CL2020001964A1 - Métodos para purificar cannabinoides usando cromatografía líquido-líquido. - Google Patents

Métodos para purificar cannabinoides usando cromatografía líquido-líquido.

Info

Publication number
CL2020001964A1
CL2020001964A1 CL2020001964A CL2020001964A CL2020001964A1 CL 2020001964 A1 CL2020001964 A1 CL 2020001964A1 CL 2020001964 A CL2020001964 A CL 2020001964A CL 2020001964 A CL2020001964 A CL 2020001964A CL 2020001964 A1 CL2020001964 A1 CL 2020001964A1
Authority
CL
Chile
Prior art keywords
liquid
cannabinoids
methods
chromatography
compositions
Prior art date
Application number
CL2020001964A
Other languages
English (en)
Inventor
Roura Xavier Nadal
Original Assignee
Phytoplant Res S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/882,516 external-priority patent/US10207198B2/en
Application filed by Phytoplant Res S L filed Critical Phytoplant Res S L
Publication of CL2020001964A1 publication Critical patent/CL2020001964A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/004—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by obtaining phenols from plant material or from animal material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0203—Solvent extraction of solids with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0492—Applications, solvents used
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1892—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns the sorbent material moving as a whole, e.g. continuous annular chromatography, true moving beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0004—Crystallisation cooling by heat exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/18—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring
    • C07C39/19—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring containing carbon-to-carbon double bonds but no carbon-to-carbon triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/19—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente memoria descriptiva da a conocer métodos para purificar uno o más cannabinoides a partir de un material vegetal usando sistemas de disolvente bifásico únicos y cromatografía líquido-líquido como cromatografía de partición centrífuga (CPC) o cromatografía a contracorriente (CCC). La presente memoria descriptiva también proporciona cannabinoides purificados tales como CBG, CBGA, CBGV, CBD, CBDA, CBDV, THC, THCA y THCV, composiciones que comprenden uno o más de estos cannabinoides producidos mediante el método dado a conocer, y métodos para tratar una enfermedad o estado empleando tales cannabinoides purificados y composiciones.
CL2020001964A 2018-01-29 2020-07-27 Métodos para purificar cannabinoides usando cromatografía líquido-líquido. CL2020001964A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15/882,516 US10207198B2 (en) 2015-01-22 2018-01-29 Methods of purifying cannabinoids using liquid:liquid chromatography

Publications (1)

Publication Number Publication Date
CL2020001964A1 true CL2020001964A1 (es) 2020-12-18

Family

ID=65276144

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020001964A CL2020001964A1 (es) 2018-01-29 2020-07-27 Métodos para purificar cannabinoides usando cromatografía líquido-líquido.

Country Status (9)

Country Link
EP (1) EP3746419A1 (es)
CN (1) CN111788171A (es)
AU (1) AU2019211188A1 (es)
CA (1) CA3089490A1 (es)
CL (1) CL2020001964A1 (es)
CO (1) CO2020009747A2 (es)
IL (1) IL276010A (es)
MX (1) MX2020007960A (es)
WO (1) WO2019145552A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220242810A1 (en) * 2019-06-14 2022-08-04 Purisys Llc Crystalline cannabigerol
CN110590511B (zh) * 2019-09-11 2021-05-28 上海同田生物技术股份有限公司 一种同时分离次大麻二酚和大麻萜酚的方法
CN112279752B (zh) * 2020-10-30 2022-11-11 云南芙雅生物科技有限公司 用于工业大麻的大麻素二氧化碳超临界提取方法
CN113135885A (zh) * 2021-04-07 2021-07-20 上海同田生物技术有限公司 一种高速逆流色谱分离纯化四氢次大麻酚的方法
AU2022376838A1 (en) 2021-10-26 2024-05-23 Ecofibre USA Inc. Methods of treating endometrial cancer using hemp extract
WO2023076937A1 (en) 2021-10-26 2023-05-04 Ecofibre Limited Methods of treating endometriosis and other non-cancer gynecological disorders with hemp extract
AU2022376837A1 (en) * 2021-10-26 2024-05-23 Ecofibre USA Inc. Systems and methods for producing hemp extracts and compositions
CN115385780B (zh) * 2022-08-26 2024-02-27 晨光生物科技集团股份有限公司 一种次大麻二酚结晶多晶型物及其制备方法和应用
WO2024091989A1 (en) 2022-10-26 2024-05-02 Ecofibre USA Inc. Stabilized compositions comprising cannabidiol

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
DE60332776D1 (de) * 2002-02-01 2010-07-08 Resolution Chemicals Ltd Herstellung von Delta-9-Tetrahydrocannabinol
US20080103193A1 (en) * 2006-10-26 2008-05-01 Trevor Percival Castor Methods for making compositions and compositions for treating pain and cachexia
US9765000B2 (en) 2015-01-22 2017-09-19 Phytoplant Research S.L. Methods of purifying cannabinoids, compositions and kits thereof
US10155708B2 (en) * 2015-01-22 2018-12-18 Phytoplant Research S.L. Methods of purifying cannabinoids, compositions and kits thereof
EP3061510A1 (de) 2015-02-27 2016-08-31 Bionorica Ethics GmbH CPC Verteilungschromatographie von Cannabinoiden
BG112018A (bg) * 2015-05-22 2016-11-30 "Побелч-Гле" Оод Метод за получаване на канабиноиден извлек от коноп

Also Published As

Publication number Publication date
IL276010A (en) 2020-08-31
CN111788171A (zh) 2020-10-16
CA3089490A1 (en) 2019-08-01
CO2020009747A2 (es) 2020-08-21
AU2019211188A1 (en) 2020-07-30
MX2020007960A (es) 2020-09-24
WO2019145552A1 (en) 2019-08-01
EP3746419A1 (en) 2020-12-09

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