CL2019002966A1 - Proceso para la preparación de enantiómeros de pirlindol y sus sales. - Google Patents
Proceso para la preparación de enantiómeros de pirlindol y sus sales.Info
- Publication number
- CL2019002966A1 CL2019002966A1 CL2019002966A CL2019002966A CL2019002966A1 CL 2019002966 A1 CL2019002966 A1 CL 2019002966A1 CL 2019002966 A CL2019002966 A CL 2019002966A CL 2019002966 A CL2019002966 A CL 2019002966A CL 2019002966 A1 CL2019002966 A1 CL 2019002966A1
- Authority
- CL
- Chile
- Prior art keywords
- preparation
- pirlindole
- enantiomers
- salts
- carbazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A UN PROCESO MEJORADO PARA LA PREPARACIÓN DE ENANTIÓMEROS DE PIRLINDOL, O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DE LOS MISMOS, QUE COMPRENDE LOS PASOS DE: CICLACIÓN ENTRE EL COMPUESTO DE LA FÓRMULA VI (S)-6-METIL-N-((S)-1-FENILETIL)-2,3,4,9- TETRAHIDRO-1H-CARBAZOL-1-AMINA O SU COMPUESTO ENANTIÓMERO DE LA FÓRMULA VIII (R)-6- METIL-N-((R)-1-FENILETIL)-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-AMINA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT11003817 | 2017-04-21 | ||
| EP17167852.7A EP3392251A1 (en) | 2017-04-21 | 2017-04-24 | Process for the preparation of pirlindole enantiomers and its salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2019002966A1 true CL2019002966A1 (es) | 2020-04-13 |
Family
ID=58632261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2019002966A CL2019002966A1 (es) | 2017-04-21 | 2019-10-17 | Proceso para la preparación de enantiómeros de pirlindol y sus sales. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US11008328B2 (es) |
| EP (2) | EP3392251A1 (es) |
| JP (1) | JP7121749B2 (es) |
| KR (1) | KR102526439B1 (es) |
| CN (1) | CN110914270B (es) |
| AU (1) | AU2018254239B2 (es) |
| BR (1) | BR112019022065A2 (es) |
| CA (1) | CA3060593A1 (es) |
| CL (1) | CL2019002966A1 (es) |
| CO (1) | CO2019012594A2 (es) |
| CY (1) | CY1124736T1 (es) |
| EA (1) | EA037179B1 (es) |
| EC (1) | ECSP19076874A (es) |
| IL (1) | IL270049B (es) |
| PE (1) | PE20191740A1 (es) |
| PT (1) | PT3612535T (es) |
| SA (1) | SA519410308B1 (es) |
| UA (1) | UA124942C2 (es) |
| WO (1) | WO2018193415A1 (es) |
| ZA (1) | ZA201907515B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011094840A1 (en) * | 2010-02-03 | 2011-08-11 | Biofume Technologies Inc. | Preservative package comprising plant material |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3288859A (en) | 1965-03-30 | 1966-11-29 | Procter & Gamble | Reactions of alkali metal salts of sulfinyl carbanions and alkanesulfenates with epoxy compounds and novel compounds derived therefrom |
| IT1312539B1 (it) * | 1999-04-16 | 2002-04-22 | Erregierre Spa | Processo per la preparazione del pirlindolo cloridrato. |
| RU2436786C1 (ru) * | 2010-07-23 | 2011-12-20 | Александр Васильевич Иващенко | Замещенные индолы, противовирусный активный компонент, способ получения и применения |
| WO2015171003A1 (en) | 2014-05-09 | 2015-11-12 | Tecnimede Sociedade Tecnico-Medicinal S.A. | Process for obtaining optically active pirlindole enantiomers and salts thereof |
| WO2015171002A1 (en) * | 2014-05-09 | 2015-11-12 | Tecnimede Sociedade Tecnico-Medicinal S.A. | Pharmaceutically acceptable salts of pirlindole enantiomers for use in medicine |
| NO3057589T3 (es) | 2014-05-09 | 2017-12-30 | ||
| CN104774208A (zh) | 2015-04-24 | 2015-07-15 | 南京靖龙药物研发有限公司 | 一种氘标记吡吲哚盐酸盐的制备方法 |
-
2017
- 2017-04-24 EP EP17167852.7A patent/EP3392251A1/en not_active Withdrawn
-
2018
- 2018-04-20 EP EP18746988.7A patent/EP3612535B1/en active Active
- 2018-04-20 BR BR112019022065A patent/BR112019022065A2/pt active Search and Examination
- 2018-04-20 PE PE2019002067A patent/PE20191740A1/es unknown
- 2018-04-20 US US16/607,051 patent/US11008328B2/en active Active
- 2018-04-20 UA UAA201910929A patent/UA124942C2/uk unknown
- 2018-04-20 JP JP2019557485A patent/JP7121749B2/ja active Active
- 2018-04-20 AU AU2018254239A patent/AU2018254239B2/en active Active
- 2018-04-20 PT PT187469887T patent/PT3612535T/pt unknown
- 2018-04-20 KR KR1020197033653A patent/KR102526439B1/ko active IP Right Grant
- 2018-04-20 WO PCT/IB2018/052756 patent/WO2018193415A1/en active Application Filing
- 2018-04-20 CN CN201880028446.1A patent/CN110914270B/zh active Active
- 2018-04-20 CA CA3060593A patent/CA3060593A1/en active Pending
- 2018-04-20 EA EA201992380A patent/EA037179B1/ru unknown
-
2019
- 2019-10-16 SA SA519410308A patent/SA519410308B1/ar unknown
- 2019-10-17 CL CL2019002966A patent/CL2019002966A1/es unknown
- 2019-10-18 IL IL270049A patent/IL270049B/en unknown
- 2019-10-30 EC ECSENADI201976874A patent/ECSP19076874A/es unknown
- 2019-11-12 CO CONC2019/0012594A patent/CO2019012594A2/es unknown
- 2019-11-13 ZA ZA201907515A patent/ZA201907515B/en unknown
-
2021
- 2021-11-19 CY CY20211101005T patent/CY1124736T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US11008328B2 (en) | 2021-05-18 |
| CN110914270A (zh) | 2020-03-24 |
| EP3612535B1 (en) | 2021-09-01 |
| ZA201907515B (en) | 2020-11-25 |
| KR102526439B1 (ko) | 2023-04-26 |
| CN110914270B (zh) | 2022-05-03 |
| EP3392251A1 (en) | 2018-10-24 |
| CA3060593A1 (en) | 2018-10-25 |
| WO2018193415A1 (en) | 2018-10-25 |
| IL270049B (en) | 2022-02-01 |
| US20200190098A1 (en) | 2020-06-18 |
| EA201992380A1 (ru) | 2020-02-21 |
| JP2020517662A (ja) | 2020-06-18 |
| UA124942C2 (uk) | 2021-12-15 |
| JP7121749B2 (ja) | 2022-08-18 |
| BR112019022065A2 (pt) | 2020-05-05 |
| CY1124736T1 (el) | 2022-07-22 |
| EA037179B1 (ru) | 2021-02-16 |
| PE20191740A1 (es) | 2019-12-12 |
| CO2019012594A2 (es) | 2020-01-17 |
| EP3612535A1 (en) | 2020-02-26 |
| AU2018254239B2 (en) | 2022-05-26 |
| SA519410308B1 (ar) | 2021-11-25 |
| AU2018254239A1 (en) | 2019-10-31 |
| KR20190140970A (ko) | 2019-12-20 |
| ECSP19076874A (es) | 2020-02-28 |
| PT3612535T (pt) | 2021-12-07 |
| WO2018193415A9 (en) | 2019-08-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR114631A1 (es) | Métodos e intermedios para preparar compuestos de piridina | |
| CR20170237A (es) | Nuevos compuestos de 5-amino-6h-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituidos para el tratamiento y profilaxis de infecciones virales. | |
| AR114827A1 (es) | Sal sódica de n-((1,2,3,5,6,7-hexahidro-s-indacen-4-il)carbamoil)-1-isopropil-1h-pirazol-3-sulfonamida | |
| CR20170392A (es) | Compuestos bicíclicos de sulfonamida cetona | |
| CR20190124A (es) | Inhibidores de ssao de aminopirimidina | |
| CL2020003022A1 (es) | Formas sólidas de 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3-fluoropropil)azetidin-3-il)amino)fenil)-3-metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)-2,2-difluoropropan-1-ol y procesos para preparar compuestos tricíclicos fusionados que comprenden un resto fenilo o piridinilo sustituido, incluidos métodos para su uso | |
| UY37487A (es) | Amidas heterocíclicas como inhibidores de quinasa | |
| GT201600085A (es) | Composiciones y métodos para modular los receptores x farnesoides | |
| CO2017001608A2 (es) | Compuestos fusionados de 11 miembros y fungicidas agrícolas/hortícolas que los contienen | |
| CO2018000589A2 (es) | Oxiesteroles y composiciones farmacéuticas que los contienen | |
| UY38837A (es) | Proceso de elaboración de moduladores de cftr | |
| AR098870A1 (es) | Formas polimorficas de una sal de clorhidrato de (s)-2-(1-(9h-purin-6-ilamino)propil)-5-fluoro-3-fenilquinazolin-4(3h)-ona | |
| SV2016005351A (es) | Derivados de indano e indolina y el uso de los mismos como activadores de la guanilato ciclasa soluble | |
| AR112276A1 (es) | Polimorfos de 5-fluoro-4-imino-3-metil-1-tosil-3,4-dihidropirimidin-2-ona | |
| CL2018002583A1 (es) | Derivado de morfolina | |
| CR20170496A (es) | Nuevos compuestos y derivados de sulfonimidoilpurinona para el tratamiento y profilaxis de infecciones víricas | |
| CL2018001067A1 (es) | Compuesto piranodipiridínico. | |
| CL2020000376A1 (es) | Compuesto pentacíclico. | |
| CL2021000903A1 (es) | Nhibidores de ror gamma (solicitud divisional de la solicitud 217-2020 | |
| MX2020003921A (es) | Proceso para producir compuestos de tipo piridazinona herbicidas. | |
| CL2018002344A1 (es) | Proceso para preparar compuestos de 7h-pirrolo[2,3-d]pirimidina | |
| CL2019002966A1 (es) | Proceso para la preparación de enantiómeros de pirlindol y sus sales. | |
| CU24560B1 (es) | N-(4,4-difluorociclohexil)-2-(3-metil-1h-pirazol-1-il)-6-morfolinopirimidin-4-amina útil como modulador de canales de potasio | |
| AR109328A1 (es) | Derivado de triazolopirazinona útil como un inhibidor de pde1 humana | |
| BR112019001153A2 (pt) | agonista s1p1 e aplicação do mesmo |