0.0400 | 0.0400 | 0.0400 | |
| Benzophenone-4 | 0.0500 | 0.0500 | 0.0500 | 0.0500 | |
| 氯化铵 | 1.4000 | 1.4000 | 1.4000 | 1.4000 | |
| 油相 | 18 | 18 | 18 | 18 | |
| 仅有水 | - | 40.999 | 61.5000 | 71.7510 |
洗发剂的加工按照与上述实施例2相似的方式进行。
实施例4
制备一组头发调理剂以反映2X、4X和8X水平的浓缩物。这三种具有适量添加水的浓缩物都能获得具有表IV所示的所得组合物。
表IV
| 相 | 组分名称 | 所得组合物(2个料流) | 2X(3个料流) | 4X(3个料流) | 8X(3个料流) |
| 水相 | 水 | 73.486 | 32.171 | 11.514 | 1.185 |
| 可可酰氨基丙基甜菜碱 | 6.028 | 6.028 | 6.028 | 6.028 | |
| Aloe Vera粉末 | 0.005 | 0.005 | 0.005 | 0.005 | |
| Benzophenone-4 | 0.100 | 0.100 | 0.100 | 0.100 | |
| 甘油 | 1.000 | 1.000 | 1.000 | 1.000 | |
| PEC-10葵花籽油 | 0.100 | 0.100 | 0.100 | 0.100 | |
| EDTA四钠 | 0.051 | 0.051 | 0.051 | 0.051 | |
| 氢氧化钠(50％水溶液) | 0.048 | 0.048 | 0.048 | 0.048 | |
| 氯化铵 | 0.325 | 0.325 | 0.325 | 0.325 | |
| Kathon CG | 0.020 | 0.020 | 0.020 | 0.020 | |
| 香料 | 1.000 | 1.000 | 1.000 | 1.000 | |
| Color Sol.Ext Violet #2(0.2％) | 0.333 | 0.333 | 0.333 | 0.333 | |
| 乙酸维生素E | 0.001 | 0.001 | 0.001 | 0.001 | |
| Dequest 2010 | 0.033 | 0.033 | 0.033 | 0.033 | |
| Polyquaternium-10 | 0.100 | 0.100 | 0.100 | 0.100 | |
| 82.630 | |||||
| 油相 | 17.37 | 17.37 | 17.37 | 17.37 | |
| 仅有水 | - | 41.315 | 61.973 | 72.301 |
所有加工按照与上述实施例2中对于各浓缩物相似的方式进行。
Claims (9)
1、一种生产个人护理组合物的方法，包括：
(i)将粘度为50-30,000厘泊的第一水相加入共混管中，所述第一水相包含基于第一相的大于5重量％的除水之外的其它组分；
(ii)将第二相加入共混管中，所述第二相或者是油相，或者是表面活性剂总含量是占第二相的15-90重量％的水相；
(iii)将第三相加入共混管中，所述第三相的粘度小于30厘泊，且包含基于第三相的不大于10重量％的除水之外的其它组分，所述第三相占该组合物的至少15％，其中第一相与第三相按照1∶1至1∶40的相对重量比加入共混管中；
(iv)将所有三相混合在一起，每个相作为液体料流在10-5000psi的压力和2.274-2270kg/分钟的流速下被泵入共混管中；和
(v)将所得混合物作为个人护理组合物回收。
2、根据权利要求1的方法，其中第一相包含基于第一相的大于40重量％的除水之外的其它组分。
3、根据权利要求1的方法，其中第一相与第三相按照1∶1至1∶10的相对重量比加入共混管中。
4、根据权利要求1的方法，其中第三相包含基于第三相的不大于2重量％的除水之外的其它组分。
5、根据权利要求1的方法，其中共混管的体积是0.0016387-1638.7cm3。
6、根据权利要求1的方法，其中共混管的体积是0.16387-81.94cm3。
7、根据权利要求1的方法，其中各相的混合是通过声波搅拌进行。
8、根据权利要求1的方法，其中进入该管的第一相的温度比进入该管的第二相低至少5℃。
9、根据权利要求1的方法，其中第一、第二和第三相在100-1000psi的压力下被泵入该管。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/320,029 US7351749B2 (en) | 2002-12-16 | 2002-12-16 | Process for manufacture of personal care products utilizing a concentrate water phase |
| US10/320,029 | 2002-12-16 |
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| US (1) | US7351749B2 (zh) |
| EP (1) | EP1575695B1 (zh) |
| JP (1) | JP2006509623A (zh) |
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| CN (1) | CN100337731C (zh) |
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| DE (1) | DE60307515T2 (zh) |
| ES (1) | ES2270125T3 (zh) |
| MX (1) | MXPA05006388A (zh) |
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| DE102004018283A1 (de) * | 2004-04-15 | 2005-11-03 | Wacker-Chemie Gmbh | Verfahren zur kontinuierlichen Herstellung von Silicon Emulsionen |
| US20070047384A1 (en) * | 2005-09-01 | 2007-03-01 | Mclaughlin Jon K | Control system for and method of combining materials |
| US8616760B2 (en) * | 2005-09-01 | 2013-12-31 | The Procter & Gamble Company | Control system for and method of combining materials |
| US8240908B2 (en) * | 2005-09-01 | 2012-08-14 | The Procter & Gamble Company | Control system for and method of combining materials |
| US20080031085A1 (en) * | 2005-09-01 | 2008-02-07 | Mclaughlin Jon K | Control system for and method of combining materials |
| US20100055052A1 (en) * | 2008-08-26 | 2010-03-04 | James Albert Berta | Processing System for Oral Care Compositions |
| WO2011018337A1 (en) | 2009-08-12 | 2011-02-17 | Unilever Plc | Concentrated liquid soap formulations having readily pumpable viscosity |
| US7884060B1 (en) | 2009-08-12 | 2011-02-08 | Conopco, Inc. | Concentrated liquid soap formulations having readily pumpable viscosity |
| US7884061B1 (en) | 2009-08-12 | 2011-02-08 | Conopco, Inc. | Concentrated liquid soap formulations with greater than 50% long chain soap and fatty acid having readily pumpable viscosity |
| JP5548429B2 (ja) * | 2009-11-05 | 2014-07-16 | 花王株式会社 | 液体の増粘方法 |
| EP2579968B1 (en) | 2010-06-09 | 2014-08-06 | The Procter and Gamble Company | Fluid mixing assembly and method of mixing a liquid composition |
| CN104768523B (zh) | 2012-10-29 | 2017-08-15 | 宝洁公司 | 10℃下具有0.30或更大损耗角正切值的个人护理组合物 |
| US9867763B2 (en) | 2013-05-10 | 2018-01-16 | Noxell Corporation | Modular emulsion-based product differentiation |
| CN107537337A (zh) * | 2017-09-20 | 2018-01-05 | 广东丽臣奥威实业有限公司 | 一种表面活性剂稀释方法 |
| EP3910294B1 (de) * | 2020-05-11 | 2024-01-31 | Siemens Schweiz AG | Bestimmung des mischungsverhältnisses insbesondere eines wasser-/glykol-gemischs mittels ultraschall sowie eine darauf basierende wärmestrommessung |
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- 2003-11-03 EP EP03775313A patent/EP1575695B1/en not_active Revoked
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Also Published As
| Publication number | Publication date |
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| KR20050085662A (ko) | 2005-08-29 |
| ES2270125T3 (es) | 2007-04-01 |
| ATE335533T1 (de) | 2006-09-15 |
| JP2006509623A (ja) | 2006-03-23 |
| EP1575695A1 (en) | 2005-09-21 |
| DE60307515D1 (de) | 2006-09-21 |
| MXPA05006388A (es) | 2005-08-29 |
| DE60307515T2 (de) | 2006-12-14 |
| CN1726075A (zh) | 2006-01-25 |
| WO2004054695A1 (en) | 2004-07-01 |
| KR101120309B1 (ko) | 2012-03-08 |
| US7351749B2 (en) | 2008-04-01 |
| AU2003283366A1 (en) | 2004-07-09 |
| ZA200503923B (en) | 2006-08-30 |
| EP1575695B1 (en) | 2006-08-09 |
| CA2507006A1 (en) | 2004-07-01 |
| CA2507006C (en) | 2011-05-31 |
| US20040115230A1 (en) | 2004-06-17 |
| AU2003283366B2 (en) | 2006-11-23 |
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