CL2014000863A1 - Una composicion oftalmologica que comprende monooleato de polioxietileno (80) sorbitan, carboximetilcelulosa sodica, glicerina, acido borico, polimero reticulado de acrilatos/acrilato de alquilo c10-30, aceite de ricino, eritritol, levocarnitina, hidroxido de sodio y agua; y su uso para tratar, mitigar o prevenir el sindrome del ojo seco. - Google Patents
Una composicion oftalmologica que comprende monooleato de polioxietileno (80) sorbitan, carboximetilcelulosa sodica, glicerina, acido borico, polimero reticulado de acrilatos/acrilato de alquilo c10-30, aceite de ricino, eritritol, levocarnitina, hidroxido de sodio y agua; y su uso para tratar, mitigar o prevenir el sindrome del ojo seco.Info
- Publication number
- CL2014000863A1 CL2014000863A1 CL2014000863A CL2014000863A CL2014000863A1 CL 2014000863 A1 CL2014000863 A1 CL 2014000863A1 CL 2014000863 A CL2014000863 A CL 2014000863A CL 2014000863 A CL2014000863 A CL 2014000863A CL 2014000863 A1 CL2014000863 A1 CL 2014000863A1
- Authority
- CL
- Chile
- Prior art keywords
- levocarnitine
- erythritol
- sorbitan
- mitigate
- glycerin
- Prior art date
Links
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 title 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 title 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 title 1
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 title 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 title 1
- 206010013774 Dry eye Diseases 0.000 title 1
- 239000004386 Erythritol Substances 0.000 title 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 title 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 title 1
- 125000005250 alkyl acrylate group Chemical group 0.000 title 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 title 1
- 239000004327 boric acid Substances 0.000 title 1
- 235000010338 boric acid Nutrition 0.000 title 1
- 239000001768 carboxy methyl cellulose Substances 0.000 title 1
- 239000004359 castor oil Substances 0.000 title 1
- 235000019438 castor oil Nutrition 0.000 title 1
- 229960001777 castor oil Drugs 0.000 title 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 title 1
- 235000019414 erythritol Nutrition 0.000 title 1
- 229940009714 erythritol Drugs 0.000 title 1
- 235000011187 glycerol Nutrition 0.000 title 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 title 1
- 229960001518 levocarnitine Drugs 0.000 title 1
- 229920000058 polyacrylate Polymers 0.000 title 1
- -1 polyoxyethylene monooleate Polymers 0.000 title 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 title 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 title 1
- 229940083608 sodium hydroxide Drugs 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/745—Polymers of hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161544151P | 2011-10-06 | 2011-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014000863A1 true CL2014000863A1 (es) | 2014-08-29 |
Family
ID=47040830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014000863A CL2014000863A1 (es) | 2011-10-06 | 2014-04-07 | Una composicion oftalmologica que comprende monooleato de polioxietileno (80) sorbitan, carboximetilcelulosa sodica, glicerina, acido borico, polimero reticulado de acrilatos/acrilato de alquilo c10-30, aceite de ricino, eritritol, levocarnitina, hidroxido de sodio y agua; y su uso para tratar, mitigar o prevenir el sindrome del ojo seco. |
Country Status (17)
| Country | Link |
|---|---|
| US (7) | US8957048B2 (es) |
| EP (1) | EP2765987A1 (es) |
| JP (1) | JP6209163B2 (es) |
| CN (2) | CN103974694A (es) |
| AU (1) | AU2012318556B2 (es) |
| BR (1) | BR112014008314B1 (es) |
| CA (1) | CA2851398C (es) |
| CL (1) | CL2014000863A1 (es) |
| HK (1) | HK1201042A1 (es) |
| IL (1) | IL231970A (es) |
| MX (1) | MX2014004203A (es) |
| MY (1) | MY169328A (es) |
| RU (1) | RU2651046C2 (es) |
| SG (1) | SG11201401323PA (es) |
| TW (1) | TWI642432B (es) |
| WO (1) | WO2013052760A1 (es) |
| ZA (1) | ZA201404121B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8957048B2 (en) * | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
| PT2787968T (pt) * | 2011-12-07 | 2020-06-16 | Allergan Inc | Administração eficaz de lípidos ao filme lacrimal humano utilizando um sistema de emulsão sensível ao sal |
| US9907826B2 (en) | 2011-12-07 | 2018-03-06 | Allergan, Inc. | Efficient lipid delivery to human tear film using a salt-sensitive emulsion system |
| US9278132B2 (en) * | 2012-02-13 | 2016-03-08 | Bausch & Lomb Incorporated | Ophthalmic pharmaceutical compositions and methods of making and using same |
| US20140377210A1 (en) * | 2013-06-21 | 2014-12-25 | Gnt, Llc | Artificial tear compositions |
| US9289494B2 (en) | 2013-11-20 | 2016-03-22 | RestorTears, LLC | Method of treating ocular disorders with compounds found in Harderian gland secretions |
| WO2016085885A1 (en) * | 2014-11-25 | 2016-06-02 | Allergan, Inc. | Stabilized omega-3 ophthalmic compositions |
| CN107106325B (zh) | 2015-01-12 | 2021-05-25 | 科达莱昂治疗公司 | 微滴递送设备和方法 |
| JP2018515153A (ja) | 2015-04-10 | 2018-06-14 | ケダリオン セラピューティックス，インコーポレイテッド | 交換式アンプルを備えた圧電式ディスペンサ |
| CN105311042B (zh) * | 2015-09-07 | 2019-04-12 | 广州国宇医药科技有限公司 | 一种糖醇组合物在制备治疗干眼症的药物中的应用 |
| EP3397136A4 (en) | 2015-12-28 | 2019-11-06 | Indiana University Research & Technology Corporation | IDENTIFICATION OF CONTACT LENS HOLDERS PREDISPOSED TO INCONFORT FROM CONTACT LENSES |
| CA3032695C (en) | 2016-08-19 | 2021-11-23 | Akrivista, LLC | Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye |
| GB201618175D0 (en) * | 2016-10-27 | 2016-12-14 | Warneford Healthcare Ltd | Pharmaceutical compositions |
| KR102550534B1 (ko) | 2017-01-20 | 2023-07-03 | 노파르티스 아게 | 압전 유체 분배기 |
| CN114376961A (zh) * | 2017-08-18 | 2022-04-22 | 阿克里维斯塔有限责任公司 | 诊断和治疗干眼综合症的方法和用于治疗人类眼睛的组合物 |
| JP7150282B2 (ja) * | 2017-09-14 | 2022-10-11 | 協同乳業株式会社 | 涙液分泌能・涙液安定性を改善するための飲食品または製剤 |
| JP7436363B2 (ja) | 2017-12-08 | 2024-02-21 | ノバルティス アーゲー | 流体送達アライメントシステム |
| US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
| BR112022020948A2 (pt) | 2020-04-17 | 2023-04-11 | Kedallion Therapeutics Inc | Sistema de distribuição livre de conservantes hidrodinamicamente atuado |
| US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| WO2022103775A1 (en) | 2020-11-12 | 2022-05-19 | Singletto Inc. | Microbial disinfection for personal protection equipment |
| US11951123B2 (en) | 2022-01-12 | 2024-04-09 | Platform Ophthalmic Innovations, LLC | Fortified nutritional lubricating drops for dry eye disease |
| CN114533582B (zh) * | 2022-02-25 | 2023-05-09 | 北京协和生物工程研究所有限公司 | 一种包含多种渗透压保护剂的眼周用组合物 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4201706A (en) | 1978-09-22 | 1980-05-06 | Burton, Parsons & Company, Inc. | Treatment of corneal edema |
| JPS56104814A (en) | 1980-01-25 | 1981-08-20 | Kunihiro Okanoe | Preparation of eye drop |
| US4649047A (en) | 1985-03-19 | 1987-03-10 | University Of Georgia Research Foundation, Inc. | Ophthalmic treatment by topical administration of cyclosporin |
| US4839342A (en) | 1987-09-03 | 1989-06-13 | University Of Georgia Research Foundation, Inc. | Method of increasing tear production by topical administration of cyclosporin |
| EP0391909B1 (en) | 1987-09-03 | 1994-08-17 | The University Of Georgia Research Foundation, Inc. | Ocular cyclosporin composition |
| IT1224795B (it) | 1988-12-01 | 1990-10-24 | Sigma Tau Ind Farmaceuti | Uso dell'acetil d-carnitina nel trattamento terapeutico del glaucoma e composizioni farmaceutiche utili in tale trattamento |
| WO1991001718A1 (fr) | 1989-08-03 | 1991-02-21 | Eisai Co., Ltd. | Procede de photostabilisation pour collyre liquide et collyre liquide photostabilise |
| US5681555A (en) | 1991-04-22 | 1997-10-28 | Gleich; Gerald J. | Method for the treatment of bronchial asthma by parenteral administration of anionic polymers |
| DE4229494A1 (de) | 1992-09-04 | 1994-03-10 | Basotherm Gmbh | Arzneimittel zur topischen Anwendung am Auge zur Behandlung des erhöhten intraokularen Drucks |
| US5474979A (en) * | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| CA2199610A1 (en) | 1994-09-14 | 1996-03-21 | Taisho Pharmaceutical Co., Ltd. | Eye drops for repairing repairing corneal damage |
| US5980865A (en) | 1995-08-18 | 1999-11-09 | Baker Norton Pharmaceuticals, Inc. | Method for treating late phase allergic reactions and inflammatory diseases |
| FI106923B (fi) | 1997-01-03 | 2001-05-15 | Cultor Ltd Finnsugar Bioproduc | Trimetyyliglysiinin käyttö kehon limakalvojen hygieniaan ja hoitoon tarkoitetuissa valmisteissa |
| AR002194A1 (es) | 1997-03-17 | 1998-01-07 | Sanchez Reynaldo Alemany | Instrumento computarizado para el analisis del movimiento. |
| US5981607A (en) | 1998-01-20 | 1999-11-09 | Allergan | Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers |
| IT1302307B1 (it) | 1998-09-01 | 2000-09-05 | Sigma Tau Healthscience Spa | Composizione ad attivita' antiossidante ed atta a migliorarel'utilizzazione metabolica del glucosio, comprendente acetil |
| US6585987B1 (en) | 1998-11-13 | 2003-07-01 | Continental Projects Limited | Complexes of hyaluronic acid/carnitines and pharmaceutical and cosmetic compositions |
| DE19859910C2 (de) | 1998-12-23 | 2001-03-22 | Ratiopharm Gmbh | Orales Arzneimittel |
| US6228392B1 (en) | 1999-04-29 | 2001-05-08 | Gene Tools, Llc | Osmotic delivery composition, solution, and method |
| CN1441679A (zh) | 2000-07-14 | 2003-09-10 | 阿勒根公司 | 包含具有提高的溶解度的治疗活性组分的组合物 |
| CA2355814C (en) | 2000-09-14 | 2010-06-29 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Pharmaceutical composition for ophthalmic use |
| JP4084997B2 (ja) | 2000-11-08 | 2008-04-30 | エフエックスエス・ベンチャーズ・エルエルシー | 防腐剤増強剤として単純糖類を含有する改良眼科用およびコンタクトレンズ用溶液 |
| US7045121B2 (en) | 2001-12-14 | 2006-05-16 | Allergan, Inc. | Ophthalmic compositions for lubricating eyes and methods for making and using same |
| US7795203B2 (en) | 2002-09-30 | 2010-09-14 | Babizhayev Mark A | Method for topical treatment of eye disease and composition and device for said treatment |
| EP1611883A1 (en) | 2003-03-26 | 2006-01-04 | Menicon Co., Ltd. | Composition for ophthalmic use |
| US20050009836A1 (en) | 2003-06-26 | 2005-01-13 | Laskar Paul A. | Ophthalmic composition containing quinolones and method of use |
| US8569367B2 (en) | 2004-11-16 | 2013-10-29 | Allergan, Inc. | Ophthalmic compositions and methods for treating eyes |
| US7288520B2 (en) | 2005-07-13 | 2007-10-30 | Allergan, Inc. | Cyclosporin compositions |
| US7297679B2 (en) | 2005-07-13 | 2007-11-20 | Allergan, Inc. | Cyclosporin compositions |
| US7659270B2 (en) | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2008027341A2 (en) | 2006-08-30 | 2008-03-06 | Merck & Co., Inc. | Topical ophthalmic formulations |
| MX2009009207A (es) * | 2007-02-28 | 2010-02-12 | Aciex Therapeutics Inc | Metodos y composiciones para normalizar las secreciones de glandulas meibomianas. |
| JP4929245B2 (ja) | 2008-07-31 | 2012-05-09 | 株式会社ベッセル工業 | 工具類のグリップ |
| CA2741288A1 (en) | 2008-10-20 | 2010-04-29 | Allergan, Inc. | Ophthalmic compositions useful for improving visual acuity |
| CN102458430A (zh) * | 2009-06-05 | 2012-05-16 | 阿勒根公司 | 人工泪液及治疗用途 |
| MY160388A (en) | 2009-10-07 | 2017-03-15 | Kerecis Ehf | A scaffold material for wound care and/or other tissue healing applications |
| US8957048B2 (en) * | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
| PT2787968T (pt) * | 2011-12-07 | 2020-06-16 | Allergan Inc | Administração eficaz de lípidos ao filme lacrimal humano utilizando um sistema de emulsão sensível ao sal |
-
2012
- 2012-10-04 US US13/645,035 patent/US8957048B2/en active Active
- 2012-10-05 MY MYPI2014001028A patent/MY169328A/en unknown
- 2012-10-05 CN CN201280060322.4A patent/CN103974694A/zh active Pending
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- 2012-10-05 WO PCT/US2012/058893 patent/WO2013052760A1/en active Application Filing
- 2012-10-05 MX MX2014004203A patent/MX2014004203A/es active IP Right Grant
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- 2012-10-05 CA CA2851398A patent/CA2851398C/en active Active
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- 2012-10-05 EP EP12773477.0A patent/EP2765987A1/en active Pending
- 2012-10-05 US US14/349,978 patent/US20140242022A1/en not_active Abandoned
- 2012-10-05 JP JP2014534753A patent/JP6209163B2/ja active Active
- 2012-10-05 TW TW101137051A patent/TWI642432B/zh active
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2014
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2015
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2018
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2020
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2021
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2023
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