GB1024908A - Pyrimidine derivatives - Google Patents

Pyrimidine derivatives

Info

Publication number
GB1024908A
GB1024908A GB4351563A GB4351563A GB1024908A GB 1024908 A GB1024908 A GB 1024908A GB 4351563 A GB4351563 A GB 4351563A GB 4351563 A GB4351563 A GB 4351563A GB 1024908 A GB1024908 A GB 1024908A
Authority
GB
United Kingdom
Prior art keywords
group
guanidinoquinazoline
acylamino
aromatic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4351563A
Inventor
Joseph Patrick Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Chemicals Ltd
Original Assignee
Monsanto Chemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Chemicals Ltd filed Critical Monsanto Chemicals Ltd
Priority to GB4351563A priority Critical patent/GB1024908A/en
Publication of GB1024908A publication Critical patent/GB1024908A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention comprises 2 - (quinazol -21-ylamino)-pyrimidines and their preparation by reacting a 2-guanidinoquinazoline with a compound that forms a pyrimidine ring by cyclization with the guanidino group of the 2-guanidinoquinazoline. Particularly preferred are compounds of the formula <FORM:1024908/C2/1> wherein R and R11 are each H, NH2, OH, aromatic, or the group A; R1 is H, a halogen, acylamino, the group A or the group A-O-, or aromatic; R1, R2, R3 and R4 have the values of R1 except acylamino; and R5 is H or alkyl; A being aliphatic, alicyclic or aralkyl. Suitable cyclizing reactants are acetylacetone, ethylacetoacetate, diethylmalonate and ethyl cycano acetate. The compounds of the invention have-microbiocidal and antioxidant properties.
GB4351563A 1963-11-04 1963-11-04 Pyrimidine derivatives Expired GB1024908A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB4351563A GB1024908A (en) 1963-11-04 1963-11-04 Pyrimidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4351563A GB1024908A (en) 1963-11-04 1963-11-04 Pyrimidine derivatives

Publications (1)

Publication Number Publication Date
GB1024908A true GB1024908A (en) 1966-04-06

Family

ID=10429085

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4351563A Expired GB1024908A (en) 1963-11-04 1963-11-04 Pyrimidine derivatives

Country Status (1)

Country Link
GB (1) GB1024908A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2229697A1 (en) * 1973-05-17 1974-12-13 Upjohn Co
WO2004092144A2 (en) * 2003-04-16 2004-10-28 F. Hoffmann-La Roche Ag Quinazoline compounds useful as p38 kinase inhibitors

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2229697A1 (en) * 1973-05-17 1974-12-13 Upjohn Co
WO2004092144A2 (en) * 2003-04-16 2004-10-28 F. Hoffmann-La Roche Ag Quinazoline compounds useful as p38 kinase inhibitors
WO2004092144A3 (en) * 2003-04-16 2005-03-24 Hoffmann La Roche Quinazoline compounds useful as p38 kinase inhibitors
US7238698B2 (en) 2003-04-16 2007-07-03 Roche Palo Alto Llc Substituted quinazoline compounds useful as p38 kinase inhibitors
US7456185B2 (en) 2003-04-16 2008-11-25 Roche Palo Alto Llc Substituted quinazoline compounds useful as p38 kinase inhibitors

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