CL2012001300A1 - Proceso de preparación de un compuesto de fórmula (i) en forma de sal iónica, que comprende las etapas de i) hidrogenar un compuesto de fórmula (ii) usando un catalizador metálico con hidrógeno y ii) filtrar el catalizador seguido de tratamiento con una solución ácida o gas. - Google Patents
Proceso de preparación de un compuesto de fórmula (i) en forma de sal iónica, que comprende las etapas de i) hidrogenar un compuesto de fórmula (ii) usando un catalizador metálico con hidrógeno y ii) filtrar el catalizador seguido de tratamiento con una solución ácida o gas.Info
- Publication number
- CL2012001300A1 CL2012001300A1 CL2012001300A CL2012001300A CL2012001300A1 CL 2012001300 A1 CL2012001300 A1 CL 2012001300A1 CL 2012001300 A CL2012001300 A CL 2012001300A CL 2012001300 A CL2012001300 A CL 2012001300A CL 2012001300 A1 CL2012001300 A1 CL 2012001300A1
- Authority
- CL
- Chile
- Prior art keywords
- compound
- formula
- catalyst
- hydrogenating
- filtering
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003054 catalyst Substances 0.000 title abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 238000001914 filtration Methods 0.000 title abstract 2
- 239000007789 gas Substances 0.000 title abstract 2
- 239000001257 hydrogen Substances 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000003839 salts Chemical group 0.000 title abstract 2
- 239000003863 metallic catalyst Substances 0.000 title 1
- 239000002184 metal Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Materials Engineering (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26753809P | 2009-12-08 | 2009-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2012001300A1 true CL2012001300A1 (es) | 2012-09-07 |
Family
ID=43416915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012001300A CL2012001300A1 (es) | 2009-12-08 | 2012-05-18 | Proceso de preparación de un compuesto de fórmula (i) en forma de sal iónica, que comprende las etapas de i) hidrogenar un compuesto de fórmula (ii) usando un catalizador metálico con hidrógeno y ii) filtrar el catalizador seguido de tratamiento con una solución ácida o gas. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20110137042A1 (OSRAM) |
| EP (1) | EP2509952A1 (OSRAM) |
| JP (1) | JP2013512954A (OSRAM) |
| KR (1) | KR20120101667A (OSRAM) |
| CN (1) | CN102596908A (OSRAM) |
| AR (1) | AR079324A1 (OSRAM) |
| AU (1) | AU2010328480A1 (OSRAM) |
| BR (1) | BR112012013582A2 (OSRAM) |
| CA (1) | CA2782384A1 (OSRAM) |
| CL (1) | CL2012001300A1 (OSRAM) |
| EA (1) | EA201200820A1 (OSRAM) |
| IL (1) | IL219274A0 (OSRAM) |
| IN (1) | IN2012DN05081A (OSRAM) |
| MX (1) | MX2012006524A (OSRAM) |
| PH (1) | PH12012501153A1 (OSRAM) |
| TW (1) | TW201144282A (OSRAM) |
| WO (1) | WO2011071730A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008327B2 (en) | 2008-04-29 | 2011-08-30 | Boehringer Ingelheim International Gmbh | Indazole compounds as CCR1 receptor antagonists |
| JP5411927B2 (ja) * | 2008-05-06 | 2014-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１アンタゴニストとしてのピラゾール化合物 |
| AU2009296839A1 (en) | 2008-09-26 | 2010-04-01 | Boehringer Ingelheim International Gmbh | Azaindazole compounds as CCR1 receptor antagonists |
| HRP20140213T1 (hr) | 2009-10-21 | 2014-04-11 | Boehringer Ingelheim International Gmbh | Spojevi indazola i pirazolopiridina kao antagonisti ccr1-receptora |
| WO2011056440A1 (en) | 2009-10-27 | 2011-05-12 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds as ccr1 receptor antagonists |
| EP2563787B1 (en) | 2010-04-30 | 2014-11-26 | Boehringer Ingelheim International GmbH | Azaindazole amide compounds as ccr1 receptor antagonists |
| EP2655371B1 (en) | 2010-12-23 | 2015-02-25 | Boehringer Ingelheim International GmbH | Pyrazolopiperidine compounds as ccr1 receptor antagonists |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5242931A (en) * | 1988-06-09 | 1993-09-07 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds as TXA2 antagonists |
| CA1338625C (en) * | 1988-06-09 | 1996-10-01 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds |
| US5750542A (en) * | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
| US5612360A (en) * | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
| WO1994001415A1 (en) * | 1992-07-03 | 1994-01-20 | Kumiai Chemical Industry Co., Ltd. | Condensed heterocyclic derivative and weedkiller |
| GB9304919D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| AU674240B2 (en) * | 1993-06-25 | 1996-12-12 | Ihara Chemical Industry Co. Ltd. | Indazolesulfonylurea derivative, use thereof, and intermediate for production thereof |
| WO1996017842A1 (en) * | 1994-12-06 | 1996-06-13 | Merck Sharp & Dohme Limited | Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists |
| GB9519563D0 (en) * | 1995-09-26 | 1995-11-29 | Merck Sharp & Dohme | Therapeutic agents |
| GB9523583D0 (en) * | 1995-11-17 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
| US5760028A (en) * | 1995-12-22 | 1998-06-02 | The Dupont Merck Pharmaceutical Company | Integrin receptor antagonists |
| GB9615449D0 (en) * | 1996-07-23 | 1996-09-04 | Merck Sharp & Dohme | Therapeutic agents |
| SK6262000A3 (en) * | 1997-11-04 | 2002-03-05 | Pfizer Prod Inc | Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors |
| US6331640B1 (en) * | 1998-10-13 | 2001-12-18 | Hoffmann-La Roche Inc. | Diaminopropionic acid derivatives |
| JP2003502314A (ja) * | 1999-06-14 | 2003-01-21 | イーライ・リリー・アンド・カンパニー | 化合物 |
| AU5895500A (en) * | 1999-06-29 | 2001-01-31 | Cor Therapeutics, Inc. | Novel indazole peptidomimetics as thrombin receptor antagonists |
| GB0030303D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030306D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030304D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030305D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| US7211594B2 (en) * | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
| US20050009876A1 (en) * | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
| US7058826B2 (en) * | 2000-09-27 | 2006-06-06 | Amphus, Inc. | System, architecture, and method for logical server and other network devices in a dynamically configurable multi-server network environment |
| US20020052373A1 (en) * | 2000-10-26 | 2002-05-02 | Zorn Stevin H. | Combination treatment for dementia or cognitive deficits associated with alzheimer's disease and parkinson's disease |
| US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| ES2338539T3 (es) * | 2001-11-01 | 2010-05-10 | Icagen, Inc. | Pirazolamidas para uso en el tratamiento del dolor. |
| KR20050004214A (ko) * | 2002-05-31 | 2005-01-12 | 에자이 가부시키가이샤 | 피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물 |
| TW200500341A (en) * | 2002-11-12 | 2005-01-01 | Astrazeneca Ab | Novel compounds |
| SE0203825D0 (sv) * | 2002-12-20 | 2002-12-20 | Astrazeneca Ab | Novel fused heterocycles and uses thereof |
| NZ542671A (en) * | 2003-03-12 | 2008-12-24 | Celgene Corp | 7-Amido-isoindolyl compounds and their pharmaceutical uses |
| US7129264B2 (en) * | 2003-04-16 | 2006-10-31 | Bristol-Myers Squibb Company | Biarylmethyl indolines and indoles as antithromboembolic agents |
| US20040220170A1 (en) * | 2003-05-01 | 2004-11-04 | Atkinson Robert N. | Pyrazole-amides and sulfonamides as sodium channel modulators |
| EP1664052B1 (en) * | 2003-08-15 | 2009-02-18 | AstraZeneca AB | Fused heterocycles as inhibitors of glutamate racemase (muri) |
| SE0302486D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| SE0302487D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| GB0504828D0 (en) * | 2005-03-09 | 2005-04-13 | Merck Sharp & Dohme | Therapeutic agents |
| AP2108A (en) * | 2005-03-16 | 2010-02-25 | Basf Ag | Novel biphenylsulfonamides |
| JP5794721B2 (ja) * | 2005-05-17 | 2015-10-14 | サーコード バイオサイエンス インコーポレイテッド | 眼障害の治療のための組成物および方法 |
| WO2007028083A2 (en) * | 2005-09-01 | 2007-03-08 | Eli Lilly And Company | 6-arylalkylamino- 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists |
| JP2009513677A (ja) * | 2005-10-25 | 2009-04-02 | スミスクライン・ビーチャム・コーポレイション | 化合物 |
| US8097617B2 (en) * | 2006-03-31 | 2012-01-17 | Novartis Ag | Organic compounds |
| PE20081775A1 (es) * | 2006-12-20 | 2008-12-18 | Bristol Myers Squibb Co | Compuestos macrociclicos como inhibidores del factor viia |
| GB0716292D0 (en) * | 2007-08-21 | 2007-09-26 | Biofocus Dpi Ltd | Imidazopyrazine compounds |
| MX2010004705A (es) * | 2007-10-31 | 2010-05-27 | Nissan Chemical Ind Ltd | Derivados de piridazinona y uso de los mismos como inhibidores del receptor p2x7. |
| US8008327B2 (en) * | 2008-04-29 | 2011-08-30 | Boehringer Ingelheim International Gmbh | Indazole compounds as CCR1 receptor antagonists |
| JP5411927B2 (ja) * | 2008-05-06 | 2014-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１アンタゴニストとしてのピラゾール化合物 |
| AU2009296839A1 (en) * | 2008-09-26 | 2010-04-01 | Boehringer Ingelheim International Gmbh | Azaindazole compounds as CCR1 receptor antagonists |
-
2010
- 2010-12-01 CA CA2782384A patent/CA2782384A1/en not_active Abandoned
- 2010-12-01 EA EA201200820A patent/EA201200820A1/ru unknown
- 2010-12-01 CN CN2010800504234A patent/CN102596908A/zh active Pending
- 2010-12-01 EP EP10787651A patent/EP2509952A1/en not_active Withdrawn
- 2010-12-01 IN IN5081DEN2012 patent/IN2012DN05081A/en unknown
- 2010-12-01 AU AU2010328480A patent/AU2010328480A1/en not_active Abandoned
- 2010-12-01 BR BR112012013582A patent/BR112012013582A2/pt not_active IP Right Cessation
- 2010-12-01 JP JP2012543154A patent/JP2013512954A/ja active Pending
- 2010-12-01 WO PCT/US2010/058594 patent/WO2011071730A1/en active Application Filing
- 2010-12-01 US US12/957,483 patent/US20110137042A1/en not_active Abandoned
- 2010-12-01 MX MX2012006524A patent/MX2012006524A/es not_active Application Discontinuation
- 2010-12-01 PH PH1/2012/501153A patent/PH12012501153A1/en unknown
- 2010-12-01 KR KR1020127014239A patent/KR20120101667A/ko not_active Withdrawn
- 2010-12-07 TW TW099142648A patent/TW201144282A/zh unknown
- 2010-12-07 AR ARP100104528A patent/AR079324A1/es unknown
-
2012
- 2012-04-19 IL IL219274A patent/IL219274A0/en unknown
- 2012-05-18 CL CL2012001300A patent/CL2012001300A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120101667A (ko) | 2012-09-14 |
| MX2012006524A (es) | 2012-07-17 |
| TW201144282A (en) | 2011-12-16 |
| EA201200820A1 (ru) | 2013-01-30 |
| IL219274A0 (en) | 2012-06-28 |
| CN102596908A (zh) | 2012-07-18 |
| CA2782384A1 (en) | 2011-06-16 |
| WO2011071730A1 (en) | 2011-06-16 |
| AR079324A1 (es) | 2012-01-18 |
| BR112012013582A2 (pt) | 2016-07-05 |
| JP2013512954A (ja) | 2013-04-18 |
| IN2012DN05081A (OSRAM) | 2015-10-09 |
| PH12012501153A1 (en) | 2012-10-22 |
| US20110137042A1 (en) | 2011-06-09 |
| EP2509952A1 (en) | 2012-10-17 |
| AU2010328480A1 (en) | 2012-05-17 |
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