HUE061584T2 - Oxazin-monoacil-glicerol-lipáz (MAGL) gátlók - Google Patents
Oxazin-monoacil-glicerol-lipáz (MAGL) gátlókInfo
- Publication number
- HUE061584T2 HUE061584T2 HUE19711920A HUE19711920A HUE061584T2 HU E061584 T2 HUE061584 T2 HU E061584T2 HU E19711920 A HUE19711920 A HU E19711920A HU E19711920 A HUE19711920 A HU E19711920A HU E061584 T2 HUE061584 T2 HU E061584T2
- Authority
- HU
- Hungary
- Prior art keywords
- magl
- oxazine
- inhibitors
- monoacylglycerol lipase
- monoacylglycerol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18163273 | 2018-03-22 | ||
| CN2019075372 | 2019-02-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE061584T2 true HUE061584T2 (hu) | 2023-07-28 |
Family
ID=65818027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE19711920A HUE061584T2 (hu) | 2018-03-22 | 2019-03-22 | Oxazin-monoacil-glicerol-lipáz (MAGL) gátlók |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US20210107920A1 (hu) |
| EP (1) | EP3768684B1 (hu) |
| JP (1) | JP7308220B2 (hu) |
| KR (1) | KR20200136425A (hu) |
| CN (1) | CN111936503B (hu) |
| AU (1) | AU2019238381B2 (hu) |
| BR (1) | BR112020014992A2 (hu) |
| CA (1) | CA3089443A1 (hu) |
| CL (1) | CL2020002423A1 (hu) |
| CO (1) | CO2020009567A2 (hu) |
| CR (1) | CR20200416A (hu) |
| DK (1) | DK3768684T3 (hu) |
| ES (1) | ES2942319T3 (hu) |
| FI (1) | FI3768684T3 (hu) |
| HR (1) | HRP20230388T1 (hu) |
| HU (1) | HUE061584T2 (hu) |
| IL (1) | IL276031B2 (hu) |
| LT (1) | LT3768684T (hu) |
| MX (1) | MX2020008894A (hu) |
| PE (1) | PE20201185A1 (hu) |
| PH (1) | PH12020500661A1 (hu) |
| PL (1) | PL3768684T3 (hu) |
| RS (1) | RS64156B1 (hu) |
| SG (1) | SG11202007608UA (hu) |
| SI (1) | SI3768684T1 (hu) |
| TW (1) | TWI818967B (hu) |
| WO (1) | WO2019180185A1 (hu) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR114136A1 (es) | 2017-10-10 | 2020-07-29 | Hoffmann La Roche | Compuestos heterocíclicos |
| TW201936602A (zh) | 2017-11-28 | 2019-09-16 | 瑞士商赫孚孟拉羅股份公司 | 新雜環化合物 |
| TW201938164A (zh) | 2018-01-08 | 2019-10-01 | 瑞士商赫孚孟拉羅股份公司 | 新穎雜環化合物 |
| MX2021001433A (es) | 2018-08-13 | 2021-04-12 | Hoffmann La Roche | Nuevos compuestos heterociclicos como inhibidores de la monoacilglicerol lipasa. |
| US20210094971A1 (en) * | 2019-09-09 | 2021-04-01 | Hoffmann-La Roche Inc. | Heterocyclic compounds |
| MX2022002311A (es) * | 2019-09-12 | 2022-03-25 | Hoffmann La Roche | Compuestos de 4,4a,5,7,8,8a-hexapirido[4,3-b][1,4]oxazin-3-ona como inhibidores de monoacilglicerol lipasa (magl). |
| PE20221450A1 (es) * | 2019-09-23 | 2022-09-21 | Hoffmann La Roche | Compuestos heterociclicos |
| EP4034602A1 (en) * | 2019-09-24 | 2022-08-03 | F. Hoffmann-La Roche AG | Fluorescent probes for monoacylglycerol lipase (magl) |
| JP2022549446A (ja) * | 2019-09-24 | 2022-11-25 | エフ．ホフマン－ラ ロシュ アーゲー | 新規複素環モノアシルグリセロールリパーゼ（ｍａｇｌ）阻害剤 |
| CN114364684A (zh) * | 2019-09-24 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 杂环化合物 |
| CN115989228A (zh) | 2020-09-03 | 2023-04-18 | 豪夫迈·罗氏有限公司 | 杂环化合物 |
| CA3234429A1 (en) * | 2021-10-15 | 2023-04-20 | Luc Farmer | Ras inhibitors, compositions and methods of use thereof |
| WO2023247670A1 (en) * | 2022-06-24 | 2023-12-28 | F. Hoffmann-La Roche Ag | New heterocyclic-carbonyl-cyclic compounds as magl inhibitors |
| WO2024061853A1 (en) * | 2022-09-20 | 2024-03-28 | F. Hoffmann-La Roche Ag | Fluorescent probes for magl |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7579495B2 (en) | 2003-12-19 | 2009-08-25 | Momentive Performance Materials Inc. | Active-releasing cyclic siloxanes |
| ES2337728T3 (es) | 2005-06-20 | 2010-04-28 | Schering Corporation | Piperidinas sustituidas unidas a carbono y sus derivados utiles como antagonistas de histamina h3. |
| US7696229B2 (en) | 2006-02-17 | 2010-04-13 | Memory Pharmaceuticals Corporation | Compounds having 5-HT6 receptor affinity |
| WO2007117557A2 (en) | 2006-04-05 | 2007-10-18 | Vitae Pharmaceuticals, Inc. | Diaminopropanol renin inhibitors |
| WO2011059118A1 (ko) | 2009-11-10 | 2011-05-19 | Kim Hyun Jeen | 후각인지능력 검사 시스템 |
| CA2836311A1 (en) | 2011-05-16 | 2012-11-22 | Bionomics Limited | Amine derivatives as potassium channel blockers |
| SI2800565T1 (sl) | 2012-01-06 | 2020-10-30 | Lundbeck La Jolla Research Center, Inc. | Karbamatne spojine in metode izdelave in uporabe le-teh |
| GB201209587D0 (en) | 2012-05-30 | 2012-07-11 | Takeda Pharmaceutical | Therapeutic compounds |
| WO2016109501A1 (en) | 2014-12-30 | 2016-07-07 | Karos Pharmaceuticals, Inc. | Amide compounds as tryptophan hydroxylase inhibitors |
| US20180148429A1 (en) | 2015-05-13 | 2018-05-31 | Selvita S.A. | Substituted quinoxaline derivatives |
| MX2017014714A (es) | 2015-05-21 | 2018-01-25 | Glaxosmithkline Ip Dev Ltd | Derivados de benzoimidazol como inhibidores de peptidil arginina deiminasa 4 (pad4). |
| WO2016205590A1 (en) | 2015-06-18 | 2016-12-22 | Cephalon, Inc. | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
| CN105198903B (zh) * | 2015-11-09 | 2016-08-24 | 代先慧 | 一种治疗急性上呼吸道感染的药物组合物 |
| EP3438109B1 (en) | 2016-03-31 | 2021-08-25 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
-
2019
- 2019-03-22 SG SG11202007608UA patent/SG11202007608UA/en unknown
- 2019-03-22 PE PE2020001119A patent/PE20201185A1/es unknown
- 2019-03-22 PL PL19711920.9T patent/PL3768684T3/pl unknown
- 2019-03-22 WO PCT/EP2019/057174 patent/WO2019180185A1/en active Application Filing
- 2019-03-22 DK DK19711920.9T patent/DK3768684T3/da active
- 2019-03-22 HU HUE19711920A patent/HUE061584T2/hu unknown
- 2019-03-22 LT LTEPPCT/EP2019/057174T patent/LT3768684T/lt unknown
- 2019-03-22 FI FIEP19711920.9T patent/FI3768684T3/fi active
- 2019-03-22 ES ES19711920T patent/ES2942319T3/es active Active
- 2019-03-22 AU AU2019238381A patent/AU2019238381B2/en active Active
- 2019-03-22 EP EP19711920.9A patent/EP3768684B1/en active Active
- 2019-03-22 KR KR1020207029587A patent/KR20200136425A/ko active IP Right Grant
- 2019-03-22 HR HRP20230388TT patent/HRP20230388T1/hr unknown
- 2019-03-22 TW TW108110005A patent/TWI818967B/zh active
- 2019-03-22 RS RS20230303A patent/RS64156B1/sr unknown
- 2019-03-22 BR BR112020014992-6A patent/BR112020014992A2/pt unknown
- 2019-03-22 CR CR20200416A patent/CR20200416A/es unknown
- 2019-03-22 CA CA3089443A patent/CA3089443A1/en active Pending
- 2019-03-22 SI SI201930519T patent/SI3768684T1/sl unknown
- 2019-03-22 JP JP2020548747A patent/JP7308220B2/ja active Active
- 2019-03-22 CN CN201980018255.1A patent/CN111936503B/zh active Active
- 2019-03-22 MX MX2020008894A patent/MX2020008894A/es unknown
-
2020
- 2020-07-13 IL IL276031A patent/IL276031B2/en unknown
- 2020-07-31 CO CONC2020/0009567A patent/CO2020009567A2/es unknown
- 2020-09-08 PH PH12020500661A patent/PH12020500661A1/en unknown
- 2020-09-18 US US17/025,155 patent/US20210107920A1/en not_active Abandoned
- 2020-09-21 CL CL2020002423A patent/CL2020002423A1/es unknown
-
2022
- 2022-08-09 US US17/818,459 patent/US20230117324A1/en not_active Abandoned
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