CL2011003097A1 - Compuestos derivados fluorados de amino-triazol, agonistas del receptor alx; composicion farmaceutica que comprende a uno de los compuestos; y su uso en la preparacion de medicamentos para el tratamiento de enfermedades inflamatorias, enfermedades obstructivas de las vias respiratorias, trastornos cardiovasculares y otras. - Google Patents

Compuestos derivados fluorados de amino-triazol, agonistas del receptor alx; composicion farmaceutica que comprende a uno de los compuestos; y su uso en la preparacion de medicamentos para el tratamiento de enfermedades inflamatorias, enfermedades obstructivas de las vias respiratorias, trastornos cardiovasculares y otras.

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Publication number
CL2011003097A1
CL2011003097A1 CL2011003097A CL2011003097A CL2011003097A1 CL 2011003097 A1 CL2011003097 A1 CL 2011003097A1 CL 2011003097 A CL2011003097 A CL 2011003097A CL 2011003097 A CL2011003097 A CL 2011003097A CL 2011003097 A1 CL2011003097 A1 CL 2011003097A1
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CL
Chile
Prior art keywords
compounds
preparation
treatment
pharmaceutical composition
diseases
Prior art date
Application number
CL2011003097A
Other languages
English (en)
Spanish (es)
Inventor
Daniel Bur
Olivier Corminboeuf
Sylvaine Cren
Corinna Grisostomi
Xavier Leroy
Sylvia Richard-Bildstein
Original Assignee
Idorsia Pharmaceuticals Ltd
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Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of CL2011003097A1 publication Critical patent/CL2011003097A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Diabetes (AREA)
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  • Dermatology (AREA)
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CL2011003097A 2009-06-09 2011-12-07 Compuestos derivados fluorados de amino-triazol, agonistas del receptor alx; composicion farmaceutica que comprende a uno de los compuestos; y su uso en la preparacion de medicamentos para el tratamiento de enfermedades inflamatorias, enfermedades obstructivas de las vias respiratorias, trastornos cardiovasculares y otras. CL2011003097A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB2009052445 2009-06-09

Publications (1)

Publication Number Publication Date
CL2011003097A1 true CL2011003097A1 (es) 2012-07-06

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CL2011003097A CL2011003097A1 (es) 2009-06-09 2011-12-07 Compuestos derivados fluorados de amino-triazol, agonistas del receptor alx; composicion farmaceutica que comprende a uno de los compuestos; y su uso en la preparacion de medicamentos para el tratamiento de enfermedades inflamatorias, enfermedades obstructivas de las vias respiratorias, trastornos cardiovasculares y otras.

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CA (1) CA2760588C (cg-RX-API-DMAC7.html)
CL (1) CL2011003097A1 (cg-RX-API-DMAC7.html)
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PT2432760E (pt) 2009-05-18 2013-10-21 Actelion Pharmaceuticals Ltd Derivados de espiro [2,4] heptano ligados em ponte como agonistas do receptor fprl2 e/ou receptor alx
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TW201305150A (zh) 2010-12-07 2013-02-01 Actelion Pharmaceuticals Ltd 作為脂氧素（ａｌｘ）受體激動劑之羥基化胺基三唑衍生物
CA2816376C (en) 2010-12-07 2018-11-20 Actelion Pharmaceuticals Ltd Oxazolyl-methylether derivatives as alx receptor agonists
MA37618B1 (fr) 2012-05-16 2017-08-31 Actelion Pharmaceuticals Ltd Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx
EP2850058B1 (en) 2012-05-16 2016-07-13 Actelion Pharmaceuticals Ltd. 1-(p-tolyl)cyclopropyl substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists
ES2617863T3 (es) 2012-06-04 2017-06-20 Actelion Pharmaceuticals Ltd. Derivados de bencimidazol-prolina
SG11201502493XA (en) 2012-10-10 2015-04-29 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives
CA2902135A1 (en) 2013-03-12 2014-09-18 Actelion Pharmaceuticals Ltd Azetidine amide derivatives as orexin receptor antagonists
JP6366195B2 (ja) 2013-04-22 2018-08-01 国立大学法人 東京大学 炎症性疾患の予防又は治療剤
AR096686A1 (es) 2013-06-25 2016-01-27 Actelion Pharmaceuticals Ltd Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx
BR112016001106A8 (pt) 2013-07-18 2017-12-26 Actelion Pharmaceuticals Ltd Derivados de espiro [2,4] heptano interligados piperazina substituídos como agonistas do receptor de alx
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
ES2696708T3 (es) 2013-12-04 2019-01-17 Idorsia Pharmaceuticals Ltd Uso de derivados de bencimidazol-prolina
CA3220193A1 (en) 2021-06-01 2022-12-08 Azcuris Co., Ltd. Novel oxazole derivative and pharmaceutical composition for preventing or treating allergic diseases comprising the same

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PT2432760E (pt) 2009-05-18 2013-10-21 Actelion Pharmaceuticals Ltd Derivados de espiro [2,4] heptano ligados em ponte como agonistas do receptor fprl2 e/ou receptor alx
CN102803237B (zh) 2009-06-12 2014-09-24 埃科特莱茵药品有限公司 作为alx受体激动剂的噁唑和噻唑衍生物

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JP5095035B2 (ja) 2012-12-12
US20120101138A1 (en) 2012-04-26
CA2760588C (en) 2017-08-08
BRPI1010738A8 (pt) 2017-12-26
CN102414207B (zh) 2015-09-30
PL2440555T3 (pl) 2016-11-30
JP2012255002A (ja) 2012-12-27
MY161243A (en) 2017-04-14
US8580831B2 (en) 2013-11-12
KR101444559B1 (ko) 2014-09-26
JP2012529491A (ja) 2012-11-22
EP2440555B1 (en) 2016-05-18
AR077032A1 (es) 2011-07-27
BRPI1010738A2 (pt) 2016-03-15
ES2587139T3 (es) 2016-10-20
RU2544862C2 (ru) 2015-03-20
AU2010258334B2 (en) 2015-02-26
CN102414207A (zh) 2012-04-11
IL216792A (en) 2014-05-28
CA2760588A1 (en) 2010-12-16
ZA201200127B (en) 2014-06-25
TW201102383A (en) 2011-01-16
MX342440B (es) 2016-09-29
NZ597453A (en) 2013-03-28
KR20120089380A (ko) 2012-08-09
IL216792A0 (en) 2012-02-29
MA33420B1 (fr) 2012-07-03
SG175363A1 (en) 2011-12-29
EP2440555A1 (en) 2012-04-18
MX2011012739A (es) 2011-12-16
JP5775496B2 (ja) 2015-09-09
AU2010258334A1 (en) 2012-02-02
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TWI404717B (zh) 2013-08-11

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