MX2021010613A - Procedimiento para la preparacion de 4-amino-5-metilpiridona. - Google Patents

Procedimiento para la preparacion de 4-amino-5-metilpiridona.

Info

Publication number
MX2021010613A
MX2021010613A MX2021010613A MX2021010613A MX2021010613A MX 2021010613 A MX2021010613 A MX 2021010613A MX 2021010613 A MX2021010613 A MX 2021010613A MX 2021010613 A MX2021010613 A MX 2021010613A MX 2021010613 A MX2021010613 A MX 2021010613A
Authority
MX
Mexico
Prior art keywords
methylpyridone
amino
preparing
formula
pyridin
Prior art date
Application number
MX2021010613A
Other languages
English (en)
Inventor
Johannes Platzek
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX2021010613A publication Critical patent/MX2021010613A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Es objeto de la presente invención un procedimiento para la preparación del intermedio de procedimiento 4-amino-5-metilpiridon a de la fórmula (I), caracterizado porque el intermedio 4-hidroxi-5-metil-1H-piridin-2-ona de la fórmula (III) se hace reaccionar con amoníaco en el autoclave con adición de una sal de bromuro de amonio.
MX2021010613A 2019-03-05 2020-02-28 Procedimiento para la preparacion de 4-amino-5-metilpiridona. MX2021010613A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19160906 2019-03-05
PCT/EP2020/055297 WO2020178177A1 (de) 2019-03-05 2020-02-28 Verfahren zur herstellung von 4-amino-5-methylpyridon

Publications (1)

Publication Number Publication Date
MX2021010613A true MX2021010613A (es) 2021-09-28

Family

ID=65991502

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021010613A MX2021010613A (es) 2019-03-05 2020-02-28 Procedimiento para la preparacion de 4-amino-5-metilpiridona.

Country Status (16)

Country Link
US (1) US20220153701A1 (es)
EP (1) EP3935044B1 (es)
JP (1) JP2022523984A (es)
KR (1) KR20210135509A (es)
CN (1) CN113412255B (es)
AU (1) AU2020233169A1 (es)
BR (1) BR112021015106A2 (es)
CA (1) CA3132402A1 (es)
CL (1) CL2021002300A1 (es)
CO (1) CO2021011555A2 (es)
IL (1) IL286006A (es)
JO (1) JOP20210243A1 (es)
MX (1) MX2021010613A (es)
PE (1) PE20220251A1 (es)
SG (1) SG11202109605TA (es)
WO (1) WO2020178177A1 (es)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE570365C (de) 1930-01-17 1933-02-15 I G Farbenindustrie Akt Ges Verfahren zur Herstellung aromatischer Amine aus Oxyverbindungen der Benzolreihe
US2376112A (en) 1942-04-21 1945-05-15 Eastman Kodak Co Amination of dihydric phenols
US4609760A (en) 1980-06-24 1986-09-02 Bayer Aktiengesellschaft Process for the preparation of 2,6-xylidine
US4400537A (en) 1981-03-25 1983-08-23 Standard Oil Company (Indiana) Process for 1,4-phenylenediamine
CA2545100A1 (en) 2003-11-08 2005-05-19 Bayer Healthcare Ag Bicyclic amide, carbamate or urea derivatives as vanilloid receptor modulators
DE102007009494A1 (de) 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
WO2008124812A1 (en) 2007-04-10 2008-10-16 The Trustees Of The University Of Pennsylvania Phen-naphthalene and phen-quinoline derivatives and their use for binding and imaging amyloid plaques
US7696227B2 (en) 2007-04-13 2010-04-13 Regents Of The University Of California Small-molecule inhibitors of the androgen receptor
US8084647B2 (en) 2007-09-07 2011-12-27 Korea University Industry and Academy Cooperation Foundation Two-photon probe for real-time monitoring of intracellular calcium ions, method for preparing the probe and method for real-time monitoring of intracellular calcium ions using the probe
US9115047B2 (en) 2011-01-26 2015-08-25 Sumitomo Rubber Industries, Ltd. Synthesis system, rubber chemical substance for tires, synthetic rubber for tires, and pneumatic tire
CN103193704B (zh) * 2013-04-12 2016-03-09 四川铂瑞生物医药有限公司 2-羟基-4-氨基-5-甲基吡啶杂环化合物
SG11201700785UA (en) 2014-08-01 2017-02-27 Bayer Pharma AG Method for the preparation of (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1-6-naphthyridine-3-carbox-amide and the purification thereof for use as an active pharmaceutical ingredient
CN113474332A (zh) * 2019-03-05 2021-10-01 拜耳公司 使用中间体化合物2-氯-5-甲基-4-吡啶胺从2-氯-5-甲基-4-硝基-吡啶-1-氧化物开始合成4-氨基-5-甲基-1h-吡啶-2(1h)-酮（用于合成mr拮抗剂非奈利酮的中间体化合物）的方法

Also Published As

Publication number Publication date
CN113412255A (zh) 2021-09-17
CA3132402A1 (en) 2020-09-10
JOP20210243A1 (ar) 2023-01-30
JP2022523984A (ja) 2022-04-27
EP3935044B1 (de) 2023-04-12
US20220153701A1 (en) 2022-05-19
EP3935044A1 (de) 2022-01-12
BR112021015106A2 (pt) 2021-10-05
CN113412255B (zh) 2024-07-02
WO2020178177A1 (de) 2020-09-10
CL2021002300A1 (es) 2022-04-08
CO2021011555A2 (es) 2021-09-20
AU2020233169A1 (en) 2021-09-23
IL286006A (en) 2021-10-31
KR20210135509A (ko) 2021-11-15
SG11202109605TA (en) 2021-10-28
PE20220251A1 (es) 2022-02-16

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