CL2019003118A1 - Proceso para convertir la ascomicina técnica en pimecrolimus puro. - Google Patents

Proceso para convertir la ascomicina técnica en pimecrolimus puro.

Info

Publication number
CL2019003118A1
CL2019003118A1 CL2019003118A CL2019003118A CL2019003118A1 CL 2019003118 A1 CL2019003118 A1 CL 2019003118A1 CL 2019003118 A CL2019003118 A CL 2019003118A CL 2019003118 A CL2019003118 A CL 2019003118A CL 2019003118 A1 CL2019003118 A1 CL 2019003118A1
Authority
CL
Chile
Prior art keywords
ascomycin
pimecrolimus
pure
convert
technical
Prior art date
Application number
CL2019003118A
Other languages
English (en)
Inventor
Borut Gabriel
Aljaz Kajtna
Anja Lukic
Souza Dominic De
Wender Hasselwander
Original Assignee
Meda Pharma Gmbh & Co Kg
Meda Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meda Pharma Gmbh & Co Kg, Meda Ab filed Critical Meda Pharma Gmbh & Co Kg
Publication of CL2019003118A1 publication Critical patent/CL2019003118A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE DESCRIPCIÓN SE DIRIGE A UN PROCESO MEJORADO PARA CONVERTIR LA ASCOMICINA EN PIMECROLIMUS. LA ASCOMICINA TÉCNICA SE CLORA CON TRIFENILFOSFINA Y N-CLOROSUCCINIMIDA (NCS) PARA PRODUCIR PIMECROLIMUS CRUDO, QUE A CONTINUACIÓN SE PURIFICA ADICIONALMENTE MEDIANTE HPLC Y POSTERIOR CRISTALIZACIÓN. LOS PROCESOS DE LA PRESENTE DESCRIPCIÓN PERMITEN LA ELIMINACIÓN DE HOMÓLOGOS CERCANOS DE PIMECROLIMUS MEDIANTE CROMATOGRAFÍA LÍQUIDA DE ALTA PRESIÓN SIN PURIFICACIÓN PREVIA DEL MATERIAL DE PARTIDA DE ASCOMICINA. ESTA MEJORA PUEDE HACER QUE LA CONVERSIÓN DE ASCOMICINA A PIMECROLIMUS SEA APLICABLE INDUSTRIALMENTE Y MENOS COSTOSA.
CL2019003118A 2017-05-01 2019-10-29 Proceso para convertir la ascomicina técnica en pimecrolimus puro. CL2019003118A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762492394P 2017-05-01 2017-05-01

Publications (1)

Publication Number Publication Date
CL2019003118A1 true CL2019003118A1 (es) 2020-02-21

Family

ID=62148339

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019003118A CL2019003118A1 (es) 2017-05-01 2019-10-29 Proceso para convertir la ascomicina técnica en pimecrolimus puro.

Country Status (13)

Country Link
US (1) US10975097B2 (es)
EP (1) EP3619215B1 (es)
KR (1) KR102592374B1 (es)
CN (1) CN110741006B (es)
CA (1) CA3060330A1 (es)
CL (1) CL2019003118A1 (es)
ES (1) ES2906158T3 (es)
HR (1) HRP20220203T1 (es)
PL (1) PL3619215T3 (es)
PT (1) PT3619215T (es)
SA (1) SA519410421B1 (es)
SI (1) SI3619215T1 (es)
WO (1) WO2018202733A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102645011B1 (ko) * 2023-10-17 2024-03-07 주식회사 라이프슈티컬 고상 추출법을 이용한 타크롤리무스의 정제방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737292A (en) 1986-06-05 1988-04-12 Separations Technology, Inc. HPLC column and a column packing method
EP0427680B1 (en) 1989-11-09 1995-08-23 Sandoz Ltd. Heteroatoms-containing tricyclic compounds
GB9618952D0 (en) 1996-09-11 1996-10-23 Sandoz Ltd Process
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
GB0012383D0 (en) 2000-05-22 2000-07-12 Novartis Ag Organic compounds
ATE378345T1 (de) 2003-07-24 2007-11-15 Teva Gyogyszergyar Zartkoeruee Verfahren zur aufreinigung von makroliden
GT200500282A (es) * 2004-10-12 2006-05-04 Heteroatomos conteniendo compuestos triciclicos.
JP2007523896A (ja) 2004-12-01 2007-08-23 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ アスコマイシンの結晶形態とその調製方法
CN101068820A (zh) * 2004-12-01 2007-11-07 特瓦药厂私人有限公司 不吸湿和粉末状的非晶态吡美莫司
TW200837067A (en) 2006-11-06 2008-09-16 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof
IT1394309B1 (it) * 2009-05-22 2012-06-06 Poli Ind Chimica Spa Nuovo approccio chimico-enzimatico alla sintesi del pimecrolimus
CN107873055B (zh) 2015-05-29 2021-09-17 库瑞瓦格房地产有限公司 包括至少一个切向流过滤步骤的产生和纯化rna的方法

Also Published As

Publication number Publication date
HRP20220203T1 (hr) 2022-05-27
WO2018202733A1 (en) 2018-11-08
CA3060330A1 (en) 2018-11-08
CN110741006B (zh) 2023-04-07
KR20200006529A (ko) 2020-01-20
EP3619215B1 (en) 2021-11-17
CN110741006A (zh) 2020-01-31
PT3619215T (pt) 2022-02-11
KR102592374B1 (ko) 2023-10-25
PL3619215T3 (pl) 2022-03-21
EP3619215A1 (en) 2020-03-11
US10975097B2 (en) 2021-04-13
SA519410421B1 (ar) 2022-03-03
ES2906158T3 (es) 2022-04-13
SI3619215T1 (sl) 2022-05-31
US20200079792A1 (en) 2020-03-12

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