CL2019001293A1 - Agentes, usos y métodos para el tratamiento de la sinucleinopatía. - Google Patents
Agentes, usos y métodos para el tratamiento de la sinucleinopatía.Info
- Publication number
- CL2019001293A1 CL2019001293A1 CL2019001293A CL2019001293A CL2019001293A1 CL 2019001293 A1 CL2019001293 A1 CL 2019001293A1 CL 2019001293 A CL2019001293 A CL 2019001293A CL 2019001293 A CL2019001293 A CL 2019001293A CL 2019001293 A1 CL2019001293 A1 CL 2019001293A1
- Authority
- CL
- Chile
- Prior art keywords
- disease
- parkinson
- treatment
- synucleinopathy
- agents
- Prior art date
Links
- 208000032859 Synucleinopathies Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000018737 Parkinson disease Diseases 0.000 abstract 2
- 208000001089 Multiple system atrophy Diseases 0.000 abstract 1
- 208000009144 Pure autonomic failure Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Psychology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCIÓN SE REFIERE A UN TRATAMIENTO COMBINATORIO QUE USA UN ANTICUERPO MONOCLONAL ANTI-ALFA-SINUCLEÍNA Y UN MEDICAMENTO ADICIONAL. LOS ANTICUERPOS PUEDEN USARSE PARA TRATAR UNA SINUCLEINOPATÍA TAL COMO LA ENFERMEDAD DE PARKINSON (INCLUYENDO FORMAS IDIOPÁTICAS Y HEREDITARIAS DE ENFERMEDAD DE PARKINSON), ENFERMEDAD DIFUSA CON CUERPOS DE LEWY (DLB), VARIANTE DE ENFERMEDAD DE ALZHEIMER CON CUERPOS DE LEWY (LBV), ENFERMEDAD COMBINADA DE ALZHEIMER Y PARKINSON, FALLO AUTONÓMICO PURO Y ATROFIA MULTISISTEMA, JUNTO CON OTRO MEDICAMENTO DE LA INVENCIÓN.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201600710 | 2016-11-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2019001293A1 true CL2019001293A1 (es) | 2019-07-19 |
Family
ID=62145269
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2019001293A CL2019001293A1 (es) | 2016-11-15 | 2019-05-10 | Agentes, usos y métodos para el tratamiento de la sinucleinopatía. |
CL2021003306A CL2021003306A1 (es) | 2016-11-15 | 2021-12-10 | Agentes, usos y métodos para el tratamiento de la sinucleinopatía. (divisional de solicitud nº 201901293) |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021003306A CL2021003306A1 (es) | 2016-11-15 | 2021-12-10 | Agentes, usos y métodos para el tratamiento de la sinucleinopatía. (divisional de solicitud nº 201901293) |
Country Status (16)
Country | Link |
---|---|
US (2) | US10889635B2 (es) |
EP (1) | EP3541836A1 (es) |
JP (1) | JP7217229B2 (es) |
KR (1) | KR102593669B1 (es) |
CN (1) | CN109937210B (es) |
AR (1) | AR110074A1 (es) |
AU (1) | AU2017359944B2 (es) |
BR (1) | BR112018014281A2 (es) |
CA (1) | CA3043651A1 (es) |
CL (2) | CL2019001293A1 (es) |
CO (1) | CO2019004755A2 (es) |
IL (1) | IL266596A (es) |
MA (1) | MA46836A (es) |
MX (1) | MX2019005594A (es) |
RU (1) | RU2019114679A (es) |
WO (1) | WO2018091444A1 (es) |
Families Citing this family (17)
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GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
JP7217229B2 (ja) * | 2016-11-15 | 2023-02-02 | ハー・ルンドベック・アクチエゼルスカベット | シヌクレイノパチーの治療のための薬剤、使用および方法 |
WO2018109058A1 (en) | 2016-12-16 | 2018-06-21 | H. Lundbeck A/S | Agents, uses and methods |
US10364286B2 (en) | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
KR102573778B1 (ko) | 2017-02-17 | 2023-08-31 | 브리스톨-마이어스 스큅 컴퍼니 | 알파-시뉴클레인에 대한 항체 및 그의 용도 |
GB201720975D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
GB201720970D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
TWI734279B (zh) * | 2018-12-14 | 2021-07-21 | 美商美國禮來大藥廠 | 抗α-突觸核蛋白抗體及其用途 |
CA3133909A1 (en) * | 2019-04-18 | 2020-10-22 | Elpida TSIKA | Novel molecules for therapy and diagnosis |
KR20220012231A (ko) * | 2019-04-24 | 2022-02-03 | 리젠엑스바이오 인크. | 완전-인간 번역 후 변형된 항체 치료제 |
CN111671757A (zh) * | 2020-07-16 | 2020-09-18 | 福建医科大学附属协和医院 | 3-[4-(4-吗啉基)-7h-吡咯并[2,3-d]嘧啶-5-基]苯甲腈制药用途 |
EP4185612A1 (en) | 2020-07-23 | 2023-05-31 | Othair Prothena Limited | Anti-abeta antibodies |
KR102701076B1 (ko) * | 2021-08-03 | 2024-09-03 | 아주대학교산학협력단 | Sncg를 표적으로 하는 퇴행성 관절염 치료 또는 진단용 조성물 |
CN117915952A (zh) * | 2021-09-16 | 2024-04-19 | H.隆德贝克有限公司 | 用于治疗突触核蛋白病的组合物和方法 |
WO2024026472A2 (en) | 2022-07-29 | 2024-02-01 | Alector Llc | Transferrin receptor antigen-binding domains and uses therefor |
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CN109846862A (zh) * | 2012-10-25 | 2019-06-07 | 通用医疗公司 | 治疗阿尔茨海默病及相关疾病的组合疗法 |
US9534044B2 (en) | 2013-02-28 | 2017-01-03 | United Arab Emirates University | Alpha-synuclein antibodies and uses thereof |
US10513555B2 (en) * | 2013-07-04 | 2019-12-24 | Prothena Biosciences Limited | Antibody formulations and methods |
EP3071597B1 (en) | 2013-11-21 | 2020-07-29 | F.Hoffmann-La Roche Ag | Anti-alpha-synuclein antibodies and methods of use |
CN107074938A (zh) * | 2014-10-16 | 2017-08-18 | 豪夫迈·罗氏有限公司 | 抗‑α‑突触核蛋白抗体和使用方法 |
RU2640981C1 (ru) * | 2014-12-22 | 2018-01-12 | Тетра Лаваль Холдингз Энд Файнэнс С.А. | Упаковочный материал и упаковочный контейнер, сформированный из такого материала |
JP2018515607A (ja) * | 2015-05-07 | 2018-06-14 | アクソファント サイエンシーズ ゲーエムベーハーAxovant Sciences Gmbh | 神経変性疾患を処置する組成物および方法 |
GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
MY188183A (en) | 2016-06-02 | 2021-11-24 | Medimmune Ltd | Antibodies to alpha-synuclein and uses thereof |
JP7217229B2 (ja) * | 2016-11-15 | 2023-02-02 | ハー・ルンドベック・アクチエゼルスカベット | シヌクレイノパチーの治療のための薬剤、使用および方法 |
WO2018109058A1 (en) | 2016-12-16 | 2018-06-21 | H. Lundbeck A/S | Agents, uses and methods |
US10364286B2 (en) | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
CA3150726A1 (en) * | 2019-09-20 | 2021-03-25 | Jing Guo | Anti-alpha-synuclein antibodies and methods of use thereof |
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2017
- 2017-11-14 JP JP2019525835A patent/JP7217229B2/ja active Active
- 2017-11-14 MA MA046836A patent/MA46836A/fr unknown
- 2017-11-14 CA CA3043651A patent/CA3043651A1/en active Pending
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- 2017-11-14 BR BR112018014281A patent/BR112018014281A2/pt unknown
- 2017-11-14 KR KR1020197016896A patent/KR102593669B1/ko active IP Right Grant
- 2017-11-14 RU RU2019114679A patent/RU2019114679A/ru not_active Application Discontinuation
- 2017-11-14 MX MX2019005594A patent/MX2019005594A/es unknown
- 2017-11-14 US US15/812,648 patent/US10889635B2/en active Active
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RU2019114679A3 (es) | 2021-03-30 |
WO2018091444A1 (en) | 2018-05-24 |
AR110074A1 (es) | 2019-02-20 |
IL266596A (en) | 2019-07-31 |
JP7217229B2 (ja) | 2023-02-02 |
MA46836A (fr) | 2019-09-25 |
US20210236634A1 (en) | 2021-08-05 |
MX2019005594A (es) | 2019-07-04 |
CO2019004755A2 (es) | 2019-05-21 |
CN109937210A (zh) | 2019-06-25 |
AU2017359944A1 (en) | 2019-05-23 |
RU2019114679A (ru) | 2020-12-17 |
AU2017359944B2 (en) | 2024-07-18 |
CL2021003306A1 (es) | 2022-07-22 |
JP2020500849A (ja) | 2020-01-16 |
US10889635B2 (en) | 2021-01-12 |
EP3541836A1 (en) | 2019-09-25 |
KR20190083356A (ko) | 2019-07-11 |
CN109937210B (zh) | 2023-09-15 |
BR112018014281A2 (pt) | 2018-12-18 |
KR102593669B1 (ko) | 2023-10-25 |
CA3043651A1 (en) | 2018-05-24 |
US20180194833A1 (en) | 2018-07-12 |
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