CL2007002743A1 - Forma cristalina del acido 3-[5-(2-fluorofenil)-[1,2,4]oxadiazol-3-il]-benzoico; composicion farmaceutica que comprende a dicha forma cristalina; y su uso para modular la terminacion prematura de traslado o decaimiento de marn, tales como carcicoma. - Google Patents
Forma cristalina del acido 3-[5-(2-fluorofenil)-[1,2,4]oxadiazol-3-il]-benzoico; composicion farmaceutica que comprende a dicha forma cristalina; y su uso para modular la terminacion prematura de traslado o decaimiento de marn, tales como carcicoma.Info
- Publication number
- CL2007002743A1 CL2007002743A1 CL200702743A CL2007002743A CL2007002743A1 CL 2007002743 A1 CL2007002743 A1 CL 2007002743A1 CL 200702743 A CL200702743 A CL 200702743A CL 2007002743 A CL2007002743 A CL 2007002743A CL 2007002743 A1 CL2007002743 A1 CL 2007002743A1
- Authority
- CL
- Chile
- Prior art keywords
- carcicoma
- marn
- oxadiazol
- fluorophenyl
- benzoic
- Prior art date
Links
- -1 2-FLUOROPHENYL Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 230000007423 decrease Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000002028 premature Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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Landscapes
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84732606P | 2006-09-25 | 2006-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2007002743A1 true CL2007002743A1 (es) | 2008-07-11 |
Family
ID=39123850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200702743A CL2007002743A1 (es) | 2006-09-25 | 2007-09-24 | Forma cristalina del acido 3-[5-(2-fluorofenil)-[1,2,4]oxadiazol-3-il]-benzoico; composicion farmaceutica que comprende a dicha forma cristalina; y su uso para modular la terminacion prematura de traslado o decaimiento de marn, tales como carcicoma. |
Country Status (29)
| Country | Link |
|---|---|
| US (10) | US7863456B2 (https=) |
| EP (2) | EP2076501B8 (https=) |
| JP (6) | JP5714228B2 (https=) |
| KR (1) | KR101430144B1 (https=) |
| CN (3) | CN104341371A (https=) |
| AR (2) | AR062963A1 (https=) |
| AU (1) | AU2007300542B2 (https=) |
| BR (1) | BRPI0717107A2 (https=) |
| CA (1) | CA2663574C (https=) |
| CL (1) | CL2007002743A1 (https=) |
| DK (1) | DK2076501T3 (https=) |
| ES (2) | ES2655338T3 (https=) |
| HK (1) | HK1207070A1 (https=) |
| HU (1) | HUE028503T2 (https=) |
| IL (1) | IL197717A (https=) |
| LT (1) | LTC2076501I2 (https=) |
| MX (2) | MX2009003160A (https=) |
| MY (1) | MY191209A (https=) |
| NO (1) | NO341858B1 (https=) |
| NZ (1) | NZ575795A (https=) |
| PE (3) | PE20120768A1 (https=) |
| PL (2) | PL2559689T3 (https=) |
| PT (1) | PT2076501E (https=) |
| SG (2) | SG10201609581TA (https=) |
| SI (1) | SI2076501T1 (https=) |
| TW (2) | TWI496775B (https=) |
| UA (1) | UA99600C2 (https=) |
| WO (1) | WO2008039431A2 (https=) |
| ZA (1) | ZA200901949B (https=) |
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| EP4101846B1 (en) | 2003-04-11 | 2023-08-02 | PTC Therapeutics, Inc. | 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease |
| PL2402002T3 (pl) * | 2005-04-08 | 2018-11-30 | Ptc Therapeutics, Inc. | Kompozycje zawierające kwas 1,2,4-oksadiazolobenzoesowy i ich zastosowania do leczenia chorób związanych z przedwczesnym kodonem stop |
| EP2387995A1 (en) | 2006-03-30 | 2011-11-23 | PTC Therapeutics, Inc. | Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith |
| NZ575795A (en) * | 2006-09-25 | 2012-03-30 | Ptc Therapeutics Inc | Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid |
| MX2009003909A (es) | 2006-10-12 | 2009-05-25 | Ptc Therapeutics Inc | Métodos para dosificar un compuesto 1,2,4, - oxadiazol oralmente activo para el tratamiento de supresión de la mutación finalizadora. |
| PT2544679T (pt) | 2010-03-12 | 2019-07-11 | Omeros Corp | Inibidores de pde-10 e composições e métodos relacionados |
| WO2014153643A1 (en) * | 2013-03-26 | 2014-10-02 | The University Of British Columbia | Compositions and methods for use thereof in the treatment of aniridia |
| WO2014165673A1 (en) | 2013-04-03 | 2014-10-09 | Colorado Energy Research Technologies, LLC | Methods and systems for generating aldehydes from organic seed oils |
| HRP20181052T1 (hr) | 2013-09-06 | 2018-09-07 | Aurigene Discovery Technologies Limited | Derivati 1,2,4-oksadiazola kao imunomodulatori |
| TWI695717B (zh) * | 2014-03-06 | 2020-06-11 | 美商 Ptc 治療公司 | １,２,４-二唑苯甲酸之鹽及醫藥組合物 |
| NZ716494A (en) | 2014-04-28 | 2017-07-28 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
| NZ630803A (en) | 2014-04-28 | 2016-03-31 | Omeros Corp | Optically active pde10 inhibitor |
| KR101703137B1 (ko) | 2014-05-30 | 2017-02-07 | 선문대학교 산학협력단 | 당 부가 아미노글리코사이드 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 |
| CN105461650B (zh) * | 2014-09-12 | 2018-04-13 | 杭州普晒医药科技有限公司 | 一种噁二唑化合物的溶剂化物及其制备方法 |
| NZ734650A (en) | 2015-03-10 | 2023-07-28 | Aurigene Oncology Ltd | 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators |
| US9879002B2 (en) | 2015-04-24 | 2018-01-30 | Omeros Corporation | PDE10 inhibitors and related compositions and methods |
| CN108348527A (zh) | 2015-10-30 | 2018-07-31 | Ptc医疗公司 | 用于治疗癫痫的方法 |
| US9920045B2 (en) | 2015-11-04 | 2018-03-20 | Omeros Corporation | Solid state forms of a PDE10 inhibitor |
| US10960018B2 (en) * | 2016-04-15 | 2021-03-30 | The Uab Research Foundation | Methods and compounds for stimulating read-through of premature termination codons |
| EP3512516A1 (en) * | 2016-09-13 | 2019-07-24 | Marco Cipolli | Method of treatment of shwachman-diamond syndrome |
| WO2019061324A1 (en) | 2017-09-29 | 2019-04-04 | Curis Inc. | CRYSTALLINE FORMS OF IMMUNOMODULATORS |
| IL273896B2 (en) | 2017-10-11 | 2025-08-01 | Aurigene Oncology Ltd | Crystalline forms of 3-substituted 1,2,4-oxadiazole |
| AU2018360386B2 (en) | 2017-11-03 | 2023-11-09 | Aurigene Oncology Limited | Dual inhibitors of TIM-3 and PD-1 pathways |
| CN111386128A (zh) | 2017-11-06 | 2020-07-07 | 奥瑞基尼探索技术有限公司 | 用于免疫调节的联合疗法 |
| EP4473971A3 (en) | 2019-04-10 | 2025-02-19 | PTC Therapeutics, Inc. | Method for treating nonsense mutation mediated duchenne muscular dystrophy in pediatric patients |
| JP7339900B2 (ja) * | 2020-02-26 | 2023-09-06 | 新 井上 | 視野異常診断方法、視野異常診断装置 |
| KR102665711B1 (ko) * | 2021-12-21 | 2024-05-14 | 재단법인 아산사회복지재단 | Ras 활성도를 이용한 신경섬유종증 치료제에 대한 감수성 예측용 바이오마커 조성물 및 Ras 활성 억제제를 포함하는 신경섬유종증 예방 또는 치료용 약학적 조성물 |
| WO2025110781A1 (ko) * | 2023-11-24 | 2025-05-30 | 재단법인 아산사회복지재단 | Ampd3를 포함하는 신경섬유종증 치료제에 대한 감수성 예측용 바이오마커 조성물 및 ampd3 저해제를 포함하는 신경섬유종증 예방 또는 치료용 약학 조성물 |
| CN118178408A (zh) * | 2024-03-22 | 2024-06-14 | 核工业总医院 | Ptc124在制备治疗血小板无力症的药物中的应用 |
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| TW264475B (https=) | 1991-09-20 | 1995-12-01 | Takeda Pharm Industry Co Ltd | |
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| KR20040004705A (ko) | 2001-06-08 | 2004-01-13 | 시토비아 인크. | 카스파제의 활성제 및 아폽토시스의 유도제로서의 치환된3-아릴-5-아릴-[1,2,4]-옥사디아졸과 유사체 및 이의 용도 |
| MY151199A (en) | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
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| US8374966B1 (en) * | 2002-08-01 | 2013-02-12 | Oracle International Corporation | In memory streaming with disk backup and recovery of messages captured from a database redo stream |
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| GB0303503D0 (en) | 2003-02-14 | 2003-03-19 | Novartis Ag | Organic compounds |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| EP4101846B1 (en) * | 2003-04-11 | 2023-08-02 | PTC Therapeutics, Inc. | 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease |
| US20050075375A1 (en) | 2003-05-14 | 2005-04-07 | Anadys Pharmaceuticals, Inc. | Heterocyclic compounds for treating hepatitis C virus |
| EP1799659A1 (en) * | 2004-10-13 | 2007-06-27 | PTC Therapeutics, Inc. | Compounds for nonsense suppression, and methods for their use |
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| PL2402002T3 (pl) * | 2005-04-08 | 2018-11-30 | Ptc Therapeutics, Inc. | Kompozycje zawierające kwas 1,2,4-oksadiazolobenzoesowy i ich zastosowania do leczenia chorób związanych z przedwczesnym kodonem stop |
| UA99265C2 (ru) | 2006-09-08 | 2012-08-10 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способ получения 1,2,4-оксадиазолбензойной кислоты и ее производных (варианты) |
| NZ575795A (en) * | 2006-09-25 | 2012-03-30 | Ptc Therapeutics Inc | Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid |
| TWI695717B (zh) * | 2014-03-06 | 2020-06-11 | 美商 Ptc 治療公司 | １,２,４-二唑苯甲酸之鹽及醫藥組合物 |
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2007
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