CL2014003317A1 - Sales de n-{4-[2,4-difluoro-3-(trifluorometil)fenil]-1,3-tiazol-2-il}-2-(1,3-dimetil-2,4-dioxo-1,2,3,4-tetrahidrotieno[2,3-d]pirimidin-5-il)acetamida; y procesos para prepararlas. - Google Patents
Sales de n-{4-[2,4-difluoro-3-(trifluorometil)fenil]-1,3-tiazol-2-il}-2-(1,3-dimetil-2,4-dioxo-1,2,3,4-tetrahidrotieno[2,3-d]pirimidin-5-il)acetamida; y procesos para prepararlas.Info
- Publication number
- CL2014003317A1 CL2014003317A1 CL2014003317A CL2014003317A CL2014003317A1 CL 2014003317 A1 CL2014003317 A1 CL 2014003317A1 CL 2014003317 A CL2014003317 A CL 2014003317A CL 2014003317 A CL2014003317 A CL 2014003317A CL 2014003317 A1 CL2014003317 A1 CL 2014003317A1
- Authority
- CL
- Chile
- Prior art keywords
- tetrahydrothiene
- thiazol
- dioxo
- pyrimidin
- difluoro
- Prior art date
Links
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 title 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1687MU2012 | 2012-06-08 | ||
| US201261665282P | 2012-06-27 | 2012-06-27 | |
| IN3519MU2012 | 2012-12-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014003317A1 true CL2014003317A1 (es) | 2015-02-13 |
Family
ID=54193746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014003317A CL2014003317A1 (es) | 2012-06-08 | 2014-12-04 | Sales de n-{4-[2,4-difluoro-3-(trifluorometil)fenil]-1,3-tiazol-2-il}-2-(1,3-dimetil-2,4-dioxo-1,2,3,4-tetrahidrotieno[2,3-d]pirimidin-5-il)acetamida; y procesos para prepararlas. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9458173B2 (en:Method) |
| EP (1) | EP2858999B1 (en:Method) |
| JP (1) | JP5989900B2 (en:Method) |
| KR (1) | KR20150015488A (en:Method) |
| CN (1) | CN104350058A (en:Method) |
| AP (1) | AP3546A (en:Method) |
| AU (1) | AU2013273118B2 (en:Method) |
| BR (1) | BR112014029155A2 (en:Method) |
| CA (1) | CA2873570C (en:Method) |
| CL (1) | CL2014003317A1 (en:Method) |
| EA (1) | EA031334B1 (en:Method) |
| HK (1) | HK1207643A1 (en:Method) |
| IL (1) | IL236084A0 (en:Method) |
| IN (1) | IN2014MN02467A (en:Method) |
| MX (1) | MX354014B (en:Method) |
| MY (1) | MY165622A (en:Method) |
| NZ (1) | NZ701721A (en:Method) |
| PE (1) | PE20142306A1 (en:Method) |
| PH (1) | PH12014502685A1 (en:Method) |
| SG (1) | SG11201408093PA (en:Method) |
| WO (1) | WO2013183035A2 (en:Method) |
| ZA (1) | ZA201500082B (en:Method) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2861604T (pt) | 2012-06-08 | 2017-05-05 | Gilead Sciences Inc | Inibidores macrocíclicos de vírus flaviridae |
| AR091279A1 (es) | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
| AP2015008919A0 (en) * | 2013-06-20 | 2015-12-31 | Glenmark Pharmaceuticals Sa | Nanoparticulate formulation comprising a trpa1 antagonist |
| WO2016023832A1 (en) * | 2014-08-11 | 2016-02-18 | Hydra Biosciences, Inc. | Thieno- and furo[2,3-d]pyrimidine-2,4[1h,3h]-dione derivatives as trpc5 modulators for the treatment of neuropsychiatric disorders |
| WO2016042501A1 (en) * | 2014-09-16 | 2016-03-24 | Glenmark Pharmaceuticals S.A. | Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain |
| TW202321229A (zh) | 2021-08-18 | 2023-06-01 | 美商富曼西公司 | 殺真菌的取代的雜環化合物 |
| CN114671875A (zh) * | 2022-04-27 | 2022-06-28 | 成都施贝康生物医药科技有限公司 | 新型二氢嘧啶类化合物、异构体或盐及其制备方法和用途 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2248231A1 (de) | 1972-10-02 | 1974-04-11 | Basf Ag | 3-aminoisothiazolo eckige klammer auf 3,4-d eckige klammer zu pyrimidine |
| SE9701398D0 (sv) | 1997-04-15 | 1997-04-15 | Astra Pharma Prod | Novel compounds |
| ES2193839B1 (es) * | 2001-06-22 | 2005-02-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de 6-fenildihidropirrolpirimidindiona. |
| AU2003253165A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
| US6890923B2 (en) | 2002-12-16 | 2005-05-10 | Astrazeneca Ab | Compounds |
| WO2004055054A1 (en) | 2002-12-18 | 2004-07-01 | Novartis Ag | Anktm1, a cold-activated trp-like channel expressed in nociceptive neurons |
| EP1657238A4 (en) * | 2003-08-22 | 2008-12-03 | Takeda Pharmaceutical | CONDENSATE PYRIMIDINE DERIVATIVE AND ITS USE |
| JP2007522214A (ja) | 2004-02-11 | 2007-08-09 | スミスクライン・ビーチャム・コーポレイション | Ｐｔｈアゴニスト |
| WO2005089206A2 (en) | 2004-03-13 | 2005-09-29 | Irm Llc | Modulators of ion channel trpa1 |
| JPWO2006083005A1 (ja) | 2005-02-03 | 2008-06-26 | 武田薬品工業株式会社 | 縮合ピリミジン誘導体およびその用途 |
| US20070032531A1 (en) | 2005-08-04 | 2007-02-08 | Apogee Biotechnology Corporation | Sphingosine kinase inhibitors and methods of their use |
| US20070105920A1 (en) | 2005-11-08 | 2007-05-10 | Akzo Nobel N.V. | 2-(Benzimidazol-1-Yl)-N-(4-phenylthiazol-2-yl) acetamide derivatives |
| TW201900217A (zh) | 2005-12-22 | 2019-01-01 | 美商海卓勒生物科學公司 | 用於調節ｔｒｐａ１功能之化合物 |
| TW200800997A (en) | 2006-03-22 | 2008-01-01 | Astrazeneca Ab | Chemical compounds |
| CN101454318A (zh) * | 2006-03-22 | 2009-06-10 | 阿斯利康(瑞典)有限公司 | 吡啶并嘧啶衍生物及其作为pde4抑制剂的用途 |
| JP2011201776A (ja) | 2008-07-23 | 2011-10-13 | Mochida Pharmaceut Co Ltd | ヘテロシクリデン−ｎ−（３，４−ジヒドロ−２（１ｈ）−キナゾリノン−５−イル）アセトアミド誘導体 |
| WO2008094909A2 (en) | 2007-01-29 | 2008-08-07 | Xenon Pharmaceuticals Inc. | Quinazolinone and fused pyrimidinone compounds and their use in treating sodium channel-mediated diseases or conditions |
| CN108042542A (zh) * | 2007-06-22 | 2018-05-18 | 海德拉生物科学公司 | 用于治疗病症的方法和组合物 |
| WO2010004390A1 (en) * | 2008-06-17 | 2010-01-14 | Glenmark Pharmaceuticals, S.A. | Quinazoline dione derivatives as trpa1 modulators |
| WO2009158719A2 (en) | 2008-06-27 | 2009-12-30 | Hydra Biosciences, Inc. | Methods and compositions for treating disorders |
| PT2411397E (pt) | 2009-03-23 | 2013-06-06 | Glenmark Pharmaceuticals Sa | Derivados de isotiazolo-pirimidinadiona como moduladores de trpa1 |
| CA2756518A1 (en) | 2009-03-23 | 2010-09-30 | Glenmark Pharmaceuticals, S.A. | Fused pyrimidinedione derivatives as trpa1 modulators |
| US8623880B2 (en) | 2009-03-23 | 2014-01-07 | Glenmark Pharmaceuticals S.A. | Fused pyrimidine-dione derivatives as TRPA1 modulators |
| US20120178766A1 (en) | 2009-03-23 | 2012-07-12 | Sachin Sundarlal Chaudhari | Furopyrimidinedione derivatives as trpai modulators |
| PE20140234A1 (es) | 2010-12-20 | 2014-03-08 | Glenmark Phamaceuticals S A | Compuestos de 2-amino-4-ariltiazol como antagonistas de trpa1 |
-
2013
- 2013-06-08 US US14/402,608 patent/US9458173B2/en not_active Expired - Fee Related
- 2013-06-08 IN IN2467MUN2014 patent/IN2014MN02467A/en unknown
- 2013-06-08 WO PCT/IB2013/054703 patent/WO2013183035A2/en not_active Ceased
- 2013-06-08 CA CA2873570A patent/CA2873570C/en active Active
- 2013-06-08 AP AP2014008076A patent/AP3546A/xx active
- 2013-06-08 KR KR1020147033855A patent/KR20150015488A/ko not_active Abandoned
- 2013-06-08 BR BR112014029155A patent/BR112014029155A2/pt not_active Application Discontinuation
- 2013-06-08 MY MYPI2014003389A patent/MY165622A/en unknown
- 2013-06-08 HK HK15108333.2A patent/HK1207643A1/xx unknown
- 2013-06-08 MX MX2014014482A patent/MX354014B/es active IP Right Grant
- 2013-06-08 EA EA201492054A patent/EA031334B1/ru unknown
- 2013-06-08 CN CN201380030184.XA patent/CN104350058A/zh active Pending
- 2013-06-08 EP EP13742279.6A patent/EP2858999B1/en active Active
- 2013-06-08 NZ NZ701721A patent/NZ701721A/en not_active IP Right Cessation
- 2013-06-08 SG SG11201408093PA patent/SG11201408093PA/en unknown
- 2013-06-08 PE PE2014002226A patent/PE20142306A1/es not_active Application Discontinuation
- 2013-06-08 AU AU2013273118A patent/AU2013273118B2/en not_active Ceased
- 2013-06-08 JP JP2015515642A patent/JP5989900B2/ja not_active Expired - Fee Related
-
2014
- 2014-12-02 PH PH12014502685A patent/PH12014502685A1/en unknown
- 2014-12-04 IL IL236084A patent/IL236084A0/en unknown
- 2014-12-04 CL CL2014003317A patent/CL2014003317A1/es unknown
-
2015
- 2015-01-07 ZA ZA2015/00082A patent/ZA201500082B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1207643A1 (en) | 2016-02-05 |
| WO2013183035A3 (en) | 2014-02-27 |
| EA201492054A1 (ru) | 2016-08-31 |
| ZA201500082B (en) | 2015-12-23 |
| AP2014008076A0 (en) | 2014-11-30 |
| PH12014502685B1 (en) | 2015-01-26 |
| US20150111038A1 (en) | 2015-04-23 |
| BR112014029155A2 (pt) | 2017-06-27 |
| AP3546A (en) | 2016-01-14 |
| JP2015520183A (ja) | 2015-07-16 |
| EP2858999A2 (en) | 2015-04-15 |
| EP2858999B1 (en) | 2017-05-10 |
| IL236084A0 (en) | 2015-02-01 |
| US9458173B2 (en) | 2016-10-04 |
| MY165622A (en) | 2018-04-18 |
| CN104350058A (zh) | 2015-02-11 |
| CA2873570A1 (en) | 2013-12-12 |
| AU2013273118B2 (en) | 2015-11-05 |
| CA2873570C (en) | 2016-11-01 |
| WO2013183035A2 (en) | 2013-12-12 |
| JP5989900B2 (ja) | 2016-09-07 |
| IN2014MN02467A (en:Method) | 2015-07-10 |
| PH12014502685A1 (en) | 2015-01-26 |
| NZ701721A (en) | 2016-03-31 |
| SG11201408093PA (en) | 2015-01-29 |
| EA031334B1 (ru) | 2018-12-28 |
| MX2014014482A (es) | 2015-06-05 |
| PE20142306A1 (es) | 2015-01-16 |
| MX354014B (es) | 2018-02-08 |
| KR20150015488A (ko) | 2015-02-10 |
| AU2013273118A1 (en) | 2014-11-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2014003317A1 (es) | Sales de n-{4-[2,4-difluoro-3-(trifluorometil)fenil]-1,3-tiazol-2-il}-2-(1,3-dimetil-2,4-dioxo-1,2,3,4-tetrahidrotieno[2,3-d]pirimidin-5-il)acetamida; y procesos para prepararlas. | |
| CY2022003I2 (el) | Παραγωγα πυρρολο[2,3-d]πυριμιδινης ως αναστολεις των σχετικων me janus (ιανος) kinασων (jak) | |
| AP3902A (en) | Novel 4-(substituted-amino)-7H-pyrrolo[2,3-d]pyrimidines as LRRK2 inhibitors | |
| CO6811863A2 (es) | Compuestos de 2-(2,4,5-anilino sustituido)pirimidina | |
| CO6801740A2 (es) | Inhibidores de quinasa relacionados con pirrolo[2,3-d]pirimidina tropomiosina | |
| IL236495A0 (en) | Heteroaromatic compounds as proton tyrosine kinase inhibitors | |
| HUE045957T2 (hu) | Proteinkináz inhibitor hatású tieno[3,2-d]pirimidin származékok | |
| HUE037064T2 (hu) | Pirrolo[3,2-d]-pirimidin származékok vírusos fertõzések és egyéb betegségek kezelésére | |
| HUE061909T2 (hu) | Pirazolo[1,5-a]pirimidinek alkalmazása ATR kináz inhibítorként, rákos megbetegedések kezelésére | |
| CO6910196A2 (es) | Derivados de pirrolopirimidina y purina | |
| IL228968A0 (en) | Kinase inhibitors pyrazolo [4,3-d]pyrimidine compounds,compositions comprising the same and uses thereof | |
| EP2916836A4 (en) | AMINOPYRIDE-CONTAINING MILK TYROSINE KINASE (SYK) INHIBITOR | |
| EP2804861A4 (en) | Substituted pyrimidine compounds and their use as SYK inhibitors | |
| HUE037637T2 (hu) | N-(3-fluorobenzil)-2-(5-(4-morfolinofenil)piridin-2-IL) acetamid, mint fehérje tirozin kináz modulátorok | |
| EA201591939A1 (ru) | ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-d]ПИРИМИДИНА В КАЧЕСТВЕ АГОНИСТОВ РЕЦЕПТОРА CB2 | |
| CL2013002026A1 (es) | Compuesto solido (r)-1-etil-3-[5-[2-(1-hidroxi-1-metil-etil)pirimidin-5-il]-7-(tetrahidrofuran-2-il)-1h-benzimidazol-2-il]-urea y metodo para prepararla. | |
| HRP20150752T1 (xx) | Piridinil- i pirazinilmetoksiarilni derivati, korisni kao inhibitori slezenske tirozinske kinaze | |
| HUE056048T2 (hu) | Helyettesített pirimidin vegyületek és SYK inhibitorként való alkalmazásuk | |
| HUE037085T2 (hu) | Karbamid vegyületek és enzim-inhibitorként történõ alkalmazásuk | |
| CO6821957A2 (es) | Formas solidas y sales de los derivados de tetrahidro-pirido-pirimidinas | |
| EP2805947A4 (en) | PIPERAZINYLPYRIMIDIN DERIVATIVES, METHOD OF MANUFACTURE AND USE THEREOF | |
| EP2922823A4 (en) | PDE10 PYRIMIDININHIBITOREN | |
| TH155635A (th) | เอไมด์ของสารประกอบ 2-อะมิโน-4-เอริลไธอะโซลและเกลือของสารประกอบดังกล่าว | |
| EP2939661A4 (en) | NOVEL MICROGRANULAR FORMULATION | |
| TH1501001335A (th) | กระบวนการที่ปรับปรุงแล้วสำหรับการเตรียมของ 2-อะมิโน-5,8-ไดเมธอกซิ[1,2,4]ไทรอะโซโล[1,5-c]ไพริมิดีนจาก 4-อะมิโน-2,5-ไดเมธอกซิไพริมิดีน |