CL2020001108A1 - Mitoflavoscinas: la fijación como objetivo de enzimas que contienen flavina elimina células madre cancerosas (cscs) al inhibir la respiración mitocondrial. - Google Patents
Mitoflavoscinas: la fijación como objetivo de enzimas que contienen flavina elimina células madre cancerosas (cscs) al inhibir la respiración mitocondrial.Info
- Publication number
- CL2020001108A1 CL2020001108A1 CL2020001108A CL2020001108A CL2020001108A1 CL 2020001108 A1 CL2020001108 A1 CL 2020001108A1 CL 2020001108 A CL2020001108 A CL 2020001108A CL 2020001108 A CL2020001108 A CL 2020001108A CL 2020001108 A1 CL2020001108 A1 CL 2020001108A1
- Authority
- CL
- Chile
- Prior art keywords
- mitoflavoscins
- flavin
- cscs
- targeting
- stem cells
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A61K31/025—Halogenated hydrocarbons carbocyclic
- A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
- C07C25/18—Polycyclic aromatic halogenated hydrocarbons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D347/00—Heterocyclic compounds containing rings having halogen atoms as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/12—Heterocyclic compounds containing pteridine ring systems containing pteridine ring systems condensed with carbocyclic rings or ring systems
- C07D475/14—Benz [g] pteridines, e.g. riboflavin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
- G01N33/5079—Mitochondria
Abstract
LA PRESENTE DESCRIPCIÓN SE REFIERE A COMPUESTOS QUE SE ENLAZAN A ENZIMAS QUE CONTIENEN FLAVINA E INHIBEN LA FUNCIÓN MITOCONDRIAL, REFERIDOS EN ESTE DOCUMENTO COMO MITOFLAVOSCINAS. SE DESCRIBEN MÉTODOS PARA EXAMINAR COMPUESTOS POR LA INHIBICIÓN MITOCONDRIAL Y PROPIEDADES ANTICANCEROSAS. TAMBIÉN SE DESCRIBEN MÉTODOS PARA USAR MITOFLAVOSCINAS PARA PREVENIR O TRATAR EL CÁNCER, INFECCIONES BACTERIANAS Y LEVADURA PATÓGENA, ASÍ COMO TAMBIÉN MÉTODOS PARA USAR MITOFLAVOSCINAS PARA PROPORCIONAR BENEFICIOS ANTI-ENVEJECIMIENTO. TAMBIÉN SE DAN A CONOCER COMPUESTOS ESPECÍFICOS DE MITOFLAVOSCINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762576287P | 2017-10-24 | 2017-10-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2020001108A1 true CL2020001108A1 (es) | 2020-10-23 |
Family
ID=66247987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020001108A CL2020001108A1 (es) | 2017-10-24 | 2020-04-24 | Mitoflavoscinas: la fijación como objetivo de enzimas que contienen flavina elimina células madre cancerosas (cscs) al inhibir la respiración mitocondrial. |
Country Status (20)
Country | Link |
---|---|
US (1) | US11497749B2 (es) |
EP (1) | EP3700512A4 (es) |
JP (1) | JP2021500374A (es) |
KR (1) | KR20200069365A (es) |
CN (1) | CN111565715A (es) |
AU (1) | AU2018354143A1 (es) |
BR (1) | BR112020008022A2 (es) |
CA (1) | CA3079952A1 (es) |
CL (1) | CL2020001108A1 (es) |
CR (1) | CR20200218A (es) |
CU (1) | CU20200039A7 (es) |
EC (1) | ECSP20027220A (es) |
IL (1) | IL274116A (es) |
MX (1) | MX2020004211A (es) |
PE (1) | PE20210166A1 (es) |
PH (1) | PH12020550476A1 (es) |
RU (1) | RU2020116649A (es) |
SG (1) | SG11202003675PA (es) |
WO (1) | WO2019083997A1 (es) |
ZA (1) | ZA202002663B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102017220539A1 (de) | 2017-11-17 | 2019-05-23 | Zf Friedrichshafen Ag | Verfahren zum Betreiben eines Systems aus einem landwirtschaftlichen Arbeitsfahrzeug und zumindest einem an diesem angeordneten Arbeitsgerät |
WO2019108729A1 (en) * | 2017-12-01 | 2019-06-06 | Lunella Biotech, Inc. | Repurposcins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells |
JP2022504204A (ja) | 2018-10-02 | 2022-01-13 | ルネラ・バイオテック・インコーポレーテッド | 老化細胞死誘導薬としてのアジスロマイシンおよびロキシスロマイシン誘導体 |
EP3976197A4 (en) | 2019-05-24 | 2023-07-19 | Lunella Biotech, Inc. | THERAPEUTIC AGENTS AND METHODS FOR PREDICTING AND OVERCOMING ENDOCRINE RESISTANCE IN BREAST CANCER |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9321558D0 (en) * | 1993-10-19 | 1993-12-08 | Radopath Ltd | Anti-viral agents |
JPH09309874A (ja) * | 1996-05-21 | 1997-12-02 | Fuji Photo Film Co Ltd | ポジ型感光性組成物 |
US6498181B1 (en) * | 1999-01-06 | 2002-12-24 | Maxim Pharmaceuticals | Synergistic tumorcidal response induced by histamine |
KR20020016844A (ko) * | 1999-07-16 | 2002-03-06 | 추후보정 | 반응성 산소 대사산물 저해제를 이용한 세포독성 림프구의활성화 및 보호 |
JP2002221787A (ja) * | 2001-01-25 | 2002-08-09 | Fuji Photo Film Co Ltd | ポジ型感放射線性組成物 |
JP4098483B2 (ja) | 2001-03-12 | 2008-06-11 | 富士フイルム株式会社 | 平版印刷版原版 |
JP2003207898A (ja) * | 2001-11-08 | 2003-07-25 | Fuji Photo Film Co Ltd | ポジ型レジスト組成物 |
KR101003960B1 (ko) * | 2003-08-22 | 2010-12-30 | 안티포딘 파마슈티칼스, 인코포레이티드 | 미토콘드리아 표적화 산화방지제로서 사용되는 미토퀴논 유도체를 포함하는 약제학적 조성물 |
JP2005091713A (ja) * | 2003-09-17 | 2005-04-07 | Fuji Photo Film Co Ltd | ポジ型レジスト組成物及びそれを用いたパターン形成方法。 |
GB0329716D0 (en) * | 2003-12-23 | 2004-01-28 | Amersham Plc | Radical trap |
WO2005099721A2 (en) * | 2004-04-15 | 2005-10-27 | The Regents Of The University Of California | Compositions comprising plant-derived polyphenolic compounds and inhibitors of reactive oxygen species and methods of using thereof |
DE102007025423A1 (de) | 2007-05-30 | 2008-12-04 | Friedrich-Schiller-Universität Jena | Triphenylphosphonium-Derivate zum gezielten Transport und Freisetzen von Substanzen in Mitochondrien sowie Verfahren zu deren Verwendung |
JP2009057330A (ja) * | 2007-08-31 | 2009-03-19 | Aspion Kk | ジフェニレンヨードニウム化合物 |
WO2009038656A1 (en) * | 2007-09-17 | 2009-03-26 | Kosta Steliou | Mitochondria-targeting antioxidant therapeutics |
EA201101639A1 (ru) * | 2009-05-20 | 2012-06-29 | Юниверсите Де Женев | Ингибиторы митохондриальной активности клеток, инициирующих рак, и их применение |
WO2013022278A2 (en) * | 2011-08-08 | 2013-02-14 | Hanall Biopharma Co., Ltd. | N1-cyclic amine-n5-substituted phenyl biguanide derivatives, methods of preparing the same and pharmaceutical composition comprising the same |
RU2522557C1 (ru) * | 2013-04-09 | 2014-07-20 | государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СибГМУ Минздрава России) | СПОСОБ ПОЛУЧЕНИЯ п-ИОДФЕНИЛЖИРНЫХ КИСЛОТ |
US9896466B2 (en) | 2013-04-24 | 2018-02-20 | Kkcg Ag | Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level |
EP3016715A4 (en) * | 2013-07-01 | 2017-02-08 | University Of Georgia Research Foundation, Inc. | Precise delivery of therapeutic agents to cell mitochondria for anti-cancer therapy |
WO2015156943A1 (en) * | 2014-03-10 | 2015-10-15 | Aravind Musuluri | Augmenting search results |
CN107137390A (zh) * | 2017-06-09 | 2017-09-08 | 中国人民解放军第三军医大学第附属医院 | 氯化二亚苯基碘鎓在制备治疗细菌感染药物中的用途 |
-
2018
- 2018-10-23 CU CU2020000039A patent/CU20200039A7/es unknown
- 2018-10-23 PE PE2020000423A patent/PE20210166A1/es unknown
- 2018-10-23 RU RU2020116649A patent/RU2020116649A/ru unknown
- 2018-10-23 BR BR112020008022-5A patent/BR112020008022A2/pt unknown
- 2018-10-23 CR CR20200218A patent/CR20200218A/es unknown
- 2018-10-23 MX MX2020004211A patent/MX2020004211A/es unknown
- 2018-10-23 CN CN201880083530.3A patent/CN111565715A/zh active Pending
- 2018-10-23 SG SG11202003675PA patent/SG11202003675PA/en unknown
- 2018-10-23 CA CA3079952A patent/CA3079952A1/en active Pending
- 2018-10-23 KR KR1020207014732A patent/KR20200069365A/ko not_active Application Discontinuation
- 2018-10-23 JP JP2020523023A patent/JP2021500374A/ja active Pending
- 2018-10-23 US US16/758,235 patent/US11497749B2/en active Active
- 2018-10-23 EP EP18871436.4A patent/EP3700512A4/en not_active Withdrawn
- 2018-10-23 WO PCT/US2018/057093 patent/WO2019083997A1/en active Search and Examination
- 2018-10-23 AU AU2018354143A patent/AU2018354143A1/en not_active Abandoned
-
2020
- 2020-04-21 IL IL274116A patent/IL274116A/en unknown
- 2020-04-23 PH PH12020550476A patent/PH12020550476A1/en unknown
- 2020-04-24 CL CL2020001108A patent/CL2020001108A1/es unknown
- 2020-05-11 ZA ZA2020/02663A patent/ZA202002663B/en unknown
- 2020-05-20 EC ECSENADI202027220A patent/ECSP20027220A/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2019083997A1 (en) | 2019-05-02 |
US20200246344A1 (en) | 2020-08-06 |
JP2021500374A (ja) | 2021-01-07 |
PE20210166A1 (es) | 2021-01-28 |
RU2020116649A (ru) | 2021-11-30 |
EP3700512A4 (en) | 2021-08-11 |
KR20200069365A (ko) | 2020-06-16 |
CR20200218A (es) | 2020-12-23 |
ZA202002663B (en) | 2022-06-29 |
US11497749B2 (en) | 2022-11-15 |
PH12020550476A1 (en) | 2021-03-15 |
BR112020008022A2 (pt) | 2020-10-27 |
EP3700512A1 (en) | 2020-09-02 |
CA3079952A1 (en) | 2019-05-02 |
IL274116A (en) | 2020-06-30 |
SG11202003675PA (en) | 2020-05-28 |
AU2018354143A1 (en) | 2020-05-14 |
CN111565715A (zh) | 2020-08-21 |
ECSP20027220A (es) | 2020-06-30 |
MX2020004211A (es) | 2020-08-13 |
CU20200039A7 (es) | 2021-03-11 |
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