CL2016000908A1 - Métodos para el tratamiento de afecciones asociados a la activación del complemento dependiente de masp-2 declaración relacionada con el listado de secuencias - Google Patents

Métodos para el tratamiento de afecciones asociados a la activación del complemento dependiente de masp-2 declaración relacionada con el listado de secuencias

Info

Publication number
CL2016000908A1
CL2016000908A1 CL2016000908A CL2016000908A CL2016000908A1 CL 2016000908 A1 CL2016000908 A1 CL 2016000908A1 CL 2016000908 A CL2016000908 A CL 2016000908A CL 2016000908 A CL2016000908 A CL 2016000908A CL 2016000908 A1 CL2016000908 A1 CL 2016000908A1
Authority
CL
Chile
Prior art keywords
masp
activation
treatment
methods
sequence listing
Prior art date
Application number
CL2016000908A
Other languages
English (en)
Inventor
Gregory A Demopulos
Thomas Dudler
Hans-Wilhelm Schwaeble
Original Assignee
Omeros Corp
Univ Leicester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Corp, Univ Leicester filed Critical Omeros Corp
Publication of CL2016000908A1 publication Critical patent/CL2016000908A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Saccharide Compounds (AREA)
CL2016000908A 2013-10-17 2016-04-15 Métodos para el tratamiento de afecciones asociados a la activación del complemento dependiente de masp-2 declaración relacionada con el listado de secuencias CL2016000908A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361892283P 2013-10-17 2013-10-17
US201462020845P 2014-07-03 2014-07-03

Publications (1)

Publication Number Publication Date
CL2016000908A1 true CL2016000908A1 (es) 2016-12-02

Family

ID=52828769

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2016000908A CL2016000908A1 (es) 2013-10-17 2016-04-15 Métodos para el tratamiento de afecciones asociados a la activación del complemento dependiente de masp-2 declaración relacionada con el listado de secuencias
CL2018001557A CL2018001557A1 (es) 2013-10-17 2018-06-12 Uso de un agente inhibidor de masp-2 que inhibe la activación del complemento dependiente de masp-2, para tratar un sujeto que padece de síndrome antifosfolipido catastrófico (safc). (solicitud divisional 201600908)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2018001557A CL2018001557A1 (es) 2013-10-17 2018-06-12 Uso de un agente inhibidor de masp-2 que inhibe la activación del complemento dependiente de masp-2, para tratar un sujeto que padece de síndrome antifosfolipido catastrófico (safc). (solicitud divisional 201600908)

Country Status (24)

Country Link
US (3) US20150166675A1 (es)
EP (2) EP3057993B1 (es)
JP (3) JP2016539919A (es)
KR (3) KR102677379B1 (es)
CN (2) CN111588855A (es)
AU (2) AU2014337047B2 (es)
BR (1) BR112016008409B1 (es)
CA (1) CA2926385A1 (es)
CL (2) CL2016000908A1 (es)
CY (1) CY1123776T1 (es)
DK (1) DK3057993T3 (es)
ES (1) ES2829913T3 (es)
HR (1) HRP20201733T1 (es)
HU (1) HUE051746T2 (es)
IL (2) IL283373B2 (es)
LT (1) LT3057993T (es)
MX (2) MX2016005017A (es)
NZ (2) NZ757986A (es)
PL (1) PL3057993T3 (es)
PT (1) PT3057993T (es)
RS (1) RS61351B1 (es)
RU (2) RU2718850C2 (es)
SI (1) SI3057993T1 (es)
WO (1) WO2015058143A1 (es)

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EP3287142B1 (en) 2011-04-08 2021-08-04 University Of Leicester Methods for treating conditions associated with masp-2 dependent complement activation
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AU2020203748B2 (en) 2022-08-04
RU2020111211A (ru) 2021-11-08
JP6953498B2 (ja) 2021-10-27
EP3057993A1 (en) 2016-08-24
RU2016118769A (ru) 2017-11-22
LT3057993T (lt) 2020-11-25
US20240124611A1 (en) 2024-04-18
KR20240101700A (ko) 2024-07-02
IL283373A (en) 2021-07-29
CN111588855A (zh) 2020-08-28
ES2829913T3 (es) 2021-06-02
MX2016005017A (es) 2016-11-07
CL2018001557A1 (es) 2018-07-20
AU2014337047B2 (en) 2020-03-12
SI3057993T1 (sl) 2021-03-31
HRP20201733T1 (hr) 2021-02-05
KR20220053057A (ko) 2022-04-28
IL245115B (en) 2022-05-01
PL3057993T3 (pl) 2021-02-08
IL283373B1 (en) 2024-04-01
JP7397037B2 (ja) 2023-12-12
RS61351B1 (sr) 2021-02-26
US20150166675A1 (en) 2015-06-18
CN105683219A (zh) 2016-06-15
KR102677379B1 (ko) 2024-06-24
IL245115A0 (en) 2016-06-30
US11525011B2 (en) 2022-12-13
NZ757986A (en) 2022-07-29
HUE051746T2 (hu) 2021-03-29
AU2014337047A1 (en) 2016-05-19
MX2021008044A (es) 2021-10-13
JP2016539919A (ja) 2016-12-22
CY1123776T1 (el) 2022-03-24
WO2015058143A1 (en) 2015-04-23
PT3057993T (pt) 2020-11-19
JP2022000467A (ja) 2022-01-04
CA2926385A1 (en) 2015-04-23
EP3057993A4 (en) 2017-09-13
BR112016008409B1 (pt) 2021-06-15
AU2020203748A1 (en) 2020-06-25
US20200157244A1 (en) 2020-05-21
IL283373B2 (en) 2024-08-01
EP3750919A1 (en) 2020-12-16
NZ719476A (en) 2022-07-29
EP3057993B1 (en) 2020-08-12
CN105683219B (zh) 2020-07-14
JP2020037568A (ja) 2020-03-12
DK3057993T3 (en) 2020-11-16
BR112016008409A2 (pt) 2017-10-03
KR20160062186A (ko) 2016-06-01
RU2016118769A3 (es) 2018-11-21
RU2718850C2 (ru) 2020-04-15

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