CL2013002241A1 - Compuestos derivados de (4,4´-bifeniilbis(1h-imidazol-4,2-diil)-2,1-pirrolidindiil((1s)-1-((2r,6r)-2,4-dimetilltetrahidro-2h-piran-4-il)-2-oxo-2,1-etandiil)))biscarbamato de dimetilo, inhibidores del vhc; compuestos intermediarios; composicion farmaceutica; combinacion farmaceutica; y uso para tratar una infeccion por vhc. - Google Patents
Compuestos derivados de (4,4´-bifeniilbis(1h-imidazol-4,2-diil)-2,1-pirrolidindiil((1s)-1-((2r,6r)-2,4-dimetilltetrahidro-2h-piran-4-il)-2-oxo-2,1-etandiil)))biscarbamato de dimetilo, inhibidores del vhc; compuestos intermediarios; composicion farmaceutica; combinacion farmaceutica; y uso para tratar una infeccion por vhc.Info
- Publication number
- CL2013002241A1 CL2013002241A1 CL2013002241A CL2013002241A CL2013002241A1 CL 2013002241 A1 CL2013002241 A1 CL 2013002241A1 CL 2013002241 A CL2013002241 A CL 2013002241A CL 2013002241 A CL2013002241 A CL 2013002241A CL 2013002241 A1 CL2013002241 A1 CL 2013002241A1
- Authority
- CL
- Chile
- Prior art keywords
- vhc
- compounds
- pyrrolidindiyl
- biphenylbis
- dimethyltetrahydro
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 2
- -1 (1h-imidazol-4,2-diyl) -2,1-pyrrolidindiyl Chemical group 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- PQJFJRGZSZKPTF-UHFFFAOYSA-N methyl carbamate Chemical compound COC(N)=O.COC(N)=O PQJFJRGZSZKPTF-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyrane Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161440086P | 2011-02-07 | 2011-02-07 | |
| US201161467602P | 2011-03-25 | 2011-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013002241A1 true CL2013002241A1 (es) | 2013-12-13 |
Family
ID=45688244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013002241A CL2013002241A1 (es) | 2011-02-07 | 2013-08-05 | Compuestos derivados de (4,4´-bifeniilbis(1h-imidazol-4,2-diil)-2,1-pirrolidindiil((1s)-1-((2r,6r)-2,4-dimetilltetrahidro-2h-piran-4-il)-2-oxo-2,1-etandiil)))biscarbamato de dimetilo, inhibidores del vhc; compuestos intermediarios; composicion farmaceutica; combinacion farmaceutica; y uso para tratar una infeccion por vhc. |
Country Status (23)
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-
2012
- 2012-01-30 US US13/361,541 patent/US8552047B2/en active Active
- 2012-02-02 PH PH1/2013/501543A patent/PH12013501543A1/en unknown
- 2012-02-02 CA CA 2826774 patent/CA2826774A1/en not_active Abandoned
- 2012-02-02 AU AU2012214767A patent/AU2012214767B2/en not_active Ceased
- 2012-02-02 KR KR20137023425A patent/KR20140048848A/ko not_active Withdrawn
- 2012-02-02 MA MA36169A patent/MA34896B1/fr unknown
- 2012-02-02 BR BR112013020042A patent/BR112013020042A2/pt not_active IP Right Cessation
- 2012-02-02 EP EP20120704582 patent/EP2673271B1/en not_active Not-in-force
- 2012-02-02 SG SG2013058748A patent/SG192267A1/en unknown
- 2012-02-02 WO PCT/US2012/023595 patent/WO2012109080A1/en not_active Ceased
- 2012-02-02 EA EA201391152A patent/EA021538B1/ru not_active IP Right Cessation
- 2012-02-02 CN CN201280008010.9A patent/CN103347878B/zh not_active Expired - Fee Related
- 2012-02-02 MX MX2013008419A patent/MX2013008419A/es active IP Right Grant
- 2012-02-02 PE PE2013001838A patent/PE20140302A1/es not_active Application Discontinuation
- 2012-02-02 ES ES12704582.1T patent/ES2540052T3/es active Active
- 2012-02-02 JP JP2013552620A patent/JP5815746B2/ja not_active Expired - Fee Related
- 2012-02-06 TW TW101103797A patent/TWI542585B/zh not_active IP Right Cessation
- 2012-02-07 UY UY0001033897A patent/UY33897A/es unknown
- 2012-02-07 AR ARP120100401 patent/AR085327A1/es unknown
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2013
- 2013-08-04 IL IL227789A patent/IL227789A0/en unknown
- 2013-08-05 CL CL2013002241A patent/CL2013002241A1/es unknown
- 2013-09-04 US US14/017,837 patent/US9340520B2/en active Active
- 2013-09-04 CO CO13209876A patent/CO6761335A2/es unknown
- 2013-09-06 ZA ZA2013/06720A patent/ZA201306720B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012109080A1 (en) | 2012-08-16 |
| JP2014504643A (ja) | 2014-02-24 |
| UY33897A (es) | 2012-08-31 |
| CN103347878A (zh) | 2013-10-09 |
| US9340520B2 (en) | 2016-05-17 |
| NZ615067A (en) | 2014-12-24 |
| US20140012020A1 (en) | 2014-01-09 |
| JP5815746B2 (ja) | 2015-11-17 |
| TW201307333A (zh) | 2013-02-16 |
| SG192267A1 (en) | 2013-09-30 |
| ES2540052T3 (es) | 2015-07-08 |
| KR20140048848A (ko) | 2014-04-24 |
| EA021538B1 (ru) | 2015-07-30 |
| MX2013008419A (es) | 2013-09-13 |
| PE20140302A1 (es) | 2014-03-24 |
| AR085327A1 (es) | 2013-09-25 |
| TWI542585B (zh) | 2016-07-21 |
| EA201391152A1 (ru) | 2013-12-30 |
| EP2673271B1 (en) | 2015-05-06 |
| BR112013020042A2 (pt) | 2016-10-25 |
| AU2012214767B2 (en) | 2016-06-02 |
| CA2826774A1 (en) | 2012-08-16 |
| ZA201306720B (en) | 2015-05-27 |
| CN103347878B (zh) | 2015-05-06 |
| US20130028859A1 (en) | 2013-01-31 |
| MA34896B1 (fr) | 2014-02-01 |
| PH12013501543A1 (en) | 2013-09-23 |
| IL227789A0 (en) | 2013-09-30 |
| AU2012214767A1 (en) | 2013-09-26 |
| EP2673271A1 (en) | 2013-12-18 |
| CO6761335A2 (es) | 2013-09-30 |
| US8552047B2 (en) | 2013-10-08 |
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