CL2007002652A1 - Compuestos derivados de isoserina, inhibidores del factor de coagulacion de la sangre ixa; procedimiento de preparacion; y su uso para preparar un medicamento para tratar enfermedades acompanadas de trombosis, embolias, hipercoagulabilidad o cambios - Google Patents

Compuestos derivados de isoserina, inhibidores del factor de coagulacion de la sangre ixa; procedimiento de preparacion; y su uso para preparar un medicamento para tratar enfermedades acompanadas de trombosis, embolias, hipercoagulabilidad o cambios

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Publication number
CL2007002652A1
CL2007002652A1 CL200702652A CL2007002652A CL2007002652A1 CL 2007002652 A1 CL2007002652 A1 CL 2007002652A1 CL 200702652 A CL200702652 A CL 200702652A CL 2007002652 A CL2007002652 A CL 2007002652A CL 2007002652 A1 CL2007002652 A1 CL 2007002652A1
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CL
Chile
Prior art keywords
embolies
isoserine
hypercoagulability
thrombosis
inhibitors
Prior art date
Application number
CL200702652A
Other languages
English (en)
Spanish (es)
Inventor
Henning Follmann Ma Steinhagen
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CL2007002652A1 publication Critical patent/CL2007002652A1/es

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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CL200702652A 2006-09-13 2007-09-12 Compuestos derivados de isoserina, inhibidores del factor de coagulacion de la sangre ixa; procedimiento de preparacion; y su uso para preparar un medicamento para tratar enfermedades acompanadas de trombosis, embolias, hipercoagulabilidad o cambios CL2007002652A1 (es)

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DE102006042926 2006-09-13

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CL2007002652A1 true CL2007002652A1 (es) 2008-02-08

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US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
WO2006084033A1 (en) 2005-02-03 2006-08-10 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
US8383636B2 (en) * 2006-09-07 2013-02-26 Industrial Research Limited Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase
CN102014897B (zh) 2008-04-21 2015-08-05 西格纳姆生物科学公司 化合物、组合物和其制备方法
AU2009322342A1 (en) 2008-12-05 2011-06-30 Merck Sharp & Dohme Corp. Morpholinone compounds as factor IXa inhibitors
EP2473491B1 (en) * 2009-08-31 2013-07-17 Mochida Pharmaceutical Co., Ltd. Morpholinone compounds as factor ixa inhibitors
WO2015160636A1 (en) 2014-04-16 2015-10-22 Merck Sharp & Dohme Corp. Factor ixa inhibitors
CN109627218B (zh) * 2018-11-27 2022-03-29 深圳市龙华区中心医院 一种抗凝小分子化合物及其应用和包含其的药物

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US20090233949A1 (en) 2009-09-17
WO2008031509A1 (de) 2008-03-20
EP2069289B1 (de) 2013-10-02
UY30585A1 (es) 2008-05-02
MY150745A (en) 2014-02-28
JP5249226B2 (ja) 2013-07-31
NO20091110L (no) 2009-06-09
ZA200900807B (en) 2009-11-25
CA2663544A1 (en) 2008-03-20
KR20090050081A (ko) 2009-05-19
CN101516834A (zh) 2009-08-26
TWI394570B (zh) 2013-05-01
SG174080A1 (en) 2011-09-29
RU2446157C2 (ru) 2012-03-27
NZ575603A (en) 2011-03-31
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MX2009002047A (es) 2009-03-06
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BRPI0716991A2 (pt) 2013-10-08
IL197504A (en) 2013-06-27
MA30707B1 (fr) 2009-09-01
EP2069289A1 (de) 2009-06-17
AU2007297013A1 (en) 2008-03-20
AU2007297013B2 (en) 2012-05-31
AR063708A1 (es) 2009-02-11
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US8097758B2 (en) 2012-01-17

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