CL2019003433A1 - Composición farmacéutica oftálmica que comprende nanopartículas mucopenetrantes, cuyo núcleo comprende un agente activo farmacéutico seleccionado entre un inhibidor de receptor tirosina quinasa (rtk), o un inhibidor de la angiogénesis, y está recubierto con un polímero modificador de superficie; y uso para tratar un trastorno del ojo (divisional de solicitud cl 2956-2014). - Google Patents
Composición farmacéutica oftálmica que comprende nanopartículas mucopenetrantes, cuyo núcleo comprende un agente activo farmacéutico seleccionado entre un inhibidor de receptor tirosina quinasa (rtk), o un inhibidor de la angiogénesis, y está recubierto con un polímero modificador de superficie; y uso para tratar un trastorno del ojo (divisional de solicitud cl 2956-2014).Info
- Publication number
- CL2019003433A1 CL2019003433A1 CL2019003433A CL2019003433A CL2019003433A1 CL 2019003433 A1 CL2019003433 A1 CL 2019003433A1 CL 2019003433 A CL2019003433 A CL 2019003433A CL 2019003433 A CL2019003433 A CL 2019003433A CL 2019003433 A1 CL2019003433 A1 CL 2019003433A1
- Authority
- CL
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- Prior art keywords
- inhibitor
- particles
- pharmaceutical composition
- treat
- mucopenetrating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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Abstract
SE PROPORCIONAN PARTÍCULAS, COMPOSICIONES QUE AYUDAN AL TRANSPORTE DE PARTÍCULAS EN EL MOCO. LAS PARTÍCULAS, COMPOSICIONES PUEDEN USARSE, EN ALGUNOS CASOS, PARA APLICACIONES OFTÁLMICAS Y/U OTRAS APLICACIONES. EN ALGUNAS MODALIDADES, LAS COMPOSICIONES Y MÉTODOS PUEDEN INVOLUCRAR MODIFICAR LOS RECUBRIMIENTOS SUPERFICIALES DE LAS PARTÍCULAS, TALES COMO PARTÍCULAS DE AGENTES FARMACÉUTICOS QUE TIENEN UNA BAJA SOLUBILIDAD ACUOSA. ESTAS COMPOSICIONES PUEDEN USARSE PARA LOGRAR UN TRANSPORTE EFICIENTE DE PARTÍCULAS DE AGENTES FARMACÉUTICOS A TRAVÉS DE LAS BARRERAS DE MOCO EN EL CUERPO PARA UN AMPLIO ESPECTRO DE APLICACIONES, INCLUYENDO APLICACIONES EN ENTREGA DE FÁRMACOS, FORMACIÓN DE IMÁGENES Y DIAGNÓSTICO. EN CIERTAS MODALIDADES, UNA COMPOSICIÓN FARMACÉUTICA QUE INCLUYE ESTAS PARTICULAS ES BIEN ADECUADA PARA APLICACIONES OFTÁLMICAS, Y PUEDE USARSE PARA ENTREGAR AGENTES FARMACÉUTICOS A LA PARTE DELANTERA DEL OJO Y/O LA PARTE DE ATRÁS DEL OJO. USO DE UNA COMPOSICIÓN FARMACÉUTICA PARA TRATAR UNA CONDICIÓN OCULAR EN UN SUJETO.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US201261642261P | 2012-05-03 | 2012-05-03 | |
US201261642313P | 2012-05-03 | 2012-05-03 | |
US201261738949P | 2012-12-18 | 2012-12-18 | |
US201361784701P | 2013-03-14 | 2013-03-14 |
Publications (1)
Publication Number | Publication Date |
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CL2019003433A1 true CL2019003433A1 (es) | 2020-05-08 |
Family
ID=48464113
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2014002956A CL2014002956A1 (es) | 2012-05-03 | 2014-10-30 | Composicion farmaceutica ocular que comprende particulas recubiertas de dimension menor a 1 micron, con un nucleo que comprende etaboato de loteprednol y un recubrimiento con modificadores de superficie; y uso para tratar la inflamacion, degeneracion macular, edema macular u otro trastorno del ojo. |
CL2019003433A CL2019003433A1 (es) | 2012-05-03 | 2019-11-25 | Composición farmacéutica oftálmica que comprende nanopartículas mucopenetrantes, cuyo núcleo comprende un agente activo farmacéutico seleccionado entre un inhibidor de receptor tirosina quinasa (rtk), o un inhibidor de la angiogénesis, y está recubierto con un polímero modificador de superficie; y uso para tratar un trastorno del ojo (divisional de solicitud cl 2956-2014). |
CL2019003432A CL2019003432A1 (es) | 2012-05-03 | 2019-11-25 | Composición farmacéutica oftálmica que comprende nanopartículas mucopenetrantes, cuyo núcleo comprende un agente activo farmacéutico seleccionado entre un inhibidor de ciclooxigenasa (cox) o un fármaco antiinflamatorio no esterioidal (aine), y está recubierto con un polímero modificador de superficie; y uso para tratar un trastorno del ojo (divisional de solicitud cl 2956-2014). |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2014002956A CL2014002956A1 (es) | 2012-05-03 | 2014-10-30 | Composicion farmaceutica ocular que comprende particulas recubiertas de dimension menor a 1 micron, con un nucleo que comprende etaboato de loteprednol y un recubrimiento con modificadores de superficie; y uso para tratar la inflamacion, degeneracion macular, edema macular u otro trastorno del ojo. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2019003432A CL2019003432A1 (es) | 2012-05-03 | 2019-11-25 | Composición farmacéutica oftálmica que comprende nanopartículas mucopenetrantes, cuyo núcleo comprende un agente activo farmacéutico seleccionado entre un inhibidor de ciclooxigenasa (cox) o un fármaco antiinflamatorio no esterioidal (aine), y está recubierto con un polímero modificador de superficie; y uso para tratar un trastorno del ojo (divisional de solicitud cl 2956-2014). |
Country Status (13)
Country | Link |
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US (4) | US20130316001A1 (es) |
EP (1) | EP2844223A1 (es) |
JP (3) | JP6720443B2 (es) |
KR (2) | KR102373259B1 (es) |
CN (5) | CN111700879A (es) |
AU (3) | AU2013256092B2 (es) |
BR (1) | BR112014027296B1 (es) |
CA (1) | CA2871748C (es) |
CL (3) | CL2014002956A1 (es) |
HK (2) | HK1208161A1 (es) |
MX (2) | MX2014013315A (es) |
NZ (5) | NZ741873A (es) |
WO (1) | WO2013166436A1 (es) |
Families Citing this family (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2538929A4 (en) | 2010-02-25 | 2014-07-09 | Univ Johns Hopkins | PROLONGED DELIVERY OF THERAPEUTIC AGENTS TO AN OCULAR COMPARTMENT |
WO2012039979A2 (en) | 2010-09-10 | 2012-03-29 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
WO2012109363A2 (en) | 2011-02-08 | 2012-08-16 | The Johns Hopkins University | Mucus penetrating gene carriers |
AU2013209452B2 (en) | 2012-01-19 | 2015-11-05 | The Johns Hopkins University | Nanoparticle formulations with enhanced mucosal penetration |
CA2867203C (en) | 2012-03-16 | 2016-09-20 | The Johns Hopkins University | Non-linear multiblock copolymer-drug conjugates for the delivery of active agents |
AU2013232297B2 (en) | 2012-03-16 | 2016-01-14 | The Johns Hopkins University | Controlled release formulations for the delivery of HIF-1 inhibitors |
US9056057B2 (en) | 2012-05-03 | 2015-06-16 | Kala Pharmaceuticals, Inc. | Nanocrystals, compositions, and methods that aid particle transport in mucus |
CA2871748C (en) * | 2012-05-03 | 2021-07-06 | Kala Pharmaceuticals, Inc. | Pharmaceutical nanoparticles showing improved mucosal transport |
US10688041B2 (en) | 2012-05-03 | 2020-06-23 | Kala Pharmaceuticals, Inc. | Compositions and methods utilizing poly(vinyl alcohol) and/or other polymers that aid particle transport in mucus |
US9827191B2 (en) * | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
US10864219B2 (en) * | 2012-05-03 | 2020-12-15 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
US9889208B2 (en) | 2012-05-04 | 2018-02-13 | The Johns Hopkins University | Lipid-based drug carriers for rapid penetration through mucus linings |
US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
US10568975B2 (en) | 2013-02-05 | 2020-02-25 | The Johns Hopkins University | Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof |
US9725451B2 (en) | 2013-03-15 | 2017-08-08 | Kala Pharmaceuticals, Inc. | Meropenem derivatives and uses thereof |
BR112015024234B1 (pt) | 2013-03-21 | 2022-11-16 | Eupraxia Pharmaceuticals USA LLC | Composição farmacêutica de liberação sustentada injetável, uso da mesma para diminuir inflamação ou controlar dor e método para formar micropartículas revestidas |
US10149823B2 (en) | 2013-04-30 | 2018-12-11 | Otitopic Inc. | Dry powder formulations and methods of use |
AU2014275198B2 (en) | 2013-05-30 | 2017-04-13 | KALA BIO, Inc. | Novel compounds and uses thereof |
CN106061261B (zh) | 2013-11-01 | 2018-04-24 | 卡拉制药公司 | 治疗化合物的结晶形式及其用途 |
WO2015127389A1 (en) | 2014-02-23 | 2015-08-27 | The Johns Hopkins University | Hypotonic enema formulations and methods of use |
JP6537532B2 (ja) | 2014-02-25 | 2019-07-03 | アキリオン ファーマシューティカルズ,インコーポレーテッド | 補体媒介障害の治療のための化合物 |
CN106459137B (zh) | 2014-05-01 | 2019-04-12 | 整体生物系统有限责任公司 | 用于治疗眼部病症的膜附着性自组装体系 |
KR101501217B1 (ko) * | 2014-07-17 | 2015-03-10 | 최명 | 필러용 폴리디옥사논 입자의 제조방법 |
US10172852B2 (en) | 2014-07-28 | 2019-01-08 | Sun Pharma Advanced Research Company Ltd. | Method of increasing bioavailability and/or prolonging ophthalmic action of a drug |
WO2016025215A1 (en) * | 2014-08-13 | 2016-02-18 | The Johns Hopkins University | Glucocorticoid-loaded nanoparticles for prevention of corneal allograft rejection and neovascularization |
AU2015329609B2 (en) * | 2014-10-09 | 2021-01-21 | Distretto Tecnologico Sicilia Micro E Nano Sistemi S.C.A.R.L. | Nanostructured formulations for the delivery of silibinin and other active ingredients for treating ocular diseases |
US20170232064A1 (en) * | 2014-10-15 | 2017-08-17 | Rapid Pathogen Screening, Inc. | Formulations for histatin therapeutics |
EP3223793B1 (en) * | 2014-11-25 | 2023-06-28 | Eximore Ltd. | Compositions and methods for delivering a bio-active agent or bio-active agents |
WO2016086026A1 (en) | 2014-11-26 | 2016-06-02 | Kala Pharmaceuticals, Inc. | Crystalline forms of a therapeutic compound and uses thereof |
AU2015360438C1 (en) | 2014-12-10 | 2019-02-07 | Kala Pharmaceuticals, Inc. | 1 -amino-triazolo(1,5-a)pyridine-substituted urea derivative and uses thereof |
WO2016094617A1 (en) * | 2014-12-11 | 2016-06-16 | Phosphorex, Inc. | Aqueous topical drug formulation with controlled release and increased stability |
MX2017007873A (es) * | 2014-12-15 | 2017-11-06 | Univ Johns Hopkins | Formulaciones de sunitinib y metodos para uso de las mismas en el tratamiento de trastornos oculares. |
US11324800B2 (en) | 2015-01-15 | 2022-05-10 | Wellspring Ophthalmics, Inc. | Aqueous suspensions of cyclosporin |
US20200237859A1 (en) | 2019-01-25 | 2020-07-30 | Newport Research, Inc. | Aqueous suspensions of cyclosporin |
AU2016211696B2 (en) | 2015-01-27 | 2018-05-10 | The Johns Hopkins University | Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces |
KR101730399B1 (ko) | 2015-04-13 | 2017-04-27 | 영남대학교 산학협력단 | 악시티닙을 포함하는 약물 전달체 및 이의 제조방법 |
CN114010787A (zh) | 2015-06-06 | 2022-02-08 | 拨云生物医药科技(广州)有限公司 | 用于治疗翼状胬肉的组合物和方法 |
KR101778004B1 (ko) * | 2015-06-22 | 2017-09-15 | (주) 에빅스젠 | 이마티닙을 유효성분으로 포함하는 안구 건조 질환 예방 및 치료용 약학 조성물 |
TWI700085B (zh) * | 2015-06-22 | 2020-08-01 | 新源生物科技股份有限公司 | 酪胺酸激酶抑制劑之眼用調配物的用途 |
US10729663B1 (en) * | 2015-08-21 | 2020-08-04 | University Of South Florida | Nanoparticles in thermoreversible gels for enhanced therapeutics |
AR105809A1 (es) | 2015-08-26 | 2017-11-08 | Achillion Pharmaceuticals Inc | Compuestos para el tratamiento de trastornos médicos |
US10000516B2 (en) | 2015-08-26 | 2018-06-19 | Achillion Pharmaceuticals, Inc. | Phosphonate compounds for treatment of medical disorders |
WO2017035351A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amino compounds for treatment of medical disorders |
WO2017035405A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amino compounds for treatment of immune and inflammatory disorders |
EP3340983B1 (en) | 2015-08-26 | 2023-10-04 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders |
AR105808A1 (es) | 2015-08-26 | 2017-11-08 | Achillion Pharmaceuticals Inc | Compuestos de amida para el tratamiento de trastornos médicos |
WO2017035361A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Disubstituted compounds for the treatment of medical disorders |
EP3340982B1 (en) | 2015-08-26 | 2021-12-15 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
US10385097B2 (en) | 2015-08-26 | 2019-08-20 | Achillion Pharmaceuticals, Inc. | Ether compounds for treatment of medical disorders |
WO2017035401A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amide compounds for treatment of immune and inflammatory disorders |
AU2016326564A1 (en) | 2015-09-22 | 2018-04-26 | Graybug Vision, Inc. | Compounds and compositions for the treatment of ocular disorders |
US10036135B2 (en) * | 2015-10-23 | 2018-07-31 | Philip S. Dunlap | Methods and systems to contain pollution and hazardous environments (CPHE) |
BR112018008415A2 (pt) | 2015-10-27 | 2018-10-30 | Eupraxia Pharmaceuticals Inc | formulações de liberação sustentada de anestésicos locais |
EP3368008A1 (en) * | 2015-10-30 | 2018-09-05 | The Johns Hopkins University | Mucus penetrating particles with high molecular weight and dense coatings |
WO2017083779A1 (en) | 2015-11-12 | 2017-05-18 | Graybug Vision, Inc. | Aggregating microparticles for therapy |
BR112018074450A2 (pt) | 2016-06-02 | 2019-03-19 | Cloudbreak Therapeutics, Llc | composições e métodos para a utilização de nintedanib para melhorar o sucesso da cirurgia do glaucoma |
TWI752083B (zh) * | 2016-09-13 | 2022-01-11 | 日商協和麒麟股份有限公司 | 醫藥組合物 |
CA3037174A1 (en) * | 2016-09-16 | 2018-03-22 | Kala Pharmaceuticals, Inc. | Particles, compositions, and methods for ophthalmic and/or other applications |
CA3037176A1 (en) * | 2016-09-16 | 2018-03-22 | Kala Pharmaceuticals, Inc. | Particles, compositions, and methods for ophthalmic and/or other applications |
ES2933513T3 (es) | 2017-03-01 | 2023-02-09 | Achillion Pharmaceuticals Inc | Compuestos macrocíclicos para el tratamiento de trastornos médicos |
EP3589628A4 (en) | 2017-03-01 | 2021-03-31 | Achillion Pharmaceuticals, Inc. | ARYL, HETEROARYL AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF MEDICAL DISEASES |
WO2018160891A1 (en) | 2017-03-01 | 2018-09-07 | Achillion Pharmaceutical, Inc. | Pharmaceutical compounds for treatment of medical disorders |
WO2018175268A1 (en) * | 2017-03-19 | 2018-09-27 | Biohealthways, Inc. | Biodegrading implantable ocular sustained release drug delivery system |
MX2019011242A (es) | 2017-03-23 | 2020-01-21 | Graybug Vision Inc | Farmacos y composiciones para el tratamiento de trastornos oculares. |
MX2019013327A (es) * | 2017-05-08 | 2020-07-27 | Inmed Pharmaceuticals Inc | Formulación para administración ocular de fármacos. |
CN111201040A (zh) | 2017-05-10 | 2020-05-26 | 灰色视觉公司 | 用于医学疗法的缓释微粒及其悬浮液 |
WO2019055028A1 (en) * | 2017-09-15 | 2019-03-21 | Kala Pharmaceuticals, Inc. | PARTICLES, COMPOSITIONS AND METHODS FOR OPHTHALMIC APPLICATIONS AND / OR OTHER APPLICATIONS |
JP2021502954A (ja) | 2017-09-22 | 2021-02-04 | オティトピック インク. | ステアリン酸マグネシウムを含む乾燥粉末組成物 |
US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
JP7221211B2 (ja) | 2017-11-15 | 2023-02-13 | 中外製薬株式会社 | ポリエチレングリコールにより修飾されたヒアルロン酸誘導体 |
WO2019213266A1 (en) * | 2018-05-02 | 2019-11-07 | Ocusoft, Inc. | Hypochlorous acid-based eyelid cleansers |
US11814391B2 (en) | 2018-09-06 | 2023-11-14 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for the treatment of medical disorders |
AU2019336238A1 (en) | 2018-09-06 | 2021-04-08 | Achillion Pharmaceuticals, Inc. | Morphic forms of Complement factor D inhibitors |
US11807627B2 (en) | 2018-09-25 | 2023-11-07 | Achillon Pharmaceuticals, Inc. | Morphic forms of complement factor D inhibitors |
CN110664757B (zh) * | 2018-11-19 | 2022-08-02 | 成都瑞沐生物医药科技有限公司 | 纳米晶滴眼剂、其制备方法及其应用 |
US20230190725A1 (en) * | 2019-04-29 | 2023-06-22 | The Board Of Trustees Of The University Of Illinois | Mek inhibitors for corneal scarring and neovascularization |
EP3999153A4 (en) * | 2019-07-16 | 2023-08-16 | The Regents Of The University Of Michigan | COMPOSITE DRUG PARTICLES AND ASSOCIATED USES |
CN114555064B (zh) * | 2019-10-01 | 2023-12-05 | 赢创有限公司 | 制备包含生物可再吸收的聚酯的粉末形式的纳米颗粒的方法 |
EP4069220A4 (en) * | 2019-12-04 | 2024-04-24 | Restore Vision Llc | OPHTHALMIC FORMULATIONS FOR THE TREATMENT OF PRESBYOPIA |
CN113214419B (zh) * | 2021-05-06 | 2022-10-25 | 温州医科大学附属眼视光医院 | 一种乳糖酸修饰的聚2-溴乙基丙烯酸酯及其制备方法与应用 |
CN113414049B (zh) * | 2021-06-04 | 2023-04-18 | 圣托马斯先进材料公司 | 一种智能雾化器及其使用方法 |
US20230111190A1 (en) * | 2021-09-14 | 2023-04-13 | Nulixir Inc. | Oral compositions with improved bioavailability and methods of making the same |
WO2023114375A2 (en) * | 2021-12-16 | 2023-06-22 | Alveolus Bio, Inc. | Inhalable or ingestible lactic acid compositions for the treatment of chronic lung disease |
WO2023141249A1 (en) * | 2022-01-24 | 2023-07-27 | Celanese Eva Performance Polymers Llc | Implantable device for delivery of a tyrosine kinase inhibitor |
WO2023235794A2 (en) * | 2022-06-01 | 2023-12-07 | The Trustees Of The University Of Pennsylvania | Adhesive particles for active delivery |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5619321B2 (es) * | 1971-09-22 | 1981-05-07 | ||
US5540930A (en) * | 1993-10-25 | 1996-07-30 | Pharmos Corporation | Suspension of loteprednol etabonate for ear, eye, or nose treatment |
DK0996429T3 (da) * | 1997-10-27 | 2003-05-26 | Merck Patent Gmbh | Faste opløsninger og faste dispersioner i vand tungtopløselige lægemidler |
US20050191359A1 (en) * | 2001-09-28 | 2005-09-01 | Solubest Ltd. | Water soluble nanoparticles and method for their production |
US7101576B2 (en) * | 2002-04-12 | 2006-09-05 | Elan Pharma International Limited | Nanoparticulate megestrol formulations |
US20040033202A1 (en) * | 2002-06-10 | 2004-02-19 | Elan Pharma International, Ltd. | Nanoparticulate sterol formulations and novel sterol combinations |
US20040208833A1 (en) * | 2003-02-04 | 2004-10-21 | Elan Pharma International Ltd. | Novel fluticasone formulations |
AU2004275594A1 (en) * | 2003-09-30 | 2005-04-07 | Solubest Ltd. | Water soluble nanoparticles inclusion complexes |
JP2007517016A (ja) * | 2003-12-31 | 2007-06-28 | ファイザー・プロダクツ・インク | 低溶解性薬剤及びポロキサマーの固体組成物 |
CN101137700B (zh) * | 2005-03-09 | 2012-07-18 | 东丽株式会社 | 微粒及医药组合物 |
DE102005011786A1 (de) * | 2005-03-11 | 2006-09-14 | Pharmasol Gmbh | Verfahren zur Herstellung ultrafeiner Submicron-Suspensionen |
US20070149480A1 (en) * | 2005-12-23 | 2007-06-28 | Alcon, Inc. | PHARMACEUTICAL COMPOSITION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE |
US20070178051A1 (en) * | 2006-01-27 | 2007-08-02 | Elan Pharma International, Ltd. | Sterilized nanoparticulate glucocorticosteroid formulations |
US7691811B2 (en) * | 2006-05-25 | 2010-04-06 | Bodor Nicholas S | Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye |
CN101317847B (zh) * | 2007-06-06 | 2010-10-13 | 深圳市瑞谷医药技术有限公司 | 一种眼用或耳鼻用药物组合物及其用途 |
CN101129385B (zh) * | 2007-08-14 | 2010-07-21 | 山东博士伦福瑞达制药有限公司 | 含加替沙星和依碳酸氯替泼诺的眼用组合物及其制备方法 |
US20110065774A1 (en) * | 2008-01-31 | 2011-03-17 | Alnylam Pharmaceuticals | Chemically modified oligonucleotides and uses thereof |
TWI580441B (zh) * | 2008-09-19 | 2017-05-01 | 愛爾康研究有限公司 | 穩定的藥學次微米懸浮液及其形成方法 |
JP2012522055A (ja) * | 2009-03-30 | 2012-09-20 | セルリアン・ファーマ・インコーポレイテッド | ポリマー‐薬剤抱合体、粒子、組成物、および関連する使用方法 |
EP2538929A4 (en) * | 2010-02-25 | 2014-07-09 | Univ Johns Hopkins | PROLONGED DELIVERY OF THERAPEUTIC AGENTS TO AN OCULAR COMPARTMENT |
JP2013543844A (ja) * | 2010-10-22 | 2013-12-09 | バインド セラピューティックス インコーポレイテッド | 高分子コポリマーを含む治療用ナノ粒子 |
CA3054532C (en) | 2010-11-05 | 2022-07-12 | The Johns Hopkins University | Compositions and methods relating to reduced mucoadhesion |
CA2871748C (en) | 2012-05-03 | 2021-07-06 | Kala Pharmaceuticals, Inc. | Pharmaceutical nanoparticles showing improved mucosal transport |
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