CL2018001194A1 - Compuestos polimericos sol-gel y usos de los mismos - Google Patents

Compuestos polimericos sol-gel y usos de los mismos

Info

Publication number
CL2018001194A1
CL2018001194A1 CL2018001194A CL2018001194A CL2018001194A1 CL 2018001194 A1 CL2018001194 A1 CL 2018001194A1 CL 2018001194 A CL2018001194 A CL 2018001194A CL 2018001194 A CL2018001194 A CL 2018001194A CL 2018001194 A1 CL2018001194 A1 CL 2018001194A1
Authority
CL
Chile
Prior art keywords
sol
polymeric compounds
gel polymeric
gel
compounds
Prior art date
Application number
CL2018001194A
Other languages
English (en)
Inventor
Sumitra Rajagopalan
Wilms Baille
Piotr Kujawa
Christopher A Zook
Rebecca R Quesnell
Dennis L Huczek
Stephen L Secreast
Laibin Luo
Tammy A Sanders
Original Assignee
Zoetis Services Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Services Llc filed Critical Zoetis Services Llc
Publication of CL2018001194A1 publication Critical patent/CL2018001194A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0041Mammary glands, e.g. breasts, udder; Intramammary administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
CL2018001194A 2015-11-03 2018-05-03 Compuestos polimericos sol-gel y usos de los mismos CL2018001194A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562250126P 2015-11-03 2015-11-03
US201662315756P 2016-03-31 2016-03-31

Publications (1)

Publication Number Publication Date
CL2018001194A1 true CL2018001194A1 (es) 2019-05-17

Family

ID=57471981

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018001194A CL2018001194A1 (es) 2015-11-03 2018-05-03 Compuestos polimericos sol-gel y usos de los mismos

Country Status (16)

Country Link
US (2) US10064870B2 (es)
EP (1) EP3370698B1 (es)
JP (1) JP6864001B2 (es)
KR (1) KR102145435B1 (es)
CN (1) CN108601723B (es)
AU (1) AU2016350868B2 (es)
BR (1) BR112018009010B1 (es)
CA (1) CA3002214C (es)
CL (1) CL2018001194A1 (es)
ES (1) ES2907686T3 (es)
MX (1) MX2018005547A (es)
PL (1) PL3370698T3 (es)
PT (1) PT3370698T (es)
RU (1) RU2761212C2 (es)
UY (1) UY36973A (es)
WO (1) WO2017079216A1 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CN109310705A (zh) * 2016-03-18 2019-02-05 加拿大农业及农业食品部 干奶时加速乳腺退化和预防乳腺感染的方法
MA44498A (fr) 2016-03-31 2019-02-06 Janssen Pharmaceuticals Inc Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue
CR20180495A (es) 2016-03-31 2018-12-06 Univ Leuven Kath Deribados de indol sustituidos como inhibidores de replicación viral del dengue
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
WO2017167952A1 (en) 2016-04-01 2017-10-05 Janssen Pharmaceuticals, Inc. Substituted indole compound derivatives as dengue viral replication inhibitors
US10406336B2 (en) 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CN110536679B (zh) 2017-04-20 2023-03-31 硕腾服务有限责任公司 用于治疗乳腺炎的兽医用组合物和相关方法
BR112019024195A2 (pt) 2017-05-22 2020-06-23 Janssen Pharmaceuticals, Inc. Composto e composição farmacêutica de derivados de indolina substituídos como inibidores da replicação viral da dengue
EP3630724B1 (en) 2017-05-22 2021-04-28 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors
EP3634378A1 (en) * 2017-06-09 2020-04-15 Zoetis Broomhill IP Limited Intramammary veterinary composition
CN109575484A (zh) * 2017-09-29 2019-04-05 天津城建大学 新型埃洛石/聚乙烯醇复合气凝胶及其制备方法和应用
JP2021504435A (ja) * 2017-12-01 2021-02-15 ゾエティス・サービシーズ・エルエルシー ヒドロゲル組成物及びその使用
US20190343875A1 (en) * 2018-01-18 2019-11-14 Zoetis Broomhill Ip Limited Internal teat sealants and their use in the prevention of bovine mastitis in the dry cow
CN113164009A (zh) * 2018-11-22 2021-07-23 学校法人自治医科大学 内窥镜的视野确保用的粘弹性组合物
WO2020118660A1 (en) * 2018-12-14 2020-06-18 Ecolab Usa Inc. Stable iodine-containing antimicrobial teat dip compositions
CN110437471B (zh) * 2019-07-11 2022-02-15 郑州轻工业学院 一种粘性复合水凝胶及其制备方法和用途
CN115003626A (zh) * 2019-12-20 2022-09-02 威利纳米有限公司 纳米结构二元凝胶组合物及其用途
CN111012947B (zh) * 2019-12-30 2021-11-12 南京财经大学 一种可注射和自愈合淀粉基水凝胶及其制备方法和应用
CN111214699A (zh) * 2020-01-08 2020-06-02 广州贝奥吉因生物科技股份有限公司 一种用于周围神经损伤修复的水凝胶及其制备方法
CN111840212B (zh) * 2020-06-18 2023-07-21 余祖功 一种非人类动物用乳头封闭剂及其制备方法
CN111825858B (zh) * 2020-07-02 2023-04-25 南京师范大学 一种基于两性离子和角蛋白的复合水凝胶及其制备方法
WO2022217069A1 (en) * 2021-04-09 2022-10-13 Colorado School Of Mines Radical crosslinked zwitterionic gels and uses thereof
EP4329790A1 (en) * 2021-04-28 2024-03-06 Mileutis Ltd. Compositions and methods for modulating mammary disorders and conditions
CN113736435B (zh) * 2021-10-08 2023-05-12 扬州工业职业技术学院 一种钻井液用纳米微乳液封堵剂及其制备方法
CN114539574B (zh) * 2022-02-28 2023-06-06 浙江农林大学 压电-摩擦电耦合感应材料的制备方法和应用
CN115990275A (zh) * 2022-10-08 2023-04-21 江苏省人民医院(南京医科大学第一附属医院) 一种黏膜下注射剂及其制备方法
CN115645635A (zh) * 2022-10-24 2023-01-31 杭州旸顺医疗科技有限公司 一种液相栓塞剂及其制备方法和用途
CN115804870B (zh) * 2022-12-02 2023-12-19 浙江大学 一种微创注射生物支架及其制造方法与应用

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4333484A (en) 1978-08-02 1982-06-08 Philip Morris Incorporated Modified cellulosic smoking material and method for its preparation
DE69629010T2 (de) 1995-01-16 2004-04-15 Baxter International Inc., Deerfield Selbsttragende flächengebilde aus vernetztem fibrin zur hemmung von postoperativen adhäsionen
ATE223201T1 (de) 1996-12-18 2002-09-15 Bimeda Res & Dev Ltd Infektionsfreie intramammäre tierarzneimittelzusammenstellung
CA2212300A1 (en) 1997-08-04 1999-02-04 Abdellatif Chenite In vitro or in vivo gelfying chitosan and therapeutic uses thereof
CA2427938C (en) 1999-11-15 2010-02-16 Bio Syntech Canada Inc. Novel temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution, composition and preparation thereof
EP1255576B1 (en) 1999-12-09 2003-08-20 Biosyntech Canada Inc. Mineral-polymer hybrid composition
US20040047892A1 (en) 2000-11-15 2004-03-11 Desrosiers Eric Andre Filler composition for soft tissue augmentation and reconstructive surgery
GB2394896B (en) 2001-09-10 2005-06-22 Bimeda Res & Dev Ltd A bio-security system
KR100474945B1 (ko) 2002-01-10 2005-03-10 알앤엘생명과학주식회사 젖소의 원유 중 체세포 감소용 및 유방염의 예방 또는치료용 조성물
RU2329064C2 (ru) * 2003-07-31 2008-07-20 Фармация Энд Апджон Компани Ллс Диспергируемая фармацевтическая композиция для лечения мастита и поражений уха
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
MXPA06008769A (es) 2004-02-02 2007-02-16 Bimeda Res & Dev Ltd Metodo y dispositivo para tratar un canal de tetilla de un animal.
US20050191270A1 (en) * 2004-02-27 2005-09-01 Hydromer, Inc. Anti-infectious hydrogel compositions
BRPI0519754A2 (pt) * 2005-01-13 2009-03-10 Cinv Ag materiais compàsitos contendo nanopartÍculas de carbono
CA2593043A1 (en) * 2005-02-03 2006-08-10 Cinvention Ag Drug delivery materials made by sol/gel technology
US9205046B2 (en) 2005-04-25 2015-12-08 The Governing Council Of The University Of Toronto Enhanced stability of inverse thermal gelling composite hydrogels
US8323683B2 (en) 2005-05-18 2012-12-04 Mcneil-Ppc, Inc. Flavoring of drug-containing chewing gums
WO2007066837A1 (en) 2005-12-06 2007-06-14 Lg Household & Health Care Ltd. Delivery system for tooth whitening component using in situ gelling
EP3381463A1 (en) 2006-06-30 2018-10-03 BioMimetic Therapeutics, LLC Pdgf-biomatrix compositions and methods for treating rotator cuff injuries
NZ549249A (en) 2006-08-18 2009-10-30 Univ Massey Methods for reducing the incidence of mastitis by administration of keratin
ZA200902544B (en) 2006-10-10 2010-08-25 Wisconsin Alumni Res Found Intra-mammary teat sealant formulation and method of using same to reduce or eliminate visual defects in aged cheeses
EP2097065A2 (en) 2006-11-29 2009-09-09 Foamix Ltd. Foamable waterless compositions with modulating agents
US8153612B2 (en) 2006-12-11 2012-04-10 Chi2Gel Ltd. Injectable chitosan mixtures forming hydrogels
US9034348B2 (en) 2006-12-11 2015-05-19 Chi2Gel Ltd. Injectable chitosan mixtures forming hydrogels
AU2007331071A1 (en) * 2006-12-11 2008-06-19 Mor Research Applications Ltd. Novel injectable chitosan mixtures forming hydrogels
EP2337544A2 (en) 2007-04-30 2011-06-29 Living Proof, Inc. Use of matrix metalloproteinase inhibitors in skin care
CN101077377A (zh) * 2007-05-09 2007-11-28 史义林 防治牛、羊乳房炎的复方碘化壳聚糖涂膜剂及其制备方法
US20090081173A1 (en) 2007-08-10 2009-03-26 The Board Of Regents Of The University Of Texas System Methods and compositions involving bacteriophage isolates
GB2461186B (en) * 2008-04-21 2010-09-01 Otonomy Inc Controlled release corticosteroid compositions and methods for the treatment of otic disorders
US8318817B2 (en) * 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
US20100092526A1 (en) * 2008-09-26 2010-04-15 Nanobio Corporation Nanoemulsion therapeutic compositions and methods of using the same
US20100143510A1 (en) * 2008-12-04 2010-06-10 Majid Razzak Intramammary teat sealant
WO2010065908A2 (en) * 2008-12-05 2010-06-10 Catchmark Jeffrey M Degradable biomolecule compositions
MY158710A (en) 2008-12-16 2016-11-15 Carlsberg As Coating of hydroxylated surfaces by gas phase grafting
US20100196347A1 (en) 2008-12-19 2010-08-05 Vladimir Kery Bone grafts with reduced protease activity and methods of selection and use
WO2011022070A2 (en) 2009-08-20 2011-02-24 The Regents Of The University Of California Perivascular stem cell composition for bone
CN101664381A (zh) * 2009-08-21 2010-03-10 天津生机集团股份有限公司 治疗奶牛乳房炎的原位凝胶缓释制剂的制备方法
CN102125516B (zh) * 2010-01-13 2014-03-26 北京大学 温敏型原位凝胶药物组合物
EP2606121B1 (en) 2010-08-19 2016-05-11 The Regents of The University of California Compositions comrpising perivascular stem cells and nell-1 protein
WO2012080494A1 (en) 2010-12-16 2012-06-21 Specialites Pet Food Method for producing highly palatable dry cat food
GB201113606D0 (en) 2011-08-05 2011-09-21 Norbrook Lab Ltd Dual chamber syringe
WO2013062995A1 (en) 2011-10-25 2013-05-02 Biomimetic Therapeutics, Inc. Compositions and methods for treating deep partial and full thickness wounds and injuries
US20130108670A1 (en) 2011-10-25 2013-05-02 Biomimetic Therapeutics, Inc. Compositions and methods for treating full thickness burn injuries
EP2917299A4 (en) 2012-11-09 2016-06-29 Bioastra Technologies Inc NANOSTRUCTURED PHASE SWITCHING MATERIALS FOR SOLID WATER HEAT MANAGEMENT
RU2521401C1 (ru) * 2012-12-07 2014-06-27 ГНУ Краснодарский научно-исследовательский ветеринарный институт Российская академия сельскохозяйственных наук (Краснодарский НИВИ) Средство для профилактики мастита у дойных коров в сухостойный период
MX360649B (es) 2013-03-13 2018-11-12 Anteis Sa Péptidos para el rejuvenecimiento de la piel y métodos de uso de los mismos.
US9968603B2 (en) 2013-03-14 2018-05-15 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
UA119642C2 (uk) * 2013-03-15 2019-07-25 Меріал, Інк. Протимікробні поліамідні композиції та лікування маститу
SG10201710796PA (en) 2013-03-15 2018-02-27 Human Biomolecular Res Institute Compounds and matrices for use in bone growth and repair
TW201532621A (zh) 2013-04-22 2015-09-01 Neocutis Sa 抗氧化劑組成物及其使用方法
CN103381139A (zh) 2013-05-10 2013-11-06 南京农业大学 黄芪多糖注射用原位凝胶及其制备方法
CA2923555C (en) 2013-09-16 2020-06-16 Zoetis Services Llc Assembly for sequentially delivering substances, and associated methods
CN104510729A (zh) 2013-09-26 2015-04-15 黄永 激活动物免疫抗性的脂肪酸及其衍生物的组合物
WO2016054592A1 (en) 2014-10-03 2016-04-07 Cytori Therapeutics, Inc. Use of regenerative cells in mitigating burn progression and improving skin graft incorporation and healing

Also Published As

Publication number Publication date
CA3002214A1 (en) 2017-05-11
AU2016350868B2 (en) 2022-03-31
RU2761212C2 (ru) 2021-12-06
EP3370698A1 (en) 2018-09-12
BR112018009010B1 (pt) 2023-09-26
PT3370698T (pt) 2022-03-02
CN108601723A (zh) 2018-09-28
UY36973A (es) 2017-06-30
US20170119785A1 (en) 2017-05-04
CA3002214C (en) 2022-01-04
BR112018009010A2 (pt) 2018-10-30
CN108601723B (zh) 2022-05-17
KR20180075646A (ko) 2018-07-04
AU2016350868A1 (en) 2018-05-10
PL3370698T3 (pl) 2022-04-25
WO2017079216A1 (en) 2017-05-11
JP2018536708A (ja) 2018-12-13
JP6864001B2 (ja) 2021-04-21
EP3370698B1 (en) 2022-01-26
US10729698B2 (en) 2020-08-04
ES2907686T3 (es) 2022-04-26
US10064870B2 (en) 2018-09-04
BR112018009010A8 (pt) 2019-02-26
RU2018115574A3 (es) 2020-03-13
MX2018005547A (es) 2018-11-09
US20190030043A1 (en) 2019-01-31
KR102145435B1 (ko) 2020-08-18
RU2018115574A (ru) 2019-10-25

Similar Documents

Publication Publication Date Title
CL2018001194A1 (es) Compuestos polimericos sol-gel y usos de los mismos
DOP2021000112A (es) Compuestos de pirrolizina sustituida y usos de los mismos
CL2016002252A1 (es) Anticuerpos anti-egfrviii y usos de los mismos
ES2966909T3 (es) Compuestos y composiciones antimicrobianos, y usos de los mismos
BR112017009204A2 (pt) Derivados de feniltriazol hidroxialquil- substituído e usos dos mesmos
CL2016000251A1 (es) Anticuerpos anti-activina y usos de los mismos
CL2016002569A1 (es) Anticuerpos, composiciones farmacéuticas y usos de los mismos
BR112016016289A2 (pt) heteroaris e usos dos mesmos
DE102016105630A8 (de) Kappe
ES2962672T8 (es) Dispositivo de seguridad extraíble
DK3313695T3 (da) Sikkerhedsanordning
CL2017002226A1 (es) Etv2 y usos de los mismos
BR112016029232A2 (pt) estruturas que compreendem fibras poliméricas
DK3163094T3 (da) Fastgørelsesanordning
DE112016002351A5 (de) Halteelement
DE112015006434A5 (de) Filtervorrichtung
DK3286392T3 (da) Låseindretning
FR3025742B1 (fr) Element de securite
ES1161084Y (es) Dispositivo para escalada
SE1651477A1 (sv) Spärrenhet
FI11467U1 (fi) Suojaverkko
ES1154583Y (es) Conjunto de protección para ciclistas
ITFI20150027U1 (it) Assorbente ascellare
UA32084S (uk) Замикальний пристрій
ES1147287Y (es) Protector intimo de uso femenino