CN100337680C - 一种解酒胶囊的制作方法 - Google Patents
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Abstract
本发明涉及一种解酒的药物组配及其制作方法：其特征是：按重量份将甘草15-25g、葛花15-25g、葛根15-25g、砂仁15-25g、高良姜15-25g、白芍10-20g、薄荷10-20g、决明子10-20g，先按中药的煎制方法制成药液后备用，将药液合并置于三效真空高能蒸发浓缩器内，减压、加热至80℃浓缩成稠液或膏状后置于干燥箱中，加热至60℃，恒温条件下干燥4小时，粉碎、过筛填充入0号胶囊，灭菌、制成成品——太白乐胶囊。
Description
本发明涉及一种解酒保健品，更具体的说是一种解酒胶囊的组配及制作方法。
酒作为一种饮品，在世界各地被人们消费，特别白酒乙醇含量较高，过量饮用可能导致酒精中毒，从前市场上也在很多解酒饮料，解酒茶等相关解酒产品，经过检索得知的有：94112549.1
1、一种解酒保健品，其特征是：它的产品配方是，人参茎叶皂甙0.5％、葛根黄豆甙元0.5％、陈皮30％、柠檬酸4％、维生素C1％、蔗糖64％。
2、根据权利要求1所述的太白饮酒乐，其特征是：所述的产品制备工艺是：按配方剂量取陈皮，碎成小块状放入容器内，以95％乙醇5倍量加入容器中，加热回流1小时，抽滤，滤液备用，残渣加50％乙醇10倍量回流1小时，两次，抽滤后合并两次50％乙醇提取液，减压回收乙醇至膏状，30℃减压真空干燥得固体干浸膏，将干浸膏粉碎，过80目筛，然后按配方剂量加入粉碎并过80目筛的柠檬酸、维生素C、蔗糖、葛根黄豆甙元、人参茎叶皂甙，搅拌均匀后，用95％乙醇提取的陈皮滤液湿润，制成软材，过16目筛制粒，依温干燥，压制成型，切成小块，包装出厂。
93107382.0
1、一种解酒的药物组合物，其特征在于它由下列组份组成：葛花、青皮、人参茎叶皂甙，各组份之间的重量比是葛花∶青皮∶人参茎叶皂甙＝25～35∶5～15∶15∶0.5～2。
2、根据权利要求1的药物组合物，其特征在于各组份之间的重量比为：
葛花∶青皮∶人参茎叶皂甙＝30∶10∶1。
3、根据权利要求1的药物组合物，其特征在于还可以加入药学上可接受的赋形剂。
4、根据权利要求3的药物组合物，其特征在于所说的赋形剂是淀粉。
5、一种解酒药物组合物，其特征在于以葛花、青皮、人参茎叶皂甙＝25～35∶5～15∶15∶0.5～2(重量比)为原料，先将葛花、青皮加水煎煮，过滤浓缩，加入人参皂甙，干燥粉碎，过筛，加适量淀粉混匀，制成药用剂型。
6、根据权利要求5的制备方法，其特征在于称取葛花和青皮用12倍水润湿后加热煮沸1小时沙布过滤，药渣再加入7-8倍水煮沸40分钟，按上法过滤，合并滤液，减压浓缩至稀糊状，加入处方量人参茎叶皂甙，60-80℃下减压干燥，干燥物粉碎后过80目筛，干粉加适量淀粉混匀，制成药用剂型。
7、根据权利要求6的制备方法，所说的药用剂型是胶囊剂、片剂和冲剂。
8、根据权利要求6的制备方法，所说的药用剂型是茶剂。
9、根据权利要求6的制备方法，其特征是在于所说的剂型是口服液。
本发明的目地是提供一种以中草药为原料炮制浓缩后装入胶囊的解酒药物。
发明内容：
解酒胶囊组配及制作，组成含量(重量)为：
甘草、葛花、葛根、砂仁、高良姜各15-25g，白芍、薄荷、决明子各10-20g。将上述药物经过精选，然后通过一系列加工程序加工成胶囊。
本发明的最佳组成含量(重量)为：
甘草、葛花、葛根、砂仁、高良姜各20g，白芍、薄荷、决明子各15g。
甘草：
[性味与归经]味甘，性平。归心、脾、肺、胃经。
[功能]润脾溢气、清热解毒、祛痰止咳、缓急止痛、调和诸药的功效。用于脾胃虚弱、倦怠乏力、咳嗽多痰、缓解药物素性、烈性。
[泡制]春秋二季采挖，除去根须，晒干。
葛根：
[性味与归经]味甘、辛，性凉。归脾、胃经。
[功能]有解肌退热、生津、透疹、升阳止泻功能。用于外感发热头痛、项强、口渴、麻疹不透、热痢、泄泻、高血压、颈项强痛、冠心病等症。
葛花：
[本草纲目]载：解酒毒。
[泡制]秋、冬采，趁解切成厚片或小块、干燥。
砂仁：
[性味与归经]味辛、性温。归脾、胃、肾经。
[功效]有健胃消食、温脾止泻、理气安胎的功能。
[泡制]秋季采收，去壳晒干或微火烘干。
高良姜：
[性未与归经]味辛，性温。归脾、胃经。
[功效]有温胃、散寒、行气、止痛的功能。用于脘腹寒痛、胃寒吐泻、消止不良等症。
附图说明
下面结合附图对本发明进一步说明。
图1是工艺流程图
原料制备：
1提取
A第一次提取：将甘草、葛根、砂仁、高良姜各阶层20g，白芍、薄荷、决明子各15g用清水清洗后，置于BT-2不锈钢提取釜中，加10倍自来水后，常温浸1小时，加热至80℃恒温提取消2小时，分离提取液，加压过滤，滤液备用。
B第二次提取：往提取釜中加入6倍量的自来水，加热至80℃恒温提取1小时，分离提取液，加压过滤，滤液备用。
C第三次提取：往提取釜中加入3倍量的自来水，加热至80℃恒温提取1小时，分离提取液，过滤，滤液备用。
2、浓缩
将三次提取的提取液合并，置于B-500型三效真空高能蒸发浓缩器内，减压(负200mmHg)，加热至80℃浓缩至稠液。备用。
配制顺序和步骤：
1、干粉的制备
在10万级洁净车间内操作，将稠膏混匀置于干燥箱中，加热至60，恒温条件下干燥4小时。
2、造粒、填充胶囊
将混合均匀的物料，置干燥设备中，在70-80℃条件下干燥24小时，然后置于粉碎机中粉碎，过筛80目筛，填充0号胶囊。
3、灭菌
将包装好的胶囊辐射灭菌。
4、检验、成品、入库。
本发明的解酒药药物具有良好的解酒功能，通过临床实验表明，具有良好的抗酒精能力和醒酒能力，并且缩短昏睡时间，是较明显的一种解酒药。
实施例一、
A、第一次提取：将甘草、葛根、砂仁、高良姜各20g，白芍、薄荷、决明子各15g，用清水清洗后，置于BT-2不锈钢提取釜中，加10倍自来水后，常温浸1小时，加热至80恒温提取2小时，分离提取液，加压过滤，滤液备用。
B、第二次提取：往提取釜中加入6倍量的自来水，加热至80℃恒温提取1小时，分离提取液，加压过滤，滤液备用。
C、第三次提取：往提取釜中加入3倍量的自来水，加热至80℃恒温提取1小时，分离提取液，过滤，滤液备用。
实施例二：
将三次提取液合并，置于B-500型三效真空高能蒸发浓缩器内，减压(负200mmHg)，加热至80℃浓缩至稠液。备用。
实施例三：
A、在10万级洁净车间内操作，将稠膏混匀置于干燥箱中，加热至60℃，恒温条件下干燥4小时。
B、将混合均匀的物料，置干燥设备中，在70-80条件下干燥4小时，然后置于粉碎机中粉碎，过筛80℃目筛，填充0号胶囊。
C、将包装好的胶囊辐射灭菌。
D、检验、成品、入库。
Claims (1)
1、一种解酒胶囊的制作方法，其特征在于：采用甘草20g、葛花20g、葛根20g、砂仁20g、高良姜20g、自芍15g、薄荷15g、决明子15g、经清水清洗后，放入BT-2不锈钢提取釜中，加水10倍量常温浸泡1小时后加热至80度恒温提取2小时后分离提取液，加压过滤，滤液备用；第二次向提取釜中加入6倍量自来水，加热至80度后恒温提取1小时，分离提取液，加压过滤，滤液备用；第三次向提取釜中加入3倍量自来水，加热至80度后恒温提取1小时，分离提取液，过滤，滤液备用；合并三次滤液放入B-500型三效真空高能蒸发浓缩器内，减压，加热至80度浓缩至稠液，备用；在10万级洁净车间内操作，将稠膏混匀置干燥箱中，加热至60度后恒温干燥4小时后，再置于干燥设备中70-80度干燥4小时，然后置于粉碎机中粉碎，过80目筛，填充0号胶囊，辐照灭菌、检验、成品、入库得解酒胶囊。
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| CN1127640A (zh) * | 1995-01-28 | 1996-07-31 | 袁长海 | 一种解酒和防醉酒的制剂及其制备方法 |
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2005
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1127640A (zh) * | 1995-01-28 | 1996-07-31 | 袁长海 | 一种解酒和防醉酒的制剂及其制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| 解救方药对酒精中毒肝损害保护作用的实验研究进展 中国中医基础医学杂志，第7卷第5期 2001 * |
| 解酒剂及保健食品的研究进展 天然产物研究与开发，第14卷第2期 2002 * |
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| CN1695698A (zh) | 2005-11-16 |
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