CL2019003432A1 - Composición farmacéutica oftálmica que comprende nanopartículas mucopenetrantes, cuyo núcleo comprende un agente activo farmacéutico seleccionado entre un inhibidor de ciclooxigenasa (cox) o un fármaco antiinflamatorio no esterioidal (aine), y está recubierto con un polímero modificador de superficie; y uso para tratar un trastorno del ojo (divisional de solicitud cl 2956-2014). - Google Patents

Composición farmacéutica oftálmica que comprende nanopartículas mucopenetrantes, cuyo núcleo comprende un agente activo farmacéutico seleccionado entre un inhibidor de ciclooxigenasa (cox) o un fármaco antiinflamatorio no esterioidal (aine), y está recubierto con un polímero modificador de superficie; y uso para tratar un trastorno del ojo (divisional de solicitud cl 2956-2014).

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Publication number
CL2019003432A1
CL2019003432A1 CL2019003432A CL2019003432A CL2019003432A1 CL 2019003432 A1 CL2019003432 A1 CL 2019003432A1 CL 2019003432 A CL2019003432 A CL 2019003432A CL 2019003432 A CL2019003432 A CL 2019003432A CL 2019003432 A1 CL2019003432 A1 CL 2019003432A1
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CL
Chile
Prior art keywords
particles
pharmaceutical composition
treat
mucopenetrating
nsaid
Prior art date
Application number
CL2019003432A
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English (en)
Inventor
Alexey Popov
Elizabeth M Enlow
Hongming Chen
Bourassa James
Original Assignee
Kala Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48464113&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2019003432(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kala Pharmaceuticals Inc filed Critical Kala Pharmaceuticals Inc
Publication of CL2019003432A1 publication Critical patent/CL2019003432A1/es

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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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Abstract

SE PROPORCIONAN PARTÍCULAS, COMPOSICIONES QUE AYUDAN AL TRANSPORTE DE PARTÍCULAS EN EL MOCO. LAS PARTÍCULAS, COMPOSICIONES PUEDEN USARSE, EN ALGUNOS CASOS, PARA APLICACIONES OFTÁLMICAS Y/U OTRAS APLICACIONES. EN ALGUNAS MODALIDADES, LAS COMPOSICIONES Y MÉTODOS PUEDEN INVOLUCRAR MODIFICAR LOS RECUBRIMIENTOS SUPERFICIALES DE LAS PARTÍCULAS, TALES COMO PARTÍCULAS DE AGENTES FARMACÉUTICOS QUE TIENEN UNA BAJA SOLUBILIDAD ACUOSA. ESTAS COMPOSICIONES PUEDEN USARSE PARA LOGRAR UN TRANSPORTE EFICIENTE DE PARTÍCULAS DE AGENTES FARMACÉUTICOS A TRAVÉS DE LAS BARRERAS DE MOCO EN EL CUERPO PARA UN AMPLIO ESPECTRO DE APLICACIONES, INCLUYENDO APLICACIONES EN ENTREGA DE FÁRMACOS, FORMACIÓN DE IMÁGENES Y DIAGNÓSTICO. EN CIERTAS MODALIDADES, UNA COMPOSICIÓN FARMACÉUTICA QUE INCLUYE ESTAS PARTICULAS ES BIEN ADECUADA PARA APLICACIONES OFTÁLMICAS, Y PUEDE USARSE PARA ENTREGAR AGENTES FARMACÉUTICOS A LA PARTE DELANTERA DEL OJO Y/O LA PARTE DE ATRÁS DEL OJO. USO DE UNA COMPOSICIÓN FARMACÉUTICA PARA TRATAR UNA CONDICIÓN OCULAR EN UN SUJETO.
CL2019003432A 2012-05-03 2019-11-25 Composición farmacéutica oftálmica que comprende nanopartículas mucopenetrantes, cuyo núcleo comprende un agente activo farmacéutico seleccionado entre un inhibidor de ciclooxigenasa (cox) o un fármaco antiinflamatorio no esterioidal (aine), y está recubierto con un polímero modificador de superficie; y uso para tratar un trastorno del ojo (divisional de solicitud cl 2956-2014). CL2019003432A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261642313P 2012-05-03 2012-05-03
US201261642261P 2012-05-03 2012-05-03
US201261738949P 2012-12-18 2012-12-18
US201361784701P 2013-03-14 2013-03-14

Publications (1)

Publication Number Publication Date
CL2019003432A1 true CL2019003432A1 (es) 2020-05-08

Family

ID=48464113

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2014002956A CL2014002956A1 (es) 2012-05-03 2014-10-30 Composicion farmaceutica ocular que comprende particulas recubiertas de dimension menor a 1 micron, con un nucleo que comprende etaboato de loteprednol y un recubrimiento con modificadores de superficie; y uso para tratar la inflamacion, degeneracion macular, edema macular u otro trastorno del ojo.
CL2019003432A CL2019003432A1 (es) 2012-05-03 2019-11-25 Composición farmacéutica oftálmica que comprende nanopartículas mucopenetrantes, cuyo núcleo comprende un agente activo farmacéutico seleccionado entre un inhibidor de ciclooxigenasa (cox) o un fármaco antiinflamatorio no esterioidal (aine), y está recubierto con un polímero modificador de superficie; y uso para tratar un trastorno del ojo (divisional de solicitud cl 2956-2014).
CL2019003433A CL2019003433A1 (es) 2012-05-03 2019-11-25 Composición farmacéutica oftálmica que comprende nanopartículas mucopenetrantes, cuyo núcleo comprende un agente activo farmacéutico seleccionado entre un inhibidor de receptor tirosina quinasa (rtk), o un inhibidor de la angiogénesis, y está recubierto con un polímero modificador de superficie; y uso para tratar un trastorno del ojo (divisional de solicitud cl 2956-2014).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2014002956A CL2014002956A1 (es) 2012-05-03 2014-10-30 Composicion farmaceutica ocular que comprende particulas recubiertas de dimension menor a 1 micron, con un nucleo que comprende etaboato de loteprednol y un recubrimiento con modificadores de superficie; y uso para tratar la inflamacion, degeneracion macular, edema macular u otro trastorno del ojo.

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2019003433A CL2019003433A1 (es) 2012-05-03 2019-11-25 Composición farmacéutica oftálmica que comprende nanopartículas mucopenetrantes, cuyo núcleo comprende un agente activo farmacéutico seleccionado entre un inhibidor de receptor tirosina quinasa (rtk), o un inhibidor de la angiogénesis, y está recubierto con un polímero modificador de superficie; y uso para tratar un trastorno del ojo (divisional de solicitud cl 2956-2014).

Country Status (13)

Country Link
US (4) US20130316001A1 (es)
EP (1) EP2844223A1 (es)
JP (3) JP6720443B2 (es)
KR (2) KR102373259B1 (es)
CN (5) CN111700878A (es)
AU (3) AU2013256092B2 (es)
BR (1) BR112014027296B1 (es)
CA (1) CA2871748C (es)
CL (3) CL2014002956A1 (es)
HK (2) HK1208161A1 (es)
MX (2) MX2014013315A (es)
NZ (5) NZ728721A (es)
WO (1) WO2013166436A1 (es)

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US9327037B2 (en) 2011-02-08 2016-05-03 The Johns Hopkins University Mucus penetrating gene carriers
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EA030318B1 (ru) 2012-03-16 2018-07-31 Дзе Джонс Хопкинс Юниверсити Конъюгаты нелинейного мультиблочного сополимера с лекарственным средством для доставки активных агентов
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
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