CL2011003162A1 - Celula huesped recombinante de yarrowia sp. que produce un aceite que comprende al menos 50% en peso de acido eicosapentaenoico (epa) y tiene una relacion epa: acido linoleico de al menos 3,1:1; y metodo para elaborar un aceite microbiano que comprende epa. - Google Patents
Celula huesped recombinante de yarrowia sp. que produce un aceite que comprende al menos 50% en peso de acido eicosapentaenoico (epa) y tiene una relacion epa: acido linoleico de al menos 3,1:1; y metodo para elaborar un aceite microbiano que comprende epa.Info
- Publication number
- CL2011003162A1 CL2011003162A1 CL2011003162A CL2011003162A CL2011003162A1 CL 2011003162 A1 CL2011003162 A1 CL 2011003162A1 CL 2011003162 A CL2011003162 A CL 2011003162A CL 2011003162 A CL2011003162 A CL 2011003162A CL 2011003162 A1 CL2011003162 A1 CL 2011003162A1
- Authority
- CL
- Chile
- Prior art keywords
- epa
- delta
- oil
- desatures
- tfa
- Prior art date
Links
- 235000020673 eicosapentaenoic acid Nutrition 0.000 title abstract 4
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 title abstract 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 title abstract 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 title abstract 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 title abstract 2
- 235000020778 linoleic acid Nutrition 0.000 title abstract 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 title abstract 2
- 241000490645 Yarrowia sp. Species 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000000813 microbial effect Effects 0.000 title 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 3
- 229930195729 fatty acid Natural products 0.000 abstract 3
- 239000000194 fatty acid Substances 0.000 abstract 3
- 150000004665 fatty acids Chemical class 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 239000003921 oil Substances 0.000 abstract 2
- 102100026665 Malonate-CoA ligase ACSF3, mitochondrial Human genes 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 241000235015 Yarrowia lipolytica Species 0.000 abstract 1
- 230000008436 biogenesis Effects 0.000 abstract 1
- 108010022240 delta-8 fatty acid desaturase Proteins 0.000 abstract 1
- 108010089734 malonyl-CoA synthetase Proteins 0.000 abstract 1
- 210000002824 peroxisome Anatomy 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6458—Glycerides by transesterification, e.g. interesterification, ester interchange, alcoholysis or acidolysis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18736609P | 2009-06-16 | 2009-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2011003162A1 true CL2011003162A1 (es) | 2012-07-20 |
Family
ID=43356704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011003162A CL2011003162A1 (es) | 2009-06-16 | 2011-12-15 | Celula huesped recombinante de yarrowia sp. que produce un aceite que comprende al menos 50% en peso de acido eicosapentaenoico (epa) y tiene una relacion epa: acido linoleico de al menos 3,1:1; y metodo para elaborar un aceite microbiano que comprende epa. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2475679B1 (https=) |
| JP (1) | JP5893555B2 (https=) |
| CN (1) | CN102803289B (https=) |
| AU (1) | AU2010260231B2 (https=) |
| BR (1) | BRPI1009649A2 (https=) |
| CA (1) | CA2761589C (https=) |
| CL (1) | CL2011003162A1 (https=) |
| DK (1) | DK2475679T3 (https=) |
| WO (1) | WO2010147904A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120040076A1 (en) * | 2010-08-11 | 2012-02-16 | E. I. Du Pont De Nemours And Company | Aquaculture feed compositions |
| CA2877334A1 (en) * | 2012-06-19 | 2013-12-27 | E. I. Du Pont De Nemours And Company | Mutant acyl-coa:lysophosphatidylcholine acyltransferases |
| CN108330114B (zh) * | 2018-03-21 | 2020-11-03 | 北京大学 | 一种利用epa的甘油二酯酰基转移酶及其应用 |
| WO2020082221A1 (zh) * | 2018-10-23 | 2020-04-30 | 利时雨 | 重组磷酸胆碱胞苷转移酶的粘红酵母携带外源多肽的活细胞脂质体及其应用 |
| CN117568177A (zh) * | 2023-11-16 | 2024-02-20 | 鲁东大学 | 一种解脂耶氏酵母提取物的制备方法及应用 |
| CN121699770A (zh) * | 2026-02-12 | 2026-03-20 | 中国水产科学研究院黄海水产研究所 | 合成多不饱和脂肪酸结合型磷脂的酵母工程菌及构建方法和应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4670285A (en) | 1982-08-06 | 1987-06-02 | The University Of Toronto Innovations Foundation | Infant formula |
| US5648564A (en) | 1995-12-21 | 1997-07-15 | Kemin Industries, Inc. | Process for the formation, isolation and purification of comestible xanthophyll crystals from plants |
| US6797303B2 (en) | 2001-09-04 | 2004-09-28 | Lycored Natural Products Industries Ltd. | Carotenoid extraction process |
| CA2517253C (en) * | 2003-02-27 | 2018-07-03 | Basf Plant Science Gmbh | Method for the production of polyunsaturated fatty acids |
| EP1613746B1 (de) | 2003-03-31 | 2013-03-06 | University Of Bristol | Neue pflanzliche acyltransferasen spezifisch für langkettige, mehrfach ungesättigte fettsäuren |
| US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7259255B2 (en) | 2003-06-25 | 2007-08-21 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
| US7504259B2 (en) | 2003-11-12 | 2009-03-17 | E. I. Du Pont De Nemours And Company | Δ12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast |
| CN101018862B (zh) * | 2004-04-22 | 2013-10-09 | 联邦科学技术研究组织 | 用重组细胞合成长链多不饱和脂肪酸 |
| US7256033B2 (en) | 2004-06-25 | 2007-08-14 | E. I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7550286B2 (en) * | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
| DE102004062294A1 (de) | 2004-12-23 | 2006-07-06 | Basf Plant Science Gmbh | Verfahren zur Herstellung von mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen |
| US7772444B2 (en) | 2005-05-19 | 2010-08-10 | E. I. Du Pont De Nemours And Company | Method for the production of resveratrol in a recombinant oleaginous microorganism |
| US7470532B2 (en) | 2005-10-19 | 2008-12-30 | E.I. Du Pont De Nemours And Company | Mortierella alpina C16/18 fatty acid elongase |
| AU2006316610B2 (en) | 2005-11-23 | 2012-06-14 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| CA2663807C (en) | 2006-10-30 | 2018-05-01 | E.I. Du Pont De Nemours And Company | .delta.17 desaturase and its use in making polyunsaturated fatty acids |
| US7709239B2 (en) | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| US8846374B2 (en) | 2006-12-12 | 2014-09-30 | E I Du Pont De Nemours And Company | Carotenoid production in a recombinant oleaginous yeast |
| DK2129777T3 (en) | 2007-04-03 | 2016-01-25 | Du Pont | MULTIZYMER AND USE THEREOF FOR THE PRODUCTION OF polyunsaturated fatty acids |
| WO2009001315A2 (en) | 2007-06-26 | 2008-12-31 | Staahl Ulf | Use of a class of genes encoding lysophospholipid acyl transferases for application in agriculture, biotechnology, and medicine |
| CA2707372C (en) | 2007-07-23 | 2015-11-24 | Suntory Holdings Limited | Fatty acid compositions having novel fatty acid rate |
| US20090117253A1 (en) * | 2007-10-03 | 2009-05-07 | E. I. Du Pont De Nemours And Company | Peroxisome biogenesis factor protein (pex) disruptions for altering polyunsaturated fatty acids and total lipid content in oleaginous eukaryotic organisms |
| JP5658034B2 (ja) * | 2007-10-03 | 2015-01-21 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | 油性真核生物中の多価不飽和脂肪酸および総脂質含量を変更するためのペルオキシソーム生合成因子（ｐｅｘ）タンパク質の中断 |
| AU2009335903B2 (en) | 2008-12-18 | 2016-04-14 | E. I. Du Pont De Nemours And Company | Reducing byproduction of malonates in a fermentation process |
-
2010
- 2010-06-14 EP EP10790007.8A patent/EP2475679B1/en not_active Not-in-force
- 2010-06-14 AU AU2010260231A patent/AU2010260231B2/en not_active Ceased
- 2010-06-14 DK DK10790007.8T patent/DK2475679T3/da active
- 2010-06-14 CN CN201080026332.7A patent/CN102803289B/zh not_active Expired - Fee Related
- 2010-06-14 JP JP2012516173A patent/JP5893555B2/ja not_active Expired - Fee Related
- 2010-06-14 CA CA2761589A patent/CA2761589C/en not_active Expired - Fee Related
- 2010-06-14 BR BRPI1009649A patent/BRPI1009649A2/pt not_active IP Right Cessation
- 2010-06-14 WO PCT/US2010/038535 patent/WO2010147904A1/en not_active Ceased
-
2011
- 2011-12-15 CL CL2011003162A patent/CL2011003162A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2761589A1 (en) | 2010-12-23 |
| EP2475679A4 (en) | 2013-04-03 |
| AU2010260231B2 (en) | 2017-03-02 |
| CA2761589C (en) | 2017-12-19 |
| EP2475679A1 (en) | 2012-07-18 |
| JP5893555B2 (ja) | 2016-03-23 |
| CN102803289B (zh) | 2015-07-22 |
| DK2475679T3 (da) | 2016-05-09 |
| BRPI1009649A2 (pt) | 2016-03-15 |
| JP2012529913A (ja) | 2012-11-29 |
| EP2475679B1 (en) | 2016-02-10 |
| WO2010147904A1 (en) | 2010-12-23 |
| CN102803289A (zh) | 2012-11-28 |
| AU2010260231A8 (en) | 2011-11-17 |
| AU2010260231A1 (en) | 2011-11-10 |
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