CL2019001293A1 - Agentes, usos y métodos para el tratamiento de la sinucleinopatía. - Google Patents

Agentes, usos y métodos para el tratamiento de la sinucleinopatía.

Info

Publication number
CL2019001293A1
CL2019001293A1 CL2019001293A CL2019001293A CL2019001293A1 CL 2019001293 A1 CL2019001293 A1 CL 2019001293A1 CL 2019001293 A CL2019001293 A CL 2019001293A CL 2019001293 A CL2019001293 A CL 2019001293A CL 2019001293 A1 CL2019001293 A1 CL 2019001293A1
Authority
CL
Chile
Prior art keywords
disease
parkinson
treatment
synucleinopathy
agents
Prior art date
Application number
CL2019001293A
Other languages
English (en)
Inventor
Pekka Kallunki
Paul E G Kristjansen
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of CL2019001293A1 publication Critical patent/CL2019001293A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Psychology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCIÓN SE REFIERE A UN TRATAMIENTO COMBINATORIO QUE USA UN ANTICUERPO MONOCLONAL ANTI-ALFA-SINUCLEÍNA Y UN MEDICAMENTO ADICIONAL. LOS ANTICUERPOS PUEDEN USARSE PARA TRATAR UNA SINUCLEINOPATÍA TAL COMO LA ENFERMEDAD DE PARKINSON (INCLUYENDO FORMAS IDIOPÁTICAS Y HEREDITARIAS DE ENFERMEDAD DE PARKINSON), ENFERMEDAD DIFUSA CON CUERPOS DE LEWY (DLB), VARIANTE DE ENFERMEDAD DE ALZHEIMER CON CUERPOS DE LEWY (LBV), ENFERMEDAD COMBINADA DE ALZHEIMER Y PARKINSON, FALLO AUTONÓMICO PURO Y ATROFIA MULTISISTEMA, JUNTO CON OTRO MEDICAMENTO DE LA INVENCIÓN.
CL2019001293A 2016-11-15 2019-05-10 Agentes, usos y métodos para el tratamiento de la sinucleinopatía. CL2019001293A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA201600710 2016-11-15

Publications (1)

Publication Number Publication Date
CL2019001293A1 true CL2019001293A1 (es) 2019-07-19

Family

ID=62145269

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2019001293A CL2019001293A1 (es) 2016-11-15 2019-05-10 Agentes, usos y métodos para el tratamiento de la sinucleinopatía.
CL2021003306A CL2021003306A1 (es) 2016-11-15 2021-12-10 Agentes, usos y métodos para el tratamiento de la sinucleinopatía. (divisional de solicitud nº 201901293)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2021003306A CL2021003306A1 (es) 2016-11-15 2021-12-10 Agentes, usos y métodos para el tratamiento de la sinucleinopatía. (divisional de solicitud nº 201901293)

Country Status (16)

Country Link
US (2) US10889635B2 (es)
EP (1) EP3541836A1 (es)
JP (1) JP7217229B2 (es)
KR (1) KR102593669B1 (es)
CN (1) CN109937210B (es)
AR (1) AR110074A1 (es)
AU (1) AU2017359944B2 (es)
BR (1) BR112018014281A2 (es)
CA (1) CA3043651A1 (es)
CL (2) CL2019001293A1 (es)
CO (1) CO2019004755A2 (es)
IL (1) IL266596A (es)
MA (1) MA46836A (es)
MX (1) MX2019005594A (es)
RU (1) RU2019114679A (es)
WO (1) WO2018091444A1 (es)

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RU2019114679A3 (es) 2021-03-30
WO2018091444A1 (en) 2018-05-24
AR110074A1 (es) 2019-02-20
IL266596A (en) 2019-07-31
JP7217229B2 (ja) 2023-02-02
MA46836A (fr) 2019-09-25
US20210236634A1 (en) 2021-08-05
MX2019005594A (es) 2019-07-04
CO2019004755A2 (es) 2019-05-21
CN109937210A (zh) 2019-06-25
AU2017359944A1 (en) 2019-05-23
RU2019114679A (ru) 2020-12-17
AU2017359944B2 (en) 2024-07-18
CL2021003306A1 (es) 2022-07-22
JP2020500849A (ja) 2020-01-16
US10889635B2 (en) 2021-01-12
EP3541836A1 (en) 2019-09-25
KR20190083356A (ko) 2019-07-11
CN109937210B (zh) 2023-09-15
BR112018014281A2 (pt) 2018-12-18
KR102593669B1 (ko) 2023-10-25
CA3043651A1 (en) 2018-05-24
US20180194833A1 (en) 2018-07-12

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