CL2021002300A1 - Procedimiento para la preparación de 4-amino-5-metilpiridona - Google Patents

Procedimiento para la preparación de 4-amino-5-metilpiridona

Info

Publication number
CL2021002300A1
CL2021002300A1 CL2021002300A CL2021002300A CL2021002300A1 CL 2021002300 A1 CL2021002300 A1 CL 2021002300A1 CL 2021002300 A CL2021002300 A CL 2021002300A CL 2021002300 A CL2021002300 A CL 2021002300A CL 2021002300 A1 CL2021002300 A1 CL 2021002300A1
Authority
CL
Chile
Prior art keywords
methylpyridone
amino
preparation
procedure
formula
Prior art date
Application number
CL2021002300A
Other languages
English (en)
Inventor
Johannes Platzek
Original Assignee
Bayer Ag
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag
Publication of CL2021002300A1 publication Critical patent/CL2021002300A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Es objeto de la presente invención un procedimiento para la preparación del intermedio de procedimiento 4–amino–5–metilpiridona de la fórmula (I), caracterizado porque el intermedio 4–hidroxi–5–metil–1H–piridin–2–ona de la fórmula (III) se hace reaccionar con amoníaco en la autoclave con adición de una sal de bromuro de amonio.
CL2021002300A 2019-03-05 2021-09-02 Procedimiento para la preparación de 4-amino-5-metilpiridona CL2021002300A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19160906 2019-03-05

Publications (1)

Publication Number Publication Date
CL2021002300A1 true CL2021002300A1 (es) 2022-04-08

Family

ID=65991502

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021002300A CL2021002300A1 (es) 2019-03-05 2021-09-02 Procedimiento para la preparación de 4-amino-5-metilpiridona

Country Status (16)

Country Link
US (1) US20220153701A1 (es)
EP (1) EP3935044B1 (es)
JP (1) JP2022523984A (es)
KR (1) KR20210135509A (es)
CN (1) CN113412255A (es)
AU (1) AU2020233169A1 (es)
BR (1) BR112021015106A2 (es)
CA (1) CA3132402A1 (es)
CL (1) CL2021002300A1 (es)
CO (1) CO2021011555A2 (es)
IL (1) IL286006A (es)
JO (1) JOP20210243A1 (es)
MX (1) MX2021010613A (es)
PE (1) PE20220251A1 (es)
SG (1) SG11202109605TA (es)
WO (1) WO2020178177A1 (es)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE570365C (de) 1930-01-17 1933-02-15 I G Farbenindustrie Akt Ges Verfahren zur Herstellung aromatischer Amine aus Oxyverbindungen der Benzolreihe
US2376112A (en) 1942-04-21 1945-05-15 Eastman Kodak Co Amination of dihydric phenols
US4609760A (en) 1980-06-24 1986-09-02 Bayer Aktiengesellschaft Process for the preparation of 2,6-xylidine
US4400537A (en) 1981-03-25 1983-08-23 Standard Oil Company (Indiana) Process for 1,4-phenylenediamine
ES2315716T3 (es) 2003-11-08 2009-04-01 Bayer Healthcare Ag Derivados de amida, carbamato o urea biciclica como moduladores del receptor vanilloide.
DE102007009494A1 (de) 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
WO2008124812A1 (en) 2007-04-10 2008-10-16 The Trustees Of The University Of Pennsylvania Phen-naphthalene and phen-quinoline derivatives and their use for binding and imaging amyloid plaques
US7696227B2 (en) 2007-04-13 2010-04-13 Regents Of The University Of California Small-molecule inhibitors of the androgen receptor
US8084647B2 (en) 2007-09-07 2011-12-27 Korea University Industry and Academy Cooperation Foundation Two-photon probe for real-time monitoring of intracellular calcium ions, method for preparing the probe and method for real-time monitoring of intracellular calcium ions using the probe
CN104498550A (zh) 2011-01-26 2015-04-08 住友橡胶工业株式会社 合成系统、轮胎用橡胶化学药品、轮胎用合成橡胶以及充气轮胎
CN103193704B (zh) * 2013-04-12 2016-03-09 四川铂瑞生物医药有限公司 2-羟基-4-氨基-5-甲基吡啶杂环化合物
CA2956529A1 (en) 2014-08-01 2016-02-04 Bayer Pharma Aktiengesellschaft Method for the preparation of (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1-6-naphthyridine-3-carbox-amide and the purification thereof for use as an active pharmaceutical ingredient

Also Published As

Publication number Publication date
MX2021010613A (es) 2021-09-28
EP3935044A1 (de) 2022-01-12
BR112021015106A2 (pt) 2021-10-05
KR20210135509A (ko) 2021-11-15
US20220153701A1 (en) 2022-05-19
IL286006A (en) 2021-10-31
JOP20210243A1 (ar) 2023-01-30
WO2020178177A1 (de) 2020-09-10
JP2022523984A (ja) 2022-04-27
CO2021011555A2 (es) 2021-09-20
AU2020233169A1 (en) 2021-09-23
SG11202109605TA (en) 2021-10-28
CA3132402A1 (en) 2020-09-10
EP3935044B1 (de) 2023-04-12
CN113412255A (zh) 2021-09-17
PE20220251A1 (es) 2022-02-16

Similar Documents

Publication Publication Date Title
BR112022012585A2 (pt) Inibidores de formas mutantes de egfr
CL2018003264A1 (es) Procesos para la preparación de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidin-1-carboxamida y sales del mismo.
CO2017012403A2 (es) Proceso para preparar 4-amino-piridazinas
BR112021024236A2 (pt) Proteínas multiespecíficas
AR116790A1 (es) PROCEDIMIENTO PARA LA PREPARACIÓN DE 3a-HIDROXI-5a-PREGNAN-20-ONA (BREXANOLONA)
MX2021000348A (es) 2-fluoro-3-nitrotolueno cristalino y procedimiento para la preparacion del mismo.
CY1123840T1 (el) Οξινη συνθεση με βαση λεοναρδιτη και αμινοξεα
MX2016009123A (es) Composicion agroquimica.
MX2019003533A (es) Reducción de pérdida de color de un material teñido mediante el uso de una sal de amina de ácido carboxílico.
MX2020014097A (es) Lipidos novedosos.
EA201992259A1 (ru) Замещенные n-(1,3,4-оксадиазол-2-ил)арилкарбоксамиды и их применение в качестве гербицидов
BR112023002939A2 (pt) Processo e intermediários para preparar um inibidor de jak1
CL2020000217A1 (es) Inhibidores de ror gamma.
BR112022002648A2 (pt) Sal
CL2018002344A1 (es) Proceso para preparar compuestos de 7h-pirrolo[2,3-d]pirimidina
AR110527A1 (es) Proceso para la preparación de compuestos de benzoxazepina oxazolidinona
CL2020001049A1 (es) Proceso para producir compuestos de piridazinona herbicida.
AR117278A1 (es) Aditivos granulares para piensos
BR112019001447A2 (pt) método de produção para composto pirazol-amida
BR112018070345A2 (pt) processo para a preparação de derivados de 4-aminoindano e amidas de aminoindano relacionadas
BR112018012325A2 (pt) métodos para a preparação de 5,6-di-hidro-6-fenilbenzo[f]isoquinolin-2-amina substituída
CL2021002300A1 (es) Procedimiento para la preparación de 4-amino-5-metilpiridona
MX2018007980A (es) Proceso para la preparacion de 1,1,3-trioxo-1,2-benzotiazol-6-carb oxamida.
MX2022002017A (es) Metodo para producir derivado de heterociclideno acetamida.
CO2021011553A2 (es) Síntesis de 4-amino-5-metil-1h-piridin-2 (1h) -on (compuesto intermedio para la síntesis del antagonista finerenona de mr) a partir de 2-cloro-5-metil-4-nitro-piridina-1-óxido usando el compuesto intermedio 2-cloro-5-metil-4-piridinamina