CL2004000806A1 - Compuestos derivados de quinazolinas, inhibidores de quinasa p38, composicion farmaceutica, procedimiento de preparacion, utiles para tratar artritis, enfermedad de crohn, alzheimer, asma, ataque al corazon, sepsis, infarto al miocardio y otras. - Google Patents

Compuestos derivados de quinazolinas, inhibidores de quinasa p38, composicion farmaceutica, procedimiento de preparacion, utiles para tratar artritis, enfermedad de crohn, alzheimer, asma, ataque al corazon, sepsis, infarto al miocardio y otras.

Info

Publication number
CL2004000806A1
CL2004000806A1 CL200400806A CL2004000806A CL2004000806A1 CL 2004000806 A1 CL2004000806 A1 CL 2004000806A1 CL 200400806 A CL200400806 A CL 200400806A CL 2004000806 A CL2004000806 A CL 2004000806A CL 2004000806 A1 CL2004000806 A1 CL 2004000806A1
Authority
CL
Chile
Prior art keywords
quinazolinas
miocard
infarto
quinasa
artritis
Prior art date
Application number
CL200400806A
Other languages
English (en)
Inventor
Patrick Dunn David Micha James
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2004000806A1 publication Critical patent/CL2004000806A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
CL200400806A 2003-04-16 2004-04-15 Compuestos derivados de quinazolinas, inhibidores de quinasa p38, composicion farmaceutica, procedimiento de preparacion, utiles para tratar artritis, enfermedad de crohn, alzheimer, asma, ataque al corazon, sepsis, infarto al miocardio y otras. CL2004000806A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46346703P 2003-04-16 2003-04-16

Publications (1)

Publication Number Publication Date
CL2004000806A1 true CL2004000806A1 (es) 2005-02-04

Family

ID=33300076

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200400806A CL2004000806A1 (es) 2003-04-16 2004-04-15 Compuestos derivados de quinazolinas, inhibidores de quinasa p38, composicion farmaceutica, procedimiento de preparacion, utiles para tratar artritis, enfermedad de crohn, alzheimer, asma, ataque al corazon, sepsis, infarto al miocardio y otras.

Country Status (14)

Country Link
US (2) US7238698B2 (es)
EP (1) EP1620408A2 (es)
JP (1) JP2006523638A (es)
KR (1) KR100812586B1 (es)
CN (1) CN1774425A (es)
AR (1) AR044516A1 (es)
AU (1) AU2004230209A1 (es)
BR (1) BRPI0409580A (es)
CA (1) CA2522522A1 (es)
CL (1) CL2004000806A1 (es)
MX (1) MXPA05011103A (es)
RU (1) RU2356896C2 (es)
TW (1) TW200423937A (es)
WO (1) WO2004092144A2 (es)

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JP2006523638A (ja) * 2003-04-16 2006-10-19 エフ．ホフマン−ラ　ロシュ　アーゲー キナゾリン化合物
US20050084835A1 (en) * 2003-10-16 2005-04-21 The Singing Machine Company, Inc. Karaoke system with built-in camera
US7906522B2 (en) 2005-04-28 2011-03-15 Kyowa Hakko Kirin Co., Ltd 2-aminoquinazoline derivatives
WO2006137421A1 (ja) * 2005-06-21 2006-12-28 Kyowa Hakko Kogyo Co., Ltd. 局所投与剤
FR2888749B1 (fr) * 2005-07-19 2007-10-12 Biocodex Composition pharmaceutique destinee a la prevention ou au traitement des oedemes cerebraux
FR2888748B1 (fr) * 2005-07-19 2007-10-12 Biocodex Composes neuroprotecteurs et compositions pharmaceutiques les comprenant
WO2008050808A1 (fr) * 2006-10-24 2008-05-02 Kyowa Hakko Kirin Co., Ltd. Dérivé de 2-aminoquinazoline
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
JPWO2009084695A1 (ja) 2007-12-28 2011-05-19 カルナバイオサイエンス株式会社 ２−アミノキナゾリン誘導体
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
RS55339B1 (sr) 2011-02-07 2017-03-31 Biogen Ma Inc Agensi koji moduliraju s1p
SG11201407336PA (en) 2012-05-25 2015-03-30 Janssen Sciences Ireland Uc Uracyl spirooxetane nucleosides
KR102532198B1 (ko) 2012-12-21 2023-05-11 얀센 바이오파마, 인코퍼레이트. 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체
EA036160B1 (ru) 2013-03-15 2020-10-08 Селджен Кар Ллс Гетероарильные соединения и их применение
US9321786B2 (en) 2013-03-15 2016-04-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
CA2907243C (en) 2013-03-15 2021-12-28 Celgene Avilomics Research, Inc. Substituted dihydropyrimidopyrimidinone compounds and pharmaceutical compositions thereof use fgfr4 inhibitor
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
EP4159212A1 (en) 2017-10-05 2023-04-05 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd

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DE9190155U1 (de) * 1990-11-06 1993-10-07 Pfizer Chinazolinderivate zur Steigerung der Antitumoraktivität
IL108630A0 (en) * 1993-02-18 1994-05-30 Fmc Corp Insecticidal substituted 2,4-diaminoquinazolines
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MXPA02003140A (es) * 1999-11-22 2002-09-30 Warner Lambert Co Quinazolinas y su uso para la inhibicion de las enzimas cinasa dependientes del ciclin.
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Also Published As

Publication number Publication date
US20040209904A1 (en) 2004-10-21
CN1774425A (zh) 2006-05-17
TW200423937A (en) 2004-11-16
JP2006523638A (ja) 2006-10-19
US20070167471A1 (en) 2007-07-19
MXPA05011103A (es) 2005-12-12
WO2004092144A2 (en) 2004-10-28
KR20050122264A (ko) 2005-12-28
AR044516A1 (es) 2005-09-14
US7238698B2 (en) 2007-07-03
BRPI0409580A (pt) 2006-04-18
AU2004230209A1 (en) 2004-10-28
RU2356896C2 (ru) 2009-05-27
KR100812586B1 (ko) 2008-03-13
EP1620408A2 (en) 2006-02-01
US7456185B2 (en) 2008-11-25
CA2522522A1 (en) 2004-10-28
RU2005135339A (ru) 2006-08-10
WO2004092144A3 (en) 2005-03-24

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