CL2012000452A1 - Acido nucleico infeccioso de virus torque teno porcino (pttv), que comprende secuencia que codifica un pttv infeccioso con una secuencia genomica de pttv 1a-va; acido nucleico, plasmido y celula hospedera que la comprenden; pttv infeccioso no virulento; vacuna. - Google Patents

Acido nucleico infeccioso de virus torque teno porcino (pttv), que comprende secuencia que codifica un pttv infeccioso con una secuencia genomica de pttv 1a-va; acido nucleico, plasmido y celula hospedera que la comprenden; pttv infeccioso no virulento; vacuna.

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Publication number
CL2012000452A1
CL2012000452A1 CL2012000452A CL2012000452A CL2012000452A1 CL 2012000452 A1 CL2012000452 A1 CL 2012000452A1 CL 2012000452 A CL2012000452 A CL 2012000452A CL 2012000452 A CL2012000452 A CL 2012000452A CL 2012000452 A1 CL2012000452 A1 CL 2012000452A1
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CL
Chile
Prior art keywords
pttv
infectious
nucleic acid
vaccine
plasmid
Prior art date
Application number
CL2012000452A
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English (en)
Inventor
Xiang Jin Huang Yaowei Meng
Original Assignee
Virginia Tech Intellectual Properties Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Virginia Tech Intellectual Properties Inc filed Critical Virginia Tech Intellectual Properties Inc
Publication of CL2012000452A1 publication Critical patent/CL2012000452A1/es

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/00021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/00022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/00034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/085—Picornaviridae, e.g. coxsackie virus, echovirus, enterovirus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)

Abstract

Ácido nucleico infeccioso de virus torque teno porcino (PTTV), que comprende secuencia que codifica un PTTV infeccioso con al menos 85% de homología con una secuencia genómica seleccionada entre PTTV 1A-VA, 1B-VA, 2B-VA y 2C-VA; ácido nucleico, plásmido y célula hospedera que la comprenden; PTTV infeccioso no virulento; vacuna.
CL2012000452A 2009-08-21 2012-02-22 Acido nucleico infeccioso de virus torque teno porcino (pttv), que comprende secuencia que codifica un pttv infeccioso con una secuencia genomica de pttv 1a-va; acido nucleico, plasmido y celula hospedera que la comprenden; pttv infeccioso no virulento; vacuna. CL2012000452A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23583309P 2009-08-21 2009-08-21
US31651910P 2010-03-23 2010-03-23
US12/861,378 US9228242B2 (en) 2009-08-21 2010-08-23 Porcine torque teno virus vaccines and diagnosis

Publications (1)

Publication Number Publication Date
CL2012000452A1 true CL2012000452A1 (es) 2013-07-05

Family

ID=43605547

Family Applications (4)

Application Number Title Priority Date Filing Date
CL2012000452A CL2012000452A1 (es) 2009-08-21 2012-02-22 Acido nucleico infeccioso de virus torque teno porcino (pttv), que comprende secuencia que codifica un pttv infeccioso con una secuencia genomica de pttv 1a-va; acido nucleico, plasmido y celula hospedera que la comprenden; pttv infeccioso no virulento; vacuna.
CL2014003562A CL2014003562A1 (es) 2009-08-21 2014-12-29 Acido nucleico infeccioso de virus torque teno porcino (pttv) que comprende secuencia que codifica un pttv infeccioso con una secuencia genómica de pttv 2b-va; acido nucleico, plásmido y célula hospedera que la comprenden; pttv infeccioso no virulento; vacuna
CL2014003561A CL2014003561A1 (es) 2009-08-21 2014-12-29 Ácido nucleico infeccioso de virus torque teno porcino (pttv) que comprende secuencia que codifica un pttv infeccioso con una secuencia genómica de pttv 1b-va; ácido nucleico, plásmido y célula hospedera que la comprenden; pttv infeccioso no virulento; vacuna.
CL2014003563A CL2014003563A1 (es) 2009-08-21 2014-12-29 Acido nucleico infeccioso de virus torque teno porcino (pttv) que comprende secuencia que codifica un pttv infeccioso con una secuencia genómica de pttv 2c-va; acido nucleico, plásmido y célula hospedera que la comprenden; pttv infeccioso no virulento; vacuna

Family Applications After (3)

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CL2014003562A CL2014003562A1 (es) 2009-08-21 2014-12-29 Acido nucleico infeccioso de virus torque teno porcino (pttv) que comprende secuencia que codifica un pttv infeccioso con una secuencia genómica de pttv 2b-va; acido nucleico, plásmido y célula hospedera que la comprenden; pttv infeccioso no virulento; vacuna
CL2014003561A CL2014003561A1 (es) 2009-08-21 2014-12-29 Ácido nucleico infeccioso de virus torque teno porcino (pttv) que comprende secuencia que codifica un pttv infeccioso con una secuencia genómica de pttv 1b-va; ácido nucleico, plásmido y célula hospedera que la comprenden; pttv infeccioso no virulento; vacuna.
CL2014003563A CL2014003563A1 (es) 2009-08-21 2014-12-29 Acido nucleico infeccioso de virus torque teno porcino (pttv) que comprende secuencia que codifica un pttv infeccioso con una secuencia genómica de pttv 2c-va; acido nucleico, plásmido y célula hospedera que la comprenden; pttv infeccioso no virulento; vacuna

Country Status (19)

Country Link
US (2) US9228242B2 (es)
EP (2) EP2851428B1 (es)
JP (3) JP6002036B2 (es)
KR (3) KR101721090B1 (es)
CN (2) CN102712930B (es)
AU (1) AU2010292848B2 (es)
BR (1) BR112012003844B1 (es)
CA (1) CA2771771C (es)
CL (4) CL2012000452A1 (es)
CO (1) CO6531416A2 (es)
ES (1) ES2767781T3 (es)
HK (1) HK1249111A1 (es)
IN (1) IN2012DN02305A (es)
MX (1) MX344015B (es)
PL (1) PL2851428T3 (es)
RU (1) RU2553223C2 (es)
SG (1) SG178512A1 (es)
WO (1) WO2011031438A2 (es)
ZA (1) ZA201201949B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2851428B1 (en) 2009-08-21 2019-04-10 Virginia Tech Intellectual Properties, Inc. Porcine torque teno virus vaccines and diagnosis
EP2530170A1 (en) * 2011-05-31 2012-12-05 Intervet International BV Torque Teno virus diagnostics
CN102590503B (zh) * 2012-01-20 2015-02-25 四川农业大学 一种猪细环病毒ⅱ型抗体间接阻断elisa检测试剂盒
CN103376317B (zh) * 2012-04-12 2015-11-18 徐超 不同疫苗适用性与经济性的现场判定方法
EP2653562A1 (en) * 2012-04-20 2013-10-23 Institut Pasteur Anellovirus genome quantification as a biomarker of immune suppression
CN102998453B (zh) * 2012-11-23 2014-10-08 广东海大畜牧兽医研究院有限公司 一种猪Ⅰ型细环病毒TTSuV1抗体间接ELISA诊断试剂盒及其制备方法
CN103014056B (zh) * 2012-11-23 2014-12-10 广东海大畜牧兽医研究院有限公司 一种猪Ⅱ型细环病毒TTSuV2-ORF1截短蛋白的酵母表达及应用
CN103235121B (zh) * 2013-03-18 2015-08-05 江苏省农业科学院 一种检测猪输血传播病毒2型抗体的间接elisa试剂盒
EP3362467A4 (en) * 2015-10-16 2019-06-12 Kansas State University Research Foundation IMMUNOGENIC COMPOSITIONS AGAINST PORCINIC CIRCOVIRUS TYPE 3 AND METHODS OF MAKING AND USING SAME
CN107604098A (zh) * 2017-11-03 2018-01-19 福建省农业科学院畜牧兽医研究所 用于检测鸽TTV的EvaGreen实时荧光定量PCR引物及试剂盒
CN109061161B (zh) * 2018-11-14 2019-02-15 湖南省植物保护研究所 用于检测辣椒脉黄病毒的检测试剂盒及其应用
AU2021288320A1 (en) * 2020-06-12 2023-01-19 Flagship Pioneering Innovations V, Inc. Tandem anellovirus constructs
IL303892A (en) * 2020-12-23 2023-08-01 Flagship Pioneering Innovations V Inc In vitro assembly of RNA-encapsulating enalavirus capsids

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CN1061377C (zh) * 1996-12-13 2001-01-31 中国预防医学科学院病毒学研究所 能用于包装重组腺病毒伴随病毒的单疱病毒载体及其用途
CN1704119A (zh) * 2004-05-28 2005-12-07 上海佳牧生物制品有限公司 猪细小病毒病油乳剂灭活疫苗
CA2664783A1 (en) * 2006-10-05 2008-10-23 Cerebus Biologicals, Inc. Methods for treating, preventing and diagnosing porcine ttv infection
KR101320192B1 (ko) * 2008-10-16 2013-10-30 조에티스 엘엘씨 토크 테노 바이러스(ｔｔｖ) 분리물 및 조성물
EP2851428B1 (en) 2009-08-21 2019-04-10 Virginia Tech Intellectual Properties, Inc. Porcine torque teno virus vaccines and diagnosis

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ZA201201949B (en) 2013-05-29
US20160216263A1 (en) 2016-07-28
US20110045019A1 (en) 2011-02-24
US9897605B2 (en) 2018-02-20
HK1249111A1 (zh) 2018-10-26
CO6531416A2 (es) 2012-09-28
EP2851428A3 (en) 2015-04-29
EP2467484A4 (en) 2013-06-12
KR101640062B1 (ko) 2016-07-18
JP2015221819A (ja) 2015-12-10
CN102712930A (zh) 2012-10-03
JP6126176B2 (ja) 2017-05-10
KR20140127903A (ko) 2014-11-04
ES2767781T3 (es) 2020-06-18
CN107522775A (zh) 2017-12-29
BR112012003844A2 (pt) 2016-11-16
EP2851428A2 (en) 2015-03-25
MX344015B (es) 2016-12-02
PL2851428T3 (pl) 2019-12-31
WO2011031438A9 (en) 2011-08-18
CL2014003562A1 (es) 2015-04-24
CN102712930B (zh) 2017-06-13
BR112012003844B1 (pt) 2021-05-04
KR101721090B1 (ko) 2017-03-29
JP2013502229A (ja) 2013-01-24
JP2017171663A (ja) 2017-09-28
EP2467484A2 (en) 2012-06-27
KR20140110101A (ko) 2014-09-16
WO2011031438A2 (en) 2011-03-17
MX2012002273A (es) 2012-09-07
CA2771771C (en) 2018-09-11
WO2011031438A3 (en) 2011-06-30
EP2851428B1 (en) 2019-04-10
SG178512A1 (en) 2012-03-29
CA2771771A1 (en) 2011-03-17
CL2014003561A1 (es) 2015-04-24
JP6002036B2 (ja) 2016-10-05
US9228242B2 (en) 2016-01-05
IN2012DN02305A (es) 2015-08-21
AU2010292848B2 (en) 2014-11-27
CL2014003563A1 (es) 2015-04-17
RU2553223C2 (ru) 2015-06-10
KR20120063489A (ko) 2012-06-15
AU2010292848A1 (en) 2012-04-12
RU2012110303A (ru) 2013-09-27

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