CL2012000582A1 - Formas polimorfas de 5-amino-1-(4-(4-clorobenzoil)-3,5-diclorobencil)-1,2,3-triazol-4-carboxamida y de su sal de acido orotico; metodos de preparacion; y uso en el tratamiento de canceres solidos, degeneracion macular, retinopatia, leucemia mieloide cronica y sida. - Google Patents
Formas polimorfas de 5-amino-1-(4-(4-clorobenzoil)-3,5-diclorobencil)-1,2,3-triazol-4-carboxamida y de su sal de acido orotico; metodos de preparacion; y uso en el tratamiento de canceres solidos, degeneracion macular, retinopatia, leucemia mieloide cronica y sida.Info
- Publication number
- CL2012000582A1 CL2012000582A1 CL2012000582A CL2012000582A CL2012000582A1 CL 2012000582 A1 CL2012000582 A1 CL 2012000582A1 CL 2012000582 A CL2012000582 A CL 2012000582A CL 2012000582 A CL2012000582 A CL 2012000582A CL 2012000582 A1 CL2012000582 A1 CL 2012000582A1
- Authority
- CL
- Chile
- Prior art keywords
- triazole
- aids
- polymorphic forms
- preparation
- treatment
- Prior art date
Links
- 208000030507 AIDS Diseases 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000007787 solid Substances 0.000 title abstract 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 title 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 title 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 title 1
- 208000017442 Retinal disease Diseases 0.000 title 1
- 206010038923 Retinopathy Diseases 0.000 title 1
- WNRZHQBJSXRYJK-UHFFFAOYSA-N carboxyamidotriazole Chemical compound NC1=C(C(=O)N)N=NN1CC(C=C1Cl)=CC(Cl)=C1C(=O)C1=CC=C(Cl)C=C1 WNRZHQBJSXRYJK-UHFFFAOYSA-N 0.000 title 1
- 208000002780 macular degeneration Diseases 0.000 title 1
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical class OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 1,2,3-triazole orotate derivative compounds Chemical class 0.000 abstract 1
- 150000000177 1,2,3-triazoles Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58444809A | 2009-09-04 | 2009-09-04 | |
| US12/807,415 US8377973B2 (en) | 2009-09-04 | 2010-09-03 | Compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2012000582A1 true CL2012000582A1 (es) | 2012-09-07 |
Family
ID=43648255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012000582A CL2012000582A1 (es) | 2009-09-04 | 2012-03-02 | Formas polimorfas de 5-amino-1-(4-(4-clorobenzoil)-3,5-diclorobencil)-1,2,3-triazol-4-carboxamida y de su sal de acido orotico; metodos de preparacion; y uso en el tratamiento de canceres solidos, degeneracion macular, retinopatia, leucemia mieloide cronica y sida. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8377973B2 (enExample) |
| EP (2) | EP2473051B1 (enExample) |
| JP (4) | JP2013503861A (enExample) |
| KR (1) | KR101597338B1 (enExample) |
| CN (2) | CN102595904B (enExample) |
| AP (1) | AP3345A (enExample) |
| AU (1) | AU2010290049B2 (enExample) |
| BR (1) | BR112012004539A2 (enExample) |
| CA (1) | CA2772075C (enExample) |
| CL (1) | CL2012000582A1 (enExample) |
| HK (1) | HK1212983A1 (enExample) |
| IL (1) | IL218430A0 (enExample) |
| MX (2) | MX2012002730A (enExample) |
| MY (1) | MY159430A (enExample) |
| NZ (2) | NZ598482A (enExample) |
| PH (1) | PH12015502088A1 (enExample) |
| RU (1) | RU2594155C2 (enExample) |
| SG (1) | SG178413A1 (enExample) |
| WO (1) | WO2011028288A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8877785B2 (en) * | 2009-09-04 | 2014-11-04 | Tactical Therapeutics Inc | Methods and compositions for enhancing sensitivity of cytotoxic drugs with timely combinatorial therapy with carboxyamidotriazole orotate |
| US9089570B2 (en) * | 2010-09-03 | 2015-07-28 | Tactical Therapeutics Inc | Compositions for treating cancers having acquired resitance to prior chemotherapeutic and targeted drugs using carboxyamidotriazole orotate |
| US10378059B2 (en) * | 2013-08-02 | 2019-08-13 | Tactical Therapeutics, Inc. | Methods and molecular pharmacodynamic biomarkers for multiple signaling pathways in response to carboxyamidotriazole orotate |
| KR102623581B1 (ko) * | 2016-07-18 | 2024-01-11 | 일동제약(주) | 항바이러스성 약물의 오로트산염, 이의 제조 방법 및 상기 염을 포함하는 약제학적 조성물 |
| CN112083109B (zh) * | 2019-07-08 | 2021-05-25 | 广东银珠医药科技有限公司 | 羧胺三唑杂质及其制备方法和检测方法 |
| US20220168276A1 (en) * | 2020-08-05 | 2022-06-02 | Tactical Therapeotics Inc. | Mehods and Compositions for Treating SARS-CoV-2 Infection using Carboxyamidotriazole Orotate |
| CN112358451B (zh) * | 2021-01-11 | 2021-04-13 | 广东银珠医药科技有限公司 | 羧胺三唑的合成方法 |
| CN113582935A (zh) * | 2021-08-27 | 2021-11-02 | 中国医学科学院放射医学研究所 | 一种炎症小体核苷酸结合寡聚化结构域样受体蛋白3抑制剂及其制备方法和应用 |
| CN113620892B (zh) * | 2021-10-12 | 2022-02-22 | 广东银珠医药科技有限公司 | 羧胺三唑单晶、制备方法及其组合物和用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2415740C2 (de) | 1974-04-01 | 1983-12-01 | Servomed Arznei GmbH & Co Pharma KG, 8000 München | Verwendung von Orotsäure bei der analgetischen Behandlung mit Dextropropoxyphen, Natriumsalicylat oder Metamizol |
| US4590201A (en) * | 1984-02-02 | 1986-05-20 | Merck & Co., Inc. | 5-amino or substituted amino 1,2,3-triazoles |
| US4847257A (en) * | 1987-08-20 | 1989-07-11 | Merck & Co., Inc. | 5-Amino or substituted amino 1,2,3,-triazoles useful as antiproliferative agents |
| JPH0356417A (ja) * | 1989-05-08 | 1991-03-12 | Merck & Co Inc | 抗転移剤として有用な５―アミノ又は置換アミノ１，２，３―トリアゾール類 |
| US5359078A (en) | 1989-05-19 | 1994-10-25 | The United States Of America As Represented By The Department Of Health And Human Services | Signal transduction inhibitor compounds |
| US5132315A (en) * | 1989-05-19 | 1992-07-21 | The United States Of America As Represented By The Department Of Health And Human Services | Therapeutic application of an anti-invasive compound |
| WO1997003668A1 (en) * | 1995-07-21 | 1997-02-06 | Constantia Gruppe | Treatment and prevention of neoplasms with salts of aminoimidazole carboxamide and 5-amino or substituted amino 1,2,3-triazoles |
| US5728707A (en) * | 1995-07-21 | 1998-03-17 | Constantia Gruppe | Treatment and prevention of primary and metastatic neoplasms with salts of aminoimidazole carboxamide |
| TW403740B (en) * | 1997-06-10 | 2000-09-01 | Novartis Ag | Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide |
| EP1753753A1 (en) * | 2004-05-25 | 2007-02-21 | AstraZeneca AB | 3-(4-(2-dihydroisoxazol-3-ylpyrdin-5-yl)phenyl)-5-triazol-1-ylmethyloxazolidin-2-one derivatives as mao inhibitors for the treatment of bacterial infections |
| US8034823B2 (en) * | 2005-02-22 | 2011-10-11 | Savvipharm Inc | Method of increasing drug oral bioavailability and compositions of less toxic orotate salts |
| US8299267B2 (en) * | 2007-09-24 | 2012-10-30 | Comentis, Inc. | (3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating |
| US20150323994A1 (en) * | 2014-05-07 | 2015-11-12 | Immersion Corporation | Dynamic haptic effect modification |
| JP2017150532A (ja) * | 2016-02-23 | 2017-08-31 | Ntn株式会社 | 回転伝達装置 |
-
2010
- 2010-09-03 KR KR1020127008653A patent/KR101597338B1/ko active Active
- 2010-09-03 MY MYPI2012000629A patent/MY159430A/en unknown
- 2010-09-03 AU AU2010290049A patent/AU2010290049B2/en active Active
- 2010-09-03 JP JP2012527868A patent/JP2013503861A/ja active Pending
- 2010-09-03 BR BR112012004539-3A patent/BR112012004539A2/pt not_active Application Discontinuation
- 2010-09-03 SG SG2012010294A patent/SG178413A1/en unknown
- 2010-09-03 CN CN201080050000.2A patent/CN102595904B/zh active Active
- 2010-09-03 MX MX2012002730A patent/MX2012002730A/es active IP Right Grant
- 2010-09-03 EP EP10814093.0A patent/EP2473051B1/en active Active
- 2010-09-03 NZ NZ598482A patent/NZ598482A/en unknown
- 2010-09-03 WO PCT/US2010/002430 patent/WO2011028288A1/en not_active Ceased
- 2010-09-03 RU RU2012111454/04A patent/RU2594155C2/ru active
- 2010-09-03 EP EP15178128.3A patent/EP2963023B1/en active Active
- 2010-09-03 CA CA2772075A patent/CA2772075C/en active Active
- 2010-09-03 US US12/807,415 patent/US8377973B2/en active Active
- 2010-09-03 CN CN201510116934.6A patent/CN104817507A/zh active Pending
- 2010-09-03 AP AP2012006187A patent/AP3345A/xx active
-
2012
- 2012-03-01 IL IL218430A patent/IL218430A0/en unknown
- 2012-03-02 MX MX2014012090A patent/MX355198B/es unknown
- 2012-03-02 CL CL2012000582A patent/CL2012000582A1/es unknown
-
2013
- 2013-02-27 NZ NZ624636A patent/NZ624636A/en unknown
-
2015
- 2015-09-11 PH PH12015502088A patent/PH12015502088A1/en unknown
- 2015-11-02 JP JP2015215891A patent/JP2016026213A/ja active Pending
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2016
- 2016-01-29 HK HK16101046.4A patent/HK1212983A1/zh unknown
-
2017
- 2017-08-03 JP JP2017150532A patent/JP2017203038A/ja active Pending
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2020
- 2020-01-31 JP JP2020014827A patent/JP2020105178A/ja active Pending
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