CL2021000362A1 - Nuevos compuestos heterocíclicos como inhibidores de la monoacilglicerol lipasa - Google Patents
Nuevos compuestos heterocíclicos como inhibidores de la monoacilglicerol lipasaInfo
- Publication number
- CL2021000362A1 CL2021000362A1 CL2021000362A CL2021000362A CL2021000362A1 CL 2021000362 A1 CL2021000362 A1 CL 2021000362A1 CL 2021000362 A CL2021000362 A CL 2021000362A CL 2021000362 A CL2021000362 A CL 2021000362A CL 2021000362 A1 CL2021000362 A1 CL 2021000362A1
- Authority
- CL
- Chile
- Prior art keywords
- heterocyclic compounds
- new heterocyclic
- lipase inhibitors
- monoacylglycerol lipase
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La invención proporciona nuevos compuestos heterocíclicos que presentan la fórmula general (I), en donde A, L, X, m, n, R1 y R2 son como se describe en la presente, composiciones que incluyen los compuestos, procesos de fabricación de los compuestos y métodos de utilización de los compuestos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18188681 | 2018-08-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021000362A1 true CL2021000362A1 (es) | 2021-07-09 |
Family
ID=63244467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021000362A CL2021000362A1 (es) | 2018-08-13 | 2021-02-10 | Nuevos compuestos heterocíclicos como inhibidores de la monoacilglicerol lipasa |
Country Status (22)
Country | Link |
---|---|
US (3) | US20200308190A1 (es) |
EP (1) | EP3837263B1 (es) |
JP (1) | JP2021534139A (es) |
KR (1) | KR20210045992A (es) |
CN (1) | CN112867720A (es) |
AR (1) | AR116666A1 (es) |
AU (1) | AU2019322538B2 (es) |
BR (1) | BR112021002298A2 (es) |
CA (1) | CA3104928A1 (es) |
CL (1) | CL2021000362A1 (es) |
CO (1) | CO2021002382A2 (es) |
CR (1) | CR20210077A (es) |
IL (1) | IL279173A (es) |
MA (1) | MA53219A (es) |
MX (1) | MX2021001433A (es) |
PE (1) | PE20211089A1 (es) |
PH (1) | PH12021500013A1 (es) |
RU (1) | RU2769507C1 (es) |
SG (1) | SG11202013064WA (es) |
TW (1) | TWI812770B (es) |
UA (1) | UA127629C2 (es) |
WO (1) | WO2020035424A1 (es) |
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AR114136A1 (es) | 2017-10-10 | 2020-07-29 | Hoffmann La Roche | Compuestos heterocíclicos |
EP3717477B1 (en) | 2017-11-28 | 2022-07-20 | F. Hoffmann-La Roche AG | New heterocyclic compounds |
TW201938164A (zh) | 2018-01-08 | 2019-10-01 | 瑞士商赫孚孟拉羅股份公司 | 新穎雜環化合物 |
US20190292188A1 (en) | 2018-02-27 | 2019-09-26 | Incyte Corporation | Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors |
CA3100731A1 (en) | 2018-05-18 | 2019-11-21 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
CA3105721A1 (en) | 2018-07-05 | 2020-01-09 | Incyte Corporation | Fused pyrazine derivatives as a2a / a2b inhibitors |
WO2020035424A1 (en) | 2018-08-13 | 2020-02-20 | F. Hoffmann-La Roche Ag | New heterocyclic compounds as monoacylglycerol lipase inhibitors |
TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
MX2022002720A (es) * | 2019-09-05 | 2022-08-10 | Lunan Pharmaceutical Group Corp | Inhibidor de magl, procedimiento de preparacion y uso del mismo. |
US20210094971A1 (en) * | 2019-09-09 | 2021-04-01 | Hoffmann-La Roche Inc. | Heterocyclic compounds |
KR20220062515A (ko) * | 2019-09-12 | 2022-05-17 | 에프. 호프만-라 로슈 아게 | Magl 억제제로서 4,4a,5,7,8,8a-헥사피리도[4,3-b][1,4]옥사진-3-온 화합물 |
CN114401969A (zh) * | 2019-09-23 | 2022-04-26 | 豪夫迈·罗氏有限公司 | 杂环化合物 |
US20210094973A1 (en) * | 2019-09-24 | 2021-04-01 | Hoffmann-La Roche Inc. | Heterocyclic compounds |
WO2021058444A1 (en) * | 2019-09-24 | 2021-04-01 | F. Hoffmann-La Roche Ag | Heterocyclic compounds |
BR112022006507A2 (pt) * | 2019-10-07 | 2022-06-28 | De Shaw Res Llc | Compostos heterocíclicos de arilmetileno como bloqueadores de canais de agitador de potássio kv1.3 |
JP2023518556A (ja) * | 2020-03-26 | 2023-05-02 | ヤンセン ファーマシューティカ エヌ.ベー. | モノアシルグリセロールリパーゼ調節因子としてのアミノシクロブタン |
CR20230115A (es) | 2020-09-03 | 2023-04-11 | Hoffmann La Roche | Compuestos heterocíclicos |
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EP3717477B1 (en) | 2017-11-28 | 2022-07-20 | F. Hoffmann-La Roche AG | New heterocyclic compounds |
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CN113767105A (zh) | 2019-04-09 | 2021-12-07 | 豪夫迈·罗氏有限公司 | 作为单酰基甘油脂肪酶(magl)的抑制剂的杂环化合物 |
WO2021001330A1 (en) | 2019-07-03 | 2021-01-07 | F. Hoffmann-La Roche Ag | Heterocyclic monoacylglycerol lipase (magl) inhibitors |
WO2021005034A1 (en) | 2019-07-09 | 2021-01-14 | F. Hoffmann-La Roche Ag | New heterocyclic compounds |
US20210094971A1 (en) | 2019-09-09 | 2021-04-01 | Hoffmann-La Roche Inc. | Heterocyclic compounds |
WO2021048241A1 (en) | 2019-09-12 | 2021-03-18 | F. Hoffmann-La Roche Ag | Radiolabeled compounds |
KR20220062515A (ko) | 2019-09-12 | 2022-05-17 | 에프. 호프만-라 로슈 아게 | Magl 억제제로서 4,4a,5,7,8,8a-헥사피리도[4,3-b][1,4]옥사진-3-온 화합물 |
CN114401969A (zh) | 2019-09-23 | 2022-04-26 | 豪夫迈·罗氏有限公司 | 杂环化合物 |
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CN114514233A (zh) | 2019-09-24 | 2022-05-17 | 豪夫迈·罗氏有限公司 | 用于单酰基甘油脂肪酶(magl)的荧光探针 |
WO2021058444A1 (en) | 2019-09-24 | 2021-04-01 | F. Hoffmann-La Roche Ag | Heterocyclic compounds |
CR20230115A (es) | 2020-09-03 | 2023-04-11 | Hoffmann La Roche | Compuestos heterocíclicos |
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2019
- 2019-08-12 WO PCT/EP2019/071520 patent/WO2020035424A1/en unknown
- 2019-08-12 KR KR1020217004221A patent/KR20210045992A/ko active Search and Examination
- 2019-08-12 CR CR20210077A patent/CR20210077A/es unknown
- 2019-08-12 MX MX2021001433A patent/MX2021001433A/es unknown
- 2019-08-12 MA MA053219A patent/MA53219A/fr unknown
- 2019-08-12 AU AU2019322538A patent/AU2019322538B2/en active Active
- 2019-08-12 UA UAA202101016A patent/UA127629C2/uk unknown
- 2019-08-12 JP JP2021507457A patent/JP2021534139A/ja active Pending
- 2019-08-12 CA CA3104928A patent/CA3104928A1/en active Pending
- 2019-08-12 BR BR112021002298-8A patent/BR112021002298A2/pt unknown
- 2019-08-12 CN CN201980053749.3A patent/CN112867720A/zh active Pending
- 2019-08-12 PE PE2021000135A patent/PE20211089A1/es unknown
- 2019-08-12 RU RU2021106145A patent/RU2769507C1/ru active
- 2019-08-12 EP EP19755855.4A patent/EP3837263B1/en active Active
- 2019-08-12 SG SG11202013064WA patent/SG11202013064WA/en unknown
- 2019-08-13 AR ARP190102303A patent/AR116666A1/es unknown
- 2019-08-13 TW TW108128734A patent/TWI812770B/zh active
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2020
- 2020-04-09 US US16/844,262 patent/US20200308190A1/en not_active Abandoned
- 2020-12-03 IL IL279173A patent/IL279173A/en unknown
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2021
- 2021-02-10 CL CL2021000362A patent/CL2021000362A1/es unknown
- 2021-02-11 PH PH12021500013A patent/PH12021500013A1/en unknown
- 2021-02-24 CO CONC2021/0002382A patent/CO2021002382A2/es unknown
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2022
- 2022-05-20 US US17/749,496 patent/US11802133B2/en active Active
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2023
- 2023-09-26 US US18/475,065 patent/US20240150373A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
RU2769507C1 (ru) | 2022-04-01 |
CA3104928A1 (en) | 2020-02-20 |
US20200308190A1 (en) | 2020-10-01 |
WO2020035424A1 (en) | 2020-02-20 |
BR112021002298A2 (pt) | 2021-05-04 |
AU2019322538A1 (en) | 2021-01-07 |
AU2019322538B2 (en) | 2021-09-30 |
EP3837263A1 (en) | 2021-06-23 |
CN112867720A (zh) | 2021-05-28 |
US20240150373A1 (en) | 2024-05-09 |
SG11202013064WA (en) | 2021-01-28 |
MA53219A (fr) | 2021-11-17 |
US20230050901A1 (en) | 2023-02-16 |
EP3837263B1 (en) | 2024-07-03 |
PE20211089A1 (es) | 2021-06-14 |
KR20210045992A (ko) | 2021-04-27 |
UA127629C2 (uk) | 2023-11-08 |
TW202021970A (zh) | 2020-06-16 |
TWI812770B (zh) | 2023-08-21 |
CO2021002382A2 (es) | 2021-03-08 |
CR20210077A (es) | 2021-03-11 |
IL279173A (en) | 2021-01-31 |
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JP2021534139A (ja) | 2021-12-09 |
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