CL2013002138A1 - Metodo para modificar geneticamente una planta para incrementar la produccion de un producto biosintetico en un tejido deseado; y metodo para modificar geneticamente una planta que tiene deposicion de lignina que es sustancialmente localizada en los vasos de tejido de xilema de la planta - Google Patents
Metodo para modificar geneticamente una planta para incrementar la produccion de un producto biosintetico en un tejido deseado; y metodo para modificar geneticamente una planta que tiene deposicion de lignina que es sustancialmente localizada en los vasos de tejido de xilema de la plantaInfo
- Publication number
- CL2013002138A1 CL2013002138A1 CL2013002138A CL2013002138A CL2013002138A1 CL 2013002138 A1 CL2013002138 A1 CL 2013002138A1 CL 2013002138 A CL2013002138 A CL 2013002138A CL 2013002138 A CL2013002138 A CL 2013002138A CL 2013002138 A1 CL2013002138 A1 CL 2013002138A1
- Authority
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- Chile
- Prior art keywords
- plant
- genetically
- tissue
- production
- increase
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8217—Gene switch
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8222—Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
- C12N15/8223—Vegetative tissue-specific promoters
- C12N15/8226—Stem-specific, e.g. including tubers, beets
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
- C12N15/8246—Non-starch polysaccharides, e.g. cellulose, fructans, levans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8255—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving lignin biosynthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
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- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Nutrition Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161437569P | 2011-01-28 | 2011-01-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2013002138A1 true CL2013002138A1 (es) | 2014-03-07 |
Family
ID=46581454
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2013002138A CL2013002138A1 (es) | 2011-01-28 | 2013-07-26 | Metodo para modificar geneticamente una planta para incrementar la produccion de un producto biosintetico en un tejido deseado; y metodo para modificar geneticamente una planta que tiene deposicion de lignina que es sustancialmente localizada en los vasos de tejido de xilema de la planta |
Country Status (6)
Country | Link |
---|---|
US (3) | US20140298539A1 (es) |
CN (2) | CN107674882B (es) |
BR (1) | BR112013018836A2 (es) |
CL (1) | CL2013002138A1 (es) |
MX (2) | MX2013008710A (es) |
WO (1) | WO2012103555A2 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2865787C (en) | 2012-02-27 | 2023-06-27 | Board Of Trustees Of Michigan State University | Control of cellulose biosynthesis by overexpession of a transcription factor myb46 |
WO2013170201A2 (en) | 2012-05-10 | 2013-11-14 | The Regents Of The University Of California | Regulation of galactan synthase expression to modify galactan content in plants |
WO2014018982A1 (en) | 2012-07-27 | 2014-01-30 | The Regents Of The University Of California | Systems and methods for enhancing gene expression |
EP2880165A4 (en) * | 2012-08-03 | 2016-03-16 | Adelaide Res &Innovation Pty Ltd | POLYSACCHARIDE SYNTHASES (X) |
GB201223097D0 (en) | 2012-12-20 | 2013-02-06 | Max Planck Gesellschaft | Stable transformation of a population and a method of biocontainment using haploinsufficiency and underdominance principles |
WO2014100742A2 (en) | 2012-12-21 | 2014-06-26 | The Regents Of The University Of California | Modulation of expression of acyltransferases to modify hydroxycinnamic acid content |
US10227573B2 (en) | 2013-03-15 | 2019-03-12 | The Regents Of The University Of California | Dominant negative mutations of Arabidopsis RWA |
CN103409441A (zh) * | 2013-07-29 | 2013-11-27 | 中国农业大学 | 柳枝稷木质素合成酶f5h2基因序列 |
AU2014337747A1 (en) * | 2013-10-21 | 2016-04-28 | Swetree Technologies Ab | Transgenic trees having reduced xylan content |
US9944939B2 (en) | 2013-11-13 | 2018-04-17 | Board Of Trustees Of Michigan State University | CslA9 gluco-mannan synthase gene |
CN103695406A (zh) * | 2013-12-16 | 2014-04-02 | 上海交通大学 | 郁金香苯丙氨酸解氨酶TfPAL蛋白及其编码基因 |
US10774338B2 (en) | 2014-01-16 | 2020-09-15 | The Regents Of The University Of California | Generation of heritable chimeric plant traits |
CN104561044B (zh) * | 2015-01-16 | 2017-07-25 | 东北林业大学 | 一种提高白桦抗逆性的基因及其编码的蛋白 |
KR101797713B1 (ko) * | 2015-05-14 | 2017-11-16 | 한국과학기술원 | 신남알데하이드의 제조 방법 |
US10253324B2 (en) | 2015-09-30 | 2019-04-09 | The United States Of America, As Represented By The Secretary Of Agriculture | Genetically altered alfalfa producing clovamide and/or related hydroxycinnamoyl amides |
CN105925591B (zh) * | 2016-04-22 | 2019-12-24 | 浙江农林大学 | 一种毛竹木聚糖合成关键基因PeIRX10的克隆及其应用 |
EP3468986A1 (en) * | 2016-06-13 | 2019-04-17 | Benson Hill Biosystems, Inc. | Increasing plant growth and yield by using a phenylalanine ammonia lyase sequence |
CN107164389B (zh) * | 2017-06-20 | 2021-09-03 | 南京农业大学 | 一种耐铝毒基因、突变体及其制备方法与应用 |
WO2019053073A1 (en) * | 2017-09-13 | 2019-03-21 | Vib Vzw | MEANS AND METHODS FOR INCREASING BIOMASS VEGETAL |
JP7039005B2 (ja) * | 2017-12-28 | 2022-03-22 | 国立大学法人東海国立大学機構 | 植物由来のアルカン合成酵素遺伝子を導入した細胞を用いるアルカンの製造方法 |
WO2019148193A1 (en) | 2018-01-29 | 2019-08-01 | Afingen, Inc. | Compositions and methods for increasing plant growth and improving multiple yield-related traits |
CN108531504A (zh) * | 2018-04-04 | 2018-09-14 | 辽宁大学 | 一种利用基因工程手段高效创制低木质素含量紫花苜蓿的方法 |
WO2020006465A1 (en) * | 2018-06-29 | 2020-01-02 | Board Of Trustees Of Michigan State University | Constitutively active form of myb46 |
CN109576284B (zh) * | 2018-12-21 | 2021-09-17 | 中国农业科学院北京畜牧兽医研究所 | 一个多功能的myb转录因子基因及其用途 |
US12037592B2 (en) | 2019-02-20 | 2024-07-16 | The Regents Of The University Of California | Plants and methods for producing muconic acid |
CN110066813B (zh) * | 2019-03-31 | 2021-01-26 | 浙江大学 | 一种调控杨树木材形成的油菜素内酯合成限速基因及其应用 |
CN110699368A (zh) * | 2019-11-21 | 2020-01-17 | 安徽农业大学 | 小麦肉桂酸-4-羟基化酶基因及其扩增引物和应用 |
CN111206039B (zh) * | 2020-03-16 | 2021-12-07 | 南京林业大学 | 一种孝顺竹转录因子BmMYB83基因及其应用 |
CN111410684A (zh) * | 2020-05-12 | 2020-07-14 | 中国农业科学院作物科学研究所 | SiMYB30蛋白质及其相关生物材料在调控植物耐逆性和产量中的应用 |
CN111499713B (zh) * | 2020-06-10 | 2022-03-18 | 华中农业大学 | 水稻粒型基因qGL6-2及其应用 |
CN113234734B (zh) * | 2021-03-22 | 2022-10-25 | 成都大学 | 一种可提高植物抗性的甜橙基因CsMYB30及其应用 |
CN113403322B (zh) * | 2021-05-14 | 2022-09-16 | 云南大学 | 一种茶树干旱响应基因CsNAC168及其编码蛋白和应用 |
CN114350676B (zh) * | 2022-01-11 | 2023-11-17 | 黑龙江省农业科学院经济作物研究所 | 一种调控亚麻纤维素合成的LuMyb基因及其应用 |
CN115820687B (zh) * | 2022-10-14 | 2024-03-19 | 海南大学 | 柚子中绿原酸生物合成途径基因CgHCT和CgC3′H及其应用 |
CN116813711B (zh) * | 2023-03-24 | 2024-02-27 | 周志图 | 降血糖抗氧化的菊芋肽、其制备方法及其应用 |
CN116987710B (zh) * | 2023-08-07 | 2024-05-28 | 西部(重庆)科学城种质创制大科学中心 | 马铃薯耐旱性相关基因StMYB55及其应用 |
CN118064491A (zh) * | 2023-12-07 | 2024-05-24 | 四川农业大学 | 水稻基因OsGUX1及其应用 |
CN118531059A (zh) * | 2024-07-26 | 2024-08-23 | 吉林农业大学 | GmMYB85基因在调控植物油脂合成中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6410718B1 (en) * | 1996-09-11 | 2002-06-25 | Genesis Research & Development Corporation Ltd. | Materials and methods for the modification of plant lignin content |
US10329575B2 (en) * | 1999-05-14 | 2019-06-25 | Ceres, Inc. | Regulatory sequence for plants |
BRPI0312121B1 (pt) * | 2002-06-14 | 2019-10-01 | Verenium Corporation | Preparação de proteina, polipeptídeo imobilizado e métodos para prepará-los e empregá-los |
US7238512B2 (en) * | 2003-10-17 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Method to produce para-hydroxybenzoic acid in the stem tissue of green plants by using a tissue-specific promoter |
AU2005295420B2 (en) * | 2004-10-18 | 2011-04-14 | The Samuel Roberts Noble Foundation, Inc. | Increased wax production in plants |
US8183432B2 (en) * | 2006-02-28 | 2012-05-22 | Japan Science And Technology Agency | Plant having reduced lignin and cellulose contents without reducing glucan content, method of producing the same and utilization thereof |
GB0718377D0 (en) * | 2007-09-21 | 2007-10-31 | Cambridge Entpr Ltd | Improvements in or relating to organic compounds |
JP5744518B2 (ja) * | 2007-10-03 | 2015-07-08 | ビーピー・コーポレーション・ノース・アメリカ・インコーポレーテッド | キシラナーゼ、キシラナーゼをコードする核酸並びにそれらを製造及び使用する方法 |
NZ597561A (en) * | 2009-07-13 | 2013-06-28 | Samuel Roberts Noble Found Inc | Plants with modified lignin content and methods for production thereof |
-
2012
- 2012-01-30 WO PCT/US2012/023182 patent/WO2012103555A2/en active Application Filing
- 2012-01-30 US US13/982,231 patent/US20140298539A1/en not_active Abandoned
- 2012-01-30 BR BR112013018836A patent/BR112013018836A2/pt not_active Application Discontinuation
- 2012-01-30 CN CN201710806695.6A patent/CN107674882B/zh active Active
- 2012-01-30 MX MX2013008710A patent/MX2013008710A/es unknown
- 2012-01-30 CN CN201280010285.6A patent/CN103403016B/zh active Active
-
2013
- 2013-07-26 CL CL2013002138A patent/CL2013002138A1/es unknown
- 2013-07-26 MX MX2018013482A patent/MX2018013482A/es unknown
-
2018
- 2018-09-06 US US16/123,739 patent/US20190062771A1/en not_active Abandoned
-
2022
- 2022-04-06 US US17/714,931 patent/US20220380790A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
MX2013008710A (es) | 2013-08-21 |
US20220380790A1 (en) | 2022-12-01 |
CN107674882B (zh) | 2021-06-25 |
US20140298539A1 (en) | 2014-10-02 |
WO2012103555A2 (en) | 2012-08-02 |
CN107674882A (zh) | 2018-02-09 |
MX2018013482A (es) | 2019-12-09 |
CN103403016B (zh) | 2017-10-24 |
US20190062771A1 (en) | 2019-02-28 |
CN103403016A (zh) | 2013-11-20 |
WO2012103555A3 (en) | 2012-10-04 |
BR112013018836A2 (pt) | 2016-07-19 |
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