CL2012002744A1 - Compuesto inhibidor no nucleosídico de la transcriptasa inversa derivado de 3-(hidrocarbiloxi aromático y alifático opcionalmente sustituido)-1-[(5-oxo-4,5-dihidro-1h-1,2,4-triazol-3-il)metil])-piridin-2(ih)-ona; composición farmacéutica que lo comprende útil en la profilaxis y tratamiento de la infección por vih y sida. - Google Patents
Compuesto inhibidor no nucleosídico de la transcriptasa inversa derivado de 3-(hidrocarbiloxi aromático y alifático opcionalmente sustituido)-1-[(5-oxo-4,5-dihidro-1h-1,2,4-triazol-3-il)metil])-piridin-2(ih)-ona; composición farmacéutica que lo comprende útil en la profilaxis y tratamiento de la infección por vih y sida.Info
- Publication number
- CL2012002744A1 CL2012002744A1 CL2012002744A CL2012002744A CL2012002744A1 CL 2012002744 A1 CL2012002744 A1 CL 2012002744A1 CL 2012002744 A CL2012002744 A CL 2012002744A CL 2012002744 A CL2012002744 A CL 2012002744A CL 2012002744 A1 CL2012002744 A1 CL 2012002744A1
- Authority
- CL
- Chile
- Prior art keywords
- triazol
- pyridin
- prophylaxis
- dihydro
- oxo
- Prior art date
Links
- -1 5-oxo-4,5-dihydro-1h-1,2,4-triazol-3-yl Chemical group 0.000 title abstract 2
- 208000030507 AIDS Diseases 0.000 title abstract 2
- 125000001931 aliphatic group Chemical group 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title abstract 2
- 229940042402 non-nucleoside reverse transcriptase inhibitor Drugs 0.000 title abstract 2
- 239000002726 nonnucleoside reverse transcriptase inhibitor Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000011321 prophylaxis Methods 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 title 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31882410P | 2010-03-30 | 2010-03-30 | |
| US32157310P | 2010-04-07 | 2010-04-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2012002744A1 true CL2012002744A1 (es) | 2012-12-14 |
Family
ID=44710363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012002744A CL2012002744A1 (es) | 2010-03-30 | 2012-09-28 | Compuesto inhibidor no nucleosídico de la transcriptasa inversa derivado de 3-(hidrocarbiloxi aromático y alifático opcionalmente sustituido)-1-[(5-oxo-4,5-dihidro-1h-1,2,4-triazol-3-il)metil])-piridin-2(ih)-ona; composición farmacéutica que lo comprende útil en la profilaxis y tratamiento de la infección por vih y sida. |
Country Status (44)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2012011379A (es) * | 2010-03-30 | 2012-11-30 | Merck Canada Inc | Inhibidores no nucleosidicos de la transcriptasa inversa. |
| WO2012048113A2 (en) | 2010-10-07 | 2012-04-12 | The General Hospital Corporation | Biomarkers of cancer |
| EP2900240B1 (en) * | 2012-09-26 | 2020-01-08 | Merck Sharp & Dohme Corp. | Crystalline form of a reverse transcriptase inhibitor |
| JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| CN104994855B (zh) * | 2012-12-05 | 2018-06-05 | 默沙东公司 | 制备逆转录酶抑制剂的方法 |
| EP3071037A4 (en) * | 2013-11-22 | 2017-08-02 | Merck Sharp & Dohme Corp. | Composition of a non-nucleoside reverse transcriptase inhibitor |
| KR101803671B1 (ko) * | 2013-12-04 | 2017-11-30 | 머크 샤프 앤드 돔 코포레이션 | 역전사효소 억제제의 제조 방법 |
| SI3125894T1 (sl) | 2014-04-01 | 2020-12-31 | Merck Sharp & Dohme Corp. | Predzdravila inhibitorjev reverzne transkriptaze HIV |
| EP3161159B1 (en) | 2014-06-25 | 2020-08-05 | The General Hospital Corporation | Targeting human satellite ii (hsatii) |
| RU2736941C2 (ru) | 2015-12-02 | 2020-11-23 | Мерк Шарп энд Доум Корп. | Фармацевтические композиции, содержащие доравирин, тенофовира дизопроксила фумарат и ламивудин |
| WO2018175271A1 (en) * | 2017-03-24 | 2018-09-27 | Merck Sharp & Dohme Corp. | Formulation for parenteral administration |
| RU2019136678A (ru) | 2017-04-18 | 2021-05-18 | Сипла Лимитед | Комбинированная терапия для применения в лечении ретровирусных инфекций |
| EP4317972A3 (en) | 2018-02-06 | 2024-03-13 | The General Hospital Corporation | Repeat rna as biomarkers of tumor immune response |
| WO2020018352A1 (en) | 2018-07-17 | 2020-01-23 | Merck Sharp & Dohme Corp. | Hiv drug combination for increasing barrier against resistance |
| MX2021007382A (es) | 2018-12-18 | 2021-07-15 | Merck Sharp & Dohme Llc | Derivados de pirimidona como agentes citotoxicos selectivos contra celulas infectadas por vih. |
| CN110801455B (zh) * | 2019-11-12 | 2020-06-02 | 河北医科大学第二医院 | 用于治疗mrsa的药物组合物及其应用 |
| CN114163309B (zh) * | 2021-12-27 | 2023-04-25 | 甘肃皓天医药科技有限责任公司 | 一种多拉韦林中间体的制备方法 |
| CN114349690B (zh) * | 2022-02-15 | 2023-04-25 | 甘肃皓天医药科技有限责任公司 | 一种多拉韦林中间体合成方法 |
| CN116903590A (zh) * | 2023-06-06 | 2023-10-20 | 延边大学 | 一种含杂环结构的吡啶酮类化合物及其制备方法和用途 |
| CN120157613A (zh) * | 2023-12-15 | 2025-06-17 | 山东诚创蓝海医药科技有限公司 | 多拉韦林中间体及其应用和合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904045D0 (sv) | 1999-11-09 | 1999-11-09 | Astra Ab | Compounds |
| TW200423930A (en) * | 2003-02-18 | 2004-11-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitors |
| TW200505441A (en) * | 2003-03-24 | 2005-02-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitorsⅠ |
| WO2004085406A1 (en) | 2003-03-24 | 2004-10-07 | F. Hoffmann-La Roche Ag | Benzyl-pyridazinons as reverse transcriptase inhibitors |
| US7166738B2 (en) | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
| AU2005235692B2 (en) | 2004-04-23 | 2011-11-10 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
| JP2008525419A (ja) | 2004-12-22 | 2008-07-17 | ファイザー・リミテッド | Ｈｉｖ−１逆転写酵素の非ヌクレオシド阻害剤 |
| AR057455A1 (es) | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| ES2320042T3 (es) | 2005-10-19 | 2009-05-18 | F. Hoffmann-La Roche Ag | Inhibidores de transcriptasa reversa con nucleosidos de n-fenil fenilacetamida. |
| EP1940781A1 (en) | 2005-10-19 | 2008-07-09 | F.Hoffmann-La Roche Ag | Phenyl-acetamide nnrt inhibitors |
| TW200831085A (en) | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
| CN101952274A (zh) | 2007-11-20 | 2011-01-19 | 默沙东公司 | 非核苷逆转录酶抑制剂 |
| MX2012011379A (es) * | 2010-03-30 | 2012-11-30 | Merck Canada Inc | Inhibidores no nucleosidicos de la transcriptasa inversa. |
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2011
- 2011-03-28 MX MX2012011379A patent/MX2012011379A/es active IP Right Grant
- 2011-03-28 PL PL15157348T patent/PL2924034T3/pl unknown
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- 2011-03-28 ME MEP-2016-282A patent/ME02570B/me unknown
- 2011-03-28 MA MA35324A patent/MA34170B1/fr unknown
- 2011-03-28 LT LTEP15157348.2T patent/LT2924034T/lt unknown
- 2011-03-28 ME MEP-2015-76A patent/ME02181B/me unknown
- 2011-03-28 RS RS20161093A patent/RS55505B1/sr unknown
- 2011-03-28 US US13/073,631 patent/US8486975B2/en active Active
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- 2011-03-28 WO PCT/CA2011/000320 patent/WO2011120133A1/en not_active Ceased
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- 2012-09-28 CL CL2012002744A patent/CL2012002744A1/es unknown
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2013
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2014
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2016
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2017
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2019
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