MX2021010613A - Procedimiento para la preparacion de 4-amino-5-metilpiridona. - Google Patents
Procedimiento para la preparacion de 4-amino-5-metilpiridona.Info
- Publication number
- MX2021010613A MX2021010613A MX2021010613A MX2021010613A MX2021010613A MX 2021010613 A MX2021010613 A MX 2021010613A MX 2021010613 A MX2021010613 A MX 2021010613A MX 2021010613 A MX2021010613 A MX 2021010613A MX 2021010613 A MX2021010613 A MX 2021010613A
- Authority
- MX
- Mexico
- Prior art keywords
- methylpyridone
- amino
- preparing
- formula
- pyridin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Es objeto de la presente invención un procedimiento para la preparación del intermedio de procedimiento 4-amino-5-metilpiridon a de la fórmula (I), caracterizado porque el intermedio 4-hidroxi-5-metil-1H-piridin-2-ona de la fórmula (III) se hace reaccionar con amoníaco en el autoclave con adición de una sal de bromuro de amonio.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19160906 | 2019-03-05 | ||
PCT/EP2020/055297 WO2020178177A1 (de) | 2019-03-05 | 2020-02-28 | Verfahren zur herstellung von 4-amino-5-methylpyridon |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021010613A true MX2021010613A (es) | 2021-09-28 |
Family
ID=65991502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021010613A MX2021010613A (es) | 2019-03-05 | 2020-02-28 | Procedimiento para la preparacion de 4-amino-5-metilpiridona. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20220153701A1 (es) |
EP (1) | EP3935044B1 (es) |
JP (1) | JP2022523984A (es) |
KR (1) | KR20210135509A (es) |
CN (1) | CN113412255B (es) |
AU (1) | AU2020233169A1 (es) |
BR (1) | BR112021015106A2 (es) |
CA (1) | CA3132402A1 (es) |
CL (1) | CL2021002300A1 (es) |
CO (1) | CO2021011555A2 (es) |
IL (1) | IL286006A (es) |
JO (1) | JOP20210243A1 (es) |
MX (1) | MX2021010613A (es) |
PE (1) | PE20220251A1 (es) |
SG (1) | SG11202109605TA (es) |
WO (1) | WO2020178177A1 (es) |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE570365C (de) | 1930-01-17 | 1933-02-15 | I G Farbenindustrie Akt Ges | Verfahren zur Herstellung aromatischer Amine aus Oxyverbindungen der Benzolreihe |
US2376112A (en) | 1942-04-21 | 1945-05-15 | Eastman Kodak Co | Amination of dihydric phenols |
US4609760A (en) | 1980-06-24 | 1986-09-02 | Bayer Aktiengesellschaft | Process for the preparation of 2,6-xylidine |
US4400537A (en) | 1981-03-25 | 1983-08-23 | Standard Oil Company (Indiana) | Process for 1,4-phenylenediamine |
CA2545100A1 (en) | 2003-11-08 | 2005-05-19 | Bayer Healthcare Ag | Bicyclic amide, carbamate or urea derivatives as vanilloid receptor modulators |
DE102007009494A1 (de) | 2007-02-27 | 2008-08-28 | Bayer Healthcare Ag | Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung |
WO2008124812A1 (en) | 2007-04-10 | 2008-10-16 | The Trustees Of The University Of Pennsylvania | Phen-naphthalene and phen-quinoline derivatives and their use for binding and imaging amyloid plaques |
US7696227B2 (en) | 2007-04-13 | 2010-04-13 | Regents Of The University Of California | Small-molecule inhibitors of the androgen receptor |
US8084647B2 (en) | 2007-09-07 | 2011-12-27 | Korea University Industry and Academy Cooperation Foundation | Two-photon probe for real-time monitoring of intracellular calcium ions, method for preparing the probe and method for real-time monitoring of intracellular calcium ions using the probe |
US9115047B2 (en) | 2011-01-26 | 2015-08-25 | Sumitomo Rubber Industries, Ltd. | Synthesis system, rubber chemical substance for tires, synthetic rubber for tires, and pneumatic tire |
CN103193704B (zh) * | 2013-04-12 | 2016-03-09 | 四川铂瑞生物医药有限公司 | 2-羟基-4-氨基-5-甲基吡啶杂环化合物 |
SG11201700785UA (en) | 2014-08-01 | 2017-02-27 | Bayer Pharma AG | Method for the preparation of (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1-6-naphthyridine-3-carbox-amide and the purification thereof for use as an active pharmaceutical ingredient |
CN113474332A (zh) * | 2019-03-05 | 2021-10-01 | 拜耳公司 | 使用中间体化合物2-氯-5-甲基-4-吡啶胺从2-氯-5-甲基-4-硝基-吡啶-1-氧化物开始合成4-氨基-5-甲基-1h-吡啶-2(1h)-酮(用于合成mr拮抗剂非奈利酮的中间体化合物)的方法 |
-
2020
- 2020-02-28 KR KR1020217027999A patent/KR20210135509A/ko unknown
- 2020-02-28 CN CN202080013542.6A patent/CN113412255B/zh active Active
- 2020-02-28 US US17/435,607 patent/US20220153701A1/en active Pending
- 2020-02-28 WO PCT/EP2020/055297 patent/WO2020178177A1/de active Application Filing
- 2020-02-28 SG SG11202109605T patent/SG11202109605TA/en unknown
- 2020-02-28 CA CA3132402A patent/CA3132402A1/en active Pending
- 2020-02-28 BR BR112021015106-0A patent/BR112021015106A2/pt not_active Application Discontinuation
- 2020-02-28 AU AU2020233169A patent/AU2020233169A1/en not_active Abandoned
- 2020-02-28 JP JP2021552648A patent/JP2022523984A/ja active Pending
- 2020-02-28 PE PE2021001411A patent/PE20220251A1/es unknown
- 2020-02-28 EP EP20706334.8A patent/EP3935044B1/de active Active
- 2020-02-28 JO JOP/2021/0243A patent/JOP20210243A1/ar unknown
- 2020-02-28 MX MX2021010613A patent/MX2021010613A/es unknown
-
2021
- 2021-08-31 CO CONC2021/0011555A patent/CO2021011555A2/es unknown
- 2021-08-31 IL IL286006A patent/IL286006A/en unknown
- 2021-09-02 CL CL2021002300A patent/CL2021002300A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN113412255A (zh) | 2021-09-17 |
CA3132402A1 (en) | 2020-09-10 |
JOP20210243A1 (ar) | 2023-01-30 |
JP2022523984A (ja) | 2022-04-27 |
EP3935044B1 (de) | 2023-04-12 |
US20220153701A1 (en) | 2022-05-19 |
EP3935044A1 (de) | 2022-01-12 |
BR112021015106A2 (pt) | 2021-10-05 |
CN113412255B (zh) | 2024-07-02 |
WO2020178177A1 (de) | 2020-09-10 |
CL2021002300A1 (es) | 2022-04-08 |
CO2021011555A2 (es) | 2021-09-20 |
AU2020233169A1 (en) | 2021-09-23 |
IL286006A (en) | 2021-10-31 |
KR20210135509A (ko) | 2021-11-15 |
SG11202109605TA (en) | 2021-10-28 |
PE20220251A1 (es) | 2022-02-16 |
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